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Cited by 53Asthma and respiratory diseasesAllergic Rhinitis and SensitizationFood Allergy and Anaphylaxis Research

Allergy in marathon runners and effect of Lactobacillus GG supplementation on allergic inflammatory markers

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Moreira, André, Kekkonen, Riina, Korpela, Riitta, Delgado, Luís, Haahtela, Tari·2007·Respiratory Medicine
DOI 10.1016/j.rmed.2006.11.015
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Abstract

Objective We studied the prevalence of asthma and allergy in non-elite marathon runners and investigated the effects of probiotic supplementation on allergic inflammatory markers.Methods Asthma and allergies were surveyed by questionnaire, and blood eosinophils, serum eosinophil cationic protein (ECP), total IgE, and Phadiatop were measured in 141 Finnish marathon runners who took part in the Helsinki City Marathon. They were also randomized to receive either Lactobacillus GG (LGG) or placebo during the 3 months of the pollen season prior to the marathon.Results Lifetime prevalence of physician-diagnosed asthma was 4.3% (six out of 139 athletes), of allergic rhinitis 17.3% (24/139), of food allergy 5.0% (7/139), and of atopic eczema 4.3% (6/139). Prevalence of atopy was 31% (35/112), and 21% (24/112) of the athletes were sensitized to birch pollen. Asthma or allergy medication was used by 20% (28/139) of the athletes. During pollen season, serum ECP increased significantly in all athletes, and total IgE and Phadiatop in atopics. The marathon induced a significant eosinopenia but had no effect on serum ECP or total IgE. No differences in changes were seen between groups receiving LGG or placebo.Conclusion Non-elite marathon runners have asthma and allergies similar to Finnish general population. LGG supplementation did not prevent the increase of allergic markers during the pollen season, or the eosinopenia induced by the marathon.

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  • In 141 non-elite marathon runners, 12 weeks of L. rhamnosus GG did not significantly affect allergic markers or incidence of URTI episodes.

    “For example, a 12-week study on 141 non-elite marathon runners during pollen season supplementing daily with L. rhammnosus GG (LGG) did not find a significant effect on allergic markers [54] or on the incidence of UTRI episodes [55].”

    From International Society of Sports Nutrition Position Stand: Probiotics (2019) · cites this paper as [54]

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Authors
Moreira, A., Kekkonen, R., Korpela, R., Delgado, L., & Haahtela, T.
Affiliations
  • University of Helsinki (FI)
  • Universidade do Porto (PT)
  • Helsinki University Hospital (FI)
ORCID
Venue
Respiratory Medicine
Publisher
Elsevier BV
Published
2007-06
Volume
101
Issue
6
Pages
1123-1131
ISSN
0954-6111 (ISSN-L)
DOI
10.1016/j.rmed.2006.11.015
OpenAlex
W1980097744
Cited by
53
References
38
Citations by year
2025: 3 · 2023: 1 · 2022: 7 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 5 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 4
FWCI
1.98
Type
journal article
Language
en
Open access
Licence
Locations
  • Respiratory Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
Valio
Topics
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
  • Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
Keywords
marathon runners, asthma, allergy, allergic rhinitis, atopic dermatitis, food allergy, atopy, Lactobacillus rhamnosus GG, probiotic supplementation, eosinopenia, eosinophil cationic protein, total IgE, Phadiatop, pollen season
MeSH terms
Adult, Asthma, Double-Blind Method, Eosinophilia, Female, Food Hypersensitivity, Rhinitis, Allergic, Seasonal, Humans, Hypersensitivity, Immunoglobulin E, Male, Middle Aged, Pollen, Running, Treatment Outcome, Inflammation Mediators, Probiotics, Eosinophil Cationic Protein, Lacticaseibacillus rhamnosus

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