Cited by 142Hedgehog Signaling Pathway StudiesGenetic and Kidney Cyst DiseasesReceptor Mechanisms and Signaling

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G-protein-coupled receptors, Hedgehog signaling and primary cilia

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Mukhopadhyay, Saikat, Rohatgi, Rajat·2014·Seminars in Cell & Developmental Biology

DOI 10.1016/j.semcdb.2014.05.002PMC PMC4130902

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Abstract

The Hedgehog (Hh) pathway has become an important model to study the cell biology of primary cilia, and reciprocally, the study of ciliary processes provides an opportunity to solve longstanding mysteries in the mechanism of vertebrate Hh signal transduction. The cilium is emerging as an unique compartment for G-protein-coupled receptor (GPCR) signaling in many systems. Two members of the GPCR family, Smoothened and Gpr161, play important roles in the Hh pathway. We review the current understanding of how these proteins may function to regulate Hh signaling and also highlight some of the critical unanswered questions being tackled by the field. Uncovering GPCR-regulated mechanisms important in Hh signaling may provide therapeutic strategies against the Hh pathway that plays important roles in development, regeneration and cancer.

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Authors: Mukhopadhyay, S., & Rohatgi, R.
Affiliations: The University of Texas Southwestern Medical Center (US)
Stanford Medicine (US)
Corresponding author: Mukhopadhyay, Saikat
Rohatgi, Rajat
ORCID: Mukhopadhyay, Saikat
Rohatgi, Rajat
Venue: Seminars in Cell & Developmental Biology
Publisher: Elsevier BV
Published: 2014-09
Volume: 33
Pages: 63-72
ISSN: 1084-9521 (ISSN-L)
DOI: 10.1016/j.semcdb.2014.05.002
PMC: PMC4130902
OpenAlex: W1986320552
Cited by: 142
References: 145
Citations by year: 2026: 4 · 2025: 10 · 2024: 7 · 2023: 9 · 2022: 3 · 2021: 13 · 2020: 15 · 2019: 14 · 2018: 17 · 2017: 14 · 2016: 19 · 2015: 15 · 2014: 2
FWCI: 1.57
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Seminars in Cell and Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: NIH Common Fund
Pew Foundation
Sontag Foundation
March of Dimes Foundation
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: Hedgehog signaling, primary cilia, G protein-coupled receptors, Smoothened, GPR161, cancer therapy
MeSH terms: Animals, Cilia, Humans, Signal Transduction, Body Patterning, Receptors, G-Protein-Coupled, Hedgehog Proteins

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G-protein-coupled receptors, Hedgehog signaling and primary cilia

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