Cited by 150Schizophrenia research and treatmentTreatment of Major DepressionTryptophan and brain disorders

Minocycline as Adjunctive Therapy for Schizophrenia: An Open-Label Study

Miyaoka, Tsuyoshi, Yasukawa, Rei, Yasuda, Hideaki, Hayashida, Maiko, Inagaki, Takuji, Horiguchi, Jun·2008·Clinical Neuropharmacology

Abstract

Minocycline is a caspase inhibitor, decreases inducible nitric oxide synthase, and has been shown to delay disease in a mouse model of neuropsychiatric disorders. Recently, we reported the antipsychotic effects of minocycline in patients with schizophrenia. In a pilot investigation, we administered minocycline (150 mg/d) for 4 weeks as an open-label adjunct to antipsychotic medication to 22 patients with schizophrenia. The Positive and Negative Syndrome Scale for schizophrenia showed statistically significant and robust clinical improvements with minocycline treatment, which were maintained at follow-up evaluation 4 weeks after the end of minocycline treatment. There were no adverse events. These results suggest that minocycline may be a safe and effective adjunct to antipsychotic medications, and that augmentation with minocycline may prove to be a viable strategy for "boosting" antipsychotic efficacy and for treating schizophrenia.

Integrity signals

Registry

Crossref · 10.1097/wnf.0b013e3181593d45

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Clinical trials using minocycline alone or as an adjunct to risperidone in patients with schizophrenia have demonstrated overall improvement in negative symptoms and executive functioning.

    “Various clinical trials have been conducted using minocycline alone or as an adjunct to risperidone in patients with schizophrenia and have demonstrated overall improvement in negative symptoms and executive functioning (Miyaoka et al., 2008; Levkovitz et al., 2010; Khodaie-Ardakani et al., 2014).”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Miyaoka, T., Yasukawa, R., Yasuda, H., Hayashida, M., Inagaki, T., & Horiguchi, J.
Affiliations
Shimane University (JP)
Corresponding author
Miyaoka, Tsuyoshi
Venue
Clinical Neuropharmacology
Published
2008-09
Volume
31
Issue
5
Pages
287-292
ISSN
0362-5664 (ISSN-L)
OpenAlex
W2018922612
Cited by
146
References
26
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 14 · 2017: 7 · 2016: 9 · 2015: 14 · 2014: 15 · 2013: 14 · 2012: 13
FWCI
6.55
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Neuropharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
minocycline, schizophrenia, adjunctive therapy, antipsychotic augmentation, caspase inhibition, inducible nitric oxide synthase, antipsychotic efficacy
MeSH terms
Adult, Female, Follow-Up Studies, Humans, Male, Middle Aged, Minocycline, Pilot Projects, Schizophrenia, Schizophrenic Psychology, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review