Contralateral targeting of the corpus callosum in normal and pathological brain function
Abstract
The corpus callosum connects the two cortical hemispheres of the mammalian brain and is susceptible to structural defects during development, which often result in significant neuropsychological dysfunction. To date, such individuals have been studied primarily with regards to the integrity of the callosal tract at the midline. However, the mechanisms regulating the contralateral targeting of the corpus callosum, after midline crossing has occurred, are less well understood. Recent evidence suggests that defects in contralateral targeting can occur in isolation from midline-tract malformations, and may have significant functional implications. We propose that contralateral targeting is a crucially important and relatively under-investigated event in callosal development, and that defects in this process may constitute an undiagnosed phenotype in several neurological disorders.
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Abnormalities in the corpus callosum and interhemispheric connectivity are linked to many neurodevelopmental disorders, including ASD and SCZ.
“a wealth of evidence links abnormalities in the corpus callosum and interhemispheric connectivity (driven by callosal projection neurons) to many neurodevelopmental disorders, among them ASD and SCZ2,3,111,112.”
From CYFIP1 governs the development of cortical axons by modulating calcium availability (2025) · cites this paper as [112]
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Layer 6 corticocortical neurons are a major route for intra- and interhemispheric feedbackPreprint
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“Finally, a wealth of evi-dencelinksabnormalitiesinthecorpuscallosumandinterhemispheric connectivity (driven by callosal projection neurons) to many neuro-developmental disorders, among them ASD and SCZ 2,3,111,112 .”
Developmental Profiling of Structural and Functional Maturation in Mouse Corpus Callosum
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- Authors
- Fenlon, L. R., & Richards, L. J.
- Affiliations
- The University of Queensland (AU)
- Corresponding author
- Richards, Linda J.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 38
- Issue
- 5
- Pages
- 264-272
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W1981890684
- Cited by
- 87
- References
- 122
- Citations by year
- 2026: 11 · 2025: 14 · 2024: 10 · 2023: 9 · 2022: 7 · 2021: 6 · 2020: 7 · 2019: 7 · 2018: 5 · 2017: 2 · 2016: 8 · 2015: 1
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council
- National Medical Research Council
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- corpus callosum, midline crossing, interhemispheric connections, neuropsychological dysfunction, neurological disorders
- MeSH terms
- Animals, Mental Disorders, Corpus Callosum, Humans, Functional Laterality, Neuroimaging
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