Medical comorbidity in patients with schizophrenia and alcohol dependence
Open accessAbstract
Background Schizophrenia and alcohol dependence are major risk factors for a variety of medical problems, yet there has been little research on the medical status of patients in whom both conditions coexist.Methods We assessed the prevalence and severity of medical illness in 80 patients with schizophrenia or schizoaffective disorder and comorbid alcohol use disorders who entered a controlled trial of monitored naltrexone treatment, and analyzed the relationship between medical illness burden and demographic variables, alcohol and other substance use, and psychosis. Participants underwent physical examination, laboratory tests, medical record review and standardized assessments of medical illness burden, alcohol and other substance use, and psychosis. Nested block multiple regression analyses were used to assess the contribution to illness burden made by demographic variables, alcohol and substance use, and psychosis severity.Results 83% of participants had at least one chronic medical illness, hypertension being the most common (43%). Medical comorbidity in this cohort was more severe than for schizophrenia patients in the CATIE trial (Chwastiak, L., Rosenheck, R., McEvoy, J.P., Keefe, R.S., Swartz, M.S., Lieberman, J.A., 2006. Interrelationships of Psychiatric Symptom Severity, Medical Comorbidity, and Functioning in Schizophrenia. Psychiatr. Serv., 57(8), 1102-1109.); the prevalence of hypertension, chronic obstructive pulmonary disease, and coronary artery disease, was more than twice greater. Medical illness burden correlated with alcohol use severity, but appeared to be independent of other substance use or psychosis severity.Conclusions Patients with co-occurring alcohol use disorder may have significantly more medical illness burden than patients with schizophrenia or schizoaffective disorder alone. Interventions to reduce alcohol use may be necessary to lessen medical morbidity.
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The prevalence of chronic obstructive pulmonary disease (chronic bronchitis and emphysema) is significantly higher among those with SMI than comparison subjects.
“The prevalence of chronic obstructive pulmonary disease, i.e. chronic bronchitis and emphysema, is significantly higher among those with SMI than comparison subjects (429-433).”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [432]
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- Authors
- Batki, S. L., Meszaros, Z. S., Strutynski, K., Dimmock, J. A., Leontieva, L., Ploutz-Snyder, R., Canfield, K., & Drayer, R. A.
- Affiliations
- San Francisco VA Medical Center (US)
- SUNY Upstate Medical University (US)
- National Aeronautics and Space Administration (US)
- University of Rochester Medicine (US)
- Corresponding author
- Batki, Steven L.
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 107
- Issue
- 2-3
- Pages
- 139-146
- ISSN
- 0920-9964 (ISSN-L)
- PMC
- PMC2649875
- OpenAlex
- W2073909219
- Cited by
- 72
- References
- 31
- Citations by year
- 2026: 2 · 2024: 4 · 2023: 1 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 6 · 2017: 8 · 2016: 6 · 2014: 4 · 2013: 3 · 2012: 7
- FWCI
- 3.98
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01aa013655-04)
- National Institute on Alcohol Abuse and Alcoholism (R01-AA-013655)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Health Professions › General Health Professions › Homelessness and Social Issues
- Keywords
- schizophrenia, alcoholism
- MeSH terms
- Adult, Alcoholism, Chronic Disease, Cross-Sectional Studies, Female, Health Status, Health Surveys, Humans, Hypertension, Male, Middle Aged, New York, Psychotic Disorders, Schizophrenia, Cohort Studies, Comorbidity, Substance-Related Disorders, Alcohol-Related Disorders, Young Adult
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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