The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Human Placenta Is a Potent Hematopoietic Niche Containing Hematopoietic Stem and Progenitor Cells throughout Development
Open accessAbstract
Hematopoietic stem cells (HSC) are responsible for the life-long production of the blood system and are pivotal cells in hematologic transplantation therapies. During mouse and human development, the first HSCs are produced in the aorta-gonad-mesonephros region. Subsequent to this emergence, HSCs are found in other anatomical sites of the mouse conceptus. While the mouse placenta contains abundant HSCs at midgestation, little is known concerning whether HSCs or hematopoietic progenitors are present and supported in the human placenta during development. In this study we show, over a range of developmental times including term, that the human placenta contains hematopoietic progenitors and HSCs. Moreover, stromal cell lines generated from human placenta at several developmental time points are pericyte-like cells and support human hematopoiesis. Immunostaining of placenta sections during development localizes hematopoietic cells in close contact with pericytes/perivascular cells. Thus, the human placenta is a potent hematopoietic niche throughout development.
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Citations
Cites
A perivascular origin for mesenchymal stem cells in multiple human organs
Crisan, M., Yap, S., Casteilla, L., Chen, C.-W., Corselli, M., Park, T. S., Andriolo, G., Sun, B., Zheng, B., Zhang, L., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.07.003 · Cited by 3,991 · cited 4×
“As previously shown (Crisan et al., 2008), the only cells coexpressing CD146, NG2, and a-SMA in situ are pericytes/perivascular cells closely associated to endothelial cells in microvessels (MV), capillaries (C), and large vessels (LV).”
InfluentialSelf-citationIsolation of Mesenchymal Stem Cells of Fetal or Maternal Origin from Human Placenta
in 't Anker, P. S., Scherjon, S. A., Kleijburg‐van der Keur, C., de Groot‐Swings, G. M. J. S., Claas, F. H. J., Fibbe, W. E., & Kanhai, H. H. H. (2004) · STEM CELLS · doi:10.1634/stemcells.2004-0058 · Cited by 1,189
Of lineage and legacy: the development of mammalian hematopoietic stem cells
Dzierzak, E., & Speck, N. A. (2008) · Nature Immunology · doi:10.1038/ni1560 · Cited by 707
Self-citationEmbryonic development of the human hematopoietic system
Tavian, M., & Peault, B. (2005) · The International Journal of Developmental Biology · doi:10.1387/ijdb.041957mt · Cited by 311
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Overview of the immune response
Chaplin, D. D. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.12.980 · Cited by 2,235
Embryonic origin of the adult hematopoietic system: advances and questions
Medvinsky, A., Rybtsov, S., & Taoudi, S. (2011) · Development · doi:10.1242/dev.040998 · Cited by 403
Perivascular Ancestors of Adult Multipotent Stem Cells
Corselli, M., Chen, C.-W., Crisan, M., Lazzari, L., & Péault, B. (2010) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.109.191643 · Cited by 309
Self-citationIvanovs, A., Rybtsov, S., Welch, L., Anderson, R. A., Turner, M. L., & Medvinsky, A. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20111688 · Cited by 286
The hematopoietic stem cell niche: from embryo to adult
Gao, X., Xu, C., Asada, N., & Frenette, P. S. (2018) · Development · doi:10.1242/dev.139691 · Cited by 247
Metadata
- Authors
- Robin, C., Bollerot, K., Mendes, S., Haak, E., Crisan, M., Cerisoli, F., Lauw, I., Kaimakis, P., Jorna, R., Vermeulen, M., Kayser, M., van der Linden, R., Imanirad, P., Verstegen, M., Nawaz-Yousaf, H., Papazian, N., Steegers, E., Cupedo, T., & Dzierzak, E.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 5
- Issue
- 4
- Pages
- 385-395
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2138873662
- Cited by
- 228
- References
- 4
- FWCI
- 11.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Robin, C., Bollerot, K., Mendes, S., Haak, E., Crisan, M., Cerisoli, F., Lauw, I., Kaimakis, P., Jorna, R., Vermeulen, M., Kayser, M., van der Linden, R., Imanirad, P., Verstegen, M., Nawaz-Yousaf, H., Papazian, N., Steegers, E., Cupedo, T., & Dzierzak, E. (2009). Human Placenta Is a Potent Hematopoietic Niche Containing Hematopoietic Stem and Progenitor Cells throughout Development. Cell Stem Cell. https://doi.org/10.1016/j.stem.2009.08.020
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
