The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: A meta-analysis
Open accessAbstract
The current systematic review and meta-analysis provides an extended and comprehensive overview of the associations between neurocognitive and social cognitive functioning and different types of functional outcome. Literature searches were conducted in MEDLINE and PsycINFO and reference lists from identified articles to retrieve relevant studies on cross-sectional associations between neurocognition, social cognition and functional outcome in individuals with non-affective psychosis. Of 285 studies identified, 52 studies comprising 2692 subjects met all inclusion criteria. Pearson correlations between cognition and outcome, demographic data, sample sizes and potential moderator variables were extracted. Forty-eight independent meta-analyses, on associations between 12 a priori identified neurocognitive and social cognitive domains and 4 domains of functional outcome yielded a number of 25 significant mean correlations. Overall, social cognition was more strongly associated with community functioning than neurocognition, with the strongest associations being between theory of mind and functional outcomes. However, as three-quarters of variance in outcome were left unexplained, cognitive remediation approaches need to be combined with therapies targeting other factors impacting on outcome.
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Individuals with psychosis often suffer from cognitive impairments.
“Given that in dividuals with psychosis often suffer from cognitive impairments (Fett et al., 2011), we chose to repeat each ACT process (behavior activation, defusion, acceptance) three times to make”
From Acceptance and Commitment Therapy for inpatients with psychosis –an acceptability and feasibility single case AB designed study (2022) · cites this paper as Fett et al., 2011
Section 4.4 (page not provided) describes a generalized cognitive deficit in schizophrenia and differences in cognitive-test performance between patients with schizophrenia and healthy controls. This supports the claim for schizophrenia, but the paper does not establish it for individuals with psychosis more broadly. (LLM, conf=0.83)
Experimental — accuracy not yet measuredSocial cognition domains account for a significant portion of the variance in social functioning.
“Because these domains account for a significant portion of the variance in social functioning [24]”
Meta-analytical evidence indicates a strong association between social cognition deficits and impaired social functioning in psychosis.
“Meta‐analytical evidence indicates a strong association between social cognition deficits and impaired social functioning in psychosis (Fett et al. 2011).”
From Social Functioning Interventions in Psychosis: A Systematic Review. (2025) · cites this paper as Fett et al. 2011
A 15-point increment on the PSP-T corresponds to a moderate effect size (Cohen's f = .40).
“A 15-point increment is considered clinically significant [24] and corresponds to a moderate effect size (Cohen’s f = .40).”
From Mindfulness-based social cognition training (SocialMIND) versus psychoeducational multicomponent intervention for people with a first episode of psychosis: A study protocol for a randomised controlled trial (2019) · cites this paper as [24]
The Statistical analysis section describes effect sizes as correlations, not Cohen’s f. A search of our full-text copy for PSP-T, a 15-point change, and Cohen’s f = .40 found no passage linking these measures; the cited paper therefore does not verify the claimed correspondence. (LLM, conf=0.76)
Experimental — accuracy not yet measuredA 15-point increment on the PSP-T is considered clinically significant.
“A 15-point increment is considered clinically significant [24] and corresponds to a moderate effect size (Cohen’s f = .40).”
From Mindfulness-based social cognition training (SocialMIND) versus psychoeducational multicomponent intervention for people with a first episode of psychosis: A study protocol for a randomised controlled trial (2019) · cites this paper as [24]
The paper’s ‘Domains of functional outcome’ section lists functioning measures, and Table 4 reports correlations between cognition and functional outcomes, but neither gives a clinically significant change threshold for the PSP-T. Searches for ‘PSP-T,’ ‘15-point,’ and clinically meaningful change found no passage addressing the claimed threshold. The indexed passages provide no page numbers. (LLM, conf=0.76)
Experimental — accuracy not yet measured
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- Authors
- Fett, A.-K. J., Viechtbauer, W., Dominguez, M.-D.-G., Penn, D. L., van Os, J., & Krabbendam, L.
- Affiliations
- Maastricht University (NL)
- University of North Carolina at Chapel Hill (US)
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 35
- Issue
- 3
- Pages
- 573-588
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2144535302
- Semantic Scholar
- 63ef6706a8292f12cc50880dc35ad4b5c855d9bf
- Cited by
- 1,833
- References
- 199
- Citations by year
- 2026: 79 · 2025: 90 · 2024: 91 · 2023: 108 · 2022: 138 · 2021: 161 · 2020: 131 · 2019: 186 · 2018: 139 · 2017: 122 · 2016: 129 · 2015: 122 · 2014: 124 · 2013: 114 · 2012: 66
- FWCI
- 9.68
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- VU Research Portal (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- Research Bank (Australian Catholic University) (submittedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Lirias (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- UNC Libraries
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- schizophrenia, neurocognitive function, social cognition, functional outcome, community functioning, theory of mind, non-affective psychosis, cognitive remediation, social functioning
- MeSH terms
- Cognition Disorders, Humans, Neuropsychological Tests, Schizophrenia, Schizophrenic Psychology, Social Behavior
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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