The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Skeletal muscle pericyte subtypes differ in their differentiation potential
Open accessAbstract
Neural progenitor cells have been proposed as a therapy for central nervous system disorders, including neurodegenerative diseases and trauma injuries, however their accessibility is a major limitation. We recently isolated Tuj1+ cells from skeletal muscle culture of Nestin-GFP transgenic mice however whether they form functional neurons in the brain is not yet known. Additionally, their isolation from nontransgenic species and identification of their ancestors is unknown. This gap of knowledge precludes us from studying their role as a valuable alternative to neural progenitors. Here, we identified two pericyte subtypes, type-1 and type-2, using a double transgenic Nestin-GFP/NG2-DsRed mouse and demonstrated that Nestin-GFP+/Tuj1+ cells derive from type-2 Nestin-GFP+/NG2-DsRed+/CD146+ pericytes located in the skeletal muscle interstitium. These cells are bipotential as they generate either Tuj1+ cells when cultured with muscle cells or become “classical” α-SMA+ pericytes when cultured alone. In contrast, type-1 Nestin-GFP-/NG2-DsRed+/CD146+ pericytes generate α-SMA+ pericytes but not Tuj1+ cells. Interestingly, type-2 pericyte derived Tuj1+ cells retain some pericytic markers (CD146+/PDGFRβ+/NG2+). Given the potential application of Nestin-GFP+/NG2-DsRed+/Tuj1+ cells for cell therapy, we found a surface marker, the nerve growth factor receptor, which is expressed exclusively in these cells and can be used to identify and isolate them from mixed cell populations in nontransgenic species for clinical purposes.
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Cites
A perivascular origin for mesenchymal stem cells in multiple human organs
Crisan, M., Yap, S., Casteilla, L., Chen, C.-W., Corselli, M., Park, T. S., Andriolo, G., Sun, B., Zheng, B., Zhang, L., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.07.003 · Cited by 3,991 · cited 6×
“This intriguing finding merits further research, as pericytes have been associated with growth and regeneration of various postnatal tissues (Crisan et al., 2008; Dellavalle et al., 2011; Dore-Duffy, 2008; Dore-Duffy et al., 2006; Feng et al., 2011).”
BackgroundInfluentialPericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice
Lindahl, P., Johansson, B. R., Levéen, P., & Betsholtz, C. (1997) · Science · doi:10.1126/science.277.5323.242 · Cited by 2,226
Adult mesenchymal stem cells for tissue engineering versus regenerative medicine
Caplan, A. I. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21200 · Cited by 1,956
A Pericyte Origin of Spinal Cord Scar Tissue
Göritz, C., Dias, D. O., Tomilin, N., Barbacid, M., Shupliakov, O., & Frisén, J. (2011) · Science · doi:10.1126/science.1203165 · Cited by 858
Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation
Satokata, I., Ma, L., Ohshima, H., Bei, M., Woo, I., Nishizawa, K., Maeda, T., Takano, Y., Uchiyama, M., Heaney, S., et al. (2000) · Nature Genetics · doi:10.1038/74231 · Cited by 737
Zawadzka, M., Rivers, L. E., Fancy, S. P. J., Zhao, C., Tripathi, R., Jamen, F., Young, K., Goncharevich, A., Pohl, H., Rizzi, M., et al. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.04.002 · Cited by 650
Canonical Wnt Signaling Regulates Organ-Specific Assembly and Differentiation of CNS Vasculature
Stenman, J. M., Rajagopal, J., Carroll, T. J., Ishibashi, M., McMahon, J., & McMahon, A. P. (2008) · Science · doi:10.1126/science.1164594 · Cited by 641
CNS Microvascular Pericytes Exhibit Multipotential Stem Cell Activity
Dore-Duffy, P., Katychev, A., Wang, X., & Van Buren, E. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600272 · Cited by 414
Bone marrow-derived cells that populate the adult mouse brain preserve their hematopoietic identity
Vallières, L., & Sawchenko, P. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05197.2003 · Cited by 245
The CNS microvascular pericyte: pericyte-astrocyte crosstalk in the regulation of tissue survival
Bonkowski, D., Katyshev, V., Balabanov, R. D., Borisov, A., & Dore-Duffy, P. (2011) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-8-8 · Cited by 207
Cited by
Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner
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Self-citationBrain and Retinal Pericytes: Origin, Function and Role
Trost, A., Lange, S., Schroedl, F., Bruckner, D., Motloch, K. A., Bogner, B., Kaser-Eichberger, A., Strohmaier, C., Runge, C., Aigner, L., et al. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00020 · Cited by 244
Development and Function of the Blood-Brain Barrier in the Context of Metabolic Control
Haddad-Tóvolli, R., Dragano, N. R. V., Ramalho, A. F. S., & Velloso, L. A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00224 · Cited by 226
Pericytes: Problems and Promises for CNS Repair
Laredo, F., Plebanski, J., & Tedeschi, A. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00546 · Cited by 44
Differentiation reveals latent features of aging and an energy barrier in murine myogenesis
Kimmel, J. C., Yi, N., Roy, M., Hendrickson, D. G., & Kelley, D. R. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109046 · Cited by 42
Metadata
- Authors
- Birbrair, A., Zhang, T., Wang, Z.-M., Messi, M. L., Enikolopov, G. N., Mintz, A., & Delbono, O.
- Venue
- Stem Cell Research
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 10
- Issue
- 1
- Pages
- 67-84
- ISSN
- 1873-5061 (ISSN-L)
- OpenAlex
- W2054417819
- Cited by
- 198
- References
- 12
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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