Methylglyoxal-derived stress: An emerging biological factor involved in the onset and progression of cancer

Biochemistry and molecular cell biology of diabetic complications

Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107 · see citing works

The Warburg Effect: How Does it Benefit Cancer Cells?

Liberti, M. V., & Locasale, J. W. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2015.12.001 · Cited by 5,150 · see citing works

Otto Warburg's contributions to current concepts of cancer metabolism

Koppenol, W. H., Bounds, P. L., & Dang, C. V. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3038 · Cited by 3,427 · see citing works

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

Ward, P. S., & Thompson, C. B. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.014 · Cited by 3,233 · see citing works

Diabetes and Cancer

Giovannucci, E., Harlan, D. M., Archer, M. C., Bergenstal, R. M., Gapstur, S. M., Habel, L. A., Pollak, M., Regensteiner, J. G., & Yee, D. (2010) · Diabetes Care · doi:10.2337/dc10-0666 · Cited by 2,366 · see citing works

The role of lipid peroxidation and antioxidants in oxidative modification of LDL

Esterbauer, H., Gebicki, J. M., Puhl, H., & Jürgens, G. (1992) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(92)90181-f · Cited by 2,307 · see citing works

Metformin—mode of action and clinical implications for diabetes and cancer

Pernicova, I., & Korbonits, M. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.256 · Cited by 1,345 · see citing works

Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose

Thornalley, P. J., LANGBORG, A., & Minhas, H. S. (1999) · Biochemical Journal · doi:10.1042/bj3440109 · Cited by 1,209 · see citing works

Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission

Hirsch, H. A., Iliopoulos, D., Tsichlis, P. N., & Struhl, K. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-2994 · Cited by 1,115 · see citing works

Effect of Collagen Turnover on the Accumulation of Advanced Glycation End Products

Verzijl, N., DeGroot, J., Thorpe, S. R., Bank, R. A., Shaw, J., Lyons, T. J., Bijlsma, J. W. J., Lafeber, F. P. J. G., Baynes, J., & TeKoppele, J. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006700200 · Cited by 964 · see citing works

Systemic Treatment with the Antidiabetic Drug Metformin Selectively Impairs p53-Deficient Tumor Cell Growth

Buzzai, M., Jones, R. G., Amaravadi, R. K., Lum, J. J., DeBerardinis, R. J., Zhao, F., Viollet, B., & Thompson, C. B. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4447 · Cited by 923 · see citing works

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

Sahra, I. B., Laurent, K., Loubat, A., Giorgetti-Peraldi, S., Colosetti, P., Auberger, P., Tanti, J. F., Le Marchand-Brustel, Y., & Bost, F. (2008) · Oncogene · doi:10.1038/sj.onc.1211024 · Cited by 861 · see citing works

Curcumin Extract for Prevention of Type 2 Diabetes

Chuengsamarn, S., Rattanamongkolgul, S., Luechapudiporn, R., Phisalaphong, C., & Jirawatnotai, S. (2012) · Diabetes Care · doi:10.2337/dc12-0116 · Cited by 636 · see citing works

The Dual Roles of NRF2 in Cancer

Menegon, S., Columbano, A., & Giordano, S. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.05.002 · Cited by 633 · see citing works

Glyoxalase I – structure, function and a critical role in the enzymatic defence against glycation

Thornalley, P. J. (2003) · Biochemical Society Transactions · doi:10.1042/bst0311343 · Cited by 615 · see citing works

N ε-(Carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins

Ahmed, M. U., Frye, E. B., Degenhardt, T. P., Thorpe, S. R., & Baynes, J. (1997) · Biochemical Journal · doi:10.1042/bj3240565 · Cited by 605 · see citing works

Action des acides amines sur les sucres : formation des melanoidines par voie methodique

Maillard, L. (1912) · Medical Entomology and Zoology · Cited by 574 · see citing works

The formation of methylglyoxal from triose phosphates

Phillips, S. A., & Thornalley, P. J. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb17638.x · Cited by 565 · see citing works

A census of amplified and overexpressed human cancer genes

Santarius, T., SHIPLEY, J. M., Brewer, D. S., Stratton, M. R., & Cooper, C. S. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2771 · Cited by 550 · see citing works

The glyoxalase system in health and disease

Thornalley, P. J. (1993) · Molecular Aspects of Medicine · doi:10.1016/0098-2997(93)90002-u · Cited by 535 · see citing works

Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro

Alimova, I. N., Liu, B., Fan, Z., Edgerton, S. M., Dillon, T., Lind, S. E., & Thor, A. D. (2009) · Cell Cycle · doi:10.4161/cc.8.6.7933 · Cited by 523 · see citing works

Glycoxidation and lipoxidation in atherogenesis

Baynes, J., & Thorpe, S. R. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00228-8 · Cited by 515 · see citing works

Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis.

Shinohara, M., Thornalley, P. J., Giardino, I., Beisswenger, P. J., Thorpe, S. R., Onorato, J., & Brownlee, M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci119885 · Cited by 513 · see citing works

The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues

Thangarajah, H., Yao, D., Chang, E. I.-F., Shi, Y., Jazayeri, L., Vial, I. N., Galiano, R. D., Du, X.-L., Grogan, R. H., Galvez, M. G., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906670106 · Cited by 469 · see citing works

Metformin reduces systemic methylglyoxal levels in type 2 diabetes.

Beisswenger, P. J., Howell, S. K., Touchette, A. D., Lal, S., & Szwergold, B. S. (1999) · Diabetes · doi:10.2337/diabetes.48.1.198 · Cited by 446 · see citing works

Methylglyoxal, glyoxalase 1 and the dicarbonyl proteome

Rabbani, N., & Thornalley, P. J. (2010) · Amino Acids · doi:10.1007/s00726-010-0783-0 · Cited by 431 · see citing works

An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer

Zender, L., Xue, W., Zuber, J. A., Semighini, C. P., Krasnitz, A., Ma, B., Zender, P., Kubicka, S., Luk, J. M., Schirmacher, P., et al. (2008) · Cell · doi:10.1016/j.cell.2008.09.061 · Cited by 425 · see citing works

Altered metabolite levels in cancer: implications for tumour biology and cancer therapy

Sullivan, L. B., Gui, D. Y., & Heiden, M. G. V. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.85 · Cited by 406 · see citing works

Metformin induces unique biological and molecular responses in triple negative breast cancer cells

Liu, B., Fan, Z., Edgerton, S. M., Deng, X.-S., Alimova, I. N., Lind, S. E., & Thor, A. D. (2009) · Cell Cycle · doi:10.4161/cc.8.13.8814 · Cited by 392 · see citing works

Methylglyoxal Modification of Protein

Oya, T., Hattori, N., Mizuno, Y., Miyata, S., Maeda, S., Osawa, T., & Uchida, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.26.18492 · Cited by 374 · see citing works

Assay of advanced glycation endproducts (AGEs): surveying AGEs by chromatographic assay with derivatization by 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate and application to N∊-carboxymethyl-lysine- and N∊-(1-carboxyethyl)lysine-modified albumin

Ahmed, N., Argirov, O. K., Minhas, H. S., CORDEIRO, C. A., & Thornalley, P. J. (2002) · Biochemical Journal · doi:10.1042/bj3640001 · Cited by 336 · see citing works

Molecular Characterization of Breast Cancer with High-Resolution Oligonucleotide Comparative Genomic Hybridization Array

André, F., Job, B., Dessen, P., Tordai, A., Michiels, S., Liedtke, C., Richon, C., Yan, K., Wang, B., Vassal, G., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1791 · Cited by 336 · see citing works

The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases

Maessen, D. E., Stehouwer, C. D. A., & Schalkwijk, C. G. (2015) · Clinical Science · doi:10.1042/cs20140683 · Cited by 335 · see citing works

Hyperglycemia as a Risk Factor for Cancer Progression

Ryu, T. Y., Park, J., & Scherer, P. E. (2014) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2014.38.5.330 · Cited by 331 · see citing works

Prevention of pancreatic cancer induction in hamsters by metformin

Schneider, M. B., Matsuzaki, H., Haorah, J., Ulrich, A. B., Standop, J., Ding, X., Adrian, T. E., & Pour, P. M. (2001) · Gastroenterology · doi:10.1053/gast.2001.23258 · Cited by 327 · see citing works

Metformin Disrupts Crosstalk between G Protein–Coupled Receptor and Insulin Receptor Signaling Systems and Inhibits Pancreatic Cancer Growth

Kisfalvi, K., Eibl, G., Sinnett‐Smith, J. W., & Rozengurt, E. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0418 · Cited by 315 · see citing works

Proteomic Study Reveals That Proteins Involved in Metabolic and Detoxification Pathways Are Highly Expressed in HER-2/neu-positive Breast Cancer

Zhang, D.-H., Tai, L. K., Wong, L. L., Chiu, L.-L., Sethi, S. K., & Koay, E. S. (2005) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m400221-mcp200 · Cited by 312 · see citing works

Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation

Xue, M., Rabbani, N., Momiji, H., Imbasi, P., Anwar, M. M., Kitteringham, N. R., Park, B. K., Souma, T., Moriguchi, T., Yamamoto, M. P., et al. (2011) · Biochemical Journal · doi:10.1042/bj20111648 · Cited by 302 · see citing works

Repositioning metformin for cancer prevention and treatment

Quinn, B. J., Kitagawa, H., Memmott, R. M., Gills, J. J., & Dennis, P. A. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.05.004 · Cited by 284 · see citing works

Reduction of trioses by NADPH-dependent aldo-keto reductases. Aldose reductase, methylglyoxal, and diabetic complications.

Jagt, D. L. V., Robinson, B., Taylor, K. K., & Hunsaker, L. A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42844-x · Cited by 280 · see citing works

Protein Modification by Methylglyoxal: Chemical Nature and Synthetic Mechanism of a Major Fluorescent Adduct

Shipanova, I. N., Glomb, M. A., & Nagaraj, R. H. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0195 · Cited by 279 · see citing works

Mechanism for the formation of methylglyoxal from triosephosphates

Richard, J. P. (1993) · Biochemical Society Transactions · doi:10.1042/bst0210549 · Cited by 272 · see citing works

HSP27, 70 and 90, anti-apoptotic proteins, in clinical cancer therapy

Wang, X., Chen, M., Zhou, J., & Zhang, X. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2399 · Cited by 272 · see citing works

Stabilization of a reaction intermediate as a catalytic device: definition of the functional role of the flexible loop in triosephosphate isomerase

Pompliano, D. L., Peyman, A., & Knowles, J. R. (1990) · Biochemistry · doi:10.1021/bi00465a005 · Cited by 272 · see citing works

In vitro metformin anti-neoplastic activity in epithelial ovarian cancer

Gotlieb, W. H., Saumet, J., Beauchamp, M.-C., Gu, J., Lau, S. K., Pollak, M., & Bruchim, I. (2008) · Gynecologic Oncology · doi:10.1016/j.ygyno.2008.04.008 · Cited by 267 · see citing works

Methylglyoxal metabolism and diabetic complications: roles of aldose reductase, glyoxalase-I, betaine aldehyde dehydrogenase and 2-oxoaldehyde dehydrogenase

Jagt, D. L. V., & Hunsaker, L. A. (2003) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(02)00212-0 · Cited by 256 · see citing works

Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1

Zhuang, Y., & Miskimins, W. K. (2008) · Journal of Molecular Signaling · doi:10.1186/1750-2187-3-18 · Cited by 247 · see citing works

Reaction of metformin with dicarbonyl compounds. possible implication in the inhibition of advanced glycation end product formation

Ruggiero-Lopez, D., Lecomte, M., Moinet, G., Patereau, G., Lagarde, M., & Wiernsperger, N. F. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00263-4 · Cited by 238 · see citing works

High Glucose Increases Angiopoietin-2 Transcription in Microvascular Endothelial Cells through Methylglyoxal Modification of mSin3A

Yao, D., Taguchi, T., Matsumura, T., Pestell, R. G., Edelstein, D., Giardino, I., Suske, G., Rabbani, N., Thornalley, P. J., Sarthy, V. P., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704703200 · Cited by 233 · see citing works

Increased Methylglyoxal and Oxidative Stress in Hypertensive Rat Vascular Smooth Muscle Cells

Wu, L., & Juurlink, B. H. J. (2002) · Hypertension · doi:10.1161/hy0302.105207 · Cited by 229 · see citing works

Molecular characteristics of methylglyoxal-modified bovine and human serum albumins. Comparison with glucose-derived advanced glycation endproduct-modified serum albumins

Westwood, M. E., & Thornalley, P. J. (1995) · Journal of Protein Chemistry · doi:10.1007/bf01886793 · Cited by 227 · see citing works

Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism

Rižner, T. L., & Penning, T. M. (2014) · Steroids · doi:10.1016/j.steroids.2013.10.012 · Cited by 217 · see citing works

The Receptor for Advanced Glycation End Products (RAGE) Specifically Recognizes Methylglyoxal-Derived AGEs

Xue, J., Ray, R., Singer, D., Böhme, D., Burz, D. S., Rai, V., Hoffmann, R., & Shekhtman, A. (2014) · Biochemistry · doi:10.1021/bi500046t · Cited by 186 · see citing works

Effect of methylglyoxal on human leukaemia 60 cell growth: Modification of DNA, G1 growth arrest and induction of apoptosis

Kang, Y., Edwards, L. G., & Thornalley, P. J. (1996) · Leukemia Research · doi:10.1016/0145-2126(95)00162-x · Cited by 182 · see citing works

Acetone Metabolism in Humans During Diabetic Ketoacidosis

Reichard, G., Skutches, C. L., Hoeldtke, R. D., & Owen, O. E. (1986) · Diabetes · doi:10.2337/diab.35.6.668 · Cited by 177 · see citing works

Methylglyoxal-induced dicarbonyl stress in aging and disease: first steps towards glyoxalase 1-based treatments

Rabbani, N., Xue, M., & Thornalley, P. J. (2016) · Clinical Science · doi:10.1042/cs20160025 · Cited by 173 · see citing works

Curcumin Inhibits Glyoxalase 1—A Possible Link to Its Anti-Inflammatory and Anti-Tumor Activity

Santel, T., Pflug, G., Hemdan, N. Y. A., Schäfer, A., Hollenbach, M., Buchold, M., Hintersdorf, A., Lindner, I., Otto, A., Bigl, M., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003508 · Cited by 171 · see citing works

Methylglyoxal in food and living organisms

Nemet, I., Varga‐Defterdarovič, L., & Turk, Z. (2006) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600065 · Cited by 170 · see citing works

Glyoxalase in tumourigenesis and multidrug resistance

Thornalley, P. J., & Rabbani, N. (2011) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2011.02.006 · Cited by 163 · see citing works

Glucose availability is a decisive factor for Nrf2-mediated gene expression

Heiß, E. H., Schachner, D., Zimmermann, K., & Dirsch, V. M. (2013) · Redox Biology · doi:10.1016/j.redox.2013.06.001 · Cited by 157 · see citing works

Chromatographic assay of glycation adducts in human serum albumin glycated in vitro by derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate and intrinsic fluorescence

Ahmed, N., & Thornalley, P. J. (2002) · Biochemical Journal · doi:10.1042/bj3640015 · Cited by 154 · see citing works

Glyoxalase I is involved in resistance of human leukemia cells to antitumor agent-induced apoptosis

Sakamoto, H., Mashima, T., Kizaki, A., Dan, S., Hashimoto, Y., Naito, M., & Tsuruo, T. (2000) · Blood · doi:10.1182/blood.v95.10.3214 · Cited by 154 · see citing works

Metformin induces apoptosis of pancreatic cancer cells

Wang, L., Li, Z., Zou, D., Jin, Z., Gao, J., & Xu, G.-M. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.7192 · Cited by 153 · see citing works

Cross-linking of proteins by maillard processes: characterization and detection of lysine–arginine cross-links derived from glyoxal and methylglyoxal

Lederer, M. O., & Klaiber, R. (1999) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(99)00212-6 · Cited by 146 · see citing works

Methylglyoxal-induced nitric oxide and peroxynitrite production in vascular smooth muscle cells

Chang, T., Wang, R., & Wu, L. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.10.034 · Cited by 140 · see citing works

Modulation of Heat-shock Protein 27 (Hsp27) Anti-apoptotic Activity by Methylglyoxal Modification

Sakamoto, H., Mashima, T., Yamamoto, K., & Tsuruo, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207485200 · Cited by 139 · see citing works

Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis

Nokin, M., Durieux, F., Peixoto, P., Chiavarina, B., Peulen, O., Blomme, A., Turtoï, A., Costanza, B., Smargiasso, N., Baiwir, D., et al. (2016) · eLife · doi:10.7554/elife.19375 · Cited by 137 · see citing works

Diabetes and cancer: Associations, mechanisms, and implications for medical practice

Xu, C. (2014) · World Journal of Diabetes · doi:10.4239/wjd.v5.i3.372 · Cited by 135 · see citing works

The Chaperone-Dependent Ubiquitin Ligase CHIP Targets HIF-1α for Degradation in the Presence of Methylglyoxal

Bento, C. F., Fernandes, R., Ramalho, J. S., Marques, C., Shang, F., Taylor, A., & Pereira, P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015062 · Cited by 132 · see citing works

Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1-associated tumour multidrug resistance

Thornalley, P. J., Waris, S., Fleming, T. H., Santarius, T., Larkin, S. J., Winklhofer‐Roob, B. M., Stratton, M. R., & Rabbani, N. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq306 · Cited by 125 · see citing works

Novel Biomarkers for Prostate Cancer Including Noncoding Transcripts

Romanuik, T. L., Ueda, T., Le, N., Haile, S., Yong, T. M. K., Thomson, T. A., Vessella, R. L., & Sadar, M. D. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080868 · Cited by 125 · see citing works

Expression of glyoxalase I and II in normal and breast cancer tissues

Rulli, A., Carli, L., Romani, R., Baroni, T., Giovannini, E., Rosi, G., & Talesa, V. N. (2001) · Breast Cancer Research and Treatment · doi:10.1023/a:1010632919129 · Cited by 125 · see citing works

Selective activation of apoptosis program by S-p-bromobenzylglutathione cyclopentyl diester in glyoxalase I-overexpressing human lung cancer cells.

Sakamoto, H., Mashima, T., Sato, S., Hashimoto, Y., Yamori, T., & Tsuruo, T. (2001) · PubMed · Cited by 124 · see citing works

Advanced glycation endproducts increase proliferation, migration and invasion of the breast cancer cell line MDA-MB-231

Sharaf, H., Matou‐Nasri, S., Wang, Q., Rabhan, Z., Al‐Eidi, H., Abdulrahman, A. A., & Ahmed, N. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.12.009 · Cited by 122 · see citing works

Genotoxicity and immunogenicity of DNA-advanced glycation end products formed by methylglyoxal and lysine in presence of Cu2+

Ahmad, S., Moinuddin, Dixit, K., Shahab, U., Alam, K., & Ali, A. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.03.064 · Cited by 121 · see citing works

Identification of aldo-keto reductases as NRF2-target marker genes in human cells

Jung, K.-A., Choi, B.-H., Nam, C.-W., Song, M., Kim, S.-T., Lee, J. Y., & Kwak, M.-K. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2012.12.026 · Cited by 113 · see citing works

Human aldehyde dehydrogenase

Kurys, G., Ambroziak, W., & Pietruszko, R. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83802-9 · Cited by 108 · see citing works

GLO1 —A novel amplified gene in human cancer

Santarius, T., Bignell, G. R., Greenman, C., Widaa, S., Chen, L., Mahoney, C., Butler, A. P., Edkins, S., Waris, S., Thornalley, P. J., et al. (2010) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20784 · Cited by 107 · see citing works

Recent advances in detection of AGEs: Immunochemical, bioanalytical and biochemical approaches: Technological Progress in Age Detection

Ashraf, J. M., Ahmad, S., Choi, I., Ahmad, N., Farhan, M., Tatyana, G., & Shahab, U. (2015) · IUBMB Life · doi:10.1002/iub.1450 · Cited by 106 · see citing works

Glycative stress from advanced glycation end products (AGEs) and dicarbonyls: An emerging biological factor in cancer onset and progression

Lin, J., Wu, C., Lu, C., Hsia, S., & Yen, G. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500759 · Cited by 105 · see citing works

Methylglyoxal Can Modify GAPDH Activity and Structure

Lee, H. J., Howell, S. K., SANFORD, R. J., & Beisswenger, P. J. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1333.017 · Cited by 104 · see citing works

Alterations in renal mitochondrial respiration in response to the reactive oxoaldehyde methylglyoxal

Rosca, M. G., Monnier, V. M., Szweda, L. I., & Weiss, M. F. (2002) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00302.2001 · Cited by 103 · see citing works

Scavenging system efficiency is crucial for cell resistance to ROS-mediated methylglyoxal injury

Amicarelli, F., Colafarina, S., Cattani, F., Cimini, A., Ilio, C. D., Cerù, M. P., & Miranda, M. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00438-6 · Cited by 103 · see citing works

Cancerostatic Action of Methylglyoxal

Együud, L. G., & Szent‐Györgyi, A. (1968) · Science · doi:10.1126/science.160.3832.1140 · Cited by 102 · see citing works

Induction of AKR1C2 by Phase II Inducers: Identification of a Distal Consensus Antioxidant Response Element Regulated by NRF2

Lou, H., Du, S., Ji, Q., & Stolz, A. (2006) · Molecular Pharmacology · doi:10.1124/mol.105.019794 · Cited by 100 · see citing works

The functional genomic studies of curcumin

Huminiecki, Ł., Horbańczuk, J. O., & Atanasov, A. G. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.04.002 · Cited by 96 · see citing works

Tumor necrosis factor-induced modulation of glyoxalase I activities through phosphorylation by PKA results in cell death and is accompanied by the formation of a specific methylglyoxal-derived AGE

Herreweghe, F. V., Mao, J., Chaplen, F. W. R., Grooten, J., Gevaert, K., Vandekerckhove, J. S., & Vancompernolle, K. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012432399 · Cited by 96 · see citing works

Posttranslational Modification of Human Glyoxalase 1 Indicates Redox-Dependent Regulation

Birkenmeier, G., Stegemann, C., Hoffmann, R., Günther, R., Huse, K., & Birkemeyer, C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010399 · Cited by 95 · see citing works

GLO1 overexpression in human malignant melanoma

Bair, W. B., Cabello, C. M., Uchida, K., Bause, A. S., & Wondrak, G. T. (2010) · Melanoma Research · doi:10.1097/cmr.0b013e3283364903 · Cited by 94 · see citing works

Methylglyoxal induces endoplasmic reticulum stress and DNA demethylation in the Keap1 promoter of human lens epithelial cells and age-related cataracts

Periyasamy, P., Bidasee, K. R., Ayaki, M., Augusteyn, R. C., Chan, J. Y., & Shinohara, T. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.04.010 · Cited by 91 · see citing works

Carnosine Inhibits the Proliferation of Human Gastric Cancer SGC-7901 Cells through Both of the Mitochondrial Respiration and Glycolysis Pathways

Shen, Y., Yang, J., Li, J., Shi, X., Ouyang, L., Tian, Y., & Lü, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104632 · Cited by 89 · see citing works

Plasma α-Oxoaldehyde Levels in Diabetic and Nondiabetic Chronic Kidney Disease Patients

Nakayama, K., Nakayama, M., Iwabuchi, M., Terawaki, H., Sato, T., Kohno, M., & Ito, S. (2008) · American Journal of Nephrology · doi:10.1159/000139653 · Cited by 87 · see citing works

Loss of Glyoxalase 1 Induces Compensatory Mechanism to Achieve Dicarbonyl Detoxification in Mammalian Schwann Cells

Morgenstern, J., Fleming, T. H., Schumacher, D., Eckstein, V., Freichel, M., Herzig, S., & Nawroth, P. P. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.760132 · Cited by 82 · see citing works

Metformin sensitizes endometrial cancer cells to chemotherapy by repressing glyoxalase I expression

Dong, L., Zhou, Q., Zhang, Z., Zhu, Y., Duan, T., & Feng, Y. (2012) · Journal of obstetrics and gynaecology research · doi:10.1111/j.1447-0756.2011.01839.x · Cited by 77 · see citing works

Vaspin prevents methylglyoxal‐induced apoptosis in human vascular endothelial cells by inhibiting reactive oxygen species generation

Phalitakul, S., Okada, M., Hara, Y., & Yamawaki, H. (2013) · Acta Physiologica · doi:10.1111/apha.12139 · Cited by 77 · see citing works

Activation of Nrf2 attenuates carbonyl stress induced by methylglyoxal in human neuroblastoma cells: Increase in GSH levels is a critical event for the detoxification mechanism

Nishimoto, S., Koike, S., Inoue, N., Suzuki, T., & Ogasawara, Y. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.01.024 · Cited by 75 · see citing works

Methylglyoxal induces G:C to C:G and G:C to T:A transversions in the supF gene on a shuttle vector plasmid replicated in mammalian cells

Murata‐Kamiya, N., Kamiya, H., Kaji, H., & Kasai, H. (2000) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(00)00044-9 · Cited by 73 · see citing works

Argpyrimidine-modified Heat Shock Protein 27 in human non-small cell lung cancer: A possible mechanism for evasion of apoptosis

van Heijst, J. W. J., Niessen, H. W. M., Musters, R. J. P., van Hinsbergh, V. W. M., Hoekman, K., & Schalkwijk, C. G. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.10.042 · Cited by 72 · see citing works

Analysis of glyoxalase-I from normal and tumor tissue

Ranganathan, S., & Tew, K. D. (1993) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(93)90074-b · Cited by 71 · see citing works

Advanced Glycation End Products of DNA: Quantification of N 2 -(1-Carboxyethyl)-2′-deoxyguanosine in Biological Samples by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry

Synold, T. W., Xi, B., Wuenschell, G. E., Tamae, D., Figarola, J. L., Rahbar, S., & Termini, J. S. (2008) · Chemical Research in Toxicology · doi:10.1021/tx800224y · Cited by 69 · see citing works

A novel mechanism of methylglyoxal cytotoxicity in prostate cancer cells

Antognelli, C., Mezzasoma, L., Fettucciari, K., & Talesa, V. N. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.01.003 · Cited by 69 · see citing works

Effects of methylglyoxal and glyoxalase I inhibition on breast cancer cells proliferation, invasion, and apoptosis through modulation of MAPKs, MMP9, and Bcl-2

Guo, Y., Zhang, Y., Yang, X., Lu, P., Yan, X., Xiao, F., Zhou, H., Wen, C., Shi, M., Lü, J., et al. (2015) · Cancer Biology & Therapy · doi:10.1080/15384047.2015.1121346 · Cited by 67 · see citing works

Genomic sequence of human glyoxalase-I: analysis of promoter activity and its regulation

Ranganathan, S., Ciaccio, P. J., Walsh, E. S., & Tew, K. D. (1999) · Gene · doi:10.1016/s0378-1119(99)00420-5 · Cited by 67 · see citing works

Heat-shock protein 27 (Hsp27) as a target of methylglyoxal in gastrointestinal cancer

Oya‐Ito, T., Naito, Y., Takagi, T., Handa, O., Matsui, H., Yamada, M., Shima, K., & Yoshikawa, T. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.03.017 · Cited by 66 · see citing works

Methylglyoxal-Mediated Stress Correlates with High Metabolic Activity and Promotes Tumor Growth in Colorectal Cancer

Chiavarina, B., Nokin, M., Bellier, J., Durieux, F., Blétard, N., Sherer, F., Lovinfosse, P., Peulen, O., Verset, L., Dehon, R., et al. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18010213 · Cited by 66 · see citing works

Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer

MacLeod, A. K., Acosta-Jimenez, L., Coates, P. J., McMahon, M. J., Carey, F. A., Honda, T., Henderson, C. J., & Wolf, C. R. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.363 · Cited by 65 · see citing works

Rapid Suppression of Mitochondrial Permeability Transition by Methylglyoxal

Speer, O., Morkūnaitė‐Haimi, Š., Liobikas, J., Franck, M. C. M., Hensbo, L., Linder, M. D., Kinnunen, P. K. J., Wallimann, T., & Eriksson, O. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301990200 · Cited by 64 · see citing works

Methylglyoxal and high glucose co‐treatment induces apoptosis or necrosis in human umbilical vein endothelial cells

Chan, W., & Wu, H. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21489 · Cited by 64 · see citing works

Fructose-induced peroxynitrite production is mediated by methylglyoxal in vascular smooth muscle cells

Wang, H., Meng, Q. H., Chang, T., & Wu, L. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.08.009 · Cited by 64 · see citing works

Characterization of an imidazolium compound formed by reaction of methylglyoxal and N α -hippuryllysine

Brinkmann, E., Wells‐Knecht, K. J., Thorpe, S. R., & Baynes, J. (1995) · Journal of the Chemical Society Perkin Transactions 1 · doi:10.1039/p19950002817 · Cited by 63 · see citing works

Aminoacetone oxidase from goat liver. Formation of methylglyoxal from aminoacetone.

Ray, M., & Ray, S. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45524-x · Cited by 62 · see citing works

Methylglyoxal mediated conformational changes in histone H2A—generation of carboxyethylated advanced glycation end products

Mir, A. R., Uddin, M., Alam, K., & Ali, A. (2014) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2014.05.057 · Cited by 62 · see citing works

Development of a 32P-postlabelling method for the analysis of 2'-deoxyguanosine-3'-monophosphate and DNA adducts of methylglyoxal

Vaca, C. E., Fang, J., Conradi, M., & Hou, S. (1994) · Carcinogenesis · doi:10.1093/carcin/15.9.1887 · Cited by 61 · see citing works

Breast cancer proteomics reveals a positive correlation between glyoxalase 1 expression and high tumor grade

Fonseca-Sánchez, M. A., Cuevas, S. R., Mendoza‐Hernández, G., Bautista‐Piña, V., Aréchaga-Ocampo, E., Hidalgo‐Miranda, A., Quintanar‐Jurado, V., Marchat, L. A., Álvarez-Sánchez, M. E., Pérez‐Plasencia, C., et al. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1478 · Cited by 60 · see citing works

Trapping of Methylglyoxal by Curcumin in Cell-Free Systems and in Human Umbilical Vein Endothelial Cells

Hu, T.-Y., Liu, C., Chyau, C.-C., & Hu, M. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf302188a · Cited by 59 · see citing works

GLYOXALASE I ACTIVITY IN HUMAN PROSTATE CANCER: A POTENTIAL MARKER AND IMPORTANCE IN CHEMOTHERAPY

Davidson, S. D., CHERRY, J. P., CHOUDHURY, M. S., Tazaki, H., Mallouh, C., & Konno, S. (1999) · The Journal of Urology · doi:10.1016/s0022-5347(01)61996-7 · Cited by 59 · see citing works

Integrated genomic and functional analyses reveal glyoxalase I as a novel metabolic oncogene in human gastric cancer

Hosoda, F., Arai, Y., Okada, N., Shimizu, H., Miyamoto, M., Kitagawa, N., Katai, H., Taniguchi, H., Yanagihara, K., Imoto, I., et al. (2014) · Oncogene · doi:10.1038/onc.2014.57 · Cited by 57 · see citing works

Triple negative tumors accumulate significantly less methylglyoxal specific adducts than other human breast cancer subtypes

Chiavarina, B., Nokin, M., Durieux, F., Bianchi, E., Turtoï, A., Peulen, O., Peixoto, P., Irigaray, P., Uchida, K., Belpomme, D., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2121 · Cited by 56 · see citing works

Glyoxalase-I Is a Novel Prognosis Factor Associated with Gastric Cancer Progression

Cheng, W., Tsai, M.-M., Tsai, C., Huang, Y., Chen, C., Chi, H., Tseng, Y., Chao, I.-W., Lin, W.-C., Wu, S.-M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034352 · Cited by 54 · see citing works

Molecular abnormality and cDNA cloning of human aldehyde dehydrogenases

Yoshida, A., Ikawa, M., Hsu, L., & Tani, K. (1985) · Alcohol · doi:10.1016/0741-8329(85)90024-2 · Cited by 52 · see citing works

Glyoxalase I (GLO1) is up-regulated in pancreatic cancerous tissues compared with related non-cancerous tissues.

Wang, Y., Kuramitsu, Y., Ueno, T., Suzuki, N., Yoshino, S., Iizuka, N., Akada, J. K., Kitagawa, T., Oka, M., & Nakamura, K. (2012) · PubMed · Cited by 51 · see citing works

Interaction of Methylglyoxal and Hydrogen Sulfide in Rat Vascular Smooth Muscle Cells

Chang, T., Untereiner, A. A., Liu, J., & Wu, L. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2918 · Cited by 50 · see citing works

Glyoxalase I in detoxification: studies using a glyoxalase I transfectant cell line

Ranganathan, S., Walsh, E. S., & Tew, K. D. (1995) · Biochemical Journal · doi:10.1042/bj3090127 · Cited by 48 · see citing works

Role of glyoxalase I in the proliferation and apoptosis control of human LNCaP and PC3 prostate cancer cells

Antognelli, C., Mezzasoma, L., Fettucciari, K., Mearini, E. E., & Talesa, V. N. (2012) · The Prostate · doi:10.1002/pros.22547 · Cited by 47 · see citing works

Immunomodulation of macrophages by methylglyoxal conjugated with chitosan nanoparticles against Sarcoma-180 tumor in mice

Chakrabarti, A., Talukdar, D., Pal, A., & Ray, M. (2013) · Cellular Immunology · doi:10.1016/j.cellimm.2013.11.006 · Cited by 46 · see citing works

Plasma advanced glycation endproduct, methylglyoxal-derived hydroimidazolone is elevated in young, complication-free patients with Type 1 diabetes

Han, Y., Randell, E. W., Vasdev, S., Gill, V. D., Curran, M., Newhook, L. A., Grant, M., Hagerty, D., & Schneider, C. (2009) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2008.12.016 · Cited by 43 · see citing works

Phosphorylation on Thr-106 and NO-modification of glyoxalase I suppress the TNF-induced transcriptional activity of NF-κB

de Hemptinne, V., Rondas, D., Toepoel, M., & Vancompernolle, K. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0031-7 · Cited by 41 · see citing works

Determination of Glycated Nucleobases in Human Urine by a New Monoclonal Antibody Specific for N2-Carboxyethyl-2‘-deoxyguanosine

Schneider, M. U., Thoss, G., Hübner-Parajsz, C., Kientsch-Engel, R., Stahl, P., & Pischetsrieder, M. (2004) · Chemical Research in Toxicology · doi:10.1021/tx049929d · Cited by 41 · see citing works

Exploring glyoxalase 1 expression in prostate cancer tissues: Targeting the enzyme by ethyl pyruvate defangs some malignancy‐associated properties

Baunacke, M., Horn, L., Trettner, S., Engel, K. M., Hemdan, N. Y. A., Wiechmann, V., Stolzenburg, J., Bigl, M., & Birkenmeier, G. (2013) · The Prostate · doi:10.1002/pros.22728 · Cited by 41 · see citing works

Glo1 genetic amplification as a potential therapeutic target in hepatocellular carcinoma.

Zhang, S., Liang, X., Zheng, X., Huang, H., Chen, X., Wu, K., Wang, B., & Ma, S. (2014) · PubMed Central · Cited by 41 · see citing works

Differing expression of enzymes of the glyoxalase system in superficial and invasive bladder carcinomas

Mearini, E. E., Romani, R., Mearini, L., Antognelli, C., Zucchi, A., Baroni, T., Porena, M., & Talesa, V. N. (2002) · European Journal of Cancer · doi:10.1016/s0959-8049(02)00236-8 · Cited by 39 · see citing works

Glyoxalase 1 is up-regulated in hepatocellular carcinoma and is essential for HCC cell proliferation

Hu, X., Yang, X., He, Q., Chen, Q., & Yu, L. (2013) · Biotechnology Letters · doi:10.1007/s10529-013-1372-6 · Cited by 38 · see citing works

Preferential recognition of methylglyoxal-modified calf thymus DNA by circulating antibodies in cancer patients.

Ahmad, M., Ahmad, S., & Moinuddin, M. (2011) · PubMed · Cited by 36 · see citing works

Erratum: Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer

MacLeod, A. K., Acosta-Jimenez, L., Coates, P. J., McMahon, M. J., Carey, F. A., Honda, T., Hayes, J. D., Henderson, C. J., & Wolf, C. R. (2017) · British Journal of Cancer · doi:10.1038/bjc.2017.80 · Cited by 36 · see citing works

Targeting the Glyoxalase Pathway Enhances TRAIL Efficacy in Cancer Cells by Downregulating the Expression of Antiapoptotic Molecules

Taniguchi, H., Horinaka, M., Yoshida, T., Yano, K., Goda, A. E., Yasuda, S., Wakada, M., & Sakai, T. (2012) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-0031 · Cited by 35 · see citing works

Methylglyoxal modulates endothelial nitric oxide synthase-associated functions in EA.hy926 endothelial cells

Su, Y., Qadri, S. M., Wu, L., & Liu, L. (2013) · Cardiovascular Diabetology · doi:10.1186/1475-2840-12-134 · Cited by 33 · see citing works

Dicarbonyl Stress and Apoptosis of Vascular Cells: Prevention by αB‐Crystallin

Nagaraj, R. H., Oya‐Ito, T., Bhat, M. B., & Liu, B.-F. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1333.020 · Cited by 33 · see citing works

Methylglyoxal activates NF-κB nuclear translocation and induces COX-2 expression via a p38-dependent pathway in synovial cells

Lin, C.-C., Chan, C.-M., Huang, Y., Hsu, S.-H., Huang, C., & Tsai, S. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.02.060 · Cited by 33 · see citing works

Methylglyoxal–Induced Apoptosis in Human Prostate Carcinoma: Potential Modality for Prostate Cancer Treatment

Milanesa, D. M., CHOUDHURY, M. S., Mallouh, C., Tazaki, H., & Konno, S. (2000) · European Urology · doi:10.1159/000020226 · Cited by 32 · see citing works

Modulation of GLO1 Expression Affects Malignant Properties of Cells

Hutschenreuther, A., Bigl, M., Hemdan, N. Y. A., Debebe, T., Gaunitz, F., & Birkenmeier, G. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122133 · Cited by 31 · see citing works

Two α-dicarbonyls downregulate migration, invasion, and adhesion of liver cancer cells in a p53-dependent manner

Loarca, L., Sassi‐Gaha, S., & Artlett, C. M. (2013) · Digestive and Liver Disease · doi:10.1016/j.dld.2013.05.005 · Cited by 29 · see citing works

A possible regulatory role of glyoxalase I in cell viability of human prostate cancer

Davidson, S., Milanesa, D. M., Mallouh, C., CHOUDHURY, M. S., Tazaki, H., & Konno, S. (2002) · Urological Research · doi:10.1007/s00240-002-0244-7 · Cited by 29 · see citing works

Neo-epitopes on methylglyoxal modified human serum albumin lead to aggressive autoimmune response in diabetes

Jyoti, J., Mir, A. R., Habib, S., Siddiqui, S. S., Ali, A., & Moinuddin, M. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.02.019 · Cited by 29 · see citing works

Troglitazone overcomes doxorubicin-resistance in resistant K562 leukemia cells

Davies, G. F., Roesler, W. J., Juurlink, B. H. J., & Harkness, T. A. A. (2005) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190500102555 · Cited by 28 · see citing works

Methylglyoxal induces mitochondria-dependent apoptosis in sarcoma

Ghosh, A., Bera, S., Ray, S., Banerjee, T., & Ray, M. (2011) · Biochemistry (Moscow) · doi:10.1134/s0006297911100105 · Cited by 27 · see citing works

Methylglyoxal suppresses human colon cancer cell lines and tumor growth in a mouse model by impairing glycolytic metabolism of cancer cells associated with down-regulation of c-Myc expression

He, T., Zhou, H., Li, C., Chen, Y., Chen, X., Li, C., Mao, J., Lyu, J., & Meng, Q. H. (2016) · Cancer Biology & Therapy · doi:10.1080/15384047.2016.1210736 · Cited by 26 · see citing works

Potential of glycative stress targeting for cancer prevention

Piperi, C., Adamopoulos, C., & Papavassiliou, A. G. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.01.020 · Cited by 25 · see citing works

Lactate formation and glyoxalase activity in normal and leukemic human leukocytes in vitro.

Gr, M., & Rw, R. (1956) · PubMed · Cited by 25 · see citing works

A possible regulatory role of 17β-estradiol and tamoxifen on glyoxalase I and glyoxalase II genes expression in MCF7 and BT20 human breast cancer cells

Rulli, A., Antognelli, C., Prezzi, E., Baldracchini, F., Piva, F., Giovannini, E., & Talesa, V. N. (2005) · Breast Cancer Research and Treatment · doi:10.1007/s10549-005-9078-7 · Cited by 24 · see citing works

Troglitazone selectively inhibits glyoxalase I gene expression

Wu, L., Eftekharpour, E., Davies, G. F., Roesler, W. J., & Juurlink, B. H. J. (2001) · Diabetologia · doi:10.1007/s001250100004 · Cited by 24 · see citing works

Methylglyoxal induces DNA crosslinks in ECV304 cells via a reactive oxygen species-independent protein carbonylation pathway

Tu, C.-Y., Chen, Y.-F., Lii, C., & Wang, T. (2013) · Toxicology in Vitro · doi:10.1016/j.tiv.2013.02.011 · Cited by 24 · see citing works

Tumour necrosis factor induces phosphorylation primarily of the nitric-oxide-responsive form of glyoxalase I

de Hemptinne, V., Rondas, D., Vandekerckhove, J. S., & Vancompernolle, K. (2007) · Biochemical Journal · doi:10.1042/bj20070379 · Cited by 23 · see citing works

Alteration of glyoxalases gene expression in response to testosterone in LNCaP and PC3 human prostate cancer cells

Antognelli, C., Buono, C. D., Baldracchini, F., Talesa, V. N., Cottini, E., Brancadoro, C., Zucchi, A., & Mearini, E. E. (2007) · Cancer Biology & Therapy · doi:10.4161/cbt.6.12.4961 · Cited by 21 · see citing works

Characterization of the Deoxyguanosine–Lysine Cross-Link of Methylglyoxal

Petrova, K. V., Millsap, A. D., Stec, D. F., & Rizzo, C. J. (2014) · Chemical Research in Toxicology · doi:10.1021/tx500068v · Cited by 16 · see citing works

Troglitazone Reduces Glyoxalase I Protein Expression in Glioma and Potentiates the Effects of Chemotherapeutic Agents

Helgager, J. J., Li, J., Lubensky, I. A., Lonser, R. R., & Zhuang, Z. (2010) · Journal of Oncology · doi:10.1155/2010/373491 · Cited by 7 · see citing works

Methylglyoxal, a Highly Reactive Dicarbonyl Compound, in Diabetes, Its Vascular Complications, and Other Age-Related Diseases

Schalkwijk, C., & Stehouwer, C. D. A. (2019) · Physiological Reviews · doi:10.1152/physrev.00001.2019 · Cited by 630 · see citing works

The metabolic landscape of RAS-driven cancers from biology to therapy

Mukhopadhyay, S., Vander Heiden, M. G., & McCormick, F. (2021) · Nature Cancer · doi:10.1038/s43018-021-00184-x · Cited by 315 · see citing works

Microbial carcinogenesis: Lactic acid bacteria in gastric cancer

Vinasco, K., Mitchell, H. M., Kaakoush, N. O., & Castaño‐Rodríguez, N. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.07.004 · Cited by 173 · see citing works

Methylglyoxal, a potent inducer of AGEs, connects between diabetes and cancer

Bellier, J., Nokin, M., Lardé, E., Karoyan, P., Peulen, O., Castronovo, V., & Bellahcène, A. (2019) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2019.01.002 · Cited by 143 · see citing works

Recent advances in the design and applications of near-infrared II responsive small molecule phototherapeutic agents

Ma, D., Bian, H., Gu, M., Wang, L., Chen, X., & Peng, X. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.215677 · Cited by 124 · see citing works

The role of protein lactylation: A kaleidoscopic post-translational modification in cancer

Iozzo, M., Pardella, E., Giannoni, E., & Chiarugi, P. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.02.011 · Cited by 122 · see citing works

Benefits, deleterious effects and mitigation of methylglyoxal in foods: A critical review

Zheng, J., Guo, H., Ou, J., Liu, P., Huang, C., Wang, M., Simal‐Gándara, J., Battino, M. A., Jafari, S. M., Zou, L., et al. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.10.031 · Cited by 102 · see citing works

Methylglyoxal – An emerging biomarker for diabetes mellitus diagnosis and its detection methods

Ramachandra, B. L., Vedantham, S., Krishnan, U. M., & Rayappan, J. B. B. (2019) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2019.03.010 · Cited by 100 · see citing works

Metabolite Repair Enzymes Control Metabolic Damage in Glycolysis

Bommer, G. T., SCHAFTINGEN, E. V., & Veiga‐da‐Cunha, M. (2019) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2019.07.004 · Cited by 94 · see citing works

Vaping, Environmental Toxicants Exposure, and Lung Cancer Risk

Shehata, S. A., Toraih, E. A., Ismail, E. A., Hagras, A. M., Elmorsy, E. M., & Fawzy, M. S. (2023) · Cancers · doi:10.3390/cancers15184525 · Cited by 101 · see citing works

Dicarbonyl Stress at the Crossroads of Healthy and Unhealthy Aging

Nigro, C., Leone, A., Fiory, F., Prevenzano, I., Nicolò, A., Mirra, P., Bèguinot, F., & Miele, C. (2019) · Cells · doi:10.3390/cells8070749 · Cited by 91 · see citing works

Methylglyoxal, a glycolysis metabolite, triggers metastasis through MEK/ERK/SMAD1 pathway activation in breast cancer

Nokin, M., Bellier, J., Durieux, F., Peulen, O., Rademaker, G., Gabriel, M., Monseur, C., Charloteaux, B., Verbeke, L. P. C., Laere, S. V., et al. (2019) · Breast Cancer Research · doi:10.1186/s13058-018-1095-7 · Cited by 89 · see citing works

Hormetic potential of methylglyoxal, a side-product of glycolysis, in switching tumours from growth to death

Nokin, M., Durieux, F., Bellier, J., Peulen, O., Uchida, K., Spiegel, D. A., Cochrane, J. R., Hutton, C. A., Castronovo, V., & Bellahcène, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-12119-7 · Cited by 88 · see citing works

The Glyoxalase System—New Insights into an Ancient Metabolism

Morgenstern, J., Campos, M., Nawroth, P. P., & Fleming, T. H. (2020) · Antioxidants · doi:10.3390/antiox9100939 · Cited by 73 · see citing works

Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer

Luengo, A., Abbott, K. L., Davidson, S. M., Hosios, A. M., Faubert, B., Chan, S. H., Freinkman, E., Zacharias, L. G., Mathews, T. P., Clish, C. B., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13419-4 · Cited by 73 · see citing works

Glyoxalases in Urological Malignancies

Antognelli, C., & Talesa, V. N. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020415 · Cited by 64 · see citing works

The Dual-Role of Methylglyoxal in Tumor Progression – Novel Therapeutic Approaches

Leone, A., Nigro, C., Nicolò, A., Prevenzano, I., Formisano, P., Bèguinot, F., & Miele, C. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.645686 · Cited by 59 · see citing works

Nanomaterial-Based Repurposing of Macrophage Metabolism and Its Applications

Meng, T., He, D., Han, Z., Shi, R., Wang, Y., Ren, B., Zhang, C., Mao, Z., Luo, G., & Deng, J. (2024) · Nano-Micro Letters · doi:10.1007/s40820-024-01455-9 · Cited by 63 · see citing works

Reactive Glycolysis Metabolite‐Activatable Nanotheranostics for NIR‐II Fluorescence Imaging‐Guided Phototherapy of Cancer

Lai, Y., Dang, Y., Li, F., Ding, C., Yu, H., Zhang, W., & Xu, Z. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202200016 · Cited by 57 · see citing works

Tumor microbiome metabolism: A game changer in cancer development and therapy

Zhou, X., Kandalai, S., Hossain, F., & Zheng, Q. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.933407 · Cited by 51 · see citing works

Methylglyoxal Formation—Metabolic Routes and Consequences

Vašková, J., Sabolová, G., Pudelský, J., Palenčár, D., & Mičková, H. (2025) · Antioxidants · doi:10.3390/antiox14020212 · Cited by 54 · see citing works

Methylglyoxal interaction with superoxide dismutase 1

Polykretis, P., Luchinat, E., Boscaro, F., & Banci, L. (2020) · Redox Biology · doi:10.1016/j.redox.2019.101421 · Cited by 46 · see citing works

Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab

Bellier, J., Nokin, M.-J., Caprasse, M., Tiamiou, A., Blomme, A., Scheijen, J. L., Koopmansch, B., MacKay, G. M., Chiavarina, B., Costanza, B., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.01.012 · Cited by 38 · see citing works

The Human Glyoxalase Gene Family in Health and Disease

Farrera, D. O., & Galligan, J. J. (2022) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.2c00182 · Cited by 39 · see citing works

Concomitant Loss of the Glyoxalase System and Glycolysis Makes the Uncultured Pathogen “Candidatus Liberibacter asiaticus” an Energy Scavenger

Jain, M., Muñoz‐Bodnar, A., & Gabriel, D. W. (2017) · Applied and Environmental Microbiology · doi:10.1128/aem.01670-17 · Cited by 38 · see citing works

Brain Senescence Caused by Elevated Levels of Reactive Metabolite Methylglyoxal on D-Galactose-Induced Aging Mice

Li, H., Zheng, L., Chen, C., Liu, X., & Zhang, W. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01004 · Cited by 37 · see citing works

A Panel of Urinary Volatile Biomarkers for Differential Diagnosis of Prostate Cancer from Other Urological Cancers

Lima, A. R., Pinto, J., Carvalho‐Maia, C., Jerónimo, C., Henrique, R., Bastos, M. D. L., Carvalho, M. C., & de Pinho, P. G. (2020) · Cancers · doi:10.3390/cancers12082017 · Cited by 34 · see citing works

Diet and Obesity-Induced Methylglyoxal Production and Links to Metabolic Disease

Hernandez-Castillo, C., & Shuck, S. C. (2021) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.1c00221 · Cited by 33 · see citing works

Imaging Tumorous Methylglyoxal by an Activatable Near-Infrared Fluorescent Probe for Monitoring Glyoxalase 1 Activity

Ding, C., Wang, F., Dang, Y., Xu, Z., Li, L., Lai, Y., Yu, H., Luo, Y., Huang, R., Zhang, A., et al. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b03600 · Cited by 31 · see citing works

The Taming of Nuclear Factor Erythroid-2-Related Factor-2 (Nrf2) Deglycation by Fructosamine-3-Kinase (FN3K)-Inhibitors-A Novel Strategy to Combat Cancers

Beeraka, N. M., Bovilla, V. R., Doreswamy, S. H., Puttalingaiah, S., Srinivasan, A., & Madhunapantula, S. V. (2021) · Cancers · doi:10.3390/cancers13020281 · Cited by 28 · see citing works

The “sweet” path to cancer: focus on cellular glucose metabolism

Iacobini, C., Vitale, M., Pugliese, G., & Menini, S. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1202093 · Cited by 24 · see citing works

The RAGE/multiligand axis: a new actor in tumor biology

Armando Rojas, R., Schneider, I., Lindner, C., González, I., & Morales, M. A. (2022) · Bioscience Reports · doi:10.1042/bsr20220395 · Cited by 23 · see citing works

Role of the Glyoxalase System in Breast Cancer and Gynecological Cancer-Implications for Therapeutic Intervention: a Review

Wang, J., Yang, X., Wang, Z., & Wang, J. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.857746 · Cited by 23 · see citing works

Gastrointestinal manifestations after Roux-en-Y gastric bypass surgery in individuals with and without type 2 diabetes

Härma, M., Adeshara, K. A., Istomin, N., Lehto, M. J., Blaut, M., Savolainen, M. J., Hörkkö, S., Groop, P., Koivukangas, V., & Hukkanen, J. (2020) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2020.10.021 · Cited by 22 · see citing works

Methylglyoxal: a novel upstream regulator of DNA methylation

Dube, G., Tiamiou, A., Bizet, M., Boumahd, Y., Gasmi, I., Crake, R., Bellier, J., Nokin, M., Calonne, E., Deplus, R., et al. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02637-w · Cited by 21 · see citing works

Detection of glucose-derived d- and l-lactate in cancer cells by the use of a chiral NMR shift reagent

Suh, E. H., Geraldes, C. F. G. C., Chirayil, S., Faubert, B., Ayala, R., DeBerardinis, R. J., & Sherry, A. D. (2021) · Cancer & Metabolism · doi:10.1186/s40170-021-00267-4 · Cited by 18 · see citing works

Activatable NIR-II Fluorescent Nanoprobe for Rapid Detection and Imaging of Methylglyoxal Facilitated by the Local Nonpolar Microenvironment

Dang, Y., Lai, Y., Chen, F., Sun, Q., Ding, C., Zhang, W., & Xu, Z. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.1c04076 · Cited by 18 · see citing works

Methylglyoxal induces ambience for cancer promotion in HepG2 cells via Warburg effect and promotes glycation

Sruthi, C. R., & Raghu, K. G. (2022) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30215 · Cited by 17 · see citing works

Leveraging histone glycation for cancer diagnostics and therapeutics

Knörlein, A., Xiao, Y. F., & David, Y. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.01.005 · Cited by 17 · see citing works

Electrophilic Signaling: The Role of Reactive Carbonyl Compounds

Kosmachevskaya, O. V., Шумаев, К. Б., & Topunov, A. F. (2019) · Biochemistry (Moscow) · doi:10.1134/s0006297919140128 · Cited by 17 · see citing works

Targeting KRAS in NSCLC: Old Failures and New Options for “Non-G12c” Patients

Jacobs, F., Cani, M., Malapelle, U., Novello, S., Napoli, V. M., & Bironzo, P. (2021) · Cancers · doi:10.3390/cancers13246332 · Cited by 17 · see citing works

H3K27 acetylation activated long noncoding RNA RP11-162G10.5 promotes breast cancer progression via the YBX1/GLO1 axis

Xie, N., Zhang, R., Bi, Z., Ren, W., You, K., Hu, H., Xu, Y. X., & Yao, H. (2022) · Cellular Oncology · doi:10.1007/s13402-022-00756-8 · Cited by 16 · see citing works

NIR-I fluorescence imaging tumorous methylglyoxal by an activatable nanoprobe based on peptide nanotubes by FRET process

Liu, J., Li, M., Dang, Y., Lou, H., Xu, Z., & Zhang, W. (2022) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2022.114068 · Cited by 15 · see citing works

Glycation Leads to Increased Invasion of Glioblastoma Cells

Schildhauer, P., Selke, P., Scheller, C., Strauß, C., Horstkorte, R., Leisz, S., & Scheer, M. (2023) · Cells · doi:10.3390/cells12091219 · Cited by 15 · see citing works

Cardio-oncology: Shared Genetic, Metabolic, and Pharmacologic Mechanism

Zhao, Y., Jia, H., Hua, X., An, T., & Song, J. (2023) · Current Cardiology Reports · doi:10.1007/s11886-023-01906-6 · Cited by 18 · see citing works

Association between diabetes and cancer. Current mechanistic insights into the association and future challenges

Armando Rojas, R., Schneider, I., Lindner, C., González, I., & Morales, M. A. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04630-x · Cited by 13 · see citing works

Glycation Interferes with the Expression of Sialyltransferases and Leads to Increased Polysialylation in Glioblastoma Cells

Schildhauer, P., Selke, P., Staege, M. S., Harder, A., Scheller, C., Strauß, C., Horstkorte, R., Scheer, M., & Leisz, S. (2023) · Cells · doi:10.3390/cells12232758 · Cited by 13 · see citing works

Eucommia ulmoides O liv. leaves flavonoids attenuate methylglyoxal‐induced endothelial cell apoptosis in vitro and in vivo by upregulating AKT ‐ N rf2 signaling and downregulating oxidative stress

Deng, X., Wu, Q., & Liu, Y. (2024) · Food Science & Nutrition · doi:10.1002/fsn3.4416 · Cited by 13 · see citing works

Glycation Interferes with the Expression of Sialyltransferases in Meningiomas

Selke, P., Bork, K., Zhang, T., Wuhrer, M., Strauß, C., Horstkorte, R., & Scheer, M. (2021) · Cells · doi:10.3390/cells10123298 · Cited by 13 · see citing works

Biotransformed Antioxidant isoflavone extracts present high-capacity to attenuate the in vitro formation of advanced glycation end products

Genova, V. M., Fernandes, A. C. F., Hiramatsu, E. Y., de Queirós, L. D., Macedo, J. A., & Macêdo, G. A. (2021) · Food Biotechnology · doi:10.1080/08905436.2020.1869564 · Cited by 12 · see citing works

Methylglyoxal produced by tumor cells through formaldehyde-enhanced Warburg effect potentiated polarization of tumor-associated macrophages

Ma, H., Ding, Z., Xie, Y., Li, L., Li, D., Lou, K., Wang, W., & Xu, H. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.115910 · Cited by 12 · see citing works

Recent Progress on Tumor Microenvironment‐Activated NIR‐II Phototheranostic Agents with Simultaneous Activation for Diagnosis and Treatment

Xiao, H., Wu, G., Tan, S., Tan, X., & Yang, Q. (2024) · Chemistry - An Asian Journal · doi:10.1002/asia.202301036 · Cited by 11 · see citing works

Molecular pathways of generation and detoxification of reactive oxygen species and induction of apoptosis in yeasts

Gull, S., Shabbir, C. A., Khan, Z., Bukhari, D. A., & Rehman, A. (2024) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2024.106069 · Cited by 10 · see citing works

Fluorescent probes for sensing and visualizing methylglyoxal: progress, challenges, and perspectives

Wen, J., Qing-ya, Z., & Zhou, L. (2024) · RSC Advances · doi:10.1039/d4ra07512a · Cited by 10 · see citing works

Identification and molecular evolution of the GLX genes in 21 plant species: a focus on the Gossypium hirsutum

Xu, M., Zuo, D., Wang, Q., Lv, L., Zhang, Y., Jiao, H., Zhang, X., Yang, Y., Song, G., & Cheng, H. (2023) · BMC Genomics · doi:10.1186/s12864-023-09524-w · Cited by 10 · see citing works

Glycation of benign meningioma cells leads to increased invasion

Selke, P., Rosenstock, P., Bork, K., Strauß, C., Horstkorte, R., & Scheer, M. (2021) · Biological Chemistry · doi:10.1515/hsz-2020-0376 · Cited by 10 · see citing works

Screening of Methylglyoxal Fluctuations in the Kidneys of Diabetic Nephropathy Mice Using a Europium(III) Complex-Based Dual-Mode Luminescence Probe

Kong, D., Huang, Y., Song, B., Zhang, X., & Yuan, J. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.4c06973 · Cited by 9 · see citing works

Methylglyoxal mutagenizes single-stranded DNA via Rev1-associated slippage and mispairing

Vijayraghavan, S., Ruggiero, A., Becker, S., Mieczkowski, P. A., Hanna, G. S., Hamann, M. T., & Saini, N. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf705 · Cited by 9 · see citing works

A glyoxal-specific aldehyde signaling axis in Pseudomonas aeruginosa that influences quorum sensing and infection

Corcoran, C. J., Cuthbert, B. J., Glanville, D. G., Terrado, M., Valverde-Mendez, D., Bratton, B. P., Schemenauer, D. E., Tokars, V. L., Martin, T. G., Rasmussen, L. W., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61469-8 · Cited by 7 · see citing works

Overexpression of Glyoxalase 2 in Human Breast Cancer Cells: Implications for Cell Proliferation and Doxorubicin Resistance

Romaldi, B., Scirè, A., Minnelli, C., Frontini, A., Casari, G., Cianfruglia, L., Mobbili, G., Lidia de, B. A. R. I., Antognelli, C., Pallardó, F. V., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252010888 · Cited by 7 · see citing works

Acid-promoted fluorescent probe for monitoring endogenous methylglyoxal in tumors and gastritis

Xu, W., Liu, S., Cao, W., & Xiong, H. (2023) · Sensors & Diagnostics · doi:10.1039/d3sd00228d · Cited by 6 · see citing works

Methylglyoxal disturbs DNA repair and glyoxalase I system in Saccharomyces cerevisiae

Pavin, S. S., Prestes, A. D. S., dos Santos, M. M., de Macedo, G. T., Ferreira, S. A., Claro, M. T., Corte, C. L. D., & Barbosa, N. V. (2020) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2020.1838019 · Cited by 6 · see citing works

Hypermetabolism of glutathione, glutamate and ornithine via redox imbalance in methylglyoxal-induced peritoneal injury rats

Hirahara, I., Kusano, E., Jin, D., & Takai, S. (2019) · The Journal of Biochemistry · doi:10.1093/jb/mvz077 · Cited by 6 · see citing works

Is Methylglyoxal a Potential Biomarker for the Warburg Effect Induced by the Lipopolysaccharide Neuroinflammation Model?

Vizuete, A. F. K., & Gonçalves, C. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04142-8 · Cited by 5 · see citing works

KNSTRN, a Poor Prognostic Biomarker, Affects the Tumor Immune Microenvironment and Immunotherapy Outcomes in Pan-Cancer

Zhang, W., Liao, Y., Liu, C., Liu, L., & Zhou, X. (2023) · Disease Markers · doi:10.1155/2023/6729717 · Cited by 5 · see citing works

Methylglyoxal Levels in Human Colorectal Precancer and Cancer: Analysis of Tumor and Peritumor Tissue

Chou, C., Yang, P.-C., Tsai, P.-Y., Yang, H., Tsai, K., Chen, T., Liao, K., Chen, C.-Y., & Lee, J. (2021) · Life · doi:10.3390/life11121319 · Cited by 5 · see citing works

RAS: Circuitry and therapeutic targeting

Singh, G., Thakur, N., & Kumar, U. (2022) · Cellular Signalling · doi:10.1016/j.cellsig.2022.110505 · Cited by 5 · see citing works

Dual-Channel NIR-II Probe for Simultaneous Tracking of Nitric Oxide and Methylglyoxal in Inflammation: Enabling Rapid Drug Efficacy Assessment

Cheng, M., He, Z., Wang, G., Yu, Y., Song, R., Qin, Y., Wang, Z., Guo, D., & Chen, H. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c11739 · Cited by 4 · see citing works

Acetaldehyde and methylglyoxal: comparative analysis of toxic electronic cigarette degradation products in 3D and 2D exposure systems using human bronchial epithelial models

Wong, M., Martínez, T., Hendricks, N., & Talbot, P. (2025) · Frontiers in Toxicology · doi:10.3389/ftox.2025.1624794 · Cited by 3 · see citing works

Effect of Different Glucose Levels and Glycation on Meningioma Cell Migration and Invasion

Selke, P., Strauß, C., Horstkorte, R., & Scheer, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251810075 · Cited by 3 · see citing works

Effects of low intracellular glutathione and CbrA-CbrB-Crc signaling on methylglyoxal sensitivity in Pseudomonas aeruginosa LasR-deficient mutants

Altamirano, A., Ruzic, M., Cryan, A. E., & Hogan, D. A. (2025) · Journal of Bacteriology · doi:10.1128/jb.00394-24 · Cited by 2 · see citing works

Nordihydroguaiaretic acid inhibits glyoxalase I, and causes the accumulation of methylglyoxal followed by cell-growth inhibition

Watanabe, M., Toyomura, T., Ikegami, R., Suwaki, Y., Sada, M., Wake, H., Nishinaka, T., Hatipoğlu, Ö. F., Takahashi, H. K., Nishibori, M., et al. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07929-6 · Cited by 2 · see citing works

Quantitation by liquid chromatography-nanoelectrospray ionization-high resolution tandem mass spectrometry of DNA adducts derived from methyl glyoxal and carboxyethylating agents in leukocytes of smokers and non-smokers

Cheng, G., Reisinger, S. A., Shields, P. G., Hatsukami, D. K., Balbo, S., & Hecht, S. S. (2020) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2020.109140 · Cited by 2 · see citing works

Identification of Further Components of an Anticancer Defense System Composed of Small Molecules Present in the Serum

Scheffer, D., Kulcsár, G., & Czömpöly, T. (2019) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2018.2673 · Cited by 2 · see citing works

Elucidating the effect of levothyroxine and triiodothyronine on methylglyoxal derived stress

Khan, H., Habib, S., Siddiqui, S. A., Ahmad, R., Husain, A., & Moinuddin, M. (2024) · Endocrine · doi:10.1007/s12020-024-03972-4 · Cited by 1 · see citing works

Methylglyoxal: Hijack-to-survive paradigm of cancer progression

Patel, M. D., Rawal, S. K., & Mani, S. (2026) · Gene Reports · doi:10.1016/j.genrep.2026.102455 · Cited by 1 · see citing works

Deciphering the mechanisms by which probiotic Lactobacillus paracasei L5 mitigates methylglyoxal toxicity: Insights from the transcriptome and metabolome

Peng, M., Deng, L., Guo, L., Shen, Z., Zhu, Y., Wang, J., Chen, Y., Gao, J., & Zhou, M. (2026) · Current Research in Food Science · doi:10.1016/j.crfs.2026.101417 · Cited by 1 · see citing works

Glycation stress in glioma: a metabolic vulnerability and therapeutic target

Umdor, S. B., & Sen, E. (2026) · Pharmacological Reports · doi:10.1007/s43440-026-00904-z · Cited by 1 · see citing works

Methylglyoxal and Its Role in Obesity-Associated Heart Failure with Preserved Ejection Fraction

Alomar, F. A., Moore, C. J., Abohelaika, S., Al‐Muhanna, F., Alshabeed, M. A., Hamel, F. G., Desouza, C. V., & Bidasee, K. R. (2021) · Advances in biochemistry in health and disease · doi:10.1007/978-3-030-84763-0_19 · Cited by 1 · see citing works

Methylglyoxal induces nuclear accumulation of p53 and γH2AX in normal and cancer cellsPreprint

Veß, A., & Hollemann, T. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.19.998773 · Cited by 1 · see citing works

Advanced Glycation Endproducts (AGEs) in Food: Health Implications and Mitigation Strategies

Birch, C., & Bonwick, G. (2019) · Royal Society of Chemistry eBooks · doi:10.1039/9781788016438-00191

EDITORIAL

Ahmad, S., Shahab, U., & Moinuddin, M. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.03.002

Glyoxal‑induced disruption of tumor cell progression in breast cancer

Rong, P., Li, Y., Nianchun, G., Qi, L., & Li, X. (2023) · Molecular and Clinical Oncology · doi:10.3892/mco.2023.2622

Nuclear localization of glyoxalase 2 and its possible role as survival factor in human MCF7 breast cancer cellsPreprint

Romaldi, B., Scirè, A., Minnelli, C., Frontini, A., Casari, G., Cianfruglia, L., Mobbili, G., Lidia de, B. A. R. I., Antognelli, C., & Armeni, T. (2023) · doi:10.22541/au.169514466.62008339/v1

Besinlerdeki Gizli Düşman: Metilglioksal

Melisa, A. K. O. L., & Taşkıran, D. (2023) · İzmir Katip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi · doi:10.61399/ikcusbfd.1274527

Additional file 7 of Identification and molecular evolution of the GLX genes in 21 plant species: a focus on the Gossypium hirsutum

Xu, M., Zuo, D., Wang, Q., Lv, L., Zhang, Y., Jiao, H., Zhang, X., Yang, Y., Song, G., & Cheng, H. (2023) · Figshare · doi:10.6084/m9.figshare.24012997

Additional file 8 of Identification and molecular evolution of the GLX genes in 21 plant species: a focus on the Gossypium hirsutum

Xu, M., Zuo, D., Wang, Q., Lv, L., Zhang, Y., Jiao, H., Zhang, X., Yang, Y., Song, G., & Cheng, H. (2023) · Figshare · doi:10.6084/m9.figshare.24013000

Additional file 9 of Identification and molecular evolution of the GLX genes in 21 plant species: a focus on the Gossypium hirsutum

Xu, M., Zuo, D., Wang, Q., Lv, L., Zhang, Y., Jiao, H., Zhang, X., Yang, Y., Song, G., & Cheng, H. (2023) · Figshare · doi:10.6084/m9.figshare.24013003

Additional file 6 of Identification and molecular evolution of the GLX genes in 21 plant species: a focus on the Gossypium hirsutum

Xu, M., Zuo, D., Wang, Q., Lv, L., Zhang, Y., Jiao, H., Zhang, X., Yang, Y., Song, G., & Cheng, H. (2023) · Figshare · doi:10.6084/m9.figshare.24012991

Additional file 11 of Identification and molecular evolution of the GLX genes in 21 plant species: a focus on the Gossypium hirsutum

Xu, M., Zuo, D., Wang, Q., Lv, L., Zhang, Y., Jiao, H., Zhang, X., Yang, Y., Song, G., & Cheng, H. (2023) · Figshare · doi:10.6084/m9.figshare.24013009

Additional file 10 of Identification and molecular evolution of the GLX genes in 21 plant species: a focus on the Gossypium hirsutum

Xu, M., Zuo, D., Wang, Q., Lv, L., Zhang, Y., Jiao, H., Zhang, X., Yang, Y., Song, G., & Cheng, H. (2023) · Figshare · doi:10.6084/m9.figshare.24013006

Effect of Aloe Vera against Natural and Chemical Toxicities

Shirvanian, K., Naghizadeh, M., Vali, R., Farkhondeh, T., Pourbagher‐Shahri, A. M., Aschner, M., Ahmadian, M., & Samarghandian, S. (2024) · Current Nutrition & Food Science · doi:10.2174/0115734013307300240906055446

Pseudomonas aeruginosa LasR-deficient mutants have increased methylglyoxal and hydrogen peroxide sensitivity due to low intracellular glutathionePreprint

Ruzic, M., Hefferan, A. I. A., Conaway, A., & Hogan, D. A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.25.615034

PIK3CA regulates lactate transport through MCT1,MCT4 in diffuse large B-cell lymphomaPreprint

Zhao, Y., Li, J., Yu, J. B., Wang, X., Pang, X., Ma, M., Ma, Z., Zhang, W., & Cui, W. (2024) · Research Square · doi:10.21203/rs.3.rs-5317703/v1

Isotope Dilution NanoLC-MS/MS Quantitation of Methylglyoxal DNA–Protein Cross-Links: Formation and Repair in Human Cells

Omondi, R. O., Barnes, E. M., Gurajala, K. C., Fisette, G., Chaudray, I. A., & Erber, L. N. (2026) · Analytical Chemistry · doi:10.1021/acs.analchem.5c06852

Additional file 1 of Identification and molecular evolution of the GLX genes in 21 plant species: a focus on the Gossypium hirsutum

Xu, M., Zuo, D., Wang, Q., Lv, L., Zhang, Y., Jiao, H., Zhang, X., Yang, Y., Song, G., & Cheng, H. (2023) · Figshare · doi:10.6084/m9.figshare.24012976

Additional file 1 of Detection of glucose-derived d- and l-lactate in cancer cells by the use of a chiral NMR shift reagent

Suh, E. H., Geraldes, C. F. G. C., Chirayil, S., Faubert, B., Ayala, R., DeBerardinis, R. J., & Sherry, A. D. (2021) · Figshare · doi:10.6084/m9.figshare.16944345

Additional file 5 of Identification and molecular evolution of the GLX genes in 21 plant species: a focus on the Gossypium hirsutum

Xu, M., Zuo, D., Wang, Q., Lv, L., Zhang, Y., Jiao, H., Zhang, X., Yang, Y., Song, G., & Cheng, H. (2023) · Figshare · doi:10.6084/m9.figshare.24012988

Additional file 4 of Identification and molecular evolution of the GLX genes in 21 plant species: a focus on the Gossypium hirsutum

Xu, M., Zuo, D., Wang, Q., Lv, L., Zhang, Y., Jiao, H., Zhang, X., Yang, Y., Song, G., & Cheng, H. (2023) · Figshare · doi:10.6084/m9.figshare.24012985

Additional file 3 of Identification and molecular evolution of the GLX genes in 21 plant species: a focus on the Gossypium hirsutum

Xu, M., Zuo, D., Wang, Q., Lv, L., Zhang, Y., Jiao, H., Zhang, X., Yang, Y., Song, G., & Cheng, H. (2023) · Figshare · doi:10.6084/m9.figshare.24012982

PO-225 Dual role of methylglyoxal, a glycolysis side-product, in cancer

Nokin, M., Durieux, F., Bellier, J., Peulen, O., Uchida, K., Spiegel, D. A., Hutton, C. A., CASTRONOVO, V., & Bellahcène, A. (2018) · ESMO Open · doi:10.1136/esmoopen-2018-eacr25.259 · Cited by 1 · see citing works

Hormetic potential of methylglyoxal, a side-product of glycolysis, in switching tumours from growth to death

Nokin, M., Durieux, F., Bellier, J., Peulen, O., Uchida, K., Spiegel, D. A., Cochrane, J. R., Hutton, C. A., Castronovo, V., & Bellahcène, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-12119-7 · Cited by 88 · see citing works

Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis

Nokin, M., Durieux, F., Peixoto, P., Chiavarina, B., Peulen, O., Blomme, A., Turtoï, A., Costanza, B., Smargiasso, N., Baiwir, D., et al. (2016) · eLife · doi:10.7554/elife.19375 · Cited by 137 · see citing works

Methylglyoxal-Mediated Stress Correlates with High Metabolic Activity and Promotes Tumor Growth in Colorectal Cancer

Chiavarina, B., Nokin, M., Bellier, J., Durieux, F., Blétard, N., Sherer, F., Lovinfosse, P., Peulen, O., Verset, L., Dehon, R., et al. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18010213 · Cited by 66 · see citing works

Le stress carbonyle induit par le méthylglyoxal dans la progression du mélanome et la réponse aux thérapies

Tiamiou, A., Durieux, F., Nokin, M., Bellier, J., Ghanem, G., Journé, F., Arrese, E. J., Bellahcene, A., & Castronovo, V. (2018) · ORBi (University of Liège)