The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
Micro- and nanoplastic induced cellular toxicity in mammals: A review
Abstract
Plastic based products are ubiquitous due to their tremendous utility in our daily lives. However, the limited biodegradable nature of plastics has recently raised pollution concerns globally, especially micro- and nanoplastics. These anthropogenic pollutants are either manufactured specifically in the small size range for various commercial applications or formed due to fragmentation of macro plastics in the environment. Micro- and nanoplastics are currently widespread in the oceans, freshwater bodies, land and even present in our food. The biological effects of micro- and nanoplastics on aquatic organisms are well documented but their impacts on mammalian system have not been rigorously investigated. This review discusses the potential routes of exposure to micro- and nanoplastics, biological effects of these particles in mammalian cells, factors influencing toxicity, and the probable mechanisms of cytotoxicity. In general, small size, positive charge, high dose, and presence of toxic additives or pollutants in the micro/nanoplastics appear to induce cellular toxicity through oxidative stress, membrane damage, immune response and genotoxicity. Understanding the cellular fate and toxicity of these materials may help extrapolate risks to mammals.
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“However, given the capability of these nanoplastic particles to cross the biological barrier, nanoparticles, despite the seemingly trivial contribution to the mass measurement, might play a predominant role in terms of toxicity evaluation (72, 73).”
From Rapid single-particle chemical imaging of nanoplastics by SRS microscopy (2024) · cites this paper as [73]
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1 retracted
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Research works printed but not linked: 1
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Li, Y., Tao, L., Wang, Q., Wang, F., Li, G., & Song, M. (2023) · Environment & Health · doi:10.1021/envhealth.3c00052 · Cited by 844
A Review of Human Exposure to Microplastics and Insights Into Microplastics as Obesogens
Kannan, K., & Vimalkumar, K. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.724989 · Cited by 669
Cellular internalization and release of polystyrene microplastics and nanoplastics
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Rapid single-particle chemical imaging of nanoplastics by SRS microscopy
Qian, N., Gao, X., Lang, X., Deng, H., Bratu, T. M., Chen, Q., Stapleton, P., Yan, B., & Min, W. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2300582121 · Cited by 467
Polystyrene microplastics induce hepatotoxicity and disrupt lipid metabolism in the liver organoids
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Metadata
- Authors
- Banerjee, A., & Shelver, W. L.
- Affiliations
- Agricultural Research Service (US)
- Corresponding author
- Shelver, Weilin L.
- Venue
- Science of The Total Environment
- Publisher
- Elsevier BV
- Published
- 2021-02
- Volume
- 755
- Issue
- Pt 2
- Pages
- 142518
- ISSN
- 0048-9697 (ISSN-L)
- OpenAlex
- W3088724696
- Cited by
- 492
- References
- 135
- Citations by year
- 2026: 70 · 2025: 96 · 2024: 114 · 2023: 89 · 2022: 82 · 2021: 38
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Science of The Total Environment (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Pollution › Microplastics and Plastic Pollution
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
- Keywords
- microplastics, nanoplastics, cytotoxicity, mammalian cells, cytotoxicity mechanism, oxidative stress, membrane damage, immune response, genotoxicity, plastic pollution, exposure pathways, plastic fragmentation, food contamination
- MeSH terms
- Microplastics, Animals, Fresh Water, Mammals, Plastics, Water Pollutants, Chemical, Aquatic Organisms
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