The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Integrin Alpha 6 Regulates Glioblastoma Stem Cells
Open accessAbstract
Summary Cancer stem cells (CSCs) are a subpopulation of tumor cells suggested to be critical for tumor maintenance, metastasis, and therapeutic resistance. Prospective identification and targeting of CSCs are therefore priorities for the development of novel therapeutic paradigms. While CSC enrichment has been achieved with cell surface proteins including CD133 (Prominin-1), the roles of current CSC markers in tumor maintenance remain unclear. We examined the glioblastoma stem cell (GSC) perivascular microenvironment in patient specimens to identify enrichment markers with a functional significance and identified integrin α6 as a candidate. Integrin α6 is co-expressed with conventional GSC markers and enriches for GSCs. Targeting integrin α6 in GSCs inhibits self-renewal, proliferation, and tumor formation capacity. Our results provide evidence that GSCs express high levels of integrin α6, which can not only serve as an enrichment marker but also as a promising anti-glioblastoma therapy.
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Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma
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Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
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p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation
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Cited by
Cancer stem cells in glioblastoma
Lathia, J. D., Mack, S. C., Mulkearns-Hubert, E. E., Valentim, C. L. L., & Rich, J. N. (2015) · Genes & Development · doi:10.1101/gad.261982.115 · Cited by 1,520
Self-citationTumour vascularization via endothelial differentiation of glioblastoma stem-like cells
Ricci-Vitiani, L., Pallini, R., Biffoni, M., Todaro, M., Invernici, G., Cenci, T., Maira, G., Parati, E. A., Stassi, G., Larocca, L. M., et al. (2010) · Nature · doi:10.1038/nature09557 · Cited by 1,379
Hematopoiesis: a human perspective
Doulatov, S., Notta, F., Laurenti, E., & Dick, J. E. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.01.006 · Cited by 895
Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance
Seguin, L., Desgrosellier, J. S., Weis, S. M., & Cheresh, D. A. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.12.006 · Cited by 685
Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma
Bhaduri, A., Di Lullo, E., Jung, D., Müller, S., Crouch, E. E., Espinosa, C. S., Ozawa, T., Alvarado, B., Spatazza, J., Cadwell, C. R., et al. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2019.11.015 · Cited by 419
Metadata
- Authors
- Lathia, J. D., Gallagher, J., Heddleston, J. M., Wang, J., Eyler, C. E., MacSwords, J., Wu, Q., Vasanji, A., McLendon, R. E., Hjelmeland, A. B., & Rich, J. N.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 6
- Issue
- 5
- Pages
- 421-432
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2004471993
- Cited by
- 660
- References
- 5
- FWCI
- 23.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lathia, J. D., Gallagher, J., Heddleston, J. M., Wang, J., Eyler, C. E., MacSwords, J., Wu, Q., Vasanji, A., McLendon, R. E., Hjelmeland, A. B., & Rich, J. N. (2010). Integrin Alpha 6 Regulates Glioblastoma Stem Cells. Cell Stem Cell. https://doi.org/10.1016/j.stem.2010.02.018
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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