Empathy in electrodermal responsive and nonresponsive patients with schizophrenia
Open accessAbstract
Skin conductance response (SCR) to emotion-evoking stimuli has in previous studies suggested the existence of two subgroups of schizophrenia patients. One is characterized by absent SCR and the other by heightened or non-habituating SCR. These subgroups have also been shown to differ in symptoms, prognosis and social integration. The present project compared social cognition in the two subgroups. SCR from 28 patients with schizophrenia and 24 matched healthy controls was measured while they watched emotion-evoking and neutral video tapes. Assessments of symptoms, neurocognition, social cognition, and social function were also performed. Event related potentials (ERP) were recorded in response to pictures of people experiencing pain or not. Subjects were divided into "SCR non-responder" and "SCR responder" groups based on SCR frequency. Schizophrenia SCR responders had significantly higher self-reported personal distress in response to others in distress and lower P300 ERP responses to others in pain than schizophrenia SCR non-responders and healthy controls. SCR responsiveness is a potential marker of subgroups of patients with schizophrenia that differ in pathophysiology, function and prognosis.
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An earlier study found no significant difference in performance on the MATRICS battery between EDA responding and non-responding patients, and a trend approaching significance for better results among EDA non-responders.
“These findings, however, contradict an earlier study that found no significant difference in performance on the MATRICS battery between EDA responding and non-responding patients, and a trend approaching significance for better results among EDA non-responders73.”
From Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health (2021) · cites this paper as [73]
Methods §2.2.2 identifies the neurocognitive measure as the MATRICS battery, and Results §3.2 reports no significant differences between the two schizophrenia SCR subgroups. The paper does not report a near-significant trend toward better MATRICS performance among non-responders; the trend-level result in Results §3.1 concerns the proportion of SCR non-responders among patients versus healthy controls, not battery performance. Page numbers were not available in our copy. (LLM, conf=0.87)
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- Authors
- Ikezawa, S., Corbera, S., Liu, J., & Wexler, B. E.
- Affiliations
- Yale University (US)
- Corresponding author
- Ikezawa, Satoru
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 142
- Issue
- 1-3
- Pages
- 71-76
- ISSN
- 0920-9964 (ISSN-L)
- PMC
- PMC3502678
- OpenAlex
- W1993033318
- Cited by
- 16
- References
- 50
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 1 · 2021: 3 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- State of Connecticut, Department of Mental Health
- Addiction Services
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
- Keywords
- schizophrenia, skin conductance response
- MeSH terms
- Adult, Analysis of Variance, Chlorpromazine, Electroencephalography, Empathy, Evoked Potentials, Female, Galvanic Skin Response, Humans, Male, Middle Aged, Neuropsychological Tests, Personality Tests, Psychiatric Status Rating Scales, Psychotic Disorders, Schizophrenia, Schizophrenic Psychology, Social Behavior, Antipsychotic Agents, Recognition, Psychology
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