The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Distinct Functions for Wnt/β-Catenin in Hair Follicle Stem Cell Proliferation and Survival and Interfollicular Epidermal Homeostasis
Open accessAbstract
SUMMARY Wnt/β-catenin signaling is a central regulator of adult stem cells. Variable sensitivity of Wnt reporter transgenes, β-catenin’s dual roles in adhesion and signaling, and hair follicle degradation and inflammation resulting from broad deletion of epithelial β-catenin, have precluded clear understanding of Wnt/β-catenin’s functions in adult skin stem cells. By inducibly deleting β-catenin globally in skin epithelia, only in hair follicle stem cells, or only in interfollicular epidermis, and comparing the phenotypes with those caused by ectopic expression of the Wnt/β-catenin inhibitor Dkk1, we show that this pathway is necessary for hair follicle stem cell proliferation. However, β-catenin is not required within hair follicle stem cells for their maintenance, and follicles resume proliferating after removal of ectopic Dkk1, indicating persistence of functional progenitors. We further unexpectedly discovered a broader role for Wnt/β-catenin signaling in contributing to progenitor cell proliferation in non-hairy epithelia and interfollicular epidermis under homeostatic, but not inflammatory, conditions.
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Cites
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WNT Signals Are Required for the Initiation of Hair Follicle Development
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Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling
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An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control
Clevers, H., Loh, K. M., & Nusse, R. (2014) · Science · doi:10.1126/science.1248012 · Cited by 1,364
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Self-citationScreening cell–cell communication in spatial transcriptomics via collective optimal transport
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Clinical and Therapeutic Implications of Cancer Stem Cells
Clarke, M. F. (2019) · New England Journal of Medicine · doi:10.1056/nejmra1804280 · Cited by 355
Interfollicular Epidermal Stem Cells Self-Renew via Autocrine Wnt Signaling
Lim, X., Tan, S. H., Koh, W. L. C., Chau, R. M. W., Yan, K. S., Kuo, C. J., van Amerongen, R., Klein, A. M., & Nusse, R. (2013) · Science · doi:10.1126/science.1239730 · Cited by 347
Metadata
- Authors
- Choi, Y. S., Zhang, Y., Xu, M., Yang, Y., Ito, M., Peng, T., Cui, Z., Nagy, A., Hadjantonakis, A.-K., Lang, R. A., Cotsarelis, G., Andl, T., Morrisey, E. E., & Millar, S. E.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 13
- Issue
- 6
- Pages
- 720-733
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W1998069891
- Cited by
- 330
- References
- 46
- FWCI
- 26.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Choi, Y. S., Zhang, Y., Xu, M., Yang, Y., Ito, M., Peng, T., Cui, Z., Nagy, A., Hadjantonakis, A.-K., Lang, R. A., Cotsarelis, G., Andl, T., Morrisey, E. E., & Millar, S. E. (2013). Distinct Functions for Wnt/β-Catenin in Hair Follicle Stem Cell Proliferation and Survival and Interfollicular Epidermal Homeostasis. Cell Stem Cell. https://doi.org/10.1016/j.stem.2013.10.003
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