Caffeine, coffee, and tea intake and urinary estrogens and estrogen metabolites in premenopausal women
Open accessAbstract
BACKGROUND: Prior studies have found weak inverse associations between breast cancer and caffeine and coffee intake, possibly mediated through their effects on sex hormones. METHODS: High-performance liquid chromatography/tandem mass spectrometry was used to quantify levels of 15 individual estrogens and estrogen metabolites (EM) among 587 premenopausal women in the Nurses' Health Study II with mid-luteal phase urine samples and caffeine, coffee, and/or tea intakes from self-reported food frequency questionnaires. Multivariate linear mixed models were used to estimate geometric means of individual EM, pathways, and ratios by intake categories, and P values for tests of linear trend. RESULTS: Compared with women in the lowest quartile of caffeine consumption, those in the top quartile had higher urinary concentrations of 16α-hydroxyestrone (28% difference; Ptrend = 0.01) and 16-epiestriol (13% difference; Ptrend = 0.04), and a decreased parent estrogens/2-, 4-, 16-pathway ratio (Ptrend = 0.03). Coffee intake was associated with higher 2-catechols, including 2-hydroxyestradiol (57% difference, ≥4 cups/day vs. ≤6 cups/week; Ptrend = 0.001) and 2-hydroxyestrone (52% difference; Ptrend = 0.001), and several ratio measures. Decaffeinated coffee was not associated with 2-pathway metabolism, but women in the highest (vs. lowest) category of intake (≥2 cups/day vs. ≤1-3 cups/month) had significantly lower levels of two 16-pathway metabolites, estriol (25% difference; Ptrend = 0.01) and 17-epiestriol (48% difference; Ptrend = 0.0004). Tea intake was positively associated with 17-epiestriol (52% difference; Ptrend = 0.01). CONCLUSION: Caffeine and coffee intake were both associated with profiles of estrogen metabolism in premenopausal women. IMPACT: Consumption of caffeine and coffee may alter patterns of premenopausal estrogen metabolism.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Caffeine changes estrogen levels in women.
“There are also reports that caffeine changes estrogen levels in women [6].”
From Effect of Caffeine Consumption on the Risk for Neurological and Psychiatric Disorders: Sex Differences in Human (2020) · cites this paper as [6]
Caffeine resistance and rate of caffeine metabolism vary greatly between people, especially depending on activity of the CYP1A2 gene.
“Caffeine resistance and the rate of caffeine metabolism vary greatly from person to person, especially depending on the activity of the cytochrome P450 1A2 (CYP1A2) gene, encoding an enzyme that breaks down caffeine [6].”
From Effect of Caffeine Consumption on the Risk for Neurological and Psychiatric Disorders: Sex Differences in Human (2020) · cites this paper as [6]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Willett, W. C. (1998) · doi:10.1093/acprof:oso/9780195122978.001.0001 · Cited by 4,541 · see citing works
Percentage Points for a Generalized ESD Many-Outlier Procedure
ROSNER, B. A. (1983) · Technometrics · doi:10.1080/00401706.1983.10487848 · Cited by 1,204 · see citing works
Functional role of estrogen metabolism in target cells: review and perspectives
Zhu, B. T. (1998) · Carcinogenesis · doi:10.1093/carcin/19.1.1 · Cited by 964 · see citing works
Prospective Study of Caffeine Consumption and Risk of Parkinson’s Disease in Men and Women
Ascherio, A., Zhang, S. M., Hernán, M. A., Kawachi, I., Colditz, G. A., Speizer, F. E., & Willett, W. C. (2001) · Annals of Neurology · doi:10.1002/ana.1052 · Cited by 677 · see citing works
Butler, M. A., Iwasaki, M., Guengerich, F. P., & Kadlubar, F. F. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.20.7696 · Cited by 638 · see citing works
Chapter 4: Estrogens as Endogenous Genotoxic Agents--DNA Adducts and Mutations
Cavalieri, E. L., Frenkel, K., Liehr, J. G., Rogan, E. G., & Roy, D. (2000) · JNCI Monographs · doi:10.1093/oxfordjournals.jncimonographs.a024247 · Cited by 595 · see citing works
Lee, A. J., Cai, M. X., Thomas, P. E., Conney, A. H., & Zhu, B. T. (2003) · Endocrinology · doi:10.1210/en.2003-0192 · Cited by 457 · see citing works
TELANG, N. T., Suto, A., Wong, G. Y., Osborne, M. P., & Bradlow, H. L. (1992) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/84.8.634 · Cited by 261 · see citing works
Chlorogenic Acids and Lactones in Regular and Water-Decaffeinated Arabica Coffees
Farah, A., de Paulis, T., Moreira, D. P., Trugo, L. C., & Martin, P. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0518305 · Cited by 243 · see citing works
Phytoestrogens and Breast Cancer Prevention: Possible Mechanisms of Action
Mense, S. M., Hei, T. K., Ganju, R. K., & Bhat, H. K. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.10538 · Cited by 229 · see citing works
Estrogen receptor-dependent and independent mechanisms of breast cancer carcinogenesis
Yue, W., Yager, J. D., Wang, J.-P., Jupe, E. R., & Santen, R. J. (2012) · Steroids · doi:10.1016/j.steroids.2012.11.001 · Cited by 228 · see citing works
Xu, X., Veenstra, T. D., Fox, S. D., Roman, J. M., Issaq, H. J., Falk, R., Saavedra, J. E., Keefer, L. K., & Ziegler, R. G. (2005) · Analytical Chemistry · doi:10.1021/ac050697c · Cited by 227 · see citing works
Caffeinated and caffeine-free beverages and risk of type 2 diabetes
Bhupathiraju, S. N., Pan, A., Malik, V. S., Manson, J. E., Willett, W. C., van Dam, R. M., & Hu, F. B. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.048603 · Cited by 222 · see citing works
Bradlow, H. L., Hershcopf, R. J., Martucci, C. P., & Fishman, J. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.18.6295 · Cited by 204 · see citing works
Contaminants in Human Milk: Weighing the Risks against the Benefits of Breastfeeding
Mead, M. N. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.116-a426 · Cited by 204 · see citing works
Meta-analyses of lignans and enterolignans in relation to breast cancer risk
Buck, K., Zaineddin, A. K., Vrieling, A., Linseisen, J., & Chang-Claude, J. C. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28573 · Cited by 182 · see citing works
Tantcheva‐Poór, I., Zaigler, M., Rietbrock, S., & Fuhr, U. (1999) · PubMed · Cited by 180 · see citing works
Kotsopoulos, J., Eliassen, A. H., Missmer, S. A., Hankinson, S. E., & Tworoger, S. S. (2009) · Cancer · doi:10.1002/cncr.24328 · Cited by 144 · see citing works
Coffee, tea, caffeine and risk of breast cancer: A 22‐year follow‐up
Ganmaa, D., Willett, W. C., Li, T. Y., Feskanich, D., van Dam, R. M., López‐García, E., Hunter, D. J., & Holmes, M. D. (2008) · International Journal of Cancer · doi:10.1002/ijc.23336 · Cited by 130 · see citing works
Vakharia, D. D., Liu, N., Pause, R., Fasco, M. J., Bessette, E. E., Zhang, Q.-Y., & Kaminsky, L. S. (2001) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2000.9087 · Cited by 130 · see citing works
Missmer, S. A., Spiegelman, D. L., Bertone‐Johnson, E. R., Barbieri, R. L., Pollak, M., & Hankinson, S. E. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0848 · Cited by 128 · see citing works
Induction of CYP1A2 by heavy coffee consumption in Serbs and Swedes
Djordjević, N., Ghotbi, R., Bertilsson, L., Јаnkovic, S., & Aklillu, E. (2007) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-007-0438-6 · Cited by 115 · see citing works
Alves, R. C., Costa, A. S. G., Jerez, M., Casal, S. I. P., Sineiro, J., Núñez, M. J., & Oliveira, M. B. P. P. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf1031229 · Cited by 111 · see citing works
Jiang, W., Wu, Y., & Jiang, X. (2013) · Gynecologic Oncology · doi:10.1016/j.ygyno.2013.03.014 · Cited by 110 · see citing works
Eliassen, A. H., Spiegelman, D. L., Xu, X., Keefer, L. K., Veenstra, T. D., Barbieri, R. L., Willett, W. C., Hankinson, S. E., & Ziegler, R. G. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-2507 · Cited by 94 · see citing works
Kotsopoulos, J., Ghadirian, P., El‐Sohemy, A., Lynch, H. T., Snyder, C., Daly, M. B., Domchek, S. M., Randall, S., Karlan, B. Y., Zhang, P., et al. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-1074 · Cited by 87 · see citing works
Seeger, H., Wallwiener, D. R., Kraemer, E., & Mueck, A. O. (2005) · Maturitas · doi:10.1016/j.maturitas.2005.08.010 · Cited by 86 · see citing works
The effect of endogenous estradiol metabolites on the proliferation of human breast cancer cells
Lippert, C., Seeger, H., & Mueck, A. O. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02305-6 · Cited by 85 · see citing works
Fortner, R. T., Eliassen, A. H., Spiegelman, D. L., Willett, W. C., Barbieri, R. L., & Hankinson, S. E. (2013) · Breast Cancer Research · doi:10.1186/bcr3394 · Cited by 78 · see citing works
Tea and coffee intake in relation to risk of breast cancer in the Black Women’s Health Study
Boggs, D. A., Palmer, J. R., Stampfer, M. J., Spiegelman, D. L., Adams-Campbell, L. L., & Rosenberg, L. A. (2010) · Cancer Causes & Control · doi:10.1007/s10552-010-9622-6 · Cited by 74 · see citing works
Falk, R. T., Xu, X., Keefer, L. K., Veenstra, T. D., & Ziegler, R. G. (2008) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0355 · Cited by 67 · see citing works
Liu, Z., & Zhu, B. T. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2003.12.003 · Cited by 66 · see citing works
Coffee consumption and risk of breast cancer: a metaanalysis
Tang, N., Zhou, B., Wang, B., & Yu, R. (2008) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2008.10.019 · Cited by 65 · see citing works
Caffeine Consumption and the Risk of Breast Cancer in a Large Prospective Cohort of Women
Ishitani, K., Lin, J., Manson, J. E., Buring, J. E., & Zhang, S. M. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.18.2022 · Cited by 63 · see citing works
Sowers, M. R., Crawford, S. L., McConnell, D. S., Randolph, J. F., Gold, E. B., Wilkin, M. K., & Lasley, B. L. (2006) · Journal of Nutrition · doi:10.1093/jn/136.6.1588 · Cited by 62 · see citing works
Jernström, H. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg047 · Cited by 60 · see citing works
Urinary Concentrations of Estrogens and Estrogen Metabolites and Smoking in Caucasian Women
Gu, F., Caporaso, N. E., Schairer, C., Fortner, R. T., Xu, X., Hankinson, S. E., Eliassen, A. H., & Ziegler, R. G. (2012) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-12-0909 · Cited by 57 · see citing works
Coffee intake and breast cancer risk in the NIH‐AARP diet and health study cohort
Gierach, G. L., Freedman, N. D., Andaya, A. A., Hollenbeck, A. R., Park, Y., Schatzkin, A. G., & Brinton, L. A. (2011) · International Journal of Cancer · doi:10.1002/ijc.26372 · Cited by 57 · see citing works
Coffee consumption modifies risk of estrogen-receptor negative breast cancer
Li, J., Seibold, P., Chang-Claude, J. C., Flesch‐Janys, D., Liu, J., Czene, K., Humphreys, K., & Hall, P. N. (2011) · Breast Cancer Research · doi:10.1186/bcr2879 · Cited by 55 · see citing works
Larsson, S. C., Bergkvist, L., & Wolk, A. (2009) · Cancer Causes & Control · doi:10.1007/s10552-009-9396-x · Cited by 49 · see citing works
Bågeman, E., Ingvar, C., Rose, C., & Jernström, H. (2008) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-0555 · Cited by 48 · see citing works
Eliassen, A. H., Ziegler, R. G., ROSNER, B. A., Veenstra, T. D., Roman, J. M., Xu, X., & Hankinson, S. E. (2009) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-09-0591 · Cited by 47 · see citing works
Zhu, B. T., Wang, P., Nagai, M., Wen, Y., & Bai, H. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.11.011 · Cited by 44 · see citing works
Schliep, K. C., Schisterman, E. F., Mumford, S. L., Perkins, N. J., Ye, A., Pollack, A. Z., Zhang, C., Porucznik, C. A., VanDerslice, J. A., Stanford, J. B., et al. (2013) · American Journal of Epidemiology · doi:10.1093/aje/kws283 · Cited by 33 · see citing works
Comparison of plasma and urinary levels of 2-hydroxyestrogen and 16α-hydroxyestrogen metabolites
Bradlow, H. L., Jernström, H., Sepkovic, D. W., Klug, T. L., & Narod, S. A. (2005) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2005.08.001 · Cited by 20 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes
Poole, R., Kennedy, O. J., Roderick, P., Fallowfield, J. A., Hayes, P. C., & Parkes, J. (2017) · BMJ · doi:10.1136/bmj.j5024 · Cited by 835 · see citing works
Logistic LASSO Regression for Dietary Intakes and Breast Cancer
McEligot, A. J., Poynor, V., Sharma, R., & Panangadan, A. V. (2020) · Nutrients · doi:10.3390/nu12092652 · Cited by 314 · see citing works
Tea consumption and disease correlations
Şanlıer, N., Gökcen, B. B., & Altuğ, M. (2018) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2018.05.026 · Cited by 155 · see citing works
Jee, H. J., Lee, S. G., Bormate, K. J., & Jung, Y.-S. (2020) · Nutrients · doi:10.3390/nu12103080 · Cited by 111 · see citing works
“Caffeine resistance and the rate of caffeine metabolism vary greatly from person to person, especially depending on the activity of the cytochrome P450 1A2 (CYP1A2) gene, encoding an enzyme that breaks down caffeine [6].”
BackgroundRole of dietary bioactive natural products in estrogen receptor-positive breast cancer
Bak, M. J., Das Gupta, S., Wahler, J., & Suh, N. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2016.03.001 · Cited by 80 · see citing works
Mínguez-Alarcón, L., Chavarro, J. E., & Gaskins, A. J. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.05.026 · Cited by 56 · see citing works
Pre-pregnancy caffeine and caffeinated beverage intake and risk of spontaneous abortion
Gaskins, A. J., Rich-Edwards, J. W., Williams, P. L., Toth, T. L., Missmer, S. A., & Chavarro, J. E. (2018) · European Journal of Nutrition · doi:10.1007/s00394-016-1301-2 · Cited by 55 · see citing works
Prospective study of a diabetes risk reduction diet and the risk of breast cancer
Kang, J. H., Peng, C., Rhee, J. J., Farvid, M. S., Willett, W. C., Hu, F. B., ROSNER, B. A., Tamimi, R. M., & Eliassen, A. H. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa268 · Cited by 52 · see citing works
Lafranconi, A., Micek, A., Galvano, F., Rossetti, S., Pup, L. D., Berretta, M., & Facchini, G. (2017) · Nutrients · doi:10.3390/nu9111223 · Cited by 49 · see citing works
van den Brandt, P. A. (2018) · European Journal of Epidemiology · doi:10.1007/s10654-018-0359-y · Cited by 50 · see citing works
Lafranconi, A., Micek, A., Paoli, P. D., Bimonte, S., Rossi, P., Quagliariello, V., & Berretta, M. (2018) · Nutrients · doi:10.3390/nu10020112 · Cited by 48 · see citing works
Association between preconception maternal beverage intake and in vitro fertilization outcomes
Machtinger, R., Gaskins, A. J., Mansur, A., Adir, M., Racowsky, C., Baccarelli, A., Hauser, R. B., & Chavarro, J. E. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.09.007 · Cited by 44 · see citing works
van Dongen, L. H., Mölenberg, F. J. M., Soedamah‐Muthu, S. S., Kromhout, D., & Geleijnse, J. M. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.117.153338 · Cited by 38 · see citing works
Begdache, L., Sadeghzadeh, S., Derose, G., & Abrams, C. (2020) · Nutrients · doi:10.3390/nu13010024 · Cited by 35 · see citing works
Coffee and Tea Intake, Dementia Risk, and Cognitive Function
Zhang, Y., Liu, Y., Li, Y., Li, Y., Gu, X., Kang, J. H., Eliassen, A. H., Wang, M., Rimm, E. B., Willett, W. C., et al. (2026) · JAMA · doi:10.1001/jama.2025.27259 · Cited by 32 · see citing works
Raj, M., & Goyal, R. N. (2019) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2019.01.018 · Cited by 31 · see citing works
Leviton, A. (2018) · Nutrients · doi:10.3390/nu10091152 · Cited by 27 · see citing works
Coffee consumption and risk of breast cancer: A Mendelian randomization study
Ellingjord‐Dale, M., Papadimitriou, N., Katsoulis, M., Yee, C., Dimou, N. L., Gill, D., Aune, D., Ong, J., MacGregor, S., Elsworth, B., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0236904 · Cited by 26 · see citing works
How does caffeine influence memory? Drug, experimental, and demographic factors
Zhang, R.-C., & Madan, C. R. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.033 · Cited by 21 · see citing works
Playdon, M. C., Coburn, S. B., Moore, S. C., Brinton, L. A., Wentzensen, N., Anderson, G. L., Wallace, R. B., Falk, R. T., Pfeiffer, R. M., Xu, X., et al. (2017) · British Journal of Cancer · doi:10.1038/bjc.2017.419 · Cited by 21 · see citing works
Is knee osteoarthritis related to coffee drinking? A nationwide cross-sectional observational study
Bang, C. H., Kim, C., Kim, J., Choi, S. J., Song, G. G., & Jung, J. H. (2018) · Clinical Rheumatology · doi:10.1007/s10067-018-4354-1 · Cited by 21 · see citing works
Metabolomic Changes after Coffee Consumption: New Paths on the Block
Favari, C., Righetti, L., Tassotti, M., Gethings, L. A., Martini, D., Rosi, A., Antonini, M., Rubert, J., Manach, C., Dei, A., et al. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000875 · Cited by 20 · see citing works
Chen, F., He, B., Hu, Z., Huang, J., Liu, F., Yan, L., Lin, Z., Zheng, X., Lin, L., Zhang, Z., et al. (2016) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-016-2123-6 · Cited by 17 · see citing works
Impact of Coffee Intake on Measures of Wellbeing in Mice
Machado, N. J., Ardais, A. P., Nunes, A., Szabó, E. C., Silveirinha, V., Silva, H. B. L., Kaster, M. P., & Cunha, R. A. (2024) · Nutrients · doi:10.3390/nu16172920 · Cited by 15 · see citing works
Adolescent caffeine consumption and mammographic breast density in premenopausal women
Yaghjyan, L., Colditz, G. A., ROSNER, B. A., Rich, S. N., Egan, K. M., & Tamimi, R. M. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-02018-0 · Cited by 14 · see citing works
Wang, S., Li, X., Yang, Y., Xie, J., Liu, M., Zhang, Y., Zhang, Y., & Zhao, Q. (2021) · Public Health Nutrition · doi:10.1017/s1368980021000720 · Cited by 14 · see citing works
Associations of coffee consumption and caffeine intake with mammographic breast density
Yaghjyan, L., Colditz, G. A., ROSNER, B. A., Gasparova, A., & Tamimi, R. M. (2018) · Breast Cancer Research and Treatment · doi:10.1007/s10549-018-4667-4 · Cited by 13 · see citing works
Yaghjyan, L., Rich, S. N., Mao, L., Mai, V., & Egan, K. M. (2018) · Cancer Causes & Control · doi:10.1007/s10552-018-1028-x · Cited by 12 · see citing works
Li, Y., & Ma, L. (2021) · Annals of Palliative Medicine · doi:10.21037/apm-20-1962 · Cited by 10 · see citing works
Coffee consumption and risk of aortic valve stenosis: A prospective study
Larsson, S. C., Wolk, A., Håkansson, N., & Bäck, M. (2018) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2018.01.016 · Cited by 11 · see citing works
Lifetime caffeine intake and the risk of epithelial ovarian cancer
Grundy, A. L., Sandhu, S. K., Arseneau, J., Gilbert, L., Gotlieb, W. H., Aronson, K. J., & Koushik, A. (2021) · Cancer Epidemiology · doi:10.1016/j.canep.2021.102058 · Cited by 10 · see citing works
Potential Intervention Targets in Utero and Early Life for Prevention of Hormone Related Cancers
Schooling, C. M., Houghton, L. C., & Terry, M. B. (2016) · PEDIATRICS · doi:10.1542/peds.2015-4268e · Cited by 9 · see citing works
Qin, X., Li, C., Wei, W., He, D., Zhao, Y., Cai, Q., Zhang, N., Chu, X., Shi, S., & Zhang, F. (2023) · Nutritional Neuroscience · doi:10.1080/1028415x.2023.2175412 · Cited by 9 · see citing works
Estrogen Metabolism in Premenopausal Women Is Related to Early Life Body Fatness
Houghton, L. C., Sisti, J. S., Hankinson, S. E., Xie, J., Xu, X., Hoover, R. N., Eliassen, A. H., & Ziegler, R. G. (2018) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-17-0595 · Cited by 8 · see citing works
Yaghjyan, L., McLaughlin, E. M., Lehman, A., Neuhouser, M. L., Rohan, T. E., Lane, D. S., Snetselaar, L. G., & Paskett, E. D. (2022) · European Journal of Nutrition · doi:10.1007/s00394-022-02899-8 · Cited by 8 · see citing works
Witkowska, A. M., Mirończuk-Chodakowska, I., Terlikowska, K. M., Kulesza, K., & Zujko, M. E. (2020) · Polish Journal of Food and Nutrition Sciences · doi:10.31883/pjfns/120017 · Cited by 6 · see citing works
Common Beverage Consumption and Benign Gynecological Conditions
Michel, R., Hazimeh, D., Saad, E., Olson, S. L., Musselman, K., Elgindy, E. A., & Borahay, M. A. (2024) · Beverages · doi:10.3390/beverages10020033 · Cited by 6 · see citing works
Meliani-Rodríguez, A., Cutillas-Tolín, A., Mendiola, J., Sánchez-Ferrer, M. L., Sánchez, E. D. L. C., Vioqué, J., & Torres-Cantero, A. M. (2024) · Nutrients · doi:10.3390/nu16142238 · Cited by 5 · see citing works
Lu, M.-Y., Lai, J. C., & Chen, S.-J. (2023) · Nutrients · doi:10.3390/nu15112576 · Cited by 5 · see citing works
Monica, M. B. L., Raub, B. J., Malone, K., Hartshorn, S., Grdic, J., Gustat, A., & Sandrock, J. E. (2023) · Nutrients · doi:10.3390/nu15214509 · Cited by 4 · see citing works
Qi, J., Zhang, K., Zhang, P., Chen, C., Zhao, C., Lü, Y., & Zhu, X. (2024) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2024.05.006 · Cited by 3 · see citing works
Fu, R., Zhang, S., Cai, C., Wang, X., Jiang, Y., Zhuang, X., Zhang, J., Ji, X., & Yang, C. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1538405 · Cited by 3 · see citing works
Effects of Polyphenol-Rich Foods on Human Health
Grosso, G. (2018) · MDPI eBooks · doi:10.3390/books978-3-03897-143-6 · Cited by 3 · see citing works
Miao, Y., Ma, S., & Wu, X. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1452137 · Cited by 2 · see citing works
Association between coffee intake and serum α-Klotho levels in adults: a population-based study
Tang, X., Tuo, H., Cao, C., Yang, Z., Zhang, S., & Du, R. (2025) · BMC Public Health · doi:10.1186/s12889-025-23812-y · Cited by 2 · see citing works
Zhou, J., & Qin, L. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1497483 · Cited by 2 · see citing works
Serio, B., Yilmaz, D., Pritschet, L., Grotzinger, H., Jacobs, E. G., Eickhoff, S. B., & Valk, S. L. (2025) · Imaging Neuroscience · doi:10.1162/imag_a_00474 · Cited by 1 · see citing works
Is coffee bad for reproduction? Maybe not, after all.
Chavarro, J. E. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2019.04.033 · Cited by 1 · see citing works
Coffee, Tea, and Mammographic Breast Density in Premenopausal Women
Odama, A. M., Otti, V., Xu, S., Adebayo, O., & Toriola, A. T. (2021) · Nutrients · doi:10.3390/nu13113852
Micek, A., Konopka, K. W., Frączek, P. A., & Wysocki, P. J. (2025) · Royal Society of Chemistry eBooks · doi:10.1039/9781839166853-00273
Elliott, D. M., Bayes, J., & Schloss, J. M. (2025) · Human Nutrition & Metabolism · doi:10.1016/j.hnm.2025.200354
Association between daily caffeine intake and uterine fibroids: Results from NHANES 1999–2006
Li, Y., Yu, Y. S., Zheng, Y., Li, Y., Hu, Y., Zhang, Y., Zhou, Z., & Tang, J. (2025) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.70727
Shi, F.-E., Yu, Z., Huang, Z., Cao, L., Chi, C., & Zhu, J. (2025) · Medicine · doi:10.1097/md.0000000000046592
Maternal coffee consumption during pregnancy and pubertal development in children: A cohort study
Lyngsø, J., Brix, N., Ernst, A., Bech, B. H., Lunddorf, L. L. H., & Ramlau‐Hansen, C. H. (2026) · Reproductive Toxicology · doi:10.1016/j.reprotox.2026.109174
Coffee and tea intake and stroke events among West Africans: findings from the SIREN Study
Asowata, O. J., Oyewole, M. O., Fakunle, A. G., Obiako, R., Komolafe, E., Adebayo, O. M., Olalusi, O., Adebajo, O. J., Oyamakin, S. O., Owoseni, I. J., et al. (2026) · BMC Health Services Research · doi:10.1186/s12913-026-14379-4
Karimi, M., Ghaemi, S., Goudarzi, R., Karimi, M. A., Kazemi, K., Haghshenas, H., & Asbaghi, O. (2026) · Health Science Reports · doi:10.1002/hsr2.72580
Abouhend, A. S., Hanafy, W. A., Watt, C., Nnachi, R. C., Shenoy, P. J., & Butler, C. S. (2026) · Water Research · doi:10.1016/j.watres.2026.126269
Epidemiology of endometriosis and adenomyosis
Upson, K., Missmer, S. A., Tellum, T., Harris, H. R., & As‐Sanie, S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-45863-7.00031-7
- Authors
- Sisti, J. S., Hankinson, S. E., Caporaso, N. E., Gu, F., Tamimi, R. M., Rosner, B., Xu, X., Ziegler, R., & Eliassen, A. H.
- Affiliations
- Harvard University (US)
- Brigham and Women's Hospital (US)
- National Cancer Institute (US)
- Frederick National Laboratory for Cancer Research (US)
- Corresponding author
- Sisti, Julia S.
- ORCID
- Venue
- Cancer Epidemiology, Biomarkers & Prevention
- Published
- 2015-08-01
- Volume
- 24
- Issue
- 8
- Pages
- 1174-1183
- ISSN
- 1055-9965 (ISSN-L)
- 1538-7755
- PMC
- PMC4526325
- OpenAlex
- W2106094885
- Cited by
- 58
- References
- 45
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 5 · 2023: 3 · 2022: 1 · 2021: 6 · 2020: 6 · 2019: 3 · 2018: 11 · 2017: 5 · 2016: 4
- FWCI
- 4.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cancer Epidemiology Biomarkers & Prevention (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (HHSN261200800001C)
- National Cancer Institute (U01CA067262, CA67262, HHSN261200800001E), CA50385, UM1CA176726, R25CA098566, R01CA050385, T32 CA900137, R01CA067262, T32CA009001)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
- Keywords
- caffeine consumption, coffee consumption, tea consumption, urinary estrogens, estrogen metabolites, estrogen metabolism, premenopausal women, 16α-hydroxyestrone, 2-hydroxyestradiol, 2-hydroxyestrone, estriol, catechol, decaffeinated coffee, breast cancer risk, Nurses' Health Study II
- MeSH terms
- Adult, Caffeine, Chromatography, Liquid, Coffee, Estrogens, Female, Humans, Middle Aged, Prospective Studies, Tea, Cohort Studies, Premenopause, Tandem Mass Spectrometry
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
