The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells
Open accessAbstract
SUMMARY Despite the remarkable regenerative capacity of mammalian skin, an adult dermal stem cell has not yet been identified. Here, we investigated whether skin-derived precursors (SKPs) might fulfill such a role. We show that SKPs derive from Sox2+ hair follicle dermal cells, and that these two cell populations are similar with regard to their transcriptome and functional properties. Both clonal SKPs and endogenous Sox2+ cells induce hair morphogenesis, differentiate into dermal cell types, and home to a hair follicle niche upon transplantation. Moreover, hair follicle-derived SKPs self-renew, maintain their multipotency, and serially reconstitute hair follicles. Finally, grafting experiments show that follicle-associated dermal cells move out of their niche to contribute cells for dermal maintenance and wound-healing. Thus, SKPs derive from Sox2+ follicle-associated dermal precursors and display functional properties predicted of a dermal stem cell, contributing to dermal maintenance, wound-healing, and hair follicle morphogenesis.
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Smyth, G. K. (2004) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1027 · Cited by 11,829
Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche
Nishimura, E. K., Granter, S. R., & Fisher, D. E. (2005) · Science · doi:10.1126/science.1099593 · Cited by 750
Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis
Driskell, R. R., Giangreco, A., Jensen, K. B., Mulder, K. W., & Watt, F. M. (2009) · Development · doi:10.1242/dev.038620 · Cited by 331
Cited by
The JAK/STAT signaling pathway: from bench to clinic
Hu, X., li, J., Fu, M., Zhao, X., & Wang, W. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00791-1 · Cited by 2,633
Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling
Festa, E., Fretz, J., Berry, R., Schmidt, B., Rodeheffer, M., Horowitz, M., & Horsley, V. (2011) · Cell · doi:10.1016/j.cell.2011.07.019 · Cited by 616
Regeneration of fat cells from myofibroblasts during wound healing
Plikus, M. V., Guerrero-Juarez, C. F., Ito, M., Li, Y. R., Dedhia, P. H., Zheng, Y., Shao, M., Gay, D. L., Ramos, R., Hsi, T.-C., et al. (2017) · Science · doi:10.1126/science.aai8792 · Cited by 584
Cell-Extracellular Matrix Interactions in Normal and Diseased Skin
Watt, F. M., & Fujiwara, H. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005124 · Cited by 384
SOX2 in development and cancer biology
Novak, D., Hüser, L., Elton, J. J., Umansky, V., Altevogt, P., & Utikal, J. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.08.007 · Cited by 328
Metadata
- Authors
- Biernaskie, J., Paris, M., Morozova, O., Fagan, B. M., Marra, M., Pevny, L., & Miller, F. D.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 5
- Issue
- 6
- Pages
- 610-623
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2043950060
- Cited by
- 359
- References
- 3
- FWCI
- 28.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Biernaskie, J., Paris, M., Morozova, O., Fagan, B. M., Marra, M., Pevny, L., & Miller, F. D. (2009). SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells. Cell Stem Cell. https://doi.org/10.1016/j.stem.2009.10.019
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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