Cited by 1,140Immune cells in cancerAngiogenesis and VEGF in CancerCancer Cells and Metastasis

Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis

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Yang, Li, DeBusk, Laura M., Fukuda, Koari, Fingleton, Barbara, Green-Jarvis, Brenda, Shyr, Yu, Matrisian, Lynn M., Carbone, David P. +1 more·2004·Cancer Cell

Abstract

We demonstrate a novel tumor-promoting role of myeloid immune suppressor Gr+CD11b+ cells, which are evident in cancer patients and tumor-bearing animals. These cells constitute approximately 5% of total cells in tumors. Tumors coinjected with Gr+CD11b+ cells exhibited increased vascular density, vascular maturation, and decreased necrosis. These immune cells produce high levels of MMP9. Deletion of MMP9 in these cells completely abolishes their tumor-promoting ability. Gr+CD11b+ cells were also found to directly incorporate into tumor endothelium. Consistent with this observation, Gr+CD11b+ cells acquire endothelial cell (EC) properties in tumor microenvironment and proangiogenic culture conditions. Our data provide evidence that Gr+CD11b+ cells of immune origin induced by tumors directly contribute to tumor growth and vascularization by producing MMP9 and differentiating into ECs.

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Crossref · 10.1016/j.ccr.2004.08.031

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  • BMDCs promote metastasis by producing chemokines that recruit tumor cells to the lung by mechanisms that include stimulation of tumor cell extravasation.

    “The BMDCs promote metastasis by producing chemokines that recruit tumor cells to the lung by mechanisms that include stimulation of tumor cell extravasation”

    From Hypoxic control of metastasis (2016) · cites this paper as [93]

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Authors
Yang, L., DeBusk, L. M., Fukuda, K., Fingleton, B., Green-Jarvis, B., Shyr, Y., Matrisian, L. M., Carbone, D. P., & Lin, P. C.
Affiliations
Vanderbilt University (US)
Corresponding author
Lin, P.Charles
Venue
Cancer Cell
Publisher
Elsevier BV
Published
2004-10
Volume
6
Issue
4
Pages
409-421
ISSN
1535-6108 (ISSN-L)
OpenAlex
W2021268612
Cited by
1,140
References
42
Citations by year
2026: 8 · 2025: 28 · 2024: 34 · 2023: 40 · 2022: 48 · 2021: 60 · 2020: 61 · 2019: 44 · 2018: 57 · 2017: 62 · 2016: 62 · 2015: 62 · 2014: 72 · 2013: 86 · 2012: 73
FWCI
11.32
Type
journal article
Language
en
Open access
Locations
  • Cancer Cell (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ca087756-03)
  • National Cancer Institute (CA095103, 5P50CA90949, P50CA095103, CA-89674, R01CA076321, CA076321, CA87756, P50CA090949, T32CA009592, R01CA089674)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords
myeloid-derived suppressor cells, tumor angiogenesis, MMP-9, tumor endothelium, endothelial differentiation, tumor microenvironment, vessel density, vascular maturation, tumor necrosis, tumor growth, tumor vascularization
MeSH terms
Animals, Bone Marrow, Cell Differentiation, Cells, Cultured, Endothelium, Female, Humans, Necrosis, Neoplasm Transplantation, Neoplasms, Neovascularization, Pathologic, Apoptosis, Mice, Knockout, Disease Progression, Stem Cell Factor, Matrix Metalloproteinase 9, CD11b Antigen, Vascular Endothelial Growth Factor A, Mice

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