Cited by 87Fetal and Pediatric Neurological DisordersAxon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanisms

Contralateral targeting of the corpus callosum in normal and pathological brain function

Fenlon, Laura R., Richards, Linda J.·2015·Trends in Neurosciences

Abstract

The corpus callosum connects the two cortical hemispheres of the mammalian brain and is susceptible to structural defects during development, which often result in significant neuropsychological dysfunction. To date, such individuals have been studied primarily with regards to the integrity of the callosal tract at the midline. However, the mechanisms regulating the contralateral targeting of the corpus callosum, after midline crossing has occurred, are less well understood. Recent evidence suggests that defects in contralateral targeting can occur in isolation from midline-tract malformations, and may have significant functional implications. We propose that contralateral targeting is a crucially important and relatively under-investigated event in callosal development, and that defects in this process may constitute an undiagnosed phenotype in several neurological disorders.

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Crossref · 10.1016/j.tins.2015.02.007

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  • Abnormalities in the corpus callosum and interhemispheric connectivity are linked to many neurodevelopmental disorders, including ASD and SCZ.

    “a wealth of evidence links abnormalities in the corpus callosum and interhemispheric connectivity (driven by callosal projection neurons) to many neurodevelopmental disorders, among them ASD and SCZ2,3,111,112.”

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Authors
Fenlon, L. R., & Richards, L. J.
Affiliations
The University of Queensland (AU)
Corresponding author
Richards, Linda J.
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2015-05
Volume
38
Issue
5
Pages
264-272
ISSN
0166-2236 (ISSN-L)
OpenAlex
W1981890684
Cited by
87
References
122
Citations by year
2026: 11 · 2025: 14 · 2024: 10 · 2023: 9 · 2022: 7 · 2021: 6 · 2020: 7 · 2019: 7 · 2018: 5 · 2017: 2 · 2016: 8 · 2015: 1
FWCI
0.81
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Health and Medical Research Council
  • National Medical Research Council
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
corpus callosum, midline crossing, interhemispheric connections, neuropsychological dysfunction, neurological disorders
MeSH terms
Animals, Mental Disorders, Corpus Callosum, Humans, Functional Laterality, Neuroimaging

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