Cross-talk between myeloid-derived suppressor cells (MDSC), macrophages, and dendritic cells enhances tumor-induced immune suppression
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The tumor microenvironment is a complex milieu of tumor and host cells. Host cells can include tumor-reactive T cells capable of killing tumor cells. However, more frequently the tumor and host components interact to generate a highly immune suppressive environment that frustrates T cell cytotoxicity and promotes tumor progression through a variety of immune and non-immune mechanisms. Myeloid-derived suppressor cells (MDSC) are a major host component contributing to the immune suppressive environment. In addition to their inherent immune suppressive function, MDSC amplify the immune suppressive activity of macrophages and dendritic cells via cross-talk. This article will review the cell-cell interactions used by MDSC to inhibit anti-tumor immunity and promote progression, and the role of inflammation in promoting cross-talk between MDSC and other cells in the tumor microenvironment.
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Tregs, MDSCs, and dendritic and stromal cell populations within the tumor can deprive T cells of necessary co-stimulatory signals or induce inhibitory signals.
“Tregs, myeloid derived suppressor cells (MDSCs), and dendritic and stromal cell populations within the tumor can deprive T cells of necessary co-stimulatory signals or induce inhibitory signals (Chen and Mellman, 2013; Ostrand-Rosenberg et al., 2012).”
From Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies (2020) · cites this paper as Ostrand-Rosenberg et al., 2012
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- Authors
- Ostrand-Rosenberg, S., Sinha, P., Beury, D. W., & Clements, V. K.
- Affiliations
- University of Maryland, Baltimore County (US)
- Venue
- Seminars in Cancer Biology
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 22
- Issue
- 4
- Pages
- 275-281
- ISSN
- 1044-579X (ISSN-L)
- PMC
- PMC3701942
- OpenAlex
- W2073606915
- Cited by
- 583
- References
- 70
- Citations by year
- 2026: 17 · 2025: 39 · 2024: 49 · 2023: 47 · 2022: 39 · 2021: 55 · 2020: 51 · 2019: 46 · 2018: 41 · 2017: 29 · 2016: 39 · 2015: 38 · 2014: 42 · 2013: 38 · 2012: 13
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Seminars in Cancer Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (RO1CA115880, RO1CA84232)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- myeloid-derived suppressor cells, tumor-associated macrophages, dendritic cells, tumor microenvironment, tumor-induced immune suppression, cell-cell interactions, inflammation, antitumor immunity, tumor progression
- MeSH terms
- Animals, Dendritic Cells, Humans, Immunotherapy, Inflammation, Macrophages, Neoplasms, Inflammation Mediators, Tumor Escape, Myeloid Cells, Tumor Microenvironment
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