Meta-analysis of magnetic resonance imaging studies of the corpus callosum in schizophrenia

Arnone, D.; McIntosh, A.M.; Tan, G.M.Y.; Ebmeier, K.P.

doi:10.1016/j.schres.2008.01.005

Cited by 161Schizophrenia research and treatmentMental Health and PsychiatryFetal and Pediatric Neurological Disorders

Meta-analysis of magnetic resonance imaging studies of the corpus callosum in schizophrenia

Arnone, D., McIntosh, A.M., Tan, G.M.Y., Ebmeier, K.P.·2008·Schizophrenia Research

DOI 10.1016/j.schres.2008.01.005

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Abstract

Objectives The corpus callosum plays a pivotal role in inter-hemispheric transfer and integration of information. Magnetic resonance studies have reported callosal abnormalities in schizophrenia but findings have been inconsistent. Uncertainty has persisted despite a meta-analytic evaluation of this structure several years ago. We set out to perform a further meta-analysis with the addition of the numerous reports published on the subject to test the hypothesis that the corpus callosum is abnormal in schizophrenia. Method A systematic search was carried out to identify suitable magnetic resonance studies which reported callosal areas in schizophrenia compared to controls. Results from the retrieved studies were compared in a meta-analysis whilst the influence of biological and clinical variables on effect size was ascertained with meta-regression analysis. Results Twenty-eight studies were identified. Corpus callosum area was reduced in schizophrenia in comparison to healthy volunteers. This effect was larger in first episode patients. Similarly, heterogeneity detected among the studies was associated with course of illness indicating that chronic subjects with schizophrenia showed larger callosal areas. There was no evidence of publication bias. Conclusions This study confirms the presence of reduced callosal areas in schizophrenia. The effect is of a larger magnitude at first presentation and less so in subjects with a chronic course generally medicated with antipsychotics.

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Marked changes to white matter in corpus callosum microstructure are seen in the Cyfip1 rat model, 15q11.2del CNV carriers, and Cyfip1-deficient mice.
“In all three species, marked changes to white matter were seen in corpus callosum microstructure, consistent with previous findings reported by Ulfarsson [5], and with reduced callosal volume observed in patients with schizophrenia [14].”
From Linking haploinsufficiency of the autism- and schizophrenia-associated gene Cyfip1 with striatal-limbic-cortical network dysfunction and cognitive inflexibility (2024) · cites this paper as [14]

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Authors: Arnone, D., McIntosh, A. M., Tan, G. M. Y., & Ebmeier, K. P.
Affiliations: University of Oxford (GB)
Royal Edinburgh Hospital (GB)
Corresponding author: Arnone, D.
ORCID: Arnone, D.
McIntosh, A.M.
Ebmeier, K.P.
Venue: Schizophrenia Research
Publisher: Elsevier BV
Published: 2008-04
Volume: 101
Issue: 1-3
Pages: 124-132
ISSN: 0920-9964 (ISSN-L)
DOI: 10.1016/j.schres.2008.01.005
OpenAlex: W1985482952
Cited by: 161
References: 77
Citations by year: 2026: 4 · 2025: 4 · 2024: 9 · 2023: 4 · 2022: 5 · 2021: 14 · 2020: 5 · 2019: 7 · 2018: 5 · 2017: 10 · 2016: 8 · 2015: 14 · 2014: 9 · 2013: 5 · 2012: 11
FWCI: 1.97
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Schizophrenia Research (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
Keywords: schizophrenia, corpus callosum
MeSH terms: Adult, Corpus Callosum, Female, Humans, Magnetic Resonance Imaging, Male, Schizophrenia, Meta-Analysis as Topic

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Meta-analysis of magnetic resonance imaging studies of the corpus callosum in schizophrenia

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