Regulatory network control of blood stem cells
Abstract
Hematopoietic stem cells (HSCs) are characterized by their ability to execute a wide range of cell fate choices, including self-renewal, quiescence, and differentiation into the many different mature blood lineages. Cell fate decision making in HSCs, as indeed in other cell types, is driven by the interplay of external stimuli and intracellular regulatory programs. Given the pivotal nature of HSC decision making for both normal and aberrant hematopoiesis, substantial research efforts have been invested over the last few decades into deciphering some of the underlying mechanisms. Central to the intracellular decision making processes are transcription factor proteins and their interactions within gene regulatory networks. More than 50 transcription factors have been shown to affect the functionality of HSCs. However, much remains to be learned about the way in which individual factors are connected within wider regulatory networks, and how the topology of HSC regulatory networks might affect HSC function. Nevertheless, important progress has been made in recent years, and new emerging technologies suggest that the pace of progress is likely to accelerate. This review will introduce key concepts, provide an integrated view of selected recent studies, and conclude with an outlook on possible future directions for this field.
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More recently, genomic approaches have helped to unravel the mechanisms by which these factors alter hematopoietic cell differentiation.
“More recently, genomic approaches have helped to unravel the mechanisms by which these factors alter hematopoietic cell differentiation (Göttgens, 2015).”
From Unraveling Hematopoiesis through the Lens of Genomics (2020) · cites this paper as Göttgens, 2015
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- Authors
- Göttgens, B.
- Affiliations
- Wellcome/MRC Cambridge Stem Cell Institute (GB)
- Corresponding author
- Göttgens, Berthold
- ORCID
- Göttgens, Berthold
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2015-04-23
- Volume
- 125
- Issue
- 17
- Pages
- 2614-2620
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2015059346
- Cited by
- 82
- References
- 77
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 7 · 2020: 11 · 2019: 8 · 2018: 10 · 2017: 14 · 2016: 10 · 2015: 4
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (97922)
- Cancer Research UK (12765)
- Directorate for Biological Sciences
- Medical Research Council (MC_PC_12009)
- Biotechnology and Biological Sciences Research Council (BB/I00050X/1)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- hematopoietic stem cells, gene regulatory networks, transcription factors, cell fate decision-making, self-renewal, quiescence, hematopoiesis, network topology, stem cell differentiation
- MeSH terms
- Animals, Hematopoiesis, Hematopoietic Stem Cells, Humans, Models, Molecular, Transcription Factors, Gene Regulatory Networks, Single-Cell Analysis, Transcriptome
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