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Cited by 80Phytoestrogen effects and researchEstrogen and related hormone effectsPhytochemicals and Antioxidant Activities

Role of dietary bioactive natural products in estrogen receptor-positive breast cancer

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Bak, Min Ji, Das Gupta, Soumyasri, Wahler, Joseph, Suh, Nanjoo·2016·Seminars in Cancer Biology
DOI 10.1016/j.semcancer.2016.03.001PMC PMC5033666
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Abstract

Estrogen receptor (ER)-positive breast cancer, including luminal-A and -B, is the most common type of breast cancer. Extended exposure to estrogen is associated with an increased risk of breast cancer. Both ER-dependent and ER-independent mechanisms have been implicated in estrogen-mediated carcinogenesis. The ER-dependent pathway involves cell growth and proliferation triggered by the binding of estrogen to the ER. The ER-independent mechanisms depend on the metabolism of estrogen to generate genotoxic metabolites, free radicals and reactive oxygen species to induce breast cancer. A better understanding of the mechanisms that drive ER-positive breast cancer will help optimize targeted approaches to prevent or treat breast cancer. A growing emphasis is being placed on alternative medicine and dietary approaches toward the prevention and treatment of breast cancer. Many natural products and bioactive compounds found in foods have been shown to inhibit breast carcinogenesis via inhibition of estrogen induced oxidative stress as well as ER signaling. This review summarizes the role of bioactive natural products that are involved in the prevention and treatment of estrogen-related and ER-positive breast cancer.

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  • Compared to SRC, ERα constitutes the central oncogenic driver in ER+ breast cancer, as ERα overexpression promotes tumorigenesis.

    “However, compared to SRC, the ERα constitutes the central oncogenic driver in ER+ breast cancer, as ERα overexpression promotes tumorigenesis50,51.”

    From Harnessing artificial intelligence to identify Bufalin as a molecular glue degrader of estrogen receptor alpha (2025) · cites this paper as [51]

    The Introduction and section 3 describe ER-dependent estrogen signaling as a contributor to breast carcinogenesis, including increased proliferation and DNA damage. They do not establish that ERα overexpression itself promotes tumorigenesis or that ERα is a more central oncogenic driver than SRC. Page numbers were not available in our copy. (LLM, conf=0.87)

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Authors
Bak, M. J., Das Gupta, S., Wahler, J., & Suh, N.
Affiliations
Rutgers, The State University of New Jersey (US)
Corresponding author
Suh, Nanjoo
ORCID
Venue
Seminars in Cancer Biology
Publisher
Elsevier BV
Published
2016-10
Volume
40-41
Pages
170-191
ISSN
1044-579X (ISSN-L)
DOI
10.1016/j.semcancer.2016.03.001
PMC
PMC5033666
OpenAlex
W2306478460
Cited by
80
References
4
Citations by year
2026: 5 · 2025: 10 · 2024: 9 · 2023: 7 · 2022: 8 · 2021: 3 · 2020: 11 · 2019: 7 · 2018: 6 · 2017: 10 · 2016: 4
FWCI
1.41
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Seminars in Cancer Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (R01AT007036, R01CA127645)
  • National Institute of Environmental Health Sciences (ES005022)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
estrogen receptor-positive breast cancer, luminal breast cancer, estrogen metabolism, reactive oxygen species, oxidative stress, estrogen receptor signaling, breast cancer prevention, breast cancer treatment, food-derived compounds
MeSH terms
Animals, Antineoplastic Agents, Phytogenic, Breast Neoplasms, Diet, Drug Screening Assays, Antitumor, Female, Humans, Plant Extracts, Receptors, Estrogen, Signal Transduction, Gene Expression Regulation, Neoplastic, Anticarcinogenic Agents

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