Relationship between white matter fractional anisotropy and other indices of cerebral health in normal aging: tract-based spatial statistics study of aging
Abstract
White matter (WM) fractional anisotropy (FA) is thought to be related to WM integrity and decline in FA is often used as an index of decreasing WM health. However, the relationship of FA to other structural indices of cerebral health has not been well studied. We hypothesized that the decline in WM health will be associated with changes in several other indices of cerebral health. In this manuscript we studied the correlation between whole-brain/hemispheric/corpus callosum FA and gray matter (GM) thickness, sulcal span, and the volume of T2-hyperintense WM in a group of 31 healthy aging individuals (12 males/19 females) aged 57-82 years old. Individual subjects' FA measures were calculated from diffusion tracing imaging (DTI) data using tract-based spatial statistics--an approach specifically designed and validated for voxel-wise multi-subject FA analysis. Age-controlled correlation analysis showed that whole-brain average FA values were significantly and positively correlated with the subject's average GM thickness and negatively correlated with hyperintense WM volume. Intra-hemispheric correlations between FA and other measures of cerebral health had generally greater effect sizes than inter-hemispheric correction, with correlation between left FA and left GM thickness being the most significant (r=0.6, p<0.01). Regional analysis of FA values showed that late-myelinating fiber tracts of the genu of corpus callosum had higher association with other cerebral health indices. These data are consistent with the hypothesis that late-myelinating regions of the brain bear the brunt of age-related degenerative changes.
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Lifetime speed of information processing is closely associated with white matter microstructure in humans and animal models.
“the lifetime speed of information processing closely associates with WM microstructure in humans and in animal models (Bartzokis et al., 2012, Kochunov et al., 2007, Lu et al., 2013)”
From Persistent psychopathology and neurocognitive impairment in COVID-19 survivors: effect of inflammatory biomarkers at three-month follow-up (2021) · cites this paper as Kochunov et al., 2007
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- Authors
- Kochunov, P., Thompson, P. M., Lancaster, J. L., Bartzokis, G., Smith, S., Coyle, T., Royall, D. R., Laird, A., & Fox, P. T.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- University of California, Los Angeles (US)
- University of Oxford (GB)
- The University of Texas at San Antonio (US)
- Corresponding author
- Kochunov, P.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2007-04
- Volume
- 35
- Issue
- 2
- Pages
- 478-487
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2069163567
- Cited by
- 250
- References
- 62
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 4 · 2023: 12 · 2022: 11 · 2021: 14 · 2020: 7 · 2019: 10 · 2018: 13 · 2017: 14 · 2016: 18 · 2015: 14 · 2014: 19 · 2013: 10 · 2012: 18
- FWCI
- 9.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Engineering and Physical Sciences Research Council (GR/R77018/01)
- National Institute on Aging (AG021431, P50AG016570, P50-AG 16570, R01AG021431)
- National Institute of Mental Health (MH066029, R01MH066029)
- National Institute on Drug Abuse (P20 MH/ DA52176)
- National Institute of Biomedical Imaging and Bioengineering (EB 01651)
- U.S. National Library of Medicine (LM 05639, R01LM005639)
- National Center for Research Resources (R21RR019771, RR019771)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Neurology › Cerebrovascular and genetic disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- white matter fractional anisotropy, normal aging, gray matter thickness, corpus callosum, corpus callosum genu, white matter integrity, diffusion tensor imaging, tract-based spatial statistics
- MeSH terms
- Aged, Aged, 80 and over, Aging, Brain, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Anisotropy
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