Effects of minocycline add-on treatment on brain morphometry and cerebral perfusion in recent-onset schizophrenia
Abstract
Increasing evidence suggests that the tetracycline antibiotic minocycline has neuroprotective effects and is a potential treatment for schizophrenia. However, the mechanisms of action of minocycline in the CNS remain elusive. The aim of this study was to investigate the effects of minocycline on brain morphology and cerebral perfusion in patients with recent-onset schizophrenia after 12months of a randomized double-blind, placebo-controlled clinical trial of minocycline add-on treatment. This study included 24 outpatients with recent-onset schizophrenia randomized for 12months of adjuvant treatment with minocycline (200mg/d) or placebo. MRI (1.5T) and [(99m)Tc]-ECD SPECT brain scans were performed at the end of the 12-month of trial. Between-condition comparisons of SPECT and MRI brain images were performed using statistical parametric mapping and analyzed by voxel-based morphometry (VBM). Minocycline adjuvant treatment significantly reduced positive and negative symptoms when compared with placebo. The VBM analysis of MRI scans showed that the patients in the placebo group had significant lower gray matter volumes in the midposterior cingulate cortex and in the precentral gyrus in comparison with the patients in the minocycline group. In addition, a decreased ECD uptake in the minocycline condition was observed in fronto-temporal areas. These results suggest that minocycline may protect against gray matter loss and modulate fronto-temporal areas involved in the pathophysiology of schizophrenia. Furthermore, minocycline add-on treatment may be a potential treatment in the early stages of schizophrenia and may ameliorate clinical deterioration and brain alterations observed in this period.
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The anti-inflammatory action of CBD could be related to its antipsychotic properties.
“This result suggests that the anti-inflammatory action of CBD (see (30), for a review), could be related to its antipsychotic properties and is consonant with recent findings that anti-inflammatory drugs such as minocycline could be useful in the treatment of schizophrenia (74).”
From Translational investigation of the therapeutic potential of Cannabidiol (CBD): Toward a new age (2018) · cites this paper as [74]
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- Authors
- Chaves, C., Marque, C. R., Maia-de-Oliveira, J. P., Wichert-Ana, L., Ferrari, T. B., Santos, A. C., Araújo, D., Machado-de-Sousa, J. P., Bressan, R. A., Elkis, H., Crippa, J. A., Guimarães, F. S., Zuardi, A. W., Baker, G. B., Dursun, S. M., & Hallak, J. E. C.
- Affiliations
- Universidade de São Paulo (BR)
- Montreal Neurological Institute and Hospital (CA)
- Universidade Federal de São Paulo (BR)
- University of Alberta (CA)
- Corresponding author
- Chaves, Cristiano
- ORCID
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 161
- Issue
- 2-3
- Pages
- 439-445
- ISSN
- 0920-9964 (ISSN-L)
- OpenAlex
- W2091932664
- Cited by
- 41
- References
- 49
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 8 · 2015: 2
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
- Funders
- CNPq (302453/2011-3)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- minocycline, recent-onset schizophrenia
- MeSH terms
- Adult, Brain, Cerebrovascular Circulation, Cysteine, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Magnetic Resonance Imaging, Male, Minocycline, Organ Size, Psychiatric Status Rating Scales, Schizophrenia, Signal Processing, Computer-Assisted, Time Factors, Antipsychotic Agents, Organotechnetium Compounds, Tomography, Emission-Computed, Single-Photon, Treatment Outcome, Radiopharmaceuticals, Young Adult
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