The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Autophagy, a guardian against neurodegeneration
Open accessAbstract
Autophagy is an intracellular degradation process responsible for the clearance of most long-lived proteins and organelles. Cytoplasmic components are enclosed by double-membrane autophagosomes, which subsequently fuse with lysosomes for degradation. Autophagy dysfunction may contribute to the pathology of various neurodegenerative disorders, which manifest abnormal protein accumulation. As autophagy induction enhances the clearance of aggregate-prone intracytoplasmic proteins that cause neurodegeneration (like mutant huntingtin, tau and ataxin 3) and confers cytoprotective roles in cell and animal models, upregulating autophagy may be a tractable therapeutic strategy for diseases caused by such proteins. Here, we will review the molecular machinery of autophagy and its role in neurodegenerative diseases. Drugs and associated signalling pathways that may be targeted for pharmacological induction of autophagy will also be discussed.
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Cites
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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
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Self-citationReactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
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Self-citationHDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS.
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Platt, F. M., Boland, B., & van der Spoel, A. C. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201208152 · Cited by 689
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Uddin, M. S., Stachowiak, A., Mamun, A. A., Tzvetkov, N. T., Takeda, S., Atanasov, A. G., Bergantin, L. B., Abdel-Daim, M. M., & Stankiewicz, A. M. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00004 · Cited by 395
Nutraceutical or Pharmacological Potential of Moringa oleifera Lam.
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Metadata
- Authors
- García-Arencibia, M., Hochfeld, W. E., Toh, P. P. C., & Rubinsztein, D. C.
- Venue
- Seminars in Cell & Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 21
- Issue
- 7
- Pages
- 691-698
- ISSN
- 1084-9521 (ISSN-L)
- OpenAlex
- W1974724055
- Cited by
- 158
- References
- 19
- FWCI
- 15.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- García-Arencibia, M., Hochfeld, W. E., Toh, P. P. C., & Rubinsztein, D. C. (2010). Autophagy, a guardian against neurodegeneration. Seminars in Cell & Developmental Biology. https://doi.org/10.1016/j.semcdb.2010.02.008
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
