Micro- and nanoplastic induced cellular toxicity in mammals: A review

Microplastics as contaminants in the marine environment: A review

Cole, M., Lindeque, P., Halsband, C., & Galloway, T. S. (2011) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2011.09.025 · Cited by 6,023

Plastic pollution in the world’s oceans: more than 5 trillion plastic pieces weighing over 250,000 tons afloat at sea

Eriksen, M., Lebreton, L. C. M., Carson, H. S., Thiel, M., Moore, C. J., Borerro, J. C., Galgani, F., Ryan, P. G., & Reisser, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111913 · Cited by 4,710

An overview of chemical additives present in plastics: Migration, release, fate and environmental impact during their use, disposal and recycling

Hahladakis, J. N., Velis, C. A., Weber, R., Iacovidou, E., & Purnell, P. (2018) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2017.10.014 · Cited by 3,873

Plastic and Human Health: A Micro Issue?

Wright, S. L., & Kelly, F. J. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b00423 · Cited by 3,413

Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis

Rejman, J., Oberle, V., Zuhorn, I. S., & Hoekstra, D. (2004) · Biochemical Journal · doi:10.1042/bj20031253 · Cited by 2,872

Environmental exposure to microplastics: An overview on possible human health effects

Prata, J. C., da Costa, J. P., Lopes, I., Duarte, A. C., & Rocha-Santos, T. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2019.134455 · Cited by 2,690

Environmental and health hazard ranking and assessment of plastic polymers based on chemical composition

Lithner, D., Larsson, Å., & Dave, G. (2011) · Science of The Total Environment · doi:10.1016/j.scitotenv.2011.04.038 · Cited by 2,684

The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles

Fröhlich, E. (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s36111 · Cited by 2,561

Microplastics as an emerging threat to terrestrial ecosystems

Machado, A. A. D. S., Kloas, W., Zarfl, C., Hempel, S., & Rillig, M. C. (2017) · Global Change Biology · doi:10.1111/gcb.14020 · Cited by 2,468

Potential Health Impact of Microplastics: A Review of Environmental Distribution, Human Exposure, and Toxic Effects

Li, Y., Tao, L., Wang, Q., Wang, F., Li, G., & Song, M. (2023) · Environment & Health · doi:10.1021/envhealth.3c00052 · Cited by 844

A Review of Human Exposure to Microplastics and Insights Into Microplastics as Obesogens

Kannan, K., & Vimalkumar, K. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.724989 · Cited by 669

Cellular internalization and release of polystyrene microplastics and nanoplastics

Liu, L., Xu, K., Zhang, B., Ye, Y., Zhang, Q., & Jiang, W. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.146523 · Cited by 483

Rapid single-particle chemical imaging of nanoplastics by SRS microscopy

Qian, N., Gao, X., Lang, X., Deng, H., Bratu, T. M., Chen, Q., Stapleton, P., Yan, B., & Min, W. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2300582121 · Cited by 467

Polystyrene microplastics induce hepatotoxicity and disrupt lipid metabolism in the liver organoids

Cheng, W., Li, X., Zhou, Y., Yu, H., Xie, Y., Guo, H., Wang, H., Li, Y., Feng, Y., & Wang, Y. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.150328 · Cited by 317

From natural environment to animal tissues: A review of microplastics(nanoplastics) translocation and hazards studies

Dong, X., Liu, X., Hou, Q., & Wang, Z. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.158686 · Cited by 279

Molecular and Cellular Effects of Microplastics and Nanoplastics: Focus on Inflammation and Senescence

Mahmud, F., Sarker, D. B., Jocelyn, J. A., & Sang, Q. A. (2024) · Cells · doi:10.3390/cells13211788 · Cited by 272

Microplastic pollution in soils, plants, and animals: A review of distributions, effects and potential mechanisms

Chang, X., Fang, Y. Q., Wang, Y., Wang, F., Shang, L., & Zhong, R. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.157857 · Cited by 260

Occurrence, human exposure, and risk of microplastics in the indoor environment

Ageel, H. K., Harrad, S., & Abdallah, M. A. (2021) · Environmental Science Processes & Impacts · doi:10.1039/d1em00301a · Cited by 257

A rapid review and meta-regression analyses of the toxicological impacts of microplastic exposure in human cells

Danopoulos, E., Twiddy, M., West, R., & Rotchell, J. M. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.127861 · Cited by 230

Micro- and nanoplastics released from biodegradable and conventional plastics during degradation: Formation, aging factors, and toxicity

Tong, H., Zhong, X., Duan, Z., Yi, X., Cheng, F., Xu, W., & Yang, X. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.155275 · Cited by 225

A critical review on microplastics, interaction with organic and inorganic pollutants, impacts and effectiveness of advanced oxidation processes applied for their removal from aqueous matrices

Ricardo, I. A., Alberto, E. A., Silva, A. C., Macuvele, D. L. P., Padoin, N., Soares, C., Riella, H. G., Starling, M. C. V. M., & Trovó, A. G. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.130282 · Cited by 221

Quantitative analysis of nanoplastics in environmental and potable waters by pyrolysis-gas chromatography–mass spectrometry

Okoffo, E. D., & Thomas, K. V. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.133013 · Cited by 223

Occurrence of Microplastics in Tap and Bottled Water: Current Knowledge

Gambino, I., Bagordo, F., Grassi, T., Panico, A., & De Donno, A. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19095283 · Cited by 213

Microplastics destabilize lipid membranes by mechanical stretching

Fleury, J., & Baulin, V. A. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2104610118 · Cited by 200

Consequences of nano and microplastic exposure in rodent models: the known and unknown

Brito, W. A. D. S., Mutter, F., Wende, K., Cecchini, A. L., Schmidt, A., & Bekeschus, S. (2022) · Particle and Fibre Toxicology · doi:10.1186/s12989-022-00473-y · Cited by 214

Effects of polyethylene microplastics on cell membranes: A combined study of experiments and molecular dynamics simulations

Wang, W., Zhang, J., Qiu, Z., Cui, Z., Li, N., Li, X., Wang, Y., Zhang, H., & Zhao, C. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.128323 · Cited by 170

Cardiovascular toxicity assessment of polyethylene nanoplastics on developing zebrafish embryos

Sun, M., Ding, R., Ma, Y., Sun, Q., Ren, X., Sun, Z., & Duan, J. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.131124 · Cited by 164

Maternal exposure to polystyrene nanoparticles retarded fetal growth and triggered metabolic disorders of placenta and fetus in mice

Chen, G., Xiong, S., Qiao, J., van Gestel, C. A. M., van Straalen, N. M., Roelofs, D., Sun, L., & Qiu, H. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.158666 · Cited by 173

Key mechanisms of micro- and nanoplastic (MNP) toxicity across taxonomic groups

Matthews, S., Mai, L., Jeong, C., Lee, J., Zeng, E. Y., & Xu, E. G. (2021) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2021.109056 · Cited by 168

Polyvinyl chloride microplastics induced gut barrier dysfunction, microbiota dysbiosis and metabolism disorder in adult mice

Chen, X., Zhuang, J., Chen, Q., Xu, L., Yue, X., & Qiao, D. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113809 · Cited by 166

Adverse effects polystyrene microplastics exert on zebrafish heart – Molecular to individual level

Dimitriadi, A., Papaefthimiou, C., Genizegkini, E., Sampsonidis, I., Kalogiannis, S., Feidantsis, K. G., Bobori, D., Kastrinaki, G., Koumoundouros, G., Lambropoulou, D. A., et al. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.125969 · Cited by 158

Microplastics in the bloodstream can induce cerebral thrombosis by causing cell obstruction and lead to neurobehavioral abnormalities

Huang, H., Hou, J., Li, M., Wei, F., Liao, Y., & Xi, B. (2025) · Science Advances · doi:10.1126/sciadv.adr8243 · Cited by 169

Distinct lipid membrane interaction and uptake of differentially charged nanoplastics in bacteria

Dai, S., Ye, R., Huang, J., Wang, B., Xie, Z., Ou, X., Yu, N., Huang, C., Hua, Y., Zhou, R., et al. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01321-z · Cited by 147

Microplastics released from food containers can suppress lysosomal activity in mouse macrophages

Deng, J., Ibrahim, M. S., Tan, L. Y., Yeo, X. Y., Lee, Y. A., Park, S. J., Wüstefeld, T., Park, J., Jung, S., & Cho, N. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.128980 · Cited by 144

Polypropylene microplastics promote metastatic features in human breast cancer

Park, J., Hong, S., Kim, O.-H., Kim, J.-H., Kim, J.-W., Kim, J.-W., Hong, S., & Lee, H. J. (2023) · Scientific Reports · doi:10.1038/s41598-023-33393-8 · Cited by 153

Human biomonitoring of microplastics and health implications: A review

Zuri, G., Karanasiou, A., & Lacorte, S. (2023) · Environmental Research · doi:10.1016/j.envres.2023.116966 · Cited by 140

Polystyrene Nanoplastics Activate Autophagy and Suppress Trophoblast Cell Migration/Invasion and Migrasome Formation to Induce Miscarriage

Wan, S., Wang, X., Chen, W., Xu, Z., Zhao, J., Huang, W., Wang, M., & Zhang, H. (2024) · ACS Nano · doi:10.1021/acsnano.3c11734 · Cited by 136

Chronic exposure to polyvinyl chloride microplastics induces liver injury and gut microbiota dysbiosis based on the integration of liver transcriptome profiles and full-length 16S rRNA sequencing data

Chen, X., Zhuang, J., Chen, Q., Xu, L., Yue, X., & Qiao, D. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.155984 · Cited by 136

Influence of the co-exposure of microplastics and tetrabromobisphenol A on human gut: Simulation in vitro with human cell Caco-2 and gut microbiota

Huang, W., Yin, H., Yang, Y., Jin, L., Lu, G., & Dang, Z. (2021) · Science of The Total Environment · doi:10.1016/j.scitotenv.2021.146264 · Cited by 125

Exposure to polystyrene nanoplastics impairs lipid metabolism in human and murine macrophages in vitro

Florance, I., Chandrasekaran, N., Gopinath, P. M., & Mukherjee, A. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113612 · Cited by 133

In vitro study on the toxicity of nanoplastics with different charges to murine splenic lymphocytes

Li, Y., Xu, M., Zhang, Z., Halimu, G., Li, Y., Li, Y., Gu, W., Zhang, B., & Wang, X. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.127508 · Cited by 127

Neurotoxic effects of polystyrene nanoplastics on memory and microglial activation: Insights from in vivo and in vitro studies

Paing, Y. M. M., Eom, Y., Song, G. B., Kim, B., Choi, M. G., Hong, S., & Lee, S. H. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.171681 · Cited by 131

Polystyrene microplastics induced nephrotoxicity associated with oxidative stress, inflammation, and endoplasmic reticulum stress in juvenile rats

Wang, W., Guan, J., Feng, Y., Nie, L., Xu, Y., Xu, H., & Fu, F. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1059660 · Cited by 126

Toxicity of nanoplastics to aquatic organisms: Genotoxicity, cytotoxicity, individual level and beyond individual level

Gong, H., Li, R., Li, F., Guo, X., Xu, L., Gan, L., Yan, M., & Wang, J. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.130266 · Cited by 119

Microplastic contamination in sewage sludge: Abundance, characteristics, and impacts on the environment and human health

Hassan, F., Prasetya, K. D., Hanun, J. N., Bùi, H. M., Rajendran, S., Kataria, N., Khoo, K. S., Wang, Y., You, S., & Jiang, J. (2023) · Environmental Technology & Innovation · doi:10.1016/j.eti.2023.103176 · Cited by 119

Impact of Microplastics and Nanoplastics on Livestock Health: An Emerging Risk for Reproductive Efficiency

Urli, S., Pause, F. C., Crociati, M., Baufeld, A., Monaci, M., & Stradaioli, G. (2023) · Animals · doi:10.3390/ani13071132 · Cited by 127

Microplastic occurrence in urban and industrial soils of Ahvaz metropolis: A city with a sustained record of air pollution

Nematollahi, M. J., Keshavarzi, B., Mohit, F., Moore, F., & Busquets, R. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.152051 · Cited by 119

Advanced epithelial lung and gut barrier models demonstrate passage of microplastic particles

Donkers, J. M., Höppener, E. M., Grigoriev, I., Will, L., Melgert, B. N., van der Zaan, B., van de Steeg, E., & Kooter, I. M. (2022) · Microplastics and Nanoplastics · doi:10.1186/s43591-021-00024-w · Cited by 120

Toxicity of micro/nanoplastics in the environment: Roles of plastisphere and eco-corona

Shi, X., Chen, Z., Wei, W., Chen, J., & Ni, B. (2023) · Soil & Environmental Health · doi:10.1016/j.seh.2023.100002 · Cited by 110

Protein Corona-Mediated Extraction for Quantitative Analysis of Nanoplastics in Environmental Waters by Pyrolysis Gas Chromatography/Mass Spectrometry

Zhou, X., He, S., Gao, Y., Li, Z.-C., Chi, H., Li, C., Wang, D.-J., & Yan, B. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c00156 · Cited by 109

Polystyrene nanoplastics and microplastics can act as Trojan horse carriers of benzo(a)pyrene to mussel hemocytes in vitro

Katsumiti, A., Losada-Carrillo, M. P., Barros, M., & Cajaraville, M. P. (2021) · Scientific Reports · doi:10.1038/s41598-021-01938-4 · Cited by 109

Eco-corona formation and associated ecotoxicological impacts of nanoplastics in the environment

Liu, S., Junaid, M., Liao, H., Liu, X., Wu, Y., & Wang, J. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.155703 · Cited by 114

Long-term exposure to polystyrene microplastics triggers premature testicular aging

Wu, D., Zhang, M., Bao, T. T., & Lan, H. (2023) · Particle and Fibre Toxicology · doi:10.1186/s12989-023-00546-6 · Cited by 111

The Pressing Issue of Micro- and Nanoplastic Contamination: Profiling the Reproductive Alterations Mediated by Oxidative Stress

Ferrante, M. C., Monnolo, A., Piano, F. D., Raso, G. M., & Meli, R. (2022) · Antioxidants · doi:10.3390/antiox11020193 · Cited by 106

Microplastic consumption induces inflammatory signatures in the colon and prolongs a viral arthritis

Rawle, D. J., Dumenil, T. D., Tang, B., Bishop, C., Yan, K., Le, T. T., & Suhrbier, A. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.152212 · Cited by 106

Size-dependent toxicity of polystyrene microplastics on the gastrointestinal tract: Oxidative stress related-DNA damage and potential carcinogenicity

Ding, R., Chen, Y., Shi, X., Li, Y., Yu, Y., Sun, Z., & Duan, J. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.169514 · Cited by 111

Effects of polystyrene micro/nanoplastics on liver cells based on particle size, surface functionalization, concentration and exposure period

Banerjee, A., Billey, L. O., McGarvey, A. M., & Shelver, W. L. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.155621 · Cited by 100

Nanoplastics induce molecular toxicity in earthworm: Integrated multi-omics, morphological, and intestinal microorganism analyses

Tang, R., Zhu, D., Luo, Y., He, D., Zhang, H., El‐Naggar, A., Palansooriya, K. N., Chen, K., Yan, Y., Lu, X., et al. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.130034 · Cited by 99

Polystyrene microplastics induced oxidative stress, inflammation and necroptosis via NF-κB and RIP1/RIP3/MLKL pathway in chicken kidney

Meng, X., Yin, K., Zhang, Y., Wang, D., Lu, H., Hou, L., Zhao, H., & Xing, M. (2022) · Toxicology · doi:10.1016/j.tox.2022.153296 · Cited by 97

Investigation of pulmonary toxicity evaluation on mice exposed to polystyrene nanoplastics: The potential protective role of the antioxidant N-acetylcysteine

Wu, Y., Yao, Y., Bai, H., Shimizu, K., Li, R., & Zhang, C. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.158851 · Cited by 100

Micro(nano)plastics and Their Potential Impact on Human Gut Health: A Narrative Review

Covello, C., Vincenzo, F. D., Cammarota, G., & Pizzoferrato, M. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46030168 · Cited by 103

Pristine and artificially-aged polystyrene microplastic particles differ in regard to cellular response

Völkl, M., Jérôme, V., Weig, A. R., Jasinski, J., Meides, N., Strohriegl, P., Scheibel, T., & Freitag, R. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.128955 · Cited by 97

Cellular absorption of polystyrene nanoplastics with different surface functionalization and the toxicity to RAW264.7 macrophage cells

Chen, J., Xu, Z., Liu, Y., Mei, A., Wang, X., & Shi, Q. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114574 · Cited by 99

Airborne microplastics: A narrative review of potential effects on the human respiratory system

Vattanasit, U., Kongpran, J., & Araki, A. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.166745 · Cited by 97

Abundance, characteristics, and distribution of microplastics in the Xiangjiang river, China

Yin, L., Wen, X., Huang, D., Zhou, Z., Xiao, R., Du, L., Hongyu, S., Wang, K., Tian, Q., Tang, Z., et al. (2022) · Gondwana Research · doi:10.1016/j.gr.2022.01.019 · Cited by 95

Endocytosis, Distribution, and Exocytosis of Polystyrene Nanoparticles in Human Lung Cells

Liu, Y.-Y., Liu, J., Wu, H., Zhang, Q., Tang, X., Li, D., Li, C., Liu, Y., Cao, A., & Wang, H. (2022) · Nanomaterials · doi:10.3390/nano13010084 · Cited by 105

Size-Dependent Uptake and Depuration of Nanoplastics in Tilapia (Oreochromis niloticus) and Distinct Intestinal Impacts

Hao, T., Gao, Y., Li, Z.-C., Zhou, X., & Yan, B. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.2c08059 · Cited by 94

Airborne micro- and nanoplastics: emerging causes of respiratory diseases

Gou, Z., Wu, H., Li, S., Liu, Z., & Zhang, Y. (2024) · Particle and Fibre Toxicology · doi:10.1186/s12989-024-00613-6 · Cited by 104

Atmospheric microplastic and nanoplastic: The toxicological paradigm on the cellular system

Choudhury, A., Simnani, F. Z., Singh, D., Patel, P., Sinha, A., Nandi, A., Ghosh, A., Saha, U., Kumari, K., Jaganathan, S. K., et al. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115018 · Cited by 101

A toxicological perspective of plastic biodegradation by insect larvae

Sanchez-Hernandez, J. C. (2021) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2021.109117 · Cited by 93

Interactions of microplastics and organic compounds in aquatic environments: A case study of augmented joint toxicity

Rubin, A. E., & Zucker, I. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.133212 · Cited by 90

Transgenerational impacts of micro(nano)plastics in the aquatic and terrestrial environment

Junaid, M., Liu, S., Chen, G., Liao, H., & Wang, J. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.130274 · Cited by 91

Polystyrene nanoparticle exposure accelerates ovarian cancer development in mice by altering the tumor microenvironment

Chen, G., Shan, H., Xiong, S., Zhao, Y., van Gestel, C. A. M., Qiu, H., & Wang, Y. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.167592 · Cited by 90

A growing crisis for One Health: Impacts of plastic pollution across layers of biological function

Morrison, M., Trevisan, R., Ranasinghe, P., Merrill, G. B., Santos, J., Hong, A., Edward, W. C., Jayasundara, N., & Somarelli, J. A. (2022) · Frontiers in Marine Science · doi:10.3389/fmars.2022.980705 · Cited by 95

Fluorescence-based detection: A review of current and emerging techniques to unveil micro/ nanoplastics in environmental samples

Morgana, S., Casentini, B., Tirelli, V., Grasso, F., & Amalfitano, S. (2024) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2024.117559 · Cited by 88

Breastfeeding promotes early neonatal regulatory T‐cell expansion and immune tolerance of non‐inherited maternal antigens

Wood, H., Acharjee, A., Pearce, H., Quraishi, M. N., Powell, R., Rossiter, A. E., Beggs, A. D., Ewer, A. K., Moss, P. A. H., & Toldi, G. (2021) · Allergy · doi:10.1111/all.14736 · Cited by 85

The gut microbiota, a key to understanding the health implications of micro(nano)plastics and their biodegradation

Jiménez-Arroyo, C., Tamargo, A., Molinero, N., & Moreno-Arribas, M. V. (2022) · Microbial Biotechnology · doi:10.1111/1751-7915.14182 · Cited by 89

Research advances of microplastics and potential health risks of microplastics on terrestrial higher mammals: a bibliometric analysis and literature review

Liu, M., Liu, J., Xiong, F., Xu, K., Pu, Y., Huang, J., Zhang, J., Pu, Y., Sun, R., & Cheng, K. (2023) · Environmental Geochemistry and Health · doi:10.1007/s10653-022-01458-8 · Cited by 88

Insights into the potential carcinogenicity of micro- and nano-plastics

Domenech, J., Annangi, B., Marcos, R., Hernández, A., & Catalán, J. (2023) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2023.108453 · Cited by 86

Polystyrene micro- and nanoplastics induce gastric toxicity through ROS mediated oxidative stress and P62/Keap1/Nrf2 pathway

Sun, R., Liu, M., Xiong, F., Xu, K., Huang, J., Liu, J., Wang, D., & Pu, Y. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.169228 · Cited by 87

Recent progress and future directions of the research on nanoplastic-induced neurotoxicity

Han, S.-W., Choi, J., & Ryu, K. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.379016 · Cited by 80

Exposure to polystyrene nanoplastics induces an anxiolytic-like effect, changes in antipredator defensive response, and DNA damage in Swiss mice

Guimarães, A. T. B., Freitas, Í. N., Mubarak, N. M., Rahman, M. M., Rodrigues, F. P., Rodrigues, A. S. D. L., Barceló, ‪., Islam, A. R. M. T., & Malafaia, G. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.130004 · Cited by 77

Size-dependent enhancement on conjugative transfer of antibiotic resistance genes by micro/nanoplastics

Zha, Y., Li, Z., Zhong, Z., Ruan, Y., Sun, L., Zuo, F., Li, L., & Hou, S. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.128561 · Cited by 76

Mass quantification of nanoplastics at wastewater treatment plants by pyrolysis–gas chromatography–mass spectrometry

Okoffo, E. D., & Thomas, K. V. (2024) · Water Research · doi:10.1016/j.watres.2024.121397 · Cited by 79

Marine Waste—Sources, Fate, Risks, Challenges and Research Needs

Dąbrowska, J., Sobota, M., Świąder, M., Borowski, P., Moryl, A., Stodolak, R., Kucharczak, E., Zięba, Z., & Kazak, J. K. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18020433 · Cited by 84

Untoward Effects of Micro- and Nanoplastics: An Expert Review of Their Biological Impact and Epigenetic Effects

Hazas, M. L. D. L., Boughanem, H., & Dávalos, A. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab154 · Cited by 81

Investigation of nephrotoxicity on mice exposed to polystyrene nanoplastics and the potential amelioration effects of DHA-enriched phosphatidylserine

Tang, Y., Zhao, R., Pu, Q., Jiang, S., Yu, F., Yang, Z., & Han, T. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.164808 · Cited by 79

Exposure to different surface-modified polystyrene nanoparticles caused anxiety, depression, and social deficit in mice via damaging mitochondria in neurons

Ma, Y., Xu, D., Wan, Z., Wei, Z., Chen, Z., Wang, Y., Han, X., & Chen, Y. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.170739 · Cited by 78

Genotoxic and neurotoxic potential of intracellular nanoplastics: A review

Casella, C., & Ballaz, S. (2024) · Journal of Applied Toxicology · doi:10.1002/jat.4598 · Cited by 77

A systematic review on the current situation of emerging pollutants in Mexico: A perspective on policies, regulation, detection, and elimination in water and wastewater

Aguilar‐Aguilar, A., de León-Martínez, L. D., Forgionny, A., Acelas, N. Y., Mendoza, S. R., & Zárate‐Guzmán, A. I. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.167426 · Cited by 77

Differences of microplastics and nanoplastics in urban waters: Environmental behaviors, hazards, and removal

Liu, S., Chen, Q., Ding, H., Song, Y., Pan, Q., Deng, H., & Zeng, E. Y. (2024) · Water Research · doi:10.1016/j.watres.2024.121895 · Cited by 73

Realistic Nanoplastics Induced Pulmonary Damage via the Crosstalk of Ferritinophagy and Mitochondrial Dysfunction

Ji, Y., Chen, L., Wang, Y., Zhang, J., Yu, Y., Wang, M., Wang, X., Liu, W., Yan, B., Xiao, L., et al. (2024) · ACS Nano · doi:10.1021/acsnano.4c02335 · Cited by 76

Harnessing PET to track micro- and nanoplastics in vivo

Keinänen, O. M., Dayts, E. J., Rodríguez, C. M. A., Sarrett, S. M., Brennan, J. M., Sarparanta, M. P., & Zeglis, B. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-90929-6 · Cited by 71

Influence of Functional Group Modification on the Toxicity of Nanoplastics

Zhang, H., Cheng, H., Wang, Y., Duan, Z., Cui, W., Shi, Y., & Qin, L. H. (2022) · Frontiers in Marine Science · doi:10.3389/fmars.2021.800782 · Cited by 72

The effect and a mechanistic evaluation of polystyrene nanoplastics on a mouse model of type 2 diabetes

Wang, Y., Wei, Z., Xu, K., Wang, X., Gao, X. Z., Han, Q., Wang, S., & Chen, M. (2023) · Food and Chemical Toxicology · doi:10.1016/j.fct.2023.113642 · Cited by 76

Effect of polystyrene nanoplastics and their degraded forms on stem cell fate

Im, G., Kim, Y. G., Jo, I.-S., Yoo, T. Y., Kim, S., Park, H. S., Hyeon, T., Yi, G., & Bhang, S. H. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.128411 · Cited by 73

Single inhalation exposure to polyamide micro and nanoplastic particles impairs vascular dilation without generating pulmonary inflammation in virgin female Sprague Dawley rats

Cary, C. M., Seymore, T., Singh, D., Vayas, K. N., Goedken, M. J., Adams, S. E., Polunas, M., Sunil, V. R., Laskin, D. L., Demokritou, P., et al. (2023) · Particle and Fibre Toxicology · doi:10.1186/s12989-023-00525-x · Cited by 76

Nanowell-enhanced Raman spectroscopy enables the visualization and quantification of nanoplastics in the environment

Chang, L., Jiang, S., Luo, J., Zhang, J., Liu, X., Lee, C. Y., & Zhang, W. (2021) · Environmental Science Nano · doi:10.1039/d1en00945a · Cited by 71

Questioning the suitability of available microplastics models for risk assessment – A critical review

Rubin, A. E., Sarkar, A. K., & Zucker, I. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.147670 · Cited by 67

Micro- and Nanoplastic-Mediated Pathophysiological Changes in Rodents, Rabbits, and Chickens: A Review

Banerjee, A., & Shelver, W. L. (2021) · Journal of Food Protection · doi:10.4315/jfp-21-117 · Cited by 70

Amino-Functionalized Polystyrene Nano-Plastics Induce Mitochondria Damage in Human Umbilical Vein Endothelial Cells

Fu, Y., Fan, M., Xu, L., Wang, H., Hu, Q., & Jin, Y. (2022) · Toxics · doi:10.3390/toxics10050215 · Cited by 67

Dose-Dependent Cytotoxicity of Polypropylene Microplastics (PP-MPs) in Two Freshwater Fishes

Bobori, D., Feidantsis, K. G., Dimitriadi, A., Datsi, N., Ripis, P., Kalogiannis, S., Sampsonidis, I., Kastrinaki, G., Ainali, N. M., Lambropoulou, D. A., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213878 · Cited by 72

Pro-Inflammatory and Cytotoxic Effects of Polystyrene Microplastics on Human and Murine Intestinal Cell Lines

Mattioda, V., Benedetti, V., Tessarolo, C., Oberto, F., Favole, A., Gallo, M., Martelli, W., Crescio, M. I., Berio, E., Masoero, L., et al. (2023) · Biomolecules · doi:10.3390/biom13010140 · Cited by 77

Polystyrene microplastics impair the functions of cultured mouse Leydig (TM3) and Sertoli (TM4) cells by inducing mitochondrial-endoplasmic reticulum damage

Grillo, G., Falvo, S., Latino, D., Baccari, G. C., Venditti, M., Fiore, M. M. D., Minucci, S., & Santillo, A. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116202 · Cited by 71

Global Scenario of Plastic Production, Consumption, and Waste Generation and Their Impacts on Environment and Human Health

Gautam, B. P. S., Qureshi, A., Gwasikoti, A., Kumar, V., & Gondwal, M. (2024) · Springer eBooks · doi:10.1007/978-3-031-55661-6_1 · Cited by 72

The detrimental effects of micro-and nano-plastics on digestive system: An overview of oxidative stress-related adverse outcome pathway

Ding, R., Ma, Y., Li, T., Sun, M., Sun, Z., & Duan, J. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.163144 · Cited by 69

Acute exposure to polystyrene nanoparticles promotes liver injury by inducing mitochondrial ROS-dependent necroptosis and augmenting macrophage-hepatocyte crosstalk

Fan, J., Liu, L., Lu, Y., Chen, Q., Fan, S., Yang, Y., Long, Y., & Liu, X. Z. (2024) · Particle and Fibre Toxicology · doi:10.1186/s12989-024-00578-6 · Cited by 62

Nanoplastics cause transgenerational toxicity through inhibiting germline microRNA mir-38 in C. elegans

Hua, X., Zhao, Y., Yuan, Y., Zhang, L., Bian, Q., & Wang, D. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.129302 · Cited by 60

Cellular and Animal Toxicities of Micro- and Nanoplastics

Dunna, M., Tulasi, C. D. S. L. N., & Chepuri, K. (2023) · Springer eBooks · doi:10.1007/978-3-031-21195-9_12 · Cited by 1

Toxicity of Microplastics and Nanoplastics in Mammalian Systems

Yong, C., Valiyaveettil, S., & Tang, B. L. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17051509 · Cited by 925

Plastic pollution and its pathophysiological impacts on mammalian cells

Joon, M., & Raparia, S. (2022) · IARJSET · doi:10.17148/iarjset.2022.9294

Cellular and Systemic Effects of Micro- and Nanoplastics in Mammals—What We Know So Far

Grote, K., Brüstle, F., & Vlacil, A.-K. (2023) · Materials · doi:10.3390/ma16083123 · Cited by 15

Toxicity Induced by Micro-and Nanoplastics through Oxidative Stress: The Role of Co-Exposure to Other Chemical Pollutants

Del Piano, F. (2021) · International Journal of Zoology and Animal Biology · doi:10.23880/izab-16000304 · Cited by 3