Brief culturally adapted CBT for psychosis (CaCBTp): A randomized controlled trial from a low income country
Abstract
Evidence for the effectiveness of Culturally adapted CBT for psychosis in Low And Middle Income Countries (LAMIC) is limited. Therefore, brief Culturally adapted CBT for psychosis (CaCBTp) targeted at symptoms of schizophrenia for outpatients plus treatment as usual (TAU) is compared with TAU. A total of 116 participants with schizophrenia were recruited from 2 hospitals in Karachi, Pakistan, and randomized into two groups with 1:1 allocation (CaCBTp plus TAU=59, TAU=57). A brief version of CaCBTp (6 individual sessions with the involvement of main carer, plus one session for the family) was provided over 4months. Psychopathology was measured using Positive and Negative Syndrome Scale of Schizophrenia (PANSS), Psychotic Symptom Rating Scales (PSYRATS), and the Schedule for Assessment of Insight (SAI) at baseline and end of therapy. Participants in treatment group, showed statistically significant improvement in all measures of psychopathology at the end of the study compared with control group. Participants in treatment group showed statistically significant improvement in Positive Symptoms (PANSS, Positive Symptoms Subscale; p=0.000), Negative Symptoms (PANSS, Negative Symptoms subscales; p=0.000), Delusions (PSYRATS, Delusions Subscale; p=0.000), Hallucinations (PSYRATS, Hallucination Subscale; p=0.000) and Insight (SAI; p=0.007). The results suggest that brief, Culturally adapted CBT for psychosis can be an effective treatment when provided in combination with TAU, for patients with schizophrenia in a LAMIC setting. This is the first trial of CBT for psychosis from outside the western world. These findings need replicating in other low and middle income countries.
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A brief culturally adapted version of CBT-p is linked with improvements in insight.
“A brief culturally adapted version of CBT-p was also linked with improvements in insight 162,163 .”
From Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments (2018) · cites this paper as [162]
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Self-citationCognitive behavioral therapy around the globe
Kuo, C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814932-4.00005-7 · Cited by 10 · see citing works
Turner, P. R., & Hodge, D. R. (2020) · Research on Social Work Practice · doi:10.1177/1049731520946824 · Cited by 9 · see citing works
“The next study examined the effectiveness of brief CaCBTp with outpatients with schizophrenia (N ¼ 116) recruited from two hospitals in Karachi, Pakistan (Naeem et al., 2015).”
BackgroundMethodInfluentialRathod, S., Phiri, P., de Visser, R. O., Moore, S., Au‐Yeung, K., Collier, O., Gu, J., Bartl, G., & Greenwood, K. (2023) · British Journal of Clinical Psychology · doi:10.1111/bjc.12423 · Cited by 8 · see citing works
Cultural Considerations for Schizophrenia Spectrum Disorders II: Assessment and Treatment
Paul, N., Maietta, J., & Allen, D. (2020) · Springer eBooks · doi:10.1007/978-3-030-32229-8_27 · Cited by 3 · see citing works
Rakitzi, S., Georgila, P., & Becker-Woitag, A. P. (2020) · European Psychologist · doi:10.1027/1016-9040/a000400 · Cited by 8 · see citing works
Pipkin, A., Hogg, L. I., & Armitage, S. (2021) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.2578 · Cited by 8 · see citing works
Cognitive Behavioural Therapies for Psychosis
Johns, L., Isham, L., & Manser, R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815012-2.00015-8 · Cited by 7 · see citing works
Cultural Adaptation of Cognitive Behavioural Therapy
Rathod, S., Kingdon, D., Pinninti, N. R., Turkington, D., & Phiri, P. (2015) · Wiley eBooks · doi:10.1002/9781118976159.ch2 · Cited by 7 · see citing works
Self-citationMoussa‐Tooks, A. B., Sheffield, J. M., Freeman, D. H., & Brinen, A. P. (2023) · Clinical Case Studies · doi:10.1177/15346501231190920 · Cited by 6 · see citing works
“Adaptations include content on culturally-speci fi c beliefs about treatment, the role of family and religion, and addressing culturally-driven stigma and beliefs about psychosis (Naeem, 2019; Naeem et al., 2015, 2021; Rathod et al., 2010, 2013).”
BackgroundPatel, K., Cardno, A. G., & Isherwood, T. (2023) · Early Intervention in Psychiatry · doi:10.1111/eip.13368 · Cited by 6 · see citing works
“Where psychological therapies have been adapted to work with presentations of psychosis, such as CBTp (Naeem et al., 2016), and in ethnic minority groups (Habib et al., 2015; Naeem et al., 2015), there is a risk that they minimize the lived realities of multiply marginalized service users.”
Lyles, S., Khan, Z., Qureshi, O., & Shaikh, M. (2023) · PLoS ONE · doi:10.1371/journal.pone.0283411 · Cited by 6 · see citing works
Aljuhani, M., Lovell, K., Price, O., & Almutairi, A. (2024) · The Cognitive Behaviour Therapist · doi:10.1017/s1754470x24000394 · Cited by 6 · see citing works
“Furthermore, studies have shown that engaged family members have an important role in CBT for psychosis in the Muslim community (Naeem et al. , 2015; Naeem et al. , 2019).”
Adapting cognitive-behavioral therapy for a Malaysian muslim
Subhas, N., Mukhtar, F., & Munawar, K. (2021) · Medical Journal of the Islamic Republic of Iran · doi:10.47176/mjiri.35.28 · Cited by 6 · see citing works
“There are a few research studies that have adapted the CBT concept to suit the client’s spiritual, religious, and cultural background (11, 37, 44-49); for instance, incorporating Taoism into CBT for the neurosis treatment (50), using CBT with Christian beliefs to treat depression (51), culturally adapted CBT for psych…”
BackgroundIntroduction to the Special Issue on Cultural Adaptations of CBT
Stone, L., Beck, A. F., Hashempour, F., & Thwaites, R. (2018) · The Cognitive Behaviour Therapist · doi:10.1017/s1754470x18000181 · Cited by 6 · see citing works
“…in Western contexts and in low- and middle-income countries, where there are challenges both in adapting the content to local values and practices, and working with considerably fewer resources than in Western contexts (e.g. Bennett-Levy et al., 2014; Naeem et al., 2014, 2015; Beck, 2016).”
BackgroundWong, J. P.-S., Ting, K. T., & Wong, A. W. S. (2019) · International Review of Psychiatry · doi:10.1080/09540261.2019.1634012 · Cited by 5 · see citing works
“In Pakistan, CBTp was found to be effective in improving positive symptoms, negative symptoms and insight (Habib, Dawood, Kingdon, & Naeem, 2015; Naeem et al., 2015).”
BackgroundTurner, P. R. (2023) · Journal of Social Work Practice · doi:10.1080/02650533.2023.2284358 · Cited by 5 · see citing works
“The argument comes from cultures where the aetiology of psychosis is believed to be more spiritual in nature and people with psychosis experiences are more likely to seek out faith healers (Naeem et al., 2015).”
Backgroundvan der Ven, E., Yang, X., Mascayano, F., Weinreich, K. J., Chen, E. Y. H., Tang, C. Y. Z., Kim, S., Burns, J. K., Chiliza, B., Mohan, G., et al. (2025) · Cambridge Prisms Global Mental Health · doi:10.1017/gmh.2024.78 · Cited by 4 · see citing works
“It has been argued that consulting traditional healers could be conceptualized as a form of social support, and there is some evidence pointing toward traditional healers having beneficial effects on common mental disorders and on individuals ’ quality of life (Naeem et al., 2015; et al., 2016).”
Husain, M. I., Umer, M., Asif, M., Khoso, A. B., Kiran, T., Ansari, M. A., Aslam, H., Bhatia, M. R., Dogar, F. A., Husain, M. O., et al. (2022) · BJPsych Open · doi:10.1192/bjo.2022.598 · Cited by 5 · see citing works
“26,27 Most cultural adaptations of psychological treatments tend to be for implementation rather than content, 28 and we use the same principle for the CaPE intervention.”
Self-citationKarat, B. G., Narikuzhy, S., Bonato, S., Sanches, M., Ahmed, S., Liang, L., Husain, M. I., Husain, M. O., Farooq, S., Ayub, M., et al. (2022) · International Journal of Cognitive Therapy · doi:10.1007/s41811-022-00153-x · Cited by 4 · see citing works
“Considering the efficacy of culturally adapted CBIs (Naeem et al., 2015a; Naeem et al., 2015b; Amin et al., 2020), clinicians and researchers should integrate culturally anchored beliefs, values, meanings, and practices in treatment interventions.”
BackgroundSelf-citationKhakbaz, H., Khanjani, M. S., Younesi, S. J., Ardakani, M. R. K., Safi, M. H., & Hosseinzadeh, S. (2023) · فصلنامه علمی پژوهشی توانبخشی · doi:10.32598/rj.24.1.1450.3 · Cited by 4 · see citing works
Brief Intervention Models in Psychosis for Developing Countries (Asia and Africa)
Irfan, M., Stone, L., Husain, N., & Phiri, P. (2016) · Springer eBooks · doi:10.1007/978-3-319-30521-9_12 · Cited by 4 · see citing works
Self-citationBrief Cognitive Behavior Therapy for Psychosis
Naeem, F., & Kingdon, D. (2016) · Springer eBooks · doi:10.1007/978-3-319-30521-9_3 · Cited by 4 · see citing works
Self-citationVarese, F., Sudell, M., Morrison, A. P., Longden, E., & Smith, C. T. (2024) · Health Technology Assessment · doi:10.3310/ncfr5074 · Cited by 3 · see citing works
Gkintoni, E., & Nikolaou, G. (2025) · European Journal of Investigation in Health Psychology and Education · doi:10.3390/ejihpe16010002 · Cited by 5 · see citing works
boroujeni, M. K., Karimi, M. T., Sharifmoradi, K., & Aghdam, H. A. (2023) · فصلنامه علمی پژوهشی توانبخشی · doi:10.32598/rj.24.1.3482.1 · Cited by 3 · see citing works
A Brief Review of Key Models in Cognitive Behaviour Therapy for Psychosis
Phiri, P., Rathod, S., Carr, H., & Kingdon, D. (2017) · Acta Psychopathologica · doi:10.4172/2469-6676.100156 · Cited by 3 · see citing works
Self-citationPsychotherapy for schizophrenia and bipolar disorder
Irfan, M., Muzaffar, S., Kingdon, D., Rathod, S., & Naeem, F. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814932-4.00010-0 · Cited by 4 · see citing works
Self-citationHusain, M. O., Khoso, A. B., Kiran, T., Chaudhry, N., Husain, M. I., Asif, M., Ansari, M., Rajput, A. H., Dawood, S., Naqvi, H., et al. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-04904-8 · Cited by 3 · see citing works
“CBT and FI, like many other modern therapies, were first developed in the West, and as such, largely represent Western cultural values [24].”
BackgroundMethodSelf-citationKhan, N., Butt, M. G., Awan, F., Abid, S., Latif, M., Aslam, M., Naz, S., Phiri, P., Zadeh, Z. F., Farooq, S., et al. (2025) · BMJ Mental Health · doi:10.1136/bmjment-2024-301389 · Cited by 3 · see citing works
Self-citationCognitive behavioral therapy for posttraumatic stress disorder in Pakistan
Khan, A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85726-0.00010-7 · Cited by 2 · see citing works
Cognitive Behavioural Therapy and Its Role in the Outcome and Recovery from Schizophrenia
Lodha, P., & Sousa, A. D. (2020) · Springer eBooks · doi:10.1007/978-3-030-19847-3_26 · Cited by 2 · see citing works
The acceptability of cognitive behaviour therapy in Indonesian community health care
Bouman, T. K., Lommen, M. J. J., & Setiyawati, D. (2022) · The Cognitive Behaviour Therapist · doi:10.1017/s1754470x22000228 · Cited by 1 · see citing works
“Three randomized controlled trials in Pakistan found culturally adapted CBT for depressed patients to be more effective than treatment as usual (Naeem et al. , 2009, 2010, 2015).”
Sivaji, P., Venkatasubramanian, P., Venkatraman, L., & Ramachandran, P. (2025) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2025.104533 · Cited by 1 · see citing works
Ullah, S., Paudyal, P., Ahmad, F., Ullah, A., Khan, M. F., Yadegarfar, G., Naeem, F., & Farooq, S. (2025) · F1000Research · doi:10.12688/f1000research.168207.1 · Cited by 1 · see citing works
Self-citationCulturally Adapted CBT for Psychosis
Naeem, F., Naz, S., & Phiri, P. (2023) · Springer eBooks · doi:10.1007/978-3-031-27003-1_7 · Cited by 1 · see citing works
Self-citationGreenwood, K., Jones, C. I., Yaziji, N., Healey, A., May, C. R., Bremner, S. A., Hooper, R., Rathod, S., Phiri, P., de Visser, R. O., et al. (2023) · Health and Social Care Delivery Research · doi:10.3310/wdwg4102 · Cited by 1 · see citing works
Wahid, R., & Rathinasamy, E. V. L. (2022) · Research Review · doi:10.52845/jmrhs/2022-5-2-3
Challenges in developing feasible and cost-effective therapies for use in LMICs
Naeem, F., Rathod, S., Khan, N. S., & Ayub, M. (2016) · The British Journal of Psychiatry · doi:10.1192/bjp.209.3.263a · Cited by 1 · see citing works
Self-citationStatistical Visualization of Big Data Through Hadoop Streaming in RStudio
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Dandgey, S. (2018) · London Met Repository (London Metropolitan University)
Assessing the effectiveness of CBTp across time : a systematic review and meta-analysis
Sitko, K. (2019) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Statistical Visualization of Big Data Through Hadoop Streaming in RStudio
Verma, C., & Pandey, R. (2021) · IGI Global eBooks · doi:10.4018/978-1-6684-3662-2.ch035
Ethno-cognitive behavioral therapy and ethnopsychotherapy: A new narrative
Naeem, F. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85726-0.00018-1
Self-citationMucić, D., & Hilty, D. M. (2024) · Springer eBooks · doi:10.1007/978-3-031-59936-1_1
Cobandag, M., & Sigala, N. (2026) · European Psychiatry · doi:10.1192/j.eurpsy.2026.10537
Okore, A. A. (2025) · Cognizance Journal of Multidisciplinary Studies · doi:10.47760/cognizance.2025.v05i05.046
Husain, M. O., Khoso, A. B., Kiran, T., Chaudhry, N., Husain, M. I., Asif, M., Ansari, M., Rajput, A. H., Dawood, S., Naqvi, H., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26597825
Self-citationAsif, M., Khoso, A. B., Husain, M., Shahzad, S., Van Hout, M.-C., Rafiq, N.-U.-Z., Lane, S., Chaudhry, I. B., & Husain, N. (2024) · Figshare · doi:10.6084/m9.figshare.26584416
Self-citationCulturally Adapted Cognitive Behavioural Therapy and First Nations Population: A Role for Nurses?
Batterbee, R., Doyle, A. K., Arii, K. T., & Hungerford, C. L. (2026) · International Journal of Mental Health Nursing · doi:10.1111/inm.70290
“Globally, the structured and individualised approach to CBT has been adapted for diverse populations, including First Nations communities (Bennett-Levy et al. 2015; Jameel et al. 2022; Naeem et al. 2015; Shea et al. 2012) with good effect (Sorenson and Harrell 2021).”
Elashry, F., Digman, C., & Hammad, J. (2026) · Geopsychiatry · doi:10.1016/j.geopsy.2026.100111
- Authors
- Naeem, F., Saeed, S., Irfan, M., Kiran, T., Mehmood, N., Gul, M., Munshi, T., Ahmad, S., Kazmi, A., Husain, N., Farooq, S., Ayub, M., & Kingdon, D.
- Affiliations
- Queen's University (CA)
- Pakistan Association of Cognitive Therapists (PK)
- Pakistan Institute of Learning and Living (PK)
- Sir Ganga Ram Hospital (PK)
- Abbasi Shaheed Hospital (PK)
- University of Manchester (GB)
- University of Staffordshire (GB)
- Southern Health NHS Foundation Trust (GB)
- Corresponding author
- Naeem, Farooq
- ORCID
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 164
- Issue
- 1-3
- Pages
- 143-148
- ISSN
- 0920-9964 (ISSN-L)
- OpenAlex
- W1972761922
- Cited by
- 96
- References
- 42
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 6 · 2023: 15 · 2022: 5 · 2021: 4 · 2020: 10 · 2019: 11 · 2018: 9 · 2017: 17 · 2016: 7 · 2015: 2
- FWCI
- 9.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (acceptedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- Pakistan Association Of Cognitive Behavior Therapists
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Counseling, Therapy, and Family Dynamics
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- psychosis
- MeSH terms
- Adult, Aged, Delusions, Female, Hallucinations, Humans, Male, Middle Aged, Outpatients, Poverty, Psychiatric Status Rating Scales, Psychotic Disorders, Cognitive Behavioral Therapy, Treatment Outcome, Culturally Competent Care
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