The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Is Akt the “Warburg kinase”?—Akt-energy metabolism interactions and oncogenesis
Open accessAbstract
The serine/threonine kinase Akt – also known as protein kinase B (PKB) – has emerged as one of the most frequently activated protein kinases in human cancer. In fact, most, if not all, tumors ultimately find a way to activate this important kinase. As such, Akt activation constitutes a hallmark of most cancer cells, and such ubiquity presumably connotes important roles in tumor genesis and/or progression. Likewise, the hypermetabolic nature of cancer cells and their increased reliance on “aerobic glycolysis”, as originally described by Otto Warburg and colleagues, are considered metabolic hallmarks of cancer cells. In this review, we address the specific contributions of Akt activation to the signature metabolic features of cancer cells, including the so-called “Warburg effect”.
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Metadata
- Authors
- Robey, R. B., & Hay, N.
- Venue
- Seminars in Cancer Biology
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 19
- Issue
- 1
- Pages
- 25-31
- ISSN
- 1044-579X (ISSN-L)
- OpenAlex
- W2080411308
- Cited by
- 540
- References
- 12
- FWCI
- 7.48
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
