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Cited by 633Circadian rhythm and melatoninSleep and Work-Related FatigueSleep and related disorders

The DOI matches its Crossref record; 110 of the 112 references it cites were found in a registry or an index.

Melatonin as a chronobiotic

Arendt, Josephine, Skene, Debra Jean·2005·Sleep Medicine Reviews
DOI 10.1016/j.smrv.2004.05.002
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Abstract

Melatonin, hormone of the pineal gland, is concerned with biological timing. It is secreted at night in all species and in ourselves is thereby associated with sleep, lowered core body temperature, and other night time events. The period of melatonin secretion has been described as 'biological night'. Its main function in mammals is to 'transduce' information about the length of the night, for the organisation of daylength dependent changes, such as reproductive competence. Exogenous melatonin has acute sleepiness-inducing and temperature-lowering effects during 'biological daytime', and when suitably timed (it is most effective around dusk and dawn) it will shift the phase of the human circadian clock (sleep, endogenous melatonin, core body temperature, cortisol) to earlier (advance phase shift) or later (delay phase shift) times. The shifts induced are sufficient to synchronise to 24 h most blind subjects suffering from non-24 h sleep-wake disorder, with consequent benefits for sleep. Successful use of melatonin's chronobiotic properties has been reported in other sleep disorders associated with abnormal timing of the circadian system: jetlag, shiftwork, delayed sleep phase syndrome, some sleep problems of the elderly. No long-term safety data exist, and the optimum dose and formulation for any application remains to be clarified.

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Research works printed but not linked: 2

  1. Macchi, 2002, Sleep, chronotype and seasonality after pineal resection in humans, Soc Res Biol Rhythms Abstr, 9, 157
  2. Arendt, 1983, Biological Rhythms, Int Med, 3, 6

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Metadata

Authors
Arendt, J., & Skene, D. J.
Affiliations
University of Surrey (GB)
ORCID
Skene, Debra Jean
Venue
Sleep Medicine Reviews
Publisher
Elsevier BV
Published
2005-02
Volume
9
Issue
1
Pages
25-39
ISSN
1087-0792 (ISSN-L)
DOI
10.1016/j.smrv.2004.05.002
OpenAlex
W2165834747
Cited by
629
References
112
Citations by year
2026: 13 · 2025: 23 · 2024: 21 · 2023: 25 · 2022: 37 · 2021: 33 · 2020: 28 · 2019: 26 · 2018: 25 · 2017: 29 · 2016: 24 · 2015: 37 · 2014: 38 · 2013: 37 · 2012: 23
FWCI
9.28
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Sleep Medicine Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
melatonin, chronobiotics, circadian rhythm, phase shift, jet lag, shift work, delayed sleep phase syndrome, sleep disorders, core body temperature, pineal gland, exogenous melatonin
MeSH terms
Animals, Chronobiology Phenomena, Circadian Rhythm, Humans, Hydrocortisone, Melatonin, Pineal Gland, Photoperiod, Sleep Disorders, Circadian Rhythm

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