Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance
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Summary Interactions between cancer cells and their surroundings can trigger essential signaling cues that determine cell fate and influence the evolution of the malignant phenotype. As the primary receptors involved in cell-matrix adhesion, integrins present on the surface of tumor and stromal cells have a profound impact on the ability to survive in specific locations, but in some cases these receptors can also function in the absence of ligand binding to promote stemness and survival in the presence of environmental and therapeutic stresses. Understanding how integrin expression and function is regulated in this context will enable the development of new therapeutic approaches to sensitize tumors to therapy and suppress their metastatic phenotype.
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Integrins can direct specific stemness-related reprogramming, providing an important role during development independent of their ligand-binding activity.
“Furthermore, integrins can direct specific stemness-related reprogramming, providing an important role during development independent of their ligand-binding activity (Seguin et al., 2015).”
From Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway (2017) · cites this paper as Seguin et al., 2015
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- Authors
- Seguin, L., Desgrosellier, J. S., Weis, S. M., & Cheresh, D. A.
- Affiliations
- University of California San Diego (US)
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 25
- Issue
- 4
- Pages
- 234-240
- ISSN
- 0962-8924 (ISSN-L)
- PMC
- PMC4380531
- OpenAlex
- W2061546218
- Semantic Scholar
- 4fe61173947bb2aa17e0bab80b98a61f9ff6362d
- Cited by
- 685
- References
- 68
- Citations by year
- 2026: 28 · 2025: 20 · 2024: 44 · 2023: 50 · 2022: 52 · 2021: 69 · 2020: 90 · 2019: 87 · 2018: 77 · 2017: 71 · 2016: 70 · 2015: 27
- FWCI
- 11.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Cancer Institute (R01CA045726, T32CA121938)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- integrins, cancer stemness, metastasis, drug resistance, cell-matrix adhesion, tumor microenvironment, stromal cells
- MeSH terms
- Cell Adhesion, Drug Resistance, Humans, Neoplasm Metastasis, Neoplasms, Stem Cells, Signal Transduction, Integrins, Stromal Cells
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