Cardamom ( Elettaria cardamomum ) perinatal exposure effects on the development, behavior and biochemical parameters in mice offspring
Open accessAbstract
Cardamom is a strong antioxidant plant, so it is called the queen of spices. In the present study, we explored the potentials of cardamom on developmental, learning ability and biochemical parameters of mice offspring. Thirty pregnant mice were allocated to three groups of ten animals in each. Groups Π and Ш received pilsbury's Diet containing 10 and 20% of cardamom (w/w) respectively, whereas Group I used as control. Cardomom was administered from the first day of pregnancy and was continued until post-natal day 15 (PD 15) and thereafter the mothers were switched to plain pilsbury's Diet. During the weaning period, three pups in each litter were color marked from the others, and were subjected to various tests (Physical assessment such body weight and eye opening and hair appearance; the neuromaturation of reflexes like righting, rotating, and cliff avoidance reflexes; learning ability and memory retention; estimation of monoamines neurotransmitters like dopamine and serotonin, non-enzymatic oxidative stress such as TBARS and GSH in forebrain at different ages of pups). The results indicated that the body weight gain was declining significantly. Hair appearance and eyes opening were delayed significantly. Righting, rotating, and cliff avoidance reflexes were delayed in treated animals. Exposure to cardamom led to enhance learning and memory retention as compared to control. Monoamines (DA, 5-HT) and GSH were elevated, whereas TBARS was inhibited significantly. In conclusion, perinatal cardamom exposure enhanced learning and memory as compared to control. Cardamom and its benefit compounds were transported via placenta or/and milk during lactation. Cardamom needs more researches to investigate its benefits on other kinds of behavior.
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Treatment with Elettaria cardamomum extracts a few weeks before and after birth completely influenced learning and memory in mice.
“an alternative investigation presented that those treated a few weeks before and after birth with the extracts of E. cardamomum completely influenced learning and memory in mice [84]”
From Phytotherapy: A promising approach for the treatment of Alzheimer's disease (2022) · cites this paper as [84]
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- Authors
- Abu-Taweel, G. M.
- Affiliations
- Imam Abdulrahman Bin Faisal University (SA)
- Corresponding author
- Abu-Taweel, Gasem Mohammad
- Venue
- Saudi Journal of Biological Sciences
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 25
- Issue
- 1
- Pages
- 186-193
- ISSN
- 1319-562X (ISSN-L)
- PMC
- PMC5775110
- OpenAlex
- W2750455866
- Cited by
- 41
- References
- 36
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 2 · 2023: 7 · 2022: 5 · 2021: 14 · 2020: 2 · 2019: 2 · 2018: 2
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Saudi Journal of Biological Sciences (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- King Saud University (RGP- VPP- 240)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- cardamom, perinatal exposure, maternal diet, offspring development, learning and memory, neuromaturation, monoamines, dopamine, serotonin, oxidative stress, glutathione, lipid peroxidation, placental transfer, lactation, developmental delay
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