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Interactive effects of polystyrene microplastics and roxithromycin on bioaccumulation and biochemical status in the freshwater fish red tilapia (Oreochromis niloticus)
Abstract
There are hundreds of thousands metric tons of microplastics (MPs) present in aquatic environments. The MPs coexist with other pollutants in water bodies, such as pharmaceuticals, and may carry and transfer them into aquatic organisms, consequently causing unpredictable ecological risks. The purpose of the present study was to evaluate the effect of the presence of polystyrene microplastics (PS-MPs) on the distribution and bioaccumulation of roxithromycin (ROX) in freshwater fish red tilapia (Oreochromis niloticus) as well as their interactive biochemical effects in red tilapia. PS-MPs were found to enhance the bioaccumulation of ROX in fish tissues compared to ROX-alone exposure. In the treatment of PS-MPs (100 μg L-1) combined with ROX (50 μg L-1), the highest concentrations of ROX reached 39,672.9 ± 6311.4, 1767.9 ± 277.8, 2907.5 ± 225.0, and 4307.1 ± 186.5 μg kg-1 in gut, gills, brain, and liver, respectively. Furthermore, compared to the ROX alone, the neurotoxicity caused by ROX was alleviated due to the presence of MPs after 14 d of exposure. The activities of cytochrome P450 (CYP) enzymes [7-ethoxyresorufin O-deethylase (EROD) and 7-benzyloxy-4-trifluoromethyl-coumarin O-dibenzyloxylase (BFCOD)] in fish livers exposed to all co-exposure treatments exhibited great variability compared to ROX alone after 14 d of exposure, suggesting that the presence of MPs may affect the metabolism of ROX in tilapia. Compared with ROX alone, the superoxide dismutase (SOD) activity increased significantly, and malondialdehyde (MDA) contents decreased in the co-exposure treatments, showing that oxidative damage in situations of co-exposure to MPs and ROX was mitigated in fish livers after 14 d of exposure. Collectively, the presence of MPs could affect the fate and toxicity of other organic pollutants in fish. The results emphasize the importance to study the interactions between MPs and other organic pollutants in aquatic environments.
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Effects of Microplastic on Fitness and PCB Bioaccumulation by the Lugworm Arenicola marina (L.)
Besseling, E., Wegner, A., Foekema, E. M., van den Heuvel-Greve, M. J., & Koelmans, A. A. (2013) · Environmental Science & Technology · doi:10.1021/es302763x · Cited by 1,012
Ding, J., Zhang, S., Razanajatovo, R. M., Zou, H., & Zhu, W. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.03.001 · Cited by 766
Self-citationAltered Behavior, Physiology, and Metabolism in Fish Exposed to Polystyrene Nanoparticles
Mattsson, K., Ekvall, M. T., Hansson, L.-A., Linse, S., Malmendal, A., & Cedervall, T. (2015) · Environmental Science & Technology · doi:10.1021/es5053655 · Cited by 581
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Environmental Side Effects of Pharmaceutical Cocktails: What We Know and What We Should Know
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Cited by
The plastic brain: neurotoxicity of micro- and nanoplastics
Prüst, M., Meijer, J., & Westerink, R. H. S. (2020) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00358-y · Cited by 811
Amelia, T. S. M., Khalik, W. M. A. W. M., Ong, M. C., Shao, Y. T., Pan, H.-J., & Bhubalan, K. (2021) · Progress in Earth and Planetary Science · doi:10.1186/s40645-020-00405-4 · Cited by 641
Xiang, Y., Jiang, L., Zhou, Y., Luo, Z., Zhi, D., Yang, J., & Lam, S. S. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.126843 · Cited by 574
Prokić, M. D., Radovanović, T. B., Gavrić, J. P., & Faggio, C. (2019) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2018.12.001 · Cited by 527
Tourinho, P. S., Kočí, V., Loureiro, S., & van Gestel, C. A. M. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.06.030 · Cited by 507
Metadata
- Authors
- Zhang, S., Ding, J., Razanajatovo, R. M., Jiang, H., Zou, H., & Zhu, W.
- Venue
- Science of The Total Environment
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 648
- Pages
- 1431-1439
- ISSN
- 0048-9697 (ISSN-L)
- OpenAlex
- W2888591149
- Cited by
- 366
- References
- 8
- FWCI
- 9.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhang, S., Ding, J., Razanajatovo, R. M., Jiang, H., Zou, H., & Zhu, W. (2019). Interactive effects of polystyrene microplastics and roxithromycin on bioaccumulation and biochemical status in the freshwater fish red tilapia (Oreochromis niloticus). Science of The Total Environment. https://doi.org/10.1016/j.scitotenv.2018.08.266
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