The DOI matches its Crossref record; 145 of the 145 references it cites were found in a registry or an index.
G-protein-coupled receptors, Hedgehog signaling and primary cilia
Open accessAbstract
The Hedgehog (Hh) pathway has become an important model to study the cell biology of primary cilia, and reciprocally, the study of ciliary processes provides an opportunity to solve longstanding mysteries in the mechanism of vertebrate Hh signal transduction. The cilium is emerging as an unique compartment for G-protein-coupled receptor (GPCR) signaling in many systems. Two members of the GPCR family, Smoothened and Gpr161, play important roles in the Hh pathway. We review the current understanding of how these proteins may function to regulate Hh signaling and also highlight some of the critical unanswered questions being tackled by the field. Uncovering GPCR-regulated mechanisms important in Hh signaling may provide therapeutic strategies against the Hh pathway that plays important roles in development, regeneration and cancer.
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“Additional ligands of the HH family includes desert (DHH) and Indian (IHH) hedgehog, which also operate via primary cilia but in a tissue-specific manner, such as in cells of the testis and in growth plate chondrocytes 105, respectively.”
From Cellular signalling by primary cilia in development, organ function and disease (2019) · cites this paper as [105]
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1 retracted
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RetractedCyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
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The structure and function of G-protein-coupled receptors
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Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
Jiang, J., & Struhl, G. (1998) · Nature · doi:10.1038/35154 · Cited by 1,735
Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants
Goodrich, L. V., Milenković, L., Higgins, K. M., & Scott, M. P. (1997) · Science · doi:10.1126/science.277.5329.1109 · Cited by 1,696
Vertebrate Smoothened functions at the primary cilium
Corbit, K. C., Aanstad, P., Singla, V., Norman, A. R., Stainier, D. Y. R., & Reiter, J. F. (2005) · Nature · doi:10.1038/nature04117 · Cited by 1,481
Inhibition of Hedgehog signaling by direct binding of cyclopamine to SmoothenedPreprint
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Patched1 Regulates Hedgehog Signaling at the Primary Cilium
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Self-citationHedgehog signalling in the mouse requires intraflagellar transport proteins
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Cited by
Sorted by citations
Cellular signalling by primary cilia in development, organ function and disease
Anvarian, Z., Mykytyn, K., Mukhopadhyay, S., Pedersen, L. B., & Christensen, S. T. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0116-9 · Cited by 845
Self-citationPrimary Cilia and Mammalian Hedgehog Signaling
Bangs, F., & Anderson, K. V. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028175 · Cited by 642
Motile and non-motile cilia in human pathology: From function to phenotypes
Mitchison, H. M., & Valente, E. M. (2017) · The Journal of Pathology · doi:10.1002/path.4843 · Cited by 448
Proteomics of Primary Cilia by Proximity Labeling
Mick, D. U., Rodrigues, R. B., Leib, R. D., Adams, C. M., Chien, A. S., Gygi, S. P., & Nachury, M. V. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.10.015 · Cited by 409
Hedgehog signaling in tissue homeostasis, cancers and targeted therapies
Jing, J., Wu, Z., Wang, J., Luo, G., Lin, H., Fan, Y., & Zhou, C. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01559-5 · Cited by 283
Metadata
- Authors
- Mukhopadhyay, S., & Rohatgi, R.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Stanford Medicine (US)
- Corresponding author
- Mukhopadhyay, Saikat
- Rohatgi, Rajat
- Venue
- Seminars in Cell & Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 33
- Pages
- 63-72
- ISSN
- 1084-9521 (ISSN-L)
- PMC
- PMC4130902
- OpenAlex
- W1986320552
- Cited by
- 142
- References
- 145
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 7 · 2023: 9 · 2022: 3 · 2021: 13 · 2020: 15 · 2019: 14 · 2018: 17 · 2017: 14 · 2016: 19 · 2015: 15 · 2014: 2
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Seminars in Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH Common Fund
- Pew Foundation
- Sontag Foundation
- March of Dimes Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- Hedgehog signaling, primary cilia, G protein-coupled receptors, Smoothened, GPR161, cancer therapy
- MeSH terms
- Animals, Cilia, Humans, Signal Transduction, Body Patterning, Receptors, G-Protein-Coupled, Hedgehog Proteins
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