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Aging alters tissue resident mesenchymal stem cell properties
Open accessAbstract
Tissue resident mesenchymal stem cells (MSCs) are known to participate in tissue regeneration that follows cell turnover, apoptosis, or necrosis. It has been long known that aging impedes an organism's repair/regeneration capabilities. In order to study the age associated changes, the molecular characteristics of adipose tissue derived MSCs (ASCs) from three age groups of healthy volunteers, i.e., young, middle aged, and aged were investigated. The number and multilineage differentiation potential of ASCs declined with age. Aging reduces the proliferative capacity along with increases in cellular senescence. A significant increase in quiescence of G2 and S phase was observed in ASCs from aged donors. The expression of genes related to senescence such as CHEK1 and cyclin-dependent kinase inhibitor p16(ink4a) was increased with age, however genes of apoptosis were downregulated. Further, an age-dependent abnormality in the expression of DNA break repair genes was observed. Global microRNA analysis revealed an abnormal expression of mir-27b, mir-106a, mir-199a, and let-7. In ubiquitously distributed adipose tissue (and ASCs), aging brings about important alterations, which might be critical for tissue regeneration and homeostasis. Our findings therefore provide a better understanding of the mechanism(s) involved in stem cell aging and regenerative potential, and this in turn may affect tissue repair that declines with aging.
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“Aging is associated with decreased PCD in several cell types.”
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Cites
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
The functions of animal microRNAs
Ambros, V. (2004) · Nature · doi:10.1038/nature02871 · Cited by 10,728
Danial, N. N., & Korsmeyer, S. J. (2004) · Cell · doi:10.1016/s0092-8674(04)00046-7 · Cited by 4,651
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
Campisi, J. (2005) · Cell · doi:10.1016/j.cell.2005.02.003 · Cited by 2,379
Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253
BRAFE600-associated senescence-like cell cycle arrest of human naevi
Michaloglou, C., Vredeveld, L. C. W., Soengas, M. S., Denoyelle, C., Kuilman, T., van der Horst, C. M. A. M., Majoor, D. M., Shay, J. W., Mooi, W. J., & Peeper, D. S. (2005) · Nature · doi:10.1038/nature03890 · Cited by 2,160
Iliopoulos, D., Hirsch, H. A., & Struhl, K. (2009) · Cell · doi:10.1016/j.cell.2009.10.014 · Cited by 1,374
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
Rudolph, K. L., Chang, S., Lee, H.-W., Blasco, M., Gottlieb, G. J., Greider, C., & DePinho, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80580-2 · Cited by 1,349
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
Janzen, V., Forkert, R., Fleming, H. E., Saito, Y., Waring, M. T., Dombkowski, D. M., Cheng, T., DePinho, R. A., Sharpless, N. E., & Scadden, D. T. (2006) · Nature · doi:10.1038/nature05159 · Cited by 1,106
p16INK4a induces an age-dependent decline in islet regenerative potential
Krishnamurthy, J., Ramsey, M. R., Ligon, K. L., Torrice, C., Koh, A., Bonner-Weir, S., & Sharpless, N. E. (2006) · Nature · doi:10.1038/nature05092 · Cited by 1,003
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Items 101–200 of 319
The role of Pin1 protein in aging of human tendon stem/progenitor cells
Chen, L., Liu, J., Tao, X., Wang, G., Wang, Q., & Liu, X. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.06.163 · Cited by 42
Correia, C. R., Santos, T. C., Pirraco, R. P., Cerqueira, M. T., Marques, A. P., Reis, R. L., & Mano, J. F. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.02.007 · Cited by 42
Castorina, A., Szychlinska, M. A., Marzagalli, R., & Musumeci, G. (2015) · Neural Regeneration Research · doi:10.4103/1673-5374.158352 · Cited by 42
Yao, B., Huang, S., Gao, D., Xie, J., Liu, N., & Fu, X. (2015) · International Wound Journal · doi:10.1111/iwj.12491 · Cited by 45
Konstantinow, A., Arnold, A., Djabali, K., Kempf, W., Gutermuth, J., Fischer, T. V., & Biedermann, T. (2017) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.14489 · Cited by 41
Takahashi, H., Sakata, N., Yoshimatsu, G., Hasegawa, S., & Kodama, S. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8020249 · Cited by 41
Lee, J., Lee, K. S., Kim, C.-L., Byeon, J. S., Gu, N., Cho, I., & Cha, S. (2017) · Journal of Veterinary Science · doi:10.4142/jvs.2017.18.2.141 · Cited by 39
Rivera‐Izquierdo, M., Cabeza, L., Ramos‐Bossini, A. J. L., Quesada, R., Perazzoli, G., Alvarez, P. J., Prados, J. C., & Melguizo, C. (2019) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2019.1563069 · Cited by 39
Strategies to improve regenerative potential of mesenchymal stem cells
Choudhery, M. S. (2021) · World Journal of Stem Cells · doi:10.4252/wjsc.v13.i12.1845 · Cited by 40
Oxidative Stress Response in Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells
Waheed, T. O., Hahn, O., Sridharan, K., Mörke, C., Kamp, G., & Peters, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113435 · Cited by 38
Mesenchymal Stromal Cell Secretome Is Affected by Tissue Source and Donor Age
Turło, A., Hammond, D. E., Ramsbottom, K. A., Soul, J., Gillen, A. M., McDonald, K., Peffers, M. J., & Clegg, P. (2023) · Stem Cells · doi:10.1093/stmcls/sxad060 · Cited by 37
Adipocyte-Specific Transgenic and Knockout Models
Kang, S., Kong, X., & Rosen, E. D. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-411619-1.00001-x · Cited by 37
Grasys, J., Kim, B., & Pallua, N. (2016) · Aesthetic Surgery Journal · doi:10.1093/asj/sjw022 · Cited by 37
Kawagishi‐Hotta, M., Hasegawa, S., Igarashi, T., Yamada, T., Takahashi, M., Numata, S., Kobayashi, T., Iwata, Y., Arima, M., Yamamoto, N., et al. (2017) · Regenerative Therapy · doi:10.1016/j.reth.2016.12.004 · Cited by 36
Fujii, Y., Hatori, A., Chikazu, D., & Ogasawara, T. (2023) · Stem Cells International · doi:10.1155/2023/2026572 · Cited by 35
Kokai, L. E., Traktuev, D. O., Zhang, L., Merfeld‐Clauss, S., DiBernardo, G., Lu, H., Marra, K. G., Donnenberg, A. D., Donnenberg, V. S., Meyer, E. M., et al. (2016) · Aesthetic Surgery Journal · doi:10.1093/asj/sjw197 · Cited by 35
Aging of Stem and Progenitor Cells: Mechanisms, Impact on Therapeutic Potential, and Rejuvenation
Nurković, J., Volarević, V., Lako, M., Armstrong, L., Arsenijević, N., & Stojković, M. (2015) · Rejuvenation Research · doi:10.1089/rej.2015.1676 · Cited by 34
Rivera, F. J., de la Fuente, A. G., Zhao, C., Silva, M. E., González, G. A., Wodnar, R., Feichtner, M., Lange, S., Errea, O., Priglinger, E., et al. (2019) · Glia · doi:10.1002/glia.23624 · Cited by 33
Wang, S. G., Hsu, N. C.-H., Wang, S. M., & Wang, F. N. (2020) · Case Reports in Dermatological Medicine · doi:10.1155/2020/4617520 · Cited by 34
Ivanovska, A., Wang, M., Arshaghi, T. E., Shaw, G., Alves, J., Byrne, A. W., Butterworth, S., Chandler, R., Cuddy, L. C., Dunne, J., et al. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.897150 · Cited by 34
Adipose tissue and ovarian aging: Potential mechanism and protective strategies
Wu, M., Huang, Y., Zhu, Q., Zhu, X., Xue, L., Xiong, J., Chen, Y., Wu, C., Guo, Y., Li, Y., et al. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101683 · Cited by 36
Restoration of CPEB4 prevents muscle stem cell senescence during aging
Zeng, W., Zhang, W., Tse, E. H. Y., Liu, J., Dong, A., Lam, K. S. W., Luan, S., Küng, W., Chan, T. C., & Cheung, T. H. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.05.012 · Cited by 35
Németh, K. (2014) · Experimental Dermatology · doi:10.1111/exd.12459 · Cited by 33
Sansone, V. C., Meroni, R., Boria, P., Pisani, S., & Maiorano, E. (2014) · Rheumatology International · doi:10.1007/s00296-014-3086-z · Cited by 33
Moradinasab, S., Pourbagheri‐Sigaroodi, A., Zafari, P., Ghaffari, S. H., & Bashash, D. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107694 · Cited by 32
Derivation and growth characteristics of dental pulp stem cells from patients of different ages
Wu, W., Zhou, J. P., XU, C.-T., Zhang, J., JIN, Y.-J., & Geng-lin, S. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4106 · Cited by 33
MW Laschke, C. G., Laschke, M. W., Gräßer, C., Kleer, S., Scheuer, C., Eglin, D., Alini, M., & Menger, M. (2014) · European Cells and Materials · doi:10.22203/ecm.v028a20 · Cited by 33
Mangır, N., Akbal, C., Tarcan, T., Şimşěk, F., & Türkeri, L. (2014) · International Journal of Urology · doi:10.1111/iju.12585 · Cited by 32
The relationship between apoptosis and aging
Lü, B., Chen, H., & Hong-Guang, H.-G. (2012) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2012.326091 · Cited by 32
Knockdown of microRNA-584 promotes dental pulp stem cells proliferation by targeting TAZ
Tian, S., Liu, Y., Dong, F., Dou, Y., Li, W., & Wang, J. (2020) · Cell Cycle · doi:10.1080/15384101.2020.1744976 · Cited by 33
Hutchinson–Gilford progeria syndrome as a model for vascular aging
Brassard, J. A., Fekete, N., Garnier, A., & Hoesli, C. A. (2015) · Biogerontology · doi:10.1007/s10522-015-9602-z · Cited by 34
Follin, B., Tratwal, J., Haack‐Sørensen, M., Elberg, J. J., Kastrup, J., & Ekblond, A. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-219 · Cited by 31
Adipose-derived stem cell secretome as a cell-free product for cutaneous wound healing
Ajit, A., & Gopalankutty, I. A. (2021) · 3 Biotech · doi:10.1007/s13205-021-02958-7 · Cited by 33
Targeted erasure of DNA methylation by TET3 drives adipogenic reprogramming and differentiation
Park, J., Lee, D. H., Ham, S., Oh, J., Noh, J., Lee, Y. K., Park, Y. J., Lee, G., Han, S. M., Han, J. S., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00597-7 · Cited by 31
Peffers, M. J., Goljanek‐Whysall, K., Collins, J., Fang, Y., Rushton, M. D., Loughlin, J. A., Proctor, C. J., & Clegg, P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0160517 · Cited by 30
Jia, Z., Yang, P., Wu, Y., Tang, Y., Zhao, Y., Wu, J., Wang, D., He, Q., & Ruan, D. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4398 · Cited by 31
Peffers, M. J., Collins, J., Loughlin, J. A., Proctor, C. J., & Clegg, P. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0384-2 · Cited by 30
Kasoju, N., Wang, H., Zhang, B., George, J. H., Gao, S., Triffitt, J. T., Cui, Z., & Ye, H. (2017) · Biotechnology Advances · doi:10.1016/j.biotechadv.2017.04.005 · Cited by 30
Impaired Neovascularization in Aging
Bonham, C. A., Kuehlmann, B. A., & Gurtner, G. C. (2019) · Advances in Wound Care · doi:10.1089/wound.2018.0912 · Cited by 31
Juntunen, M., Heinonen, S., Huhtala, H., Rissanen, A., Kaprio, J. A., Kuismanen, K., Pietiläinen, K. H., Miettinen, S., & Patrikoski, M. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02587-0 · Cited by 30
Efficiency of Exosome Production Correlates Inversely with the Developmental Maturity of MSC Donor
Yeo, R. W. Y. (2013) · Journal of Stem Cell Research & Therapy · doi:10.4172/2157-7633.1000145 · Cited by 29
Horinouchi, C. D. D. S., Barisón, M. J., Robert, A. W., Kuligovski, C., de Aguiar, A. M., & Dallagiovanna, B. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i12.1640 · Cited by 29
Guidotti, S., Facchini, A., Platano, D., Olivotto, E., Minguzzi, M., Trisolino, G., Filardo, G., Cetrullo, S., Tantini, B., Martucci, E., et al. (2013) · Stem Cells and Development · doi:10.1089/scd.2012.0399 · Cited by 29
Cardiometabolic implications of adipose tissue aging
Ahmed, B., Farb, M. G., & Gokce, N. (2024) · Obesity Reviews · doi:10.1111/obr.13806 · Cited by 32
Luck, J. E., Weil, B. D., Lowdell, M. W., & Mosahebi, A. (2019) · Aesthetic Surgery Journal · doi:10.1093/asj/sjz214 · Cited by 28
Siennicka, K., Zołocińska, A., Dębski, T., & Pojda, Z. (2021) · Stem Cells International · doi:10.1155/2021/6665358 · Cited by 30
Murine Cardiosphere-Derived Cells Are Impaired by Age but Not by Cardiac Dystrophic Dysfunction
Hsiao, L., Perbellini, F., Gomes, R. S. M., Tan, J. J., Vieira, S., Faggian, G. G., Clarke, K. J., & Carr, C. A. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0388 · Cited by 28
Putative mesenchymal stem cells isolated from adult human ovaries
Štimpfel, M., Cerkovnik, P., Novaković, S., Maver, A., & Virant‐Klun, I. (2014) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-014-0254-8 · Cited by 28
Ok, J., Song, S. B., & Hwang, E. S. (2018) · International Journal of Stem Cells · doi:10.15283/ijsc18033 · Cited by 28
Yu, F., Fan, Y., Sun, H., Li, T., Dong, Y., & Pan, S. (2022) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2022.109881 · Cited by 28
Arezoo, N., Mohammad, H., & Monsefi, M. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02543-y · Cited by 27
Ning, T., Shao, J., Zhang, X., Luo, X., Huang, X., Wu, H., Xu, S., Wu, B., & Ma, D. (2019) · International Endodontic Journal · doi:10.1111/iej.13205 · Cited by 26
Chronological Age Affects MSC Senescence In Vitro—A Systematic Review
Kapetanos, K., Asimakopoulos, D., Christodoulou, N., Vogt, A., & Khan, W. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157945 · Cited by 28
Bone marrow adipocytes: key players in vascular niches, aging, and disease
Fan, Y., El-Khalek, M. K. A., Zhang, Y., Liu, L., Tian, Q., Chueakula, N., Ramasamy, S. K., Dalan, R., Habib, S. J., & Kusumbe, A. P. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1633801 · Cited by 27
Inhibitory effect of celastrol on adipogenic differentiation of human adipose-derived stem cells
Hong, W., Park, J., Yun, W., Kang, P. J., Son, D., Jang, J., Kim, I. Y., & You, S. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.11.014 · Cited by 25
Li, T., Xu, Y., Wang, Y., & Jiang, Y. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-02040-8 · Cited by 26
Age-related alteration in characteristics, function, and transcription features of ADSCs
Li, K., Shi, G., Lei, X., Huang, Y., Li, X., Bai, L., & Qin, C. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02509-0 · Cited by 26
Hamid, H. A., Sarmadi, V. H., Prasad, V., Ramasamy, R., & Miskon, A. (2022) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2100443 · Cited by 25
Nurzyńska, D., Meglio, F. D., Romano, V., Miraglia, R., Sacco, A. M., Latino, F., Bancone, C., Corte, A. D., Maiello, C., Amarelli, C., et al. (2012) · Basic Research in Cardiology · doi:10.1007/s00395-012-0320-2 · Cited by 25
Adipocyte biology: It is time to upgrade to a new model
Gijsen, H. S. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27266 · Cited by 28
Solakoğlu, Ö., Götz, W., Kiessling, M. C., Alt, C., Schmitz, C., & Alt, E. (2019) · World Journal of Stem Cells · doi:10.4252/wjsc.v11.i2.124 · Cited by 24
Extrinsic modulation of integrin α6 and progenitor cell behavior in mesenchymal stem cells
Nieto‐Nicolau, N., de la Torre, R. M., Fariñas, Ó., Savio, A., Vilarrodona, A., & Casaroli-Marano, R. P. (2020) · Stem Cell Research · doi:10.1016/j.scr.2020.101899 · Cited by 24
Effects of harvesting sites and ages on adipose tissue-derived stem cells in rat
Jung, H.-G., Ahn, E.-K., Lee, J.-H., Kim, Y.-H., Leem, S., Heo, J., & Kim, H. (2014) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-014-0410-3 · Cited by 24
Chen, J., Du, X., Chen, Q., & Xiang, C. (2015) · PubMed Central · Cited by 24
Mesenchymal Stem Cell Senescence and Osteogenesis
Tjempakasari, A., Suroto, H., & Santoso, D. (2021) · Medicina · doi:10.3390/medicina58010061 · Cited by 25
DNA Methylation Modulates Aging Process in Adipocytes
Xie, H., Liu, X., Zhou, Q., Huang, T., Zhang, L., Gao, J. L., Wang, Y., Liu, Y., Yan, T., Zhang, S., et al. (2022) · Aging and Disease · doi:10.14336/ad.2021.0904 · Cited by 23
Raileanu, V., Whiteley, J., Chow, T., Kollara, A., Mohamed, A., Keating, A., & Rogers, I. M. (2019) · Stem Cells Translational Medicine · doi:10.1002/sctm.19-0022 · Cited by 23
Allogeneic mesenchymal stem cell therapy: A regenerative medicine approach to geroscience
Oliva, A. A., McClain‐Moss, L., Pena, A., Drouillard, A., & Hare, J. M. (2019) · Aging Medicine · doi:10.1002/agm2.12079 · Cited by 23
Mesenchymal Stem Cells for Periodontal Tissue Regeneration in Elderly Patients
Ledesma-Martínez, E., Mendoza-Núñez, V. M., & Santiago‐Osorio, E. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly227 · Cited by 22
Archacka, K., Bem, J., Brzóska, E., Czerwińska, A. M., Grabowska, I., Kasprzycka, P., Hoinkis, D., Siennicka, K., Pojda, Z., Bernas, P., et al. (2020) · Cells · doi:10.3390/cells9061479 · Cited by 22
Multidifferentiation potential of dental-derived stem cells
Yin, J., Luo, X., Feng, W., Miao, S., Ning, T., Lei, Q., Jiang, T., & Ma, D. (2021) · World Journal of Stem Cells · doi:10.4252/wjsc.v13.i5.342 · Cited by 21
Lin, W., Chen, S., Wang, Y., Wang, M., Lee, W., Jiang, X., & Li, G. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03912-4 · Cited by 23
Somanna, N. K., Wörner, P. M., Murthy, S. N., Pankey, E. A., Schächtele, D. J., Hilaire, R. S., Jansen, D., Chaffin, A. E., Nossaman, B. D., Alt, E., et al. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00589.2013 · Cited by 20
Le, T. Y. L., Pickett, H. A., Yang, A., Ho, J. W. K., Thavapalachandran, S., Igoor, S., Yang, S. F., Farraha, M., Voges, H. K., Hudson, J. E., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-47022-w · Cited by 20
Pax8 plays a pivotal role in regulation of cardiomyocyte growth and senescence
Wu, Y., Zhou, X., Huang, X., Xia, Q., Chen, Z., Zhang, X., Yang, D., & Geng, Y. (2016) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12779 · Cited by 20
Paik, K. J., Maan, Z. N., Zielins, E. R., Duscher, D., Whittam, A. J., Morrison, S. D., Brett, E. A., Ransom, R. C., Hu, M. S.-M., Wu, J. C., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150927 · Cited by 18
Research update of adipose tissue-based therapies in regenerative dermatology
Bellei, B., Migliano, E., & Picardo, M. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-022-10328-w · Cited by 20
Tan, D., Huang, Z., Zhao, Z., Chen, X., Liu, J., Wang, D., Deng, Z., & Li, W. (2023) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2023.5326 · Cited by 18
Long-Term Biobanking of Intact Tissue from Lipoaspirate
Badowski, M., Muise, A., & Harris, D. T. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8030327 · Cited by 18
Jhala, D., Rather, H., & Vasita, R. (2020) · Biomedical Materials · doi:10.1088/1748-605x/ab772e · Cited by 18
Leśniak, M., Zdanowski, R., Suska, M., Brewczyńska, A., Stankiewicz, W., Kloc, M., Kubiak, J. Z., & Lewicki, S. (2018) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-017-0103-9 · Cited by 18
The emerging studies on mesenchymal progenitors in the long bone
Shen, F., Huang, X., He, G., & Shi, Y. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01039-x · Cited by 19
Wright, A., Snyder, L., Knights, K., Hong Bin, H. E., Springer, N. L., Lillich, J. D., & Weiss, M. L. (2020) · Stem Cells and Development · doi:10.1089/scd.2019.0145 · Cited by 17
Payr, S., Schuseil, T., Unger, M., Seeliger, C., Tiefenboeck, T. M., Balmayor, E. R., & van Griensven, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-67254-5 · Cited by 17
The Emerging Roles of microRNAs in Stem Cell Aging
Dietrich, C., Singh, M. P., Kumar, N., & Singh, S. R. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-74470-4_2 · Cited by 16
Barreto-Durán, E., Mejía-Cruz, C. C., Leal-García, E., Pérez-Núñez, R., & Rodríguez-Pardo, V. M. (2018) · Europe PMC (PubMed Central) · Cited by 16
Wang, W., Yan, M., Aarabi, G., Peters, U., Freytag, M., Gosau, M., Smeets, R., & Beikler, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911485 · Cited by 16
Inference of Target Gene Regulation via miRNAs during Cell Senescence by Using the MiRaGE Server
Taguchi, Y. (2012) · Communications in computer and information science · doi:10.1007/978-3-642-31837-5_64 · Cited by 16
A genome-wide comparison of mesenchymal stem cells derived from human placenta and umbilical cord
Teng, S., Lo, Y., Liu, W.-T., Hsuan, Y. C.-Y., & Lin, W. (2017) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2017.08.016 · Cited by 15
Yang, K. Y., Song, H., he, S. T., Yin, W., Fan, X., Ru, F., Gong, H., Zhai, X., Zhang, J., Peng, Z., et al. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14456 · Cited by 16
Eisa, N. H., Periyasamy‐Thandavan, S., Mas, S., Herberg, S., Volkman, B. F., Aguilar‐Perez, A., Kondrikov, D., Elmansi, A. M., Reitman, C. A., Shi, X., et al. (2021) · Bone · doi:10.1016/j.bone.2021.116154 · Cited by 14
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Zhang, J., Wang, Y., Zhao, B., Fan, L., Bai, X., Yang, L., Chang, P., Hu, D., & Liu, X. (2015) · Aesthetic Plastic Surgery · doi:10.1007/s00266-015-0505-9 · Cited by 15
Bourebaba, L., Bourebaba, N., Galuppo, L. D., & Marycz, K. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2024.119806 · Cited by 14
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McCarthy, M. E., Brown, T., Wiśniewska, J., Bunnell, B. A., Frazier, T. P., Wu, X., & Gimble, J. M. (2018) · Current Stem Cell Reports · doi:10.1007/s40778-018-0125-9 · Cited by 14
Lazzarini, R., Caffarini, M., Tang, H., Cerqueni, G., Pellegrino, P., Monsurrò, V., Primio, R. D., & Orciani, M. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.02.014 · Cited by 14
Singh, A. K., Peng, B., Chien, S.-T., Chan, C.-H., Deng, Y.-H., Pai, H., Wei, H.-J., Wang, M.-F., Wang, S., Wu, C.-Y., et al. (2023) · Biomaterials Science · doi:10.1039/d2bm01997c · Cited by 13
Leyendecker, A., Pinheiro, C. C. G., Tanikawa, D. Y. S., Ferreira, J. R. M., Amano, M. T., & Bueno, D. F. (2020) · Stem Cells International · doi:10.1155/2020/3670412 · Cited by 13
Sato, M., Kawase‐Koga, Y., Yamakawa, D., Fujii, Y., & Chikazu, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207731 · Cited by 13
Metadata
- Authors
- Alt, E. U., Senst, C., Murthy, S. N., Slakey, D. P., Dupin, C. L., Chaffin, A. E., Kadowitz, P. J., & Izadpanah, R.
- Affiliations
- Tulane University (US)
- Louisiana State University (US)
- Corresponding author
- Izadpanah, Reza
- ORCID
- Venue
- Stem Cell Research
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 8
- Issue
- 2
- Pages
- 215-225
- ISSN
- 1873-5061 (ISSN-L)
- OpenAlex
- W2023538191
- Cited by
- 316
- References
- 55
- Citations by year
- 2026: 8 · 2025: 17 · 2024: 15 · 2023: 21 · 2022: 24 · 2021: 34 · 2020: 27 · 2019: 25 · 2018: 22 · 2017: 18 · 2016: 13 · 2015: 27 · 2014: 30 · 2013: 25 · 2012: 10
- FWCI
- 10.48
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Stem Cell Research (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Alliance of Cardiovascular Researchers
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- aging, mesenchymal stem cells, adipose-derived stem cells, cellular senescence, multilineage differentiation, cell proliferation, cell cycle quiescence, DNA repair genes, microRNA expression, p16INK4a, Chk1, tissue regeneration, stem cell aging
- MeSH terms
- Adipose Tissue, Adolescent, Adult, Aged, Aging, Cell Count, Cell Cycle, Cell Differentiation, DNA Repair, Female, Humans, Male, Middle Aged, Apoptosis, Gene Expression Regulation, Developmental, Cell Lineage, MicroRNAs, Cell Proliferation, Young Adult, Transcriptome, Mesenchymal Stem Cells
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