Development and application of prime editing in plants

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J. A., & Charpentier, E. (2012) · Science · doi:10.1126/science.1225829 · Cited by 17,116 · see citing works

Multiplex Genome Engineering Using CRISPR/Cas Systems

Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339 · see citing works

RNA-Guided Human Genome Engineering via Cas9

Mali, P., Yang, L., Esvelt, K. M., Aach, J., Guell, M., DiCarlo, J. E., Norville, J. E., & Church, G. M. (2013) · Science · doi:10.1126/science.1232033 · Cited by 9,210 · see citing works

Search-and-replace genome editing without double-strand breaks or donor DNA

Anzalone, A. V., Randolph, P. B., Davis, J. R., Sousa, A. A., Koblan, L. W., Levy, J. M., Chen, P. J., Wilson, C., Newby, G. A., Raguram, A., et al. (2019) · Nature · doi:10.1038/s41586-019-1711-4 · Cited by 4,767 · see citing works

Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

Gaudelli, N. M., Komor, A. C., Rees, H. A., Packer, M. S., Badran, A. H., Bryson, D. I., & Liu, D. R. (2017) · Nature · doi:10.1038/nature24644 · Cited by 4,184 · see citing works

Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors

Boch, J., Scholze, H., Schornack, S., Landgraf, A., Hahn, S., Kay, S., Lahaye, T., Nickstadt, A., & Bonas, U. (2009) · Science · doi:10.1126/science.1178811 · Cited by 2,707 · see citing works

A Simple Cipher Governs DNA Recognition by TAL Effectors

Moscou, M., & Bogdanove, A. J. (2009) · Science · doi:10.1126/science.1178817 · Cited by 1,992 · see citing works

Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements

Kosicki, M., Tomberg, K., & Bradley, A. (2018) · Nature Biotechnology · doi:10.1038/nbt.4192 · Cited by 1,883 · see citing works

Evolution in Action: Plants Resistant to Herbicides

Powles, S. B., & Yu, Q. P. (2010) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042809-112119 · Cited by 1,726 · see citing works

Genome engineering for crop improvement and future agriculture

Gao, C. (2021) · Cell · doi:10.1016/j.cell.2021.01.005 · Cited by 1,037 · see citing works

Prime genome editing in rice and wheat

Lin, Q., Zong, Y., Xue, C., Wang, S., Jin, S., Zhu, Z., Wang, Y., Anzalone, A. V., Raguram, A., Doman, J. L., et al. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0455-x · Cited by 873 · see citing works

Applications of CRISPR–Cas in agriculture and plant biotechnology

Zhu, H., Li, C., & Gao, C. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00288-9 · Cited by 870 · see citing works

Broad-spectrum resistance to bacterial blight in rice using genome editing

Oliva, R. F., Ji, C., Atienza, G., Huguet‐Tapia, J. C., Pérez‐Quintero, Á. L., Li, T., Eom, J., Li, C., Nguyen, H., Liu, B., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0267-z · Cited by 860 · see citing works

Enhancing Gene Targeting with Designed Zinc Finger Nucleases

Bibikova, M. V., Beumer, K. J., Trautman, J. K., & Carroll, D. (2003) · Science · doi:10.1126/science.1079512 · Cited by 824 · see citing works

Enhanced prime editing systems by manipulating cellular determinants of editing outcomes

Chen, P. J., Hussmann, J. A., Yan, J., Knipping, F., Ravisankar, P., Chen, P.-F., Chen, C.-D., Nelson, J. W., Newby, G. A., Şahin, M., et al. (2021) · Cell · doi:10.1016/j.cell.2021.09.018 · Cited by 820 · see citing works

Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos

Zuo, E., Sun, Y., Wei, W., Yuan, T., Ying, W., Sun, H., Yuan, L., Steinmetz, L. M., Li, Y., & Yang, H. (2019) · Science · doi:10.1126/science.aav9973 · Cited by 782 · see citing works

Engineered pegRNAs improve prime editing efficiency

Nelson, J. W., Randolph, P. B., Shen, S. P., Everette, K. A., Chen, P. J., Anzalone, A. V., An, M., Newby, G. A., Chen, J. C., Hsu, A., et al. (2022) · Nature Biotechnology · doi:10.1038/s41587-021-01039-7 · Cited by 727 · see citing works

DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1

Ira, G., Pellicioli, A., Balijja, A., Wang, X., Fiorani, S., Carotenuto, W., Liberi, G., Bressan, D., Wan, L., Hollingsworth, N. M., et al. (2004) · Nature · doi:10.1038/nature02964 · Cited by 722 · see citing works

Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors

Grünewald, J., Zhou, R., Garcia, S. P., Iyer, S., Lareau, C. A., Aryee, M. J., & Joung, J. K. (2019) · Nature · doi:10.1038/s41586-019-1161-z · Cited by 663 · see citing works

Prime editing for precise and highly versatile genome manipulation

Chen, P. J., & Liu, D. R. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00541-1 · Cited by 621 · see citing works

Programmable deletion, replacement, integration and inversion of large DNA sequences with twin prime editing

Anzalone, A. V., Gao, X. D., Podracky, C. J., Nelson, A. T., Koblan, L. W., Raguram, A., Levy, J. M., Mercer, J. A. M., & Liu, D. R. (2022) · Nature Biotechnology · doi:10.1038/s41587-021-01133-w · Cited by 613 · see citing works

CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells

Kurt, I. C., Zhou, R., Iyer, S., Garcia, S. P., Miller, B. R., Langner, L. M., Grünewald, J., & Joung, J. K. (2021) · Nature Biotechnology · doi:10.1038/s41587-020-0609-x · Cited by 573 · see citing works

The AID/APOBEC family of nucleic acid mutators

Conticello, S. G. (2008) · Genome biology · doi:10.1186/gb-2008-9-6-229 · Cited by 544 · see citing works

Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases

Yarnall, M. T. N., Ioannidi, E. I., Schmitt-Ulms, C., Krajeski, R. N., Lim, J., Villiger, L., Zhou, W., Jiang, K., Garushyants, S. K., Roberts, N., et al. (2022) · Nature Biotechnology · doi:10.1038/s41587-022-01527-4 · Cited by 490 · see citing works

Homing endonucleases: structural and functional insight into the catalysts of intron/intein mobility

Chevalier, B. S. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.18.3757 · Cited by 483 · see citing works

CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations

Cullot, G., Boutin, J., Toutain, J., Prat, F., Pennamen, P., Rooryck, C., Teichmann, M., Rousseau, E., Lamrissi-Garcia, I., Guyonnet-Duperat, V., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09006-2 · Cited by 474 · see citing works

PnB Designer: a web application to design prime and base editor guide RNAs for animals and plants

Siegner, S. M., Karasu, M. E., Schröder, M., Kontarakis, Z., & Corn, J. E. (2021) · BMC Bioinformatics · doi:10.1186/s12859-021-04034-6 · Cited by 433 · see citing works

Targeted, random mutagenesis of plant genes with dual cytosine and adenine base editors

Li, C., Zhang, R., Meng, X., Chen, S., Zong, Y., Lu, C., Qiu, J., Chen, Y., Li, J., & Gao, C. (2020) · Nature Biotechnology · doi:10.1038/s41587-019-0393-7 · Cited by 410 · see citing works

Comparison of the Differential Context-dependence of DNA Deamination by APOBEC Enzymes: Correlation with Mutation Spectra in Vivo

Beale, R. C. L., Petersen‐Mahrt, S. K., Watt, I. N., Harris, R. S., Rada, C. A., & Neuberger, M. S. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.01.046 · Cited by 337 · see citing works

High-efficiency prime editing with optimized, paired pegRNAs in plants

Lin, Q., Jin, S., Zong, Y., Yu, H., Zhu, Z., Liu, G., Kou, L., Wang, Y., Qiu, J.-L., Li, J., et al. (2021) · Nature Biotechnology · doi:10.1038/s41587-021-00868-w · Cited by 325 · see citing works

XA23 Is an Executor R Protein and Confers Broad-Spectrum Disease Resistance in Rice

Wang, C., Zhang, X., Fan, Y., Gao, Y., Zhu, Q., Zheng, C., Qin, T., Li, Y., Che, J., Zhang, M., et al. (2015) · Molecular Plant · doi:10.1016/j.molp.2014.10.010 · Cited by 290 · see citing works

Prime editing efficiently generates W542L and S621I double mutations in two ALS genes in maize

Jiang, Y., Chai, Y., Lu, M., Han, X., Lin, Q., Zhang, Y., Zhang, Q., Zhou, Y., Wang, X., Gao, C., et al. (2020) · Genome biology · doi:10.1186/s13059-020-02170-5 · Cited by 281 · see citing works

Precise genomic deletions using paired prime editing

Choi, J., Chen, W., Suiter, C. C., Lee, C., Chardon, F. M., Yang, W., Leith, A., Daza, R. M., Martin, B., & Shendure, J. (2021) · Nature Biotechnology · doi:10.1038/s41587-021-01025-z · Cited by 253 · see citing works

UTR-Dependent Control of Gene Expression in Plants

Srivastava, A. K., Lu, Y., Zinta, G., Lang, Z., & Zhu, J. (2017) · Trends in Plant Science · doi:10.1016/j.tplants.2017.11.003 · Cited by 249 · see citing works

An engineered prime editor with enhanced editing efficiency in plants

Zong, Y., Liu, Y., Xue, C., Li, B., Li, X., Wang, Y., Li, J., Liu, G., Huang, X., Cao, X., et al. (2022) · Nature Biotechnology · doi:10.1038/s41587-022-01254-w · Cited by 248 · see citing works

Engineering herbicide resistance via prime editing in rice

Butt, H., Rao, G. S., Sedeek, K., Aman, R., Kamel, R., & Mahfouz, M. (2020) · Plant Biotechnology Journal · doi:10.1111/pbi.13399 · Cited by 220 · see citing works

Development of Plant Prime-Editing Systems for Precise Genome Editing

Xu, R., Li, J., Liu, X., Shan, T., Qin, R., & Wei, P. (2020) · Plant Communications · doi:10.1016/j.xplc.2020.100043 · Cited by 209 · see citing works

Precise integration of large DNA sequences in plant genomes using PrimeRoot editors

Sun, C., Yuan, L., Li, B., Gao, Q., Li, Y., Cao, W., Yang, C., Li, H., Wang, Z., Li, Y., et al. (2023) · Nature Biotechnology · doi:10.1038/s41587-023-01769-w · Cited by 206 · see citing works

Deletion and replacement of long genomic sequences using prime editing

Jiang, T., Zhang, X.-O., Weng, Z., & Xue, W. (2021) · Nature Biotechnology · doi:10.1038/s41587-021-01026-y · Cited by 204 · see citing works

Precise Modifications of Both Exogenous and Endogenous Genes in Rice by Prime Editing

Li, H., Li, J., Chen, J., Yan, L., & Xia, L. (2020) · Molecular Plant · doi:10.1016/j.molp.2020.03.011 · Cited by 202 · see citing works

Plant Prime Editors Enable Precise Gene Editing in Rice Cells

Tang, X. D., Sretenovic, S., Ren, Q., Jia, X., Li, M., Fan, T., Yin, D., Xiang, S., Guo, Y., Liu, L., et al. (2020) · Molecular Plant · doi:10.1016/j.molp.2020.03.010 · Cited by 194 · see citing works

PrimeDesign software for rapid and simplified design of prime editing guide RNAs

Hsu, J. Y., Grünewald, J., Szalay, R. N., Shih, J., Anzalone, A. V., Lam, K. C., Shen, M. W., Petri, K., Liu, D. R., Joung, J. K., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21337-7 · Cited by 189 · see citing works

Efficient targeted insertion of large DNA fragments without DNA donors

Wang, J., Zhou, H., Wang, G., Zhang, R., Duan, J., Gao, P., Lei, X., Qiu, H.-Y., Zhang, C., Zhang, Y., et al. (2022) · Nature Methods · doi:10.1038/s41592-022-01399-1 · Cited by 173 · see citing works

Precision genome engineering in rice using prime editing system

Hua, K., Jiang, Y., Tao, X., & Zhu, J. (2020) · Plant Biotechnology Journal · doi:10.1111/pbi.13395 · Cited by 171 · see citing works

A split prime editor with untethered reverse transcriptase and circular RNA template

Liu, B., Dong, X., Cheng, H., Zheng, C., Chen, Z., Rodríguez, T., Liang, S., Xue, W., & Sontheimer, E. J. (2022) · Nature Biotechnology · doi:10.1038/s41587-022-01255-9 · Cited by 169 · see citing works

Versatile Nucleotides Substitution in Plant Using an Improved Prime Editing System

Xu, W., Zhang, C., Yang, Y., Zhao, S., Kang, G., He, X., Song, J., & Yang, J. (2020) · Molecular Plant · doi:10.1016/j.molp.2020.03.012 · Cited by 165 · see citing works

A web tool for the design of prime-editing guide RNAs

Chow, R. D.-W., Chen, J., Shen, J., & Chen, S. (2020) · Nature Biomedical Engineering · doi:10.1038/s41551-020-00622-8 · Cited by 165 · see citing works

Precise genome modification in tomato using an improved prime editing system

Lu, Y., Tian, Y., Shen, R., Yao, Q., Zhong, D., Zhang, X., & Zhu, J. (2020) · Plant Biotechnology Journal · doi:10.1111/pbi.13497 · Cited by 164 · see citing works

Identification of herbicide resistance OsACC1 mutations via in planta prime-editing-library screening in rice

Xu, R., Liu, X., Li, J., Qin, R., & Wei, P. (2021) · Nature Plants · doi:10.1038/s41477-021-00942-w · Cited by 123 · see citing works

Tuning plant phenotypes by precise, graded downregulation of gene expression

Xue, C., Qiu, F., Wang, Y., Li, B., Zhao, K. T., Chen, K., & Gao, C. (2023) · Nature Biotechnology · doi:10.1038/s41587-023-01707-w · Cited by 122 · see citing works

Enhancement of prime editing via xrRNA motif-joined pegRNA

Zhang, G., Liu, Y., Huang, S., Qu, S., Cheng, D., Yao, Y., Ji, Q., Wang, X., Huang, X., & Liu, J. (2022) · Nature Communications · doi:10.1038/s41467-022-29507-x · Cited by 113 · see citing works

Engineered prime editors with PAM flexibility

Kweon, J., Yoon, J.-K., Jang, A.-H., Shin, H. R., See, J.-E., Jang, G., Kim, J., & Kim, Y. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.02.022 · Cited by 108 · see citing works

Targeted mutagenesis in rice using CRISPR-Cpf1 system

Hu, X., Wang, C., Liu, Q., Fu, Y., & Wang, K. (2016) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2016.12.001 · Cited by 106 · see citing works

A novel amino acid substitution Ala‐122‐Tyr in ALS confers high‐level and broad resistance across ALS‐inhibiting herbicides

Han, H., Yu, Q. P., Purba, E., Li, M., Walsh, M., Friesen, S., & Powles, S. B. (2012) · Pest Management Science · doi:10.1002/ps.3278 · Cited by 104 · see citing works

Optimized prime editing efficiently generates glyphosate-resistant rice plants carrying homozygous TAP-IVS mutation in EPSPS

Jiang, Y., Chai, Y., Qiao, D., Wang, J., Xin, C., Sun, W. Y., Cao, Z., Zhang, Y., Zhou, Y., Wang, X., et al. (2022) · Molecular Plant · doi:10.1016/j.molp.2022.09.006 · Cited by 103 · see citing works

A novel triple amino acid substitution in the EPSPS found in a high‐level glyphosate‐resistant Amaranthus hybridus population from Argentina

Perotti, V., Larran, A. S., Palmieri, V. E., Martinatto, A. K., Álvarez, C. E., Tuesca, D., & Permingeat, H. R. (2018) · Pest Management Science · doi:10.1002/ps.5303 · Cited by 102 · see citing works

A design optimized prime editor with expanded scope and capability in plants

Xu, W., Yang, Y., Yang, B., Krueger, C. J., Xiao, Q., Zhao, S., Zhang, L., Kang, G., Wang, F., Yi, H., et al. (2021) · Nature Plants · doi:10.1038/s41477-021-01043-4 · Cited by 101 · see citing works

High‐efficiency prime editing enables new strategies for broad‐spectrum resistance to bacterial blight of rice

Gupta, A., Liu, B., Chen, Q., & Yang, B. (2023) · Plant Biotechnology Journal · doi:10.1111/pbi.14049 · Cited by 100 · see citing works

Molecular breeding of a novel herbicide‐tolerant rice by gene targeting

Endo, M., Osakabe, K., Ono, K., Handa, H., Shimizu, T., & Toki, S. (2007) · The Plant Journal · doi:10.1111/j.1365-313x.2007.03230.x · Cited by 95 · see citing works

Development of a highly efficient prime editor 2 system in plants

Li, J., Chen, L., Liang, J. Y., Xu, R., Jiang, Y., Li, Y., Ding, J., Li, M., Qin, R., & Wei, P. (2022) · Genome biology · doi:10.1186/s13059-022-02730-x · Cited by 95 · see citing works

Genome-wide maps of ribosomal occupancy provide insights into adaptive evolution and regulatory roles of uORFs during Drosophila development

Zhang, H., Dou, S., He, F., Luo, J., Wei, L., & Lü, J. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2003903 · Cited by 91 · see citing works

Generation of a more efficient prime editor 2 by addition of the Rad51 DNA-binding domain

Song, M., Lim, J. M., Min, S., Oh, J., Kim, D. Y., Woo, J., Nishimasu, H., Cho, S., Yoon, S., & Kim, S. (2021) · Nature Communications · doi:10.1038/s41467-021-25928-2 · Cited by 88 · see citing works

Resistance to herbicides caused by single amino acid mutations in acetyl‐ C o A carboxylase in resistant populations of grassy weeds

Jang, S., Marjanovic, J., & Górnicki, P. (2013) · New Phytologist · doi:10.1111/nph.12117 · Cited by 87 · see citing works

xC as9 expands the scope of genome editing with reduced efficiency in rice

Wang, J., Meng, X., Hu, X., Sun, T., Li, J., Wang, K., & Yu, H. J. (2018) · Plant Biotechnology Journal · doi:10.1111/pbi.13053 · Cited by 87 · see citing works

Bi-PE: bi-directional priming improves CRISPR/Cas9 prime editing in mammalian cells

Tao, R. X., Wang, Y., Jiao, Y., Hu, Y. F., Li, L., Jiang, L., Zhou, L., Qu, J., Chen, Q., & Yao, S. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac506 · Cited by 83 · see citing works

Optimized prime editing efficiently generates heritable mutations in maize

Qiao, D., Wang, J., Lu, M., Xin, C., Chai, Y., Jiang, Y., Sun, W. Y., Cao, Z., Guo, S., Wang, X., et al. (2022) · Journal of Integrative Plant Biology · doi:10.1111/jipb.13428 · Cited by 77 · see citing works

uORFs: Important Cis-Regulatory Elements in Plants

Zhang, T., Wu, A., Yue, Y., & Zhao, Y. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176238 · Cited by 71 · see citing works

Improving the efficiency of CRISPR-Cas12a-based genome editing with site-specific covalent Cas12a-crRNA conjugates

Ling, X., Chang, L., Chen, H., Gao, X., Yin, J., Zuo, Y., Huang, Y., Zhang, B., Hu, J., & Liu, T. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.09.021 · Cited by 71 · see citing works

Enhancing prime editing efficiency by modified pegRNA with RNA G-quadruplexes

Li, X., Wang, X., Sun, W., Huang, S., Zhong, M., Yao, Y., Ji, Q., & Huang, X. (2022) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjac022 · Cited by 69 · see citing works

Multiplex precision gene editing by a surrogate prime editor in rice

Li, H., Zhu, Z., Li, S., Li, J., Yan, L., Zhang, C., Ma, Y., & Xia, L. (2022) · Molecular Plant · doi:10.1016/j.molp.2022.05.009 · Cited by 68 · see citing works

Peptide fusion improves prime editing efficiency

Velimirovic, M., Zanetti, L. C., Shen, M. W., Fife, J. D., Lin, L., Cha, M., Akıncı, E., Barnum, D., Yu, T., & Sherwood, R. I. (2022) · Nature Communications · doi:10.1038/s41467-022-31270-y · Cited by 63 · see citing works

Efficient C‐to‐G editing in rice using an optimized base editor

Tian, Y., Shen, R., Li, Z., Yao, Q., Zhang, X., Zhong, D., Tan, X., Song, M., Han, H., Zhu, J., et al. (2022) · Plant Biotechnology Journal · doi:10.1111/pbi.13841 · Cited by 59 · see citing works

Prime editing-mediated precise knockin of protein tag sequences in the rice genome

Li, J., Ding, J., Zhu, J., Xu, R., Gu, D., Liu, X., Liang, J. Y., Qiu, C., Wang, H., Li, M., et al. (2023) · Plant Communications · doi:10.1016/j.xplc.2023.100572 · Cited by 57 · see citing works

A novel mutant acetolactate synthase gene from rice cells, which confers resistance to ALS-inhibiting herbicides

Kawai, K., Kaku, K., Izawa, N., Shimizu, T., Fukuda, A., & Tanaka, Y. (2007) · Journal of Pesticide Science · doi:10.1584/jpestics.g06-40 · Cited by 51 · see citing works

CRISPR/Cas9-Targeted Knockout of Rice Susceptibility Genes OsDjA2 and OsERF104 Reveals Alternative Sources of Resistance to Pyricularia oryzae

Távora, F. T. P. K., Meunier, A., Vernet, A., Portefaix, M., Milazzo, J., Adreit, H., Tharreau, D., Franco, O. L., & Mehta, Â. (2022) · Rice Science · doi:10.1016/j.rsci.2022.04.001 · Cited by 50 · see citing works

Prime Editing Guide RNA Design Automation Using PINE-CONE

Standage-Beier, K., Tekel, S. J., Brafman, D. A., & Wang, X. (2021) · ACS Synthetic Biology · doi:10.1021/acssynbio.0c00445 · Cited by 45 · see citing works

Improving the efficiency of prime editing with epegRNAs and high-temperature treatment in rice

Zou, J., Meng, X., Liu, Q., Shang, M., Wang, K., Li, J., Yu, H. J., & Wang, C. (2022) · Science China Life Sciences · doi:10.1007/s11427-022-2147-2 · Cited by 45 · see citing works

A novel mutated acetolactate synthase gene conferring specific resistance to pyrimidinyl carboxy herbicides in rice

Okuzaki, A., Shimizu, T., Kaku, K., Kawai, K., & Toriyama, K. (2007) · Plant Molecular Biology · doi:10.1007/s11103-007-9146-y · Cited by 43 · see citing works

The dark side of homology-directed repair

Al-Zain, A., & Symington, L. S. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103181 · Cited by 41 · see citing works

Addition of the T5 exonuclease increases the prime editing efficiency in plants

Liang, Z., Wu, Y., Guo, Y., & Wei, S. (2023) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2023.03.008 · Cited by 41 · see citing works

Enhancement of a prime editing system via optimal recruitment of the pioneer transcription factor P65

Chen, R., Cao, Y., Liu, Y., Zhao, D., Li, J., Cheng, Z., Bi, C., & Zhang, X. (2023) · Nature Communications · doi:10.1038/s41467-023-35919-0 · Cited by 31 · see citing works

Genome Editing Strategies Towards Enhancement of Rice Disease Resistance

Mishra, R., Zheng, W., Joshi, R. K., & Zhao, K. (2021) · Rice Science · doi:10.1016/j.rsci.2021.01.003 · Cited by 30 · see citing works

Increasing the Targeting Scope of CRISPR Base Editing System Beyond NGG

Yu, S.-Y., Birkenshaw, A., Thomson, T., Carlaw, T., Zhang, L., & Ross, C. J. (2022) · The CRISPR Journal · doi:10.1089/crispr.2021.0109 · Cited by 23 · see citing works

ScCas9 recognizes NNG protospacer adjacent motif in genome editing of rice

Xu, Y., Meng, X., Wang, J., Qin, B., Wang, K., Li, J., Wang, C., & Yu, H. J. (2020) · Science China Life Sciences · doi:10.1007/s11427-019-1630-2 · Cited by 18 · see citing works

Introduction of mutations in plants with prime editing

Hao, L., Pu, X., & Song, J. (2021) · Methods · doi:10.1016/j.ymeth.2021.03.014 · Cited by 14 · see citing works

MS2 RNA aptamer enhances prime editing in ricePreprint

Chai, Y., Jiang, Y., Wang, J., Qiao, D., Zhang, Y., Xin, C., Zhou, Y., Wang, X., & Chen, Q. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.20.465209 · Cited by 8 · see citing works

Indirect DNA Sequence Readout by LAGLIDADG Homing Endonucleases

Bochtler, M. (2016) · Structure · doi:10.1016/j.str.2016.05.008 · Cited by 2 · see citing works

Emerging applications of gene editing technologies for the development of climate-resilient crops

Chavhan, R. L., Jaybhaye, S. G., Hinge, V. R., Deshmukh, A. S., Shaikh, U. S., Jadhav, P. K., Kadam, U. S., & Hong, J. C. (2025) · Frontiers in Genome Editing · doi:10.3389/fgeed.2025.1524767 · Cited by 43 · see citing works

Gene-Based Developments in Improving Quality of Tomato: Focus on Firmness, Shelf Life, and Pre- and Post-Harvest Stress Adaptations

Nie, H., Yang, X., Zheng, S., & Hou, L. (2024) · Horticulturae · doi:10.3390/horticulturae10060641 · Cited by 47 · see citing works

CRISPR/Cas-Mediated Genome Engineering in Plants: Application and Prospectives

Mishra, S., Nayak, S., Tuteja, N., Poosapati, S., Swain, D. M., & Sahoo, R. K. (2024) · Plants · doi:10.3390/plants13141884 · Cited by 32 · see citing works

Evolution of agricultural biotechnology is the paradigm shift in crop resilience and development: a review

Riaz, M., Yasmeen, E., Saleem, B., Hameed, M. K., Almheiri, M. T. S., Mir, R. O. S. A., Alameri, G., Alghafri, J. S. K., & Gururani, M. A. (2025) · Frontiers in Plant Science · doi:10.3389/fpls.2025.1585826 · Cited by 28 · see citing works

Breeding herbicide-resistant rice using CRISPR-Cas gene editing and other technologies

Luo, Q., & Liu, Y. (2024) · Plant Communications · doi:10.1016/j.xplc.2024.101172 · Cited by 27 · see citing works

Genome-Editing Products Line up for the Market: Will Europe Harvest the Benefits from Science and Innovation?

Polidoros, A. N., Nianiou‐Obeidat, I., Τσακιρπάλογλου, Ν., Petrou, N., Deligiannidou, E., & Makri, N.-M. (2024) · Genes · doi:10.3390/genes15081014 · Cited by 20 · see citing works

Enhancing drought resilience in crops: mechanistic approaches in the face of climate challenge

Parmar, H., Goel, A., Gelaw, T. A., & Reddy, M. K. (2025) · Plant Molecular Biology · doi:10.1007/s11103-025-01616-3 · Cited by 15 · see citing works

Progress on Molecular Mechanism of Heat Tolerance in Rice

Fu, Y., Jiayelu, W., Wu, M., Ye, S., Zhai, R., Ye, J., Zhu, G., Yu, F., Lu, Y., & Xiaoming, Z. (2024) · Rice Science · doi:10.1016/j.rsci.2024.07.001 · Cited by 10 · see citing works

Decrypting molecular mechanism of heat stress tolerance in rice to tackle climate change challenges through recent approaches

Kumar, N., Khatibi, S. M. H., Sharma, D., Azeem, F., Koutu, G. K., & Ali, J. (2026) · Frontiers in Plant Science · doi:10.3389/fpls.2025.1722694 · Cited by 7 · see citing works

Plant tissue culture and genetic transformation in crop improvement

Koti, P., & Bill, T. (2025) · Journal of Bacteriology & Mycology Open Access · doi:10.15406/jbmoa.2025.13.00400 · Cited by 6 · see citing works

Improving Rice Quality by Regulating the Heading Dates of Rice Varieties without Yield Penalties

Liu, J., Yi, Q., Dong, G., Chen, Y., Guo, L., Gao, Z., Zhu, L., Ren, D., Zhang, Q., Li, Q., et al. (2024) · Plants · doi:10.3390/plants13162221 · Cited by 6 · see citing works

Application of CRISPR/Cas genome editing in woody plant trait improvement

Yuan, X., Yao, F., An, Y., Jiang, C., Chen, N., Huang, L., Lu, M., & Zhang, J. (2023) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/tb-2023-1125 · Cited by 4 · see citing works

Recombinase-Based Engineering of Plant Genomes in the Era of Genome Editing

Розов, С. М., & Дейнеко, Е. В. (2025) · Molecular Biology · doi:10.1134/s0026893325700323 · Cited by 2 · see citing works

Prime editing: a new frontier in precision genome engineering for rice improvement

Al-Saadi, N. H., Hatawsh, A., Elkordy, F., Sharkawi, A., Abdelhamid, A. M., Abdelhady, S., Auf, S., Tran, B. Q., Rehan, M., Venkatesh, J., et al. (2026) · Frontiers in Plant Science · doi:10.3389/fpls.2026.1804263 · Cited by 2 · see citing works

Genome Editing in Banana: Tools, Techniques, and Challenges

Tripathi, J. N., Muiruri, S., Waweru, D. N., & Tripathi, L. (2025) · Springer eBooks · doi:10.1007/978-981-95-0309-4_3 · Cited by 1 · see citing works

Oriented Generation of Novel Thermo-Sensitive Genic Male Sterile Lines with Improved Grain Shape and Outcrossing Rate in Early-Season Rice

Zhang, H., Chen, J., Ruiqing, L., Huimei, W., Dai, D., Minmin, L., Wu, M., & Liang-yong, M. (2023) · Rice Science · doi:10.1016/j.rsci.2023.11.006

Novel Genomic Techniques and Applications on the Horizon

Clark, L. F., & Hobbs, J. E. (2024) · SpringerBriefs in environmental science · doi:10.1007/978-3-031-63917-3_4

CRISPR/Cas9 and Beyond: Genome Editing for Precision Trait Enhancement in Tomatoes

Irum, S., Rehman, N., Inam, S., Khan, M. Z. F., Uzair, M., Muhammad, A., & Khan, M. R. (2025) · Springer eBooks · doi:10.1007/978-981-96-3890-1_9

Plant Heat Resilience Based on Epigenetic Regulation

Singh, A. P., Naveen, A., Bhargavi, H. A., Basavaraj, P. S., Das, D., & Atta, K. (2025) · CABI climate change series. · doi:10.1079/9781800626102.0016

Characterizing and editing the gene network regulating flowering in soybean to develop early-flowering varieties adapted to European Cultivation

Monfort, M. (2025) · doi:10.70675/fa90a50ezbaffz4b1azac3dz623643ef8b40

Site-Specific Editing of OsMTL Generates Alleles with Enhanced Haploid Induction Rate or Fertility

Ren, J., Liang, X., Huang, Y., Yufeng, H., Huang, D., Kejian, W., & Chaolei, L. (2026) · Rice Science · doi:10.1016/j.rsci.2026.10.001

Introduction of mutations in plants with prime editing

Hao, L., Pu, X., & Song, J. (2021) · Methods · doi:10.1016/j.ymeth.2021.03.014 · Cited by 14 · see citing works

Prime editing: evolution of CRISPR–Cas system for a robust next-generation genome editing in plants

Bargoti, T., Nain, V., & Singh, D. (2026) · Planta · doi:10.1007/s00425-026-05040-9 · Cited by 1 · see citing works

Recent advance of prime editing in plants

Peng, C., Bai, M., & Guan, Y. (2023) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/tb-2023-1111 · Cited by 1 · see citing works

Plant genome precise editing technology-prime editing

Zhou, S., Li, F., Li, J., Wu, X., Wu, D., Xu, R., & Wei, P. (2024) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/tb-2023-1105

Prime editing in plants and mammalian cells: Mechanism, achievements, limitations, and future prospects

Hillary, V. E., & Ceasar, S. A. (2022) · BioEssays · doi:10.1002/bies.202200032 · Cited by 45 · see citing works