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Cited by 115Psychosomatic Disorders and Their TreatmentsHeart Rate Variability and Autonomic ControlCardiovascular Syncope and Autonomic Disorders

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Altered Patterns of Heartbeat-Evoked Potentials in Depersonalization/Derealization Disorder: Neurophysiological Evidence for Impaired Cortical Representation of Bodily Signals

Schulz, André, Köster, Susann, Beutel, Manfred E., Schächinger, Hartmut, Vögele, Claus, Rost, Silke, Rauh, Manfred, Michal, Matthias·2015·Psychosomatic Medicine
DOI 10.1097/psy.0000000000000195
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Abstract

Objective Core features of depersonalization/derealization disorder (DPD) are emotional numbing and feelings of disembodiment. Although there are several neurophysiological findings supporting subjective emotional numbing, the psychobiology of disembodiment remains unclear. Methods Heartbeat-evoked potentials (HEPs), which are considered psychophysiological indicators for the cortical representation of afferent signals originating from the cardiovascular system, were assessed in 23 patients with DPD and 24 healthy control individuals during rest and while performing a heartbeat perception task. Results Absolute HEP amplitudes did not differ between groups. Nevertheless, healthy individuals showed higher HEPs during the heartbeat perception task than during rest, whereas no such effect was found in patients with DPD (p = .031). Patients with DPD had higher total levels of salivary α-amylase than did healthy individuals (9626.6 [8200.0] versus 5344.3 [3745.8] kU min/l; p = .029), but there were no group differences in cardiovascular measures (heart rate = 76.2 [10.1] versus 74.3 [7.5] beats/min, p = .60; normalized low-frequency heart rate variability = 0.63 [0.15] versus 0.56 [0.15] normalized units, p = .099; low frequency/high frequency ratio = 249.3 [242.7] versus 164.8 [108.8], p = .10), salivary cortisol (57.5 [46.7] versus 55.1 [43.6] nmol min/l, p = .86), or cortisone levels (593.2 [260.3] versus 543.8 [257.1] nmol min/l, p = .52). Conclusions These results suggest alte…

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Metadata

Authors
Schulz, A., Köster, S., Beutel, M. E., Schächinger, H., Vögele, C., Rost, S., Rauh, M., & Michal, M.
Affiliations
University of Luxembourg (LU)
Corresponding author
Schulz, André
ORCID
Venue
Psychosomatic Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2015-06
Volume
77
Issue
5
Pages
506-516
ISSN
0033-3174 (ISSN-L)
DOI
10.1097/psy.0000000000000195
OpenAlex
W313592428
Cited by
115
References
16
Citations by year
2026: 10 · 2025: 17 · 2024: 16 · 2023: 7 · 2022: 7 · 2021: 14 · 2020: 13 · 2019: 6 · 2018: 7 · 2017: 10 · 2016: 6 · 2015: 2
FWCI
6.76
Type
journal article
Language
en
Open access
closed
Locations
  • Psychosomatic Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Open Repository and Bibliography (University of Luxembourg) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
Keywords
depersonalization disorder, heartbeat-evoked potentials, disembodiment, emotional numbing, heartbeat perception, salivary amylase, sympathetic nervous system, heart rate variability, salivary cortisol, cortisone, body awareness, psychobiology
MeSH terms
Adult, Afferent Pathways, Depersonalization, Evoked Potentials, Female, Heart Rate, Humans, Male, Neurophysiology, Young Adult, Interoception

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