The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Molecular Analyses of Human Induced Pluripotent Stem Cells and Embryonic Stem Cells
Open accessAbstract
Recent work from our group and others has argued that human induced pluripotent stem cells (hiPSCs) generated by the introduction of four viruses bearing reprogramming factors differ from human embryonic stem cells (hESCs) at the level of gene expression. Many of the differences seen were common across independent labs and, at least to some extent, are thought to be a result of residual expression of donor cell-specific genes (Chin et al., 2009; Ghosh et al., 2010; Marchetto et al., 2009). Two new reports re-analyze similar expression datasets as those used in Chin et al., (Chin et al., 2009) and come to different conclusions (Newman et al., 2010, Guenther et al., 2010). Here, we compare various approaches to perform gene expression meta-analysis that all support our original conclusions and present new data to demonstrate that polycistronic delivery of the reprogramming factors and extended culture brings hiPSCs transcriptionally much closer to hESCs than older methods.
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Citations
Cites
Generation of human induced pluripotent stem cells from dermal fibroblasts
Lowry, W. E., Richter, L., Yachechko, R., Pyle, A. D., Tchieu, J., Sridharan, R., Clark, A. T., & Plath, K. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711983105 · Cited by 1,041
Self-citationInduced Pluripotent Stem Cell Generation Using a Single Lentiviral Stem Cell Cassette
Sommer, C. A., Stadtfeld, M., Murphy, G. J., Hochedlinger, K., Kotton, D. N., & Mostoslavsky, G. (2009) · Stem Cells · doi:10.1634/stemcells.2008-1075 · Cited by 676
A High-Efficiency System for the Generation and Study of Human Induced Pluripotent Stem Cells
Maherali, N., Ahfeldt, T., Rigamonti, A., Utikal, J., Cowan, C., & Hochedlinger, K. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.08.003 · Cited by 563 · cited 2×
“It has since been shown that lentivirus is suitable for delivering the reprogramming factors (Brambrink et al., 2008; Maherali et al., 2008; Stadtfeld et al., 2008), and newer methods use polycistronic vectors to deliver all four reprogramming factors in one virus and were shown to be very effective at generating hiPS…”
BackgroundMethod
Cited by
Bock, C., Kiskinis, E., Verstappen, G., Gu, H., Boulting, G., Smith, Z. D., Ziller, M., Croft, G. F., Amoroso, M. W., Oakley, D. H., et al. (2011) · Cell · doi:10.1016/j.cell.2010.12.032 · Cited by 1,009
The tumorigenicity of human embryonic and induced pluripotent stem cells
Ben-David, U., & Benvenisty, N. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3034 · Cited by 889
Open chromatin in pluripotency and reprogramming
Gaspar-Maia, A., Alajem, A., Meshorer, E., & Ramalho-Santos, M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3036 · Cited by 573
Genetic and Epigenetic Variations in iPSCs: Potential Causes and Implications for Application
Liang, G., & Zhang, Y. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.07.001 · Cited by 369
DNA Methylation Dynamics in Human Induced Pluripotent Stem Cells over Time
Nishino, K., Toyoda, M., Yamazaki-Inoue, M., Fukawatase, Y., Chikazawa, E., Sakaguchi, H., Akutsu, H., & Umezawa, A. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002085 · Cited by 314
Metadata
- Authors
- Chin, M. H., Pellegrini, M., Plath, K., & Lowry, W. E.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 7
- Issue
- 2
- Pages
- 263-269
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2147547310
- Cited by
- 160
- References
- 3
- FWCI
- 9.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chin, M. H., Pellegrini, M., Plath, K., & Lowry, W. E. (2010). Molecular Analyses of Human Induced Pluripotent Stem Cells and Embryonic Stem Cells. Cell Stem Cell. https://doi.org/10.1016/j.stem.2010.06.019
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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