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G-protein-coupled receptors, Hedgehog signaling and primary cilia
Open accessAbstract
The Hedgehog (Hh) pathway has become an important model to study the cell biology of primary cilia, and reciprocally, the study of ciliary processes provides an opportunity to solve longstanding mysteries in the mechanism of vertebrate Hh signal transduction. The cilium is emerging as an unique compartment for G-protein-coupled receptor (GPCR) signaling in many systems. Two members of the GPCR family, Smoothened and Gpr161, play important roles in the Hh pathway. We review the current understanding of how these proteins may function to regulate Hh signaling and also highlight some of the critical unanswered questions being tackled by the field. Uncovering GPCR-regulated mechanisms important in Hh signaling may provide therapeutic strategies against the Hh pathway that plays important roles in development, regeneration and cancer.
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“Additional ligands of the HH family includes desert (DHH) and Indian (IHH) hedgehog, which also operate via primary cilia but in a tissue-specific manner, such as in cells of the testis and in growth plate chondrocytes 105, respectively.”
From Cellular signalling by primary cilia in development, organ function and disease (2019) · cites this paper as [105]
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Cites
1 retracted
Soetedjo, L., Glover, D. A., & Jin, H. (2013) · Biology Open · doi:10.1242/bio.20134747 · Cited by 17
RetractedCyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
Chiang, C. C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H., & Beachy, P. A. (1996) · Nature · doi:10.1038/383407a0 · Cited by 3,062
The structure and function of G-protein-coupled receptors
Rosenbaum, D. M., Rasmussen, S. G. F., & Kobilka, B. K. (2009) · Nature · doi:10.1038/nature08144 · Cited by 2,534
Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
Jiang, J., & Struhl, G. (1998) · Nature · doi:10.1038/35154 · Cited by 1,735
Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants
Goodrich, L. V., Milenković, L., Higgins, K. M., & Scott, M. P. (1997) · Science · doi:10.1126/science.277.5329.1109 · Cited by 1,696
Vertebrate Smoothened functions at the primary cilium
Corbit, K. C., Aanstad, P., Singla, V., Norman, A. R., Stainier, D. Y. R., & Reiter, J. F. (2005) · Nature · doi:10.1038/nature04117 · Cited by 1,481
Inhibition of Hedgehog signaling by direct binding of cyclopamine to SmoothenedPreprint
Chen, J., Taipale, J., Cooper, M. K., & Beachy, P. A. (2002) · Genes & Development · doi:10.1101/gad.1025302 · Cited by 1,464
Patched1 Regulates Hedgehog Signaling at the Primary Cilium
Rohatgi, R., Milenkovic, L., & Scott, M. P. (2007) · Science · doi:10.1126/science.1139740 · Cited by 1,426
Self-citationHedgehog signalling in the mouse requires intraflagellar transport proteins
Huangfu, D., Liu, A., Rakeman, A. S., Murcia, N. S., Niswander, L., & Anderson, K. V. (2003) · Nature · doi:10.1038/nature02061 · Cited by 1,425
Rosenbaum, J. L., & Witman, G. B. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm952 · Cited by 1,423
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Items 101–142 of 142
Lupu, F. I., Burnett, J. B., & Eggenschwiler, J. T. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.10.022 · Cited by 13
Vasu, M., Ahlawat, S., Arora, R., & Sharma, R. (2025) · Mammalian Genome · doi:10.1007/s00335-025-10109-z · Cited by 11
Hua, K., & Ferland, R. J. (2018) · BioEssays · doi:10.1002/bies.201700132 · Cited by 13
Praktiknjo, S. D., Saad, F., Maier, D., Ip, P., & Hipfner, D. R. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.001953 · Cited by 11
Sonic Hedgehog activates prostaglandin signaling to stabilize primary cilium length
Ansari, S. S., Dillard, M. E., Zhang, Y., Austria, M. A., Boatwright, N., Shelton, E. L., Stewart, D. P., Johnson, A. J., Wang, C. E., Young, B. M., et al. (2024) · The Journal of Cell Biology · doi:10.1083/jcb.202306002 · Cited by 12
C11ORF74 interacts with the IFT-A complex and participates in ciliary BBSome localization
Takahara, M., Kunii, M., Nakamura, K., Harada, A., Hirano, T., Katoh, Y., & Nakayama, K. (2018) · The Journal of Biochemistry · doi:10.1093/jb/mvy100 · Cited by 11
New insights into ion channel‐dependent signalling during left‐right patterning
Tajhya, R. B., & Delling, M. (2019) · The Journal of Physiology · doi:10.1113/jp277835 · Cited by 13
Nonredundant roles of DIAPHs in primary ciliogenesis
Palander, O., Lam, A., Collins, R. F., Moraes, T. J., & Trimble, W. S. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100680 · Cited by 10
Mellis, D. J., Staines, K. A., Peluso, S., Georgiou, I. C., Dorà, N. J., Kubiak, M., Hof, R. V., Grillo, M., Farquharson, C., Kinsella, E., et al. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009275 · Cited by 9
FBW7 couples structural integrity with functional output of primary cilia
Petsouki, E., Gerakopoulos, V., Szeto, N., Chang, W., Humphrey, M. B., & Tsiokas, L. (2021) · Communications Biology · doi:10.1038/s42003-021-02504-4 · Cited by 8
G Protein-coupled Receptors in Cancer Stem Cells
Jiang, Y., Zhuo, X., & Mao, C. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200305130009 · Cited by 8
Cilia proteins getting to work – how do they commute from the cytoplasm to the base of cilia?
Hibbard, J. V. K., Vázquez, N., & Wallingford, J. B. (2022) · Journal of Cell Science · doi:10.1242/jcs.259444 · Cited by 9
Developmental function of Piezo1 in mouse submandibular gland morphogenesis
Pokharel, E., Aryal, Y. P., Kim, T., Kim, A., Kim, J., Yamamoto, H., Cho, S. W., Sohn, W., Kim, J.-Y., & Jung, J. (2023) · Histochemistry and Cell Biology · doi:10.1007/s00418-023-02181-w · Cited by 8
Wang, Z., Sa, G., Zheng, L. W., Wei, Z., Zhang, Z., Hu, Y., & Yang, X. (2022) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2022.105548 · Cited by 6
Assessing Smoothened-mediated Hedgehog signaling in zebrafish
Tena, T. C., & Philipp, M. (2015) · Methods in cell biology · doi:10.1016/bs.mcb.2015.10.001 · Cited by 5
G Protein‐Coupled Receptor Signal Intersection at the Primary Cilium
Wang, C. E., & Ogden, S. K. (2025) · BioEssays · doi:10.1002/bies.70015 · Cited by 5
Human SMOOTHENED inhibits human immunodeficiency virus type 1 infection
Yoshida, T., Hamano, A., Ueda, A., Takeuchi, H., & Yamaoka, S. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.09.063 · Cited by 4
Singh, P., Nayak, V., Verma, R., Natarajan, A., Singh, J., Pandey, S. S., & Singh, K. R. (2024) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2024.103457 · Cited by 3
Paralog-specific TTC30 regulation of Sonic hedgehog signaling
Hoffmann, F., Bolz, S., Junger, K., Klose, F., Stehle, I. F., Ueffing, M., Boldt, K., & Beyer, T. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1268722 · Cited by 3
Using Primary Neurosphere Cultures to Study Primary Cilia
Shimada, I. S., Badgandi, H., Somatilaka, B. N., & Mukhopadhyay, S. (2017) · Journal of Visualized Experiments · doi:10.3791/55315 · Cited by 4
Self-citationDetermination and Analysis of Cellular Metabolic Changes by Noncanonical Hedgehog Signaling
Teperino, R., & Pospisilik, J. A. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2772-2_16 · Cited by 2
Methods for Studying Ciliary Import Mechanisms
Takao, D., & Verhey, K. J. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3789-9_1 · Cited by 2
Conkar, D., Odabasi, E., Deretic, J., Batman, U., Frikstad, K.-A. M., Patzke, S., & Firat‐Karalar, E. N. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.10.487777 · Cited by 2
Ott, C. M. (2020) · Wiley eBooks · doi:10.1002/9781119436812.ch5 · Cited by 3
Immunomodulatory potential of primary cilia in the skin
Sun, J., Yuan, H., Yu, Y., Li, A., Zhao, Z., Tang, Y., & Zheng, F. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1456875 · Cited by 1
The role of Sonic Hedgehog (SHH) in the formation of motor neurons and neurodegenerative diseases
Esmaeli, M., Dehabadi, M. D., Ghanbari, A., & Yancheshmeh, F. S. A. (2025) · Discover Medicine · doi:10.1007/s44337-025-00480-w · Cited by 1
Berggreen, C. R., Laplace, J., Campestre, F., Petersen, A.-L. W., Fixdahl, A. M., Mary, B., Ghazanfar, S., Li, G., Wagner, L. E., Rezi, C. K., et al. (2026) · BMC Molecular and Cell Biology · doi:10.1186/s12860-026-00571-1 · Cited by 1
Cilia and Polycystic Kidney Disease
Landis, D. E., Henke, S. J., & Yoder, B. K. (2018) · Springer eBooks · doi:10.1007/978-1-4939-7784-0_5 · Cited by 1
Deretic, J., Cengiz-Emek, S., Seyrek, E., & Firat‐Karalar, E. N. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.16.599243 · Cited by 1
Akter, S., Mirhosseiniardakani, S., Takekoshi, Y., Qiu, L., Baker, K., Jiang, K. W., Lyon, M., Hattori, M., & Chen, X. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.24.672028 · Cited by 1
Modulation of the Hedgehog Signaling Pathway by Sterol-based Small Molecules
Maschinot, C. A. (2018) · OpenCommons at University of Connecticut (University of Connecticut)
Cilium length regulation in Caenorhabditis elegans
Park, K. (2019) · Summit (Simon Fraser University)
Faculty Opinions recommendation of Rab35 controls cilium length, function and membrane composition.
Westlake, C. J. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736471974.793582061
Kenney, A. M., Castellino, R. C., Moots, P. L., Corso, C. D., & Mehta, M. P. (2017) · Wiley eBooks · doi:10.1002/9781119196235.ch65
Receptor Allostery Promotes Context-Dependent Sonic Hedgehog Signaling During Embryonic DevelopmentPreprint
Ansari, S. S., Dillard, M. E., Ghonim, M., Zhang, Y., Stewart, D. P., Canac, R., Moskowitz, I. P. G., Wright, W. C., Daly, C. A., Pruett‐Miller, S. M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.28.635336
Signal transduction and second messengers
Hofer, A. M. (2025) · Elsevier eBooks · doi:10.1016/b978-0-12-811114-7.00009-8
Rab23 GTPase and IFT43 regulate the trafficking of prostaglandin E receptor 4 to primary cilia
Chen, Y., Zhou, Y., Qi, Y., Miao, T., Shi, J., Jin, D., & Zhong, T. P. (2025) · Communications Biology · doi:10.1038/s42003-025-09298-9
Singh, S., Chaudhary, A., Patel, A., Trivedi, M., Johri, P. K., & Tiwari, R. (2026) · Nanotechnology in the life sciences · doi:10.1007/978-981-95-4913-9_6
The Transcription Factor Barhl2 Inhibits Wnt Canonical Signaling during Xenopus Embryogenesis
Sena, E. (2018) · theses.fr (ABES) · doi:10.70675/726fabd1z44f1z4cc7zb539z72feb45e5378
Rab8 and TNPO1 function as the ciliary transport adapters for GPCRs
Mahajan, D., Madugula, V., Chia, H. M., & Lei, L. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.112202
Piyush, R., Giri, P., & Shinde, S. R. (2026) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2026.102675
Metadata
- Authors
- Mukhopadhyay, S., & Rohatgi, R.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Stanford Medicine (US)
- Corresponding author
- Mukhopadhyay, Saikat
- Rohatgi, Rajat
- Venue
- Seminars in Cell & Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 33
- Pages
- 63-72
- ISSN
- 1084-9521 (ISSN-L)
- PMC
- PMC4130902
- OpenAlex
- W1986320552
- Cited by
- 142
- References
- 145
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 7 · 2023: 9 · 2022: 3 · 2021: 13 · 2020: 15 · 2019: 14 · 2018: 17 · 2017: 14 · 2016: 19 · 2015: 15 · 2014: 2
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Seminars in Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH Common Fund
- Pew Foundation
- Sontag Foundation
- March of Dimes Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- Hedgehog signaling, primary cilia, G protein-coupled receptors, Smoothened, GPR161, cancer therapy
- MeSH terms
- Animals, Cilia, Humans, Signal Transduction, Body Patterning, Receptors, G-Protein-Coupled, Hedgehog Proteins
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