Pericytes: Problems and Promises for CNS Repair
Open accessAbstract
Microvascular complications are often associated with slow and progressive damage of various organs. Pericytes are multi-functional mural cells of the microcirculation that control blood flow, vascular permeability and homeostasis. Whereas accumulating evidence suggests that these cells are also implicated in a variety of diseases, pericytes represent promising targets that can be manipulated for therapeutic gain. Here, we review the role of pericytes in angiogenesis, blood-brain barrier (BBB) function, neuroinflammation, tissue fibrosis, axon regeneration failure, and neurodegeneration. In addition, we outline strategies altering pericyte behavior to point out problems and promises for axon regeneration and central nervous system (CNS) repair following injury or disease.
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Pericytes are an attractive therapeutic target for AD therapy by tuning neuroinflammation.
“Owing to the numerous roles of pericytes in neuroinflammation,512,513 they are thought to be an attractive therapeutic target for AD therapy by tuning neuroinflammation.”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [513]
The Alzheimer’s Disease section calls pericytes an attractive treatment target for AD, citing their roles in blood–brain barrier function, cerebral blood flow, and Aβ clearance. The Neurovascular Inflammation section separately proposes targeting pericytes to promote neuronal survival by tuning neuroinflammation, but does not specifically present that approach as an AD therapy. (LLM, conf=0.84)
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Endothelium‐specific platelet‐derived growth factor‐B ablation mimics diabetic retinopathy
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Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury
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Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss
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“When pleiotrophin was restored through CSF infusions, the neuronal loss and behavioral deficits observed were prevented (Nikolakopoulou et al., 2019), highlighting a potential neuroprotective element that pericytes may possess.”
BackgroundNogo limits neural plasticity and recovery from injury
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Brain Pericytes As Mediators of Neuroinflammation
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Can disturbed brain microcirculation cause Alzheimer’s disease?
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“Pericyte stimulation with LPS causes translocation of the nuclear factor kappa-B (NF-kB) protein complex, a prototypical pro-inflammatory signaling pathway (Lawrence, 2009), into the nucleus with consequent activation of its downstream effectors (Guijarro-Muñoz et al., 2014).”
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“Given that a single pericyte can establish contacts with multiple endothelial cells, pericyte coverage can vary based on blood vessel function and location (Hirschi et al., 1999; Armulik et al., 2005, 2011).”
BackgroundPlastic roles of pericytes in the blood–retinal barrier
Park, D. Y., Lee, J., Kim, J., Kim, K., Hong, S., Han, S., Kubota, Y., Augustin, H. G., Ding, L., Kim, J. W., et al. (2017) · Nature Communications · doi:10.1038/ncomms15296 · Cited by 325 · cited 5× · see citing works
“Endothelial cells, glial cells, and pericytes together comprise the inner blood-retinal barrier (Cunha-Vaz et al., 2011; Park et al., 2017).”
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“The fibronectin isoform containing the extra domain A has been implicated in pathological fibrosis in experimental models of wound healing (Muro et al., 2003).”
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Diabetic retinopathy: pathogenesis, clinical grading, management and future developments
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“Current treatment options for diabetic retinopathies are invasive, have limited effectiveness and mostly address the chronic stages of the disease with minimal improvement in repairing vision (Heng et al., 2013; Hendrick et al., 2015).”
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Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner
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The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS
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“…a growth-competent state and to eliminate extracellular growth inhibitors (O’Donovan et al., 2014; Wang et al., 2015, 2018; Cartoni et al., 2016; Tedeschi et al., 2016, 2019; Fink et al., 2017; Kim et al., 2018; Bray et al., 2019; Kumamaru et al., 2019; Sekine et al., 2019), other extrinsic…”
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A population study on blood-brain barrier function in 85-year-olds
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Early Loss of Pericytes and Perivascular Stromal Cell-Induced Scar Formation after Stroke
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“, anti-VEGF agents) directly into the eye (Hendrick et al., 2015).”
BackgroundAssessing Burrowing, Nest Construction, and Hoarding in Mice
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“Furthermore, these mice also exhibit a decrease in neuron density in the S1 cortex and CA1 hippocampal region and changes in burrowing and nest-building behavior that are considered early signs of AD in mice (Deacon, 2012; Kisler et al., 2017b).”
BackgroundThe fibronectin gene as a model for splicing and transcription studies
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Skeletal muscle pericyte subtypes differ in their differentiation potential
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Myelin-associated inhibitors in axonal growth after CNS injury
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“, 2010; Tedeschi and Bradke, 2017) and the hostile environment that develops as a result of trauma or disease (Geoffroy and Zheng, 2014; Schwab and Strittmatter, 2014; Chen et al., 2018; Dias et al., 2018) are major obstacles to neurological recovery.”
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Chronic in vivo imaging in the mouse spinal cord using an implanted chamber
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The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration
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Pericytes, mesenchymal stem cells and their contributions to tissue repair
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Microvascular Remodeling and Wound Healing: A Role for Pericytes
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Type-1 pericytes participate in fibrous tissue deposition in aged skeletal muscle
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Pericytes impair capillary blood flow and motor function after chronic spinal cord injury
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Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells
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Self-citationFibrotic scarring following lesions to the central nervous system
Dias, D. O., & Göritz, C. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.02.009 · Cited by 151 · see citing works
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“Pericytes are among the first cells to invade the lesion site in experimental models of brain and spinal cord injury (SCI; Göritz et al., 2011; Birbrair et al., 2014; Dias et al., 2018; Hesp et al., 2018), presumably contributing to the remodeling of the vasculature after trauma.”
BackgroundInfluentialShedding of soluble platelet-derived growth factor receptor-β from human brain pericytes
Sagare, A. P., Sweeney, M. D., Makshanoff, J., & Zlokovic, B. V. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.09.025 · Cited by 142 · see citing works
Region-specific permeability of the blood–brain barrier upon pericyte loss
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Microvascular Mural Cell Organotypic Heterogeneity and Functional Plasticity
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“Pericytes function in a tissue- and context-dependent manner (Holm et al., 2018).”
BackgroundPericytes secrete pro-regenerative molecules in response to platelet-derived growth factor-BB
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“Along this line, expression of the potent angiogenic factor VEGF and its receptor have been shown to increase in diabetic retinas (Penn et al., 2008).”
BackgroundInfluentialFibronectin Matrix Assembly after Spinal Cord Injury
Zhu, Y., Soderblom, C., Trojanowsky, M., Lee, D.-H., & Lee, J. K. (2014) · Journal of Neurotrauma · doi:10.1089/neu.2014.3703 · Cited by 120 · see citing works
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Dysfunction of brain pericytes in chronic neuroinflammation
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“Nonetheless, experimental evidence has shown that upon reactivation of axon growth programs, several classes of regeneration-competent axons including dorsal column sensory, rubrospinal, nociceptive and propriospinal axons preferentially associate with NG2 and CD13 (e.g., common markers for FIGURE 2 | Pericyte/NG2+ gl…”
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“80% reduction in pericyte coverage) where PDGF-B binding to heparan sulfate proteoglycans is disrupted and PDGFRβF7/F7 mice which have approximately 40% of the pericytes coverage of control littermates, have elucidated the impact that loss of pericytes has on the BBB (Lindblom et al., 2003; Armulik et al., 2010; Danem…”
BackgroundADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in the Adult CNS
Tedeschi, A., Dupraz, S., Curcio, M., Laskowski, C. J., Schaffran, B., Flynn, K. C., Santos, T. E., Stern, S., Hilton, B. J., Larson, M. J. E., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.07.007 · Cited by 102 · see citing works
Self-citationNG2 Colocalizes With Axons and Is Expressed by a Mixed Cell Population in Spinal Cord Lesions
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“This provides a tangible prospect of using pericyte bridges to encourage axon regeneration through the lesion site (Jones et al., 2003; McTigue et al., 2006; Anderson et al., 2018).”
BackgroundZehendner, C. M., Sebastiani, A., Hugonnet, A. V., Bischoff, F. C., Luhmann, H. J., & Thal, S. C. (2015) · Scientific Reports · doi:10.1038/srep13497 · Cited by 97 · cited 1× · see citing works
“Five days after a controlled cortical impact, a well-characterized experimental model that reproduces pathophysiological changes observed in human traumatic brain injury, the proliferation marker Ki67 increases together with PDGFRβ at the lesion core (Zehendner et al., 2015).”
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“In spite of new discoveries and technological applications that allow reprogramming adult mammalian neurons into a growth-competent state and to eliminate extracellular growth inhibitors (O’Donovan et al., 2014; Wang et al., 2015, 2018; Cartoni et al., 2016; Tedeschi et al., 2016, 2019; Fink et al., 2017; Kim et al.,…”
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“Moreover, the administration of the periostin neutralizing antibody has proven similarly effective in suppressing the formation of the fibrotic scar as well as promoting recovery after SCI (Yokota et al., 2017).”
BackgroundInfluentialLearning to swim, again: Axon regeneration in fish
Rasmussen, J. P., & Sagasti, A. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.02.022 · Cited by 89 · see citing works
Identification of Intrinsic Axon Growth Modulators for Intact CNS Neurons after Injury
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A Neuronal piRNA Pathway Inhibits Axon Regeneration in C. elegans
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The pericyte secretome: Potential impact on regeneration
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Fibronectin EDA forms the chronic fibrotic scar after contusive spinal cord injury
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High Glucose-induced Retinal Pericyte Apoptosis Depends on Association of GAPDH and Siah1
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Choroidal pericytes promote subretinal fibrosis after experimental photocoagulation
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Pericyte transplantation improves skeletal muscle recovery following hindlimb immobilization
Munroe, M., Dvoretskiy, S., Lopez, A., Leong, J., Dyle, M. C., Kong, H., Adams, C. M., & Boppart, M. D. (2019) · The FASEB Journal · doi:10.1096/fj.201802580r · Cited by 33 · cited 1× · see citing works
“Pericyte transplantation has been recently shown to improve skeletal muscle recovery in a mouse model of disuse-mediated muscle atrophy (Munroe et al., 2019).”
BackgroundVEGF-A stimulates podosome-mediated collagen-IV proteolysis in microvascular endothelial cells
Daubon, T., Spuul, P., Alonso, F., Frémaux, I., & Genot, E. M. (2016) · Journal of Cell Science · doi:10.1242/jcs.186585 · Cited by 25 · see citing works
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“The fact that regeneration of the corticospinal tract can be promoted in adulthood by partially eliminating a cellular component of the fibrotic scar is striking, especially considering the lively debate on the extent to which scarring can be beneficial to axon regeneration and functional recovery (Narang and Zheng, 2…”
BackgroundAβ inhibits mesenchymal stem cell–pericyte transition through MAPK pathway
Xu, L., Li, J., Luo, Z., Wu, Q., Fan, W., Yao, X., Li, Q., Yan, H., & Wang, J. (2018) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmy072 · Cited by 11 · cited 1× · see citing works
“When intracellular Aβ accumulation overrides the clearance capacity of pericytes, it causes a loss of pericytes that results in an increase in Aβ preventing mesenchymal stem cells from transitioning into pericytes (Xu et al., 2018).”
Background
Flagged first, then by citations
Cited by
Sorted by citations
Role of neuroinflammation in neurodegeneration development
Zhang, W., Xiao, D., Mao, Q., & Xia, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01486-5 · Cited by 1,668 · see citing works
Peng, Y., Zhuang, J., Ying, G., Zeng, H., Zhou, H., Cao, Y., Chen, H., Xu, C., Fu, X., Xu, H., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01830-4 · Cited by 140 · see citing works
RetractedKim, S., Jung, U. J., & Kim, S. R. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14020386 · Cited by 123 · see citing works
Natural Compounds and Autophagy: Allies Against Neurodegeneration
Stacchiotti, A., & Corsetti, G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.555409 · Cited by 105 · see citing works
Single Cell Transcriptomic Analysis Reveals Organ Specific Pericyte Markers and Identities
Baek, S. H., Maiorino, E., Kim, H., Glass, K., Raby, B. A., & Yuan, K. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.876591 · Cited by 82 · see citing works
In vivo methods for imaging blood–brain barrier function and dysfunction
Harris, W. J., Asselin, M., Hinz, R., Parkes, L. M., Allan, S. M., Schießl, I., Boutin, H., & Dickie, B. (2022) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-022-05997-1 · Cited by 87 · see citing works
Glial Cell-Axonal Growth Cone Interactions in Neurodevelopment and Regeneration
Rigby, M. J., Gómez, T. M., & Puglielli, L. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00203 · Cited by 76 · see citing works
“These migrating neural crest cells form Schwann cell precursors (SCPs) and then immature Schwann cells that begin to associate with axons; an additional branching lineage includes the formation of satellite cells that eventually associate with peripheral ganglia (Le Douarin and Ziller, 1993).”
BackgroundFibrotic Scar in Neurodegenerative Diseases
D’Ambrosi, N., & Apolloni, S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01394 · Cited by 77 · see citing works
“An increasing attention is now given to the role of pericyte cells as an attractive target involved in the pathogenesis, progression and potential treatment of AD (18).”
BackgroundResultSARS-CoV-2 deregulates the vascular and immune functions of brain pericytes via Spike protein
Khaddaj‐Mallat, R., Aldib, N., Bernard, M., Paquette, A.-S., Ferreira, A., Lecordier, S., Saghatelyan, A., Flamand, L., & ElAli, A. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105561 · Cited by 67 · see citing works
“Similarly, S protein at 10 nM triggered the expression of fibronectin, a major extracellular protein involved in the fibrotic response (Fernández-Klett et al., 2013; Laredo et al., 2019), as early as 6 h after stimulation (Fig.”
Muangsanit, P., Roberton, V. H., Costa, E., et al. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.03.039 · Cited by 65 · see citing works
“28 possible that the interaction between Schwann cells and HUVECs in the co-culture constructs, which was apparently detrimental to regeneration, vascularisation and Schwann cell migration, could be improved by decreasing the Schwann cell seeding density, the addition of exogenous angiogenic factors or the incorporati…”
BackgroundTargetability of the neurovascular unit in inflammatory diseases of the central nervous system
Smith, B. C., Tinkey, R. A., Shaw, B. C., & Williams, J. L. (2022) · Immunological Reviews · doi:10.1111/imr.13121 · Cited by 53 · see citing works
Morató, X., Pytel, V., Jofresa, S., Ruiz, A., & Boada, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169305 · Cited by 53 · see citing works
“In these disorders, pericyte malfunction often leads to BBB disruption and/or a decrease of CBF, thus causing secondary neurological damage [180].”
BackgroundPathophysiology of blood-brain barrier in brain tumor. Novel therapeutic advances using nanomedicine
Sharma, H. S., Muresanu, D. F., Nozari, A., Lafuente, J. V., Tian, Z. R., Sahib, S., Bryukhovetskiy, I., Bryukhovetskiy, A. S., Buzoianu, A. D., Patnaik, R., et al. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.03.001 · Cited by 50 · see citing works
Pericytes Across the Lifetime in the Central Nervous System
Bennett, H. C., & Kim, Y. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.627291 · Cited by 47 · see citing works
Chen, X., Zhang, X., Gong, Z., Yang, Y., Zhang, X., Wang, Q., Wang, Y., & Xie, R. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2022.1040319 · Cited by 30 · see citing works
“Loss of pericytes and podocytes leads to increased microvascular permeability and vascular leakage (41, 42).”
BackgroundAdvances in Hydrogel-Based Microfluidic Blood–Brain-Barrier Models in Oncology Research
Sood, A., Kumar, A., Dev, A., Gupta, V. K., & Han, S. S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14050993 · Cited by 28 · see citing works
“The PCs rests on the ablumenal surface of the microvascular endothelium and are rooted in the vascular basal membrane [39].”
BackgroundRole of pericytes in the development of cerebral cavernous malformations
Dai, Z., Li, J., Li, Y., Wang, R., Yan, H., Xiong, Z., Wu, S., Yang, X., Lu, D., Zhang, D., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105642 · Cited by 27 · see citing works
“In addition, pericytes are a major source of fibronectin.(24,25) The increased deposition of fibronectin was detected in CCM lesions.”
BackgroundSekine, Y., Algarate, P. T., Cafferty, W. B. J., & Strittmatter, S. M. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2996-18.2019 · Cited by 25 · see citing works
Reactive Fibroblasts in Response to Optic Nerve Crush Injury
Liu, X., Liu, Y., Jin, H., Khodeiry, M. M., Kong, W., Wang, N., Lee, J. K., & Lee, R. K. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02199-4 · Cited by 24 · see citing works
Ferraiuolo, L., & Maragakis, N. J. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135911 · Cited by 24 · see citing works
Schreiner, T. G., Creangă-Murariu, I., Tamba, B.-I., Lucanu, N., & Popescu, B. O. (2022) · Biomolecules · doi:10.3390/biom12081136 · Cited by 22 · see citing works
“The support of pericytes for BMECs is manifest from the developmental stages of the cerebral microvasculature, with recent research demonstrating the role of pericytes in the maintenance of a proper brain microcirculation [44].”
BackgroundSingle‐cell RNA sequencing for traumatic spinal cord injury
Cao, Y., Zhu, S., Yu, B., & Yao, C. (2022) · The FASEB Journal · doi:10.1096/fj.202200943r · Cited by 23 · see citing works
Endothelial inflammation and dysfunction in COVID-19
Sbirkov, Y., Dzharov, V., Todorova, K. O., Hayrabedyan, S., & Sarafian, V. S. (2022) · VASA · doi:10.1024/0301-1526/a000991 · Cited by 21 · see citing works
Kurmann, L., Okoniewski, M. J., & Dubey, R. K. (2021) · Cells · doi:10.3390/cells10092314 · Cited by 20 · see citing works
Liu, C., Zhang, D., Lu, Z., Man, J., Zhang, Z., Fu, X., Cui, K., & Wang, J. (2022) · Neuroscience Letters · doi:10.1016/j.neulet.2022.136708 · Cited by 17 · see citing works
Tuleta, I., & Frangogiannis, N. G. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00403.2025 · Cited by 15 · see citing works
The Therapeutic Potential of Pericytes in Bone Tissue Regeneration
Issabekova, A., Sekenova, A., Ogay, V. B., Kudaibergen, G. K., Eskendirova, S., Sarsenova, M., Dairov, A., Mukhlis, S., Baidarbekov, M., & Temirzhan, A. (2023) · Biomedicines · doi:10.3390/biomedicines12010021 · Cited by 16 · see citing works
Need for a Paradigm Shift in the Treatment of Ischemic Stroke: The Blood-Brain Barrier
Alonso-Alonso, M. L., Sampedro‐Viana, A., Fernández‐Rodicio, S., Bazarra‐Barreiros, M., Ouro, A., Sobrino, T., Campos, F., Castillo, J., Hervella, P., & Iglesias‐Rey, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169486 · Cited by 14 · see citing works
“It has been shown that they are important in the development of the BBB, in angiogenesis, and can even act as stem cells of the CNS [53,54].”
BackgroundLi, M., Sun, H., Shen, T., Xue, S., Zhao, Y. W., Leng, B., Zhang, J., Li, Z., & Xia, Z. (2021) · Sleep Medicine · doi:10.1016/j.sleep.2021.10.009 · Cited by 12 · see citing works
Плотников, М. Б., Анищенко, А. М., Khlebnikov, А. I., & Schepetkin, I. A. (2025) · Molecules · doi:10.3390/molecules30112353 · Cited by 13 · see citing works
“Pericytes plays a crucial role in regulating the permeability of the BBB [156].”
Sun, W., Dion, E., Laredo, F., Okonak, A., Sepeda, J. A., Haykal, E., Zhou, M., El‐Hodiri, H. M., Fischer, A. J., Silver, J., et al. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.04.020 · Cited by 10 · see citing works
“17,18 While revascularization and vascular normalization ensure the delivery of oxygen and nutrients needed to sustain the high metabolic demands of neural networks, aberrant reorganization of microvasculature networks and perivascular cell function blunts axon regeneration after SCI in adult mice.”
Self-citationChopra, M., Bhagwani, A., & Kumar, H. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01266-9 · Cited by 9 · see citing works
Pericyte derivation and transplantation for blood-CNS barrier reconstitution in CNS disorders
Kim, H., Wu, K. L., Tam, K.-W., Chan, Y., & Shum, D. K. (2024) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2023.12.007 · Cited by 7 · see citing works
“At present, pericyte differentiation is induced by commercial MSC-supporting medium containing fetal bovine serum (FBS), supplemented with a combination of PDGF-BB, basic fibroblast growth factor (bFGF), or transforming growth factor β (TGF-β ) (Faal et al., 2019; Stebbins et al., 2019; Sun et al., 2020; Vidal et al.,…”
BackgroundInfluentialThe Role of Pericytes in Inner Ear Disorders: A Comprehensive Review
Maniaci, A., Briglia, M., Allia, F., Montalbano, G., Romano, G. L., Zaoualí, M. A., Hmida, D., Gagliano, C., Malaguarnera, R., Lentini, M., et al. (2024) · Biology · doi:10.3390/biology13100802 · Cited by 7 · see citing works
“Biology 2024 , 13 , 802 3 of 31 However, pericyte dysfunction can have profound implications for various pathological conditions such as neurodegenerative diseases, diabetic retinopathy, and tumor angiogenesis [23–25].”
BackgroundIntegrative Spatial Omics for Systems-Level Mapping of Pathological NichesPreprint
Kruse, A. R. S., Lardenoije, R., Migas, L. G., Scott, C. F., Marshall, C. R., Malek, M. C., Eskaros, A., Pham, T. H., Aamodt, K. I., Colley, M. E., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.12.675904 · Cited by 6 · see citing works
“Fibrosis likely also plays an important role in neurodegeneration, involving microglia, endothelial cells, and pericytes [72, 73].”
TGF-β-induced fibrotic scar formation limits recovery of spinal cord injury
Pan, D., Wu, P., Noller, K., Cahan, P., & Cao, X. (2026) · Bone Research · doi:10.1038/s41413-026-00507-7 · Cited by 8 · see citing works
Khaddaj‐Mallat, R., Aldib, N., Paquette, A.-S., Ferreira, A., Lecordier, S., Bernard, M., Saghatelyan, A., & ElAli, A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.30.442194 · Cited by 4 · see citing works
“cord injury (SCI) [29, 30, 31, 38], to contribute to fibrotic scar formation that could mitigate tissue regeneration.”
BackgroundRole of pericytes in regulating penile angiogenesis and nerve regeneration
Yin, G. N., & Ryu, J.-K. (2024) · Asian Journal of Andrology · doi:10.4103/aja202455 · Cited by 3 · see citing works
Pieczonka, K., McIntyre, W. B., Khazaei, M., & Fehlings, M. G. (2022) · Springer eBooks · doi:10.1007/978-981-16-6016-0_14-1 · Cited by 1 · see citing works
Pericytes as Cell Therapy for Locomotor Recovery
Mayo, J. N., & Bearden, S. E. (2020) · Current Tissue Microenvironment Reports · doi:10.1007/s43152-020-00024-7
Pieczonka, K., McIntyre, W. B., Khazaei, M., & Fehlings, M. G. (2022) · Springer eBooks · doi:10.1007/978-981-19-2655-6_14
Unveiling Central Nervous System Pericytes: Immunofluorescence Protocol and Confocal Microscopy
d’Amati, A., Ribatti, D., Virgintino, D., & Errede, M. (2025) · Methods in molecular biology · doi:10.1007/978-1-0716-4706-6_8
Xu, M., Li, Y., Luan, J., Yang, A., Zhu, L., Shu, N., Ouyang, G., Xue, Y., Zhang, L., & Ma, G. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107228
Morphological and transcriptomic change of brain pericytes by lipopolysaccharide treatment
Asai, T., Yonezu, Y., Uyeda, A., Watanabe, H., Suzuki, T., Misawa, H., & Muramatsu, R. (2026) · Frontiers in Neural Circuits · doi:10.3389/fncir.2026.1725431
“Their loss or dysfunction has been linked to diverse disorders ranging from neurodegeneration to spinal cord injury (Laredo et al., 2019).”
- Authors
- Laredo, F., Plebanski, J., & Tedeschi, A.
- Affiliations
- University of Nottingham (GB)
- The Ohio State University Wexner Medical Center (US)
- Corresponding author
- Tedeschi, Andrea
- ORCID
- Tedeschi, Andrea
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2019-12-06
- Volume
- 13
- Pages
- 546-546
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC6908836
- OpenAlex
- W2990491849
- Semantic Scholar
- 1ba4a81fbbb5e43f8a451eb52042f135e8d85bc4
- Cited by
- 44
- References
- 158
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 3 · 2023: 3 · 2022: 14 · 2021: 7 · 2020: 7 · 2019: 1
- FWCI
- 3.19
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke
- Craig H. Neilsen Foundation
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- pericytes, central nervous system repair, angiogenesis, blood-brain barrier, neuroinflammation, fibrosis, axon regeneration, neurodegeneration, microcirculation, vascular permeability
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