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Long-Term Propagation of Distinct Hematopoietic Differentiation Programs In Vivo

Dykstra, Brad, Kent, David, Bowie, Michelle, McCaffrey, Lindsay, Hamilton, Melisa, Lyons, Kristin, Lee, Shang-Jung, Brinkman, Ryan, Eaves, Connie·2007·Cell Stem Cell
DOI 10.1016/j.stem.2007.05.015
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Abstract

Heterogeneity in the differentiation behavior of hematopoietic stem cells is well documented but poorly understood. To investigate this question at a clonal level, we isolated a subpopulation of adult mouse bone marrow that is highly enriched for multilineage in vivo repopulating cells and transplanted these as single cells, or their short-term clonal progeny generated in vitro, into 352 recipients. Of the mice, 93 showed a donor-derived contribution to the circulating white blood cells for at least 4 months in one of four distinct patterns. Serial transplantation experiments indicated that two of the patterns were associated with extensive self-renewal of the original cell transplanted. However, within 4 days in vitro, the repopulation patterns subsequently obtained in vivo shifted in a clone-specific fashion to those with less myeloid contribution. Thus, primitive hematopoietic cells can maintain distinct repopulation properties upon serial transplantation in vivo, although these properties can also alter rapidly in vitro.

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Cited by

Metadata

Authors
Dykstra, B., Kent, D., Bowie, M., McCaffrey, L., Hamilton, M., Lyons, K., Lee, S.-J., Brinkman, R., & Eaves, C.
Venue
Cell Stem Cell
Publisher
Elsevier BV
Published
2007-08
Volume
1
Issue
2
Pages
218-229
ISSN
1934-5909
DOI
10.1016/j.stem.2007.05.015
Cited by
609
References
2
Language
en
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