Notch-Dependent Repression of miR-155 in the Bone Marrow Niche Regulates Hematopoiesis in an NF-κB-Dependent Manner
Open accessAbstract
The microRNA miR-155 has been implicated in regulating inflammatory responses and tumorigenesis, but its precise role in linking inflammation and cancer has remained elusive. Here, we identify a connection between miR-155 and Notch signaling in this context. Loss of Notch signaling in the bone marrow (BM) niche alters hematopoietic homeostasis and leads to lethal myeloproliferative-like disease. Mechanistically, Notch signaling represses miR-155 expression by promoting binding of RBPJ to the miR-155 promoter. Loss of Notch/RBPJ signaling upregulates miR-155 in BM endothelial cells, leading to miR-155-mediated targeting of the nuclear factor κB (NF-κB) inhibitor κB-Ras1, NF-κB activation, and increased proinflammatory cytokine production. Deletion of miR-155 in the stroma of RBPJ(-/-) mice prevented the development of myeloproliferative-like disease and cytokine induction. Analysis of BM from patients carrying myeloproliferative neoplasia also revealed elevated expression of miR-155. Thus, the Notch/miR-155/κB-Ras1/NF-κB axis regulates the inflammatory state of the BM niche and affects the development of myeloproliferative disorders.
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Macrophage development is regulated by miR-155 and miR-146a expression.
“Macrophage development is regulated by miR-155 and miR-146a expression [54,55,56,57].”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [56]
The Results section on RBPJ-dependent myeloproliferative disease links miR-155 to myeloid-cell expansion, but does not establish a specific role in macrophage development. The Results section on miR-155 up-regulation reports no significant change in miR-146a expression under the studied conditions, so this paper does not support attributing regulation of macrophage development to both microRNAs. (LLM, conf=0.85)
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Cites
Notch Signaling: Cell Fate Control and Signal Integration in Development
Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999) · Science · doi:10.1126/science.284.5415.770 · Cited by 5,909 · see citing works
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
Kopan, R., & Ilagan, M. X. G. (2009) · Cell · doi:10.1016/j.cell.2009.03.045 · Cited by 3,631 · see citing works
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
De Strooper, B., Annaert, W., Cupers, P., Saftig, P., Craessaerts, K., Mumm, J. S., Schroeter, E. H., Schrijvers, V., Wolfe, M. S., Ray, W. J., et al. (1999) · Nature · doi:10.1038/19083 · Cited by 2,100 · see citing works
Endothelial and perivascular cells maintain haematopoietic stem cells
Ding, L., Saunders, T. L., Enikolopov, G., & Morrison, S. J. (2012) · Nature · doi:10.1038/nature10783 · Cited by 1,934 · see citing works
Miranda, K. C., Huynh, T., Tay, Y., Ang, Y.-S., Tam, W.-L., Thomson, A. M., Lim, B., & Rigoutsos, I. (2006) · Cell · doi:10.1016/j.cell.2006.07.031 · Cited by 1,739 · see citing works
Signalling downstream of activated mammalian Notch
Jarriault, S., Brou, C., Logeat, F., Schroeter, E. H., Kopan, R., & Israël, A. (1995) · Nature · doi:10.1038/377355a0 · Cited by 1,390 · see citing works
MicroRNAs: new regulators of immune cell development and function
Baltimore, D., Boldin, M., O’Connell, R. M., Rao, D. S., & Taganov, K. D. (2008) · Nature Immunology · doi:10.1038/ni.f.209 · Cited by 1,083 · see citing works
Faust, N., Varas, F., Kelly, L. M., Heck, S., & Graf, T. (2000) · Blood · doi:10.1182/blood.v96.2.719 · Cited by 751 · see citing works
O'Connell, R. M., Rao, D. S., Chaudhuri, A. A., Boldin, M. P., Taganov, K. D., Nicoll, J., Paquette, R. L., & Baltimore, D. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072108 · Cited by 681 · see citing works
Tefferi, A., Vaidya, R., Caramazza, D., Finke, C. M., Lasho, T. L., & Pardanani, A. D. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.32.9490 · Cited by 608 · see citing works
Han, H., Tanigaki, K., Yamamoto, N., Kuroda, K., Yoshimoto, M., Nakahata, T., Ikuta, K., & Honjo, T. (2002) · International Immunology · doi:10.1093/intimm/dxf030 · Cited by 587 · see citing works
A histone deacetylase corepressor complex regulates the Notch signal transduction pathwayPreprint
Kao, H., Ordentlich, P., Koyano‐Nakagawa, N., Tang, Z., Downes, M., Kintner, C. R., Evans, R. M., & Kadesch, T. R. (1998) · Genes & Development · doi:10.1101/gad.12.15.2269 · Cited by 579 · see citing works
A Microenvironment-Induced Myeloproliferative Syndrome Caused by Retinoic Acid Receptor γ Deficiency
Walkley, C. R., Olsen, G. H., Dworkin, S., Fabb, S. A., Swann, J. B., McArthur, G. A., Westmoreland, S. V., Chambon, P., Scadden, D. T., & Purton, L. E. (2007) · Cell · doi:10.1016/j.cell.2007.05.014 · Cited by 535 · see citing works
C/EBPβ is required for 'emergency' granulopoiesis
Hirai, H., Zhang, P., Dayaram, T., Hetherington, C. J., Mizuno, S.-I., Imanishi, J., Akashi, K., & Tenen, D. G. (2006) · Nature Immunology · doi:10.1038/ni1354 · Cited by 425 · see citing works
Myeloid or Lymphoid Promiscuity as a Critical Step in Hematopoietic Lineage Commitment
Miyamoto, T., Iwasaki, H., Reizis, B., Ye, M., Graf, T., Weissman, I. L., & Akashi, K. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00201-0 · Cited by 415 · see citing works
Davis, R. L., & Turner, D. L. (2001) · Oncogene · doi:10.1038/sj.onc.1205094 · Cited by 387 · see citing works
miR-155 : On the Crosstalk Between Inflammation and Cancer
Tili, E., Croce, C. M., & Michaille, J. (2009) · International Reviews of Immunology · doi:10.1080/08830180903093796 · Cited by 343 · see citing works
Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow
Ueda, Y., Kondo, M., & Kelsoe, G. H. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041419 · Cited by 343 · see citing works
Dynamic binding of RBPJ is determined by Notch signaling statusPreprint
Castel, D., Mourikis, P., Bartels, S. J. J., Brinkman, A. B., Tajbakhsh, S., & Stunnenberg, H. G. (2013) · Genes & Development · doi:10.1101/gad.211912.112 · Cited by 256 · see citing works
Pruessmeyer, J., & Ludwig, A. (2008) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2008.09.005 · Cited by 234 · see citing works
Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155
Chang, S., Wang, R., Akagi, K., Kim, K.-A., Martin, B. K., Cavallone, L., Haines, D. C., Basik, M., Mai, P., Poggi, E. A., et al. (2011) · Nature Medicine · doi:10.1038/nm.2459 · Cited by 224 · see citing works
A novel tumor suppressor function for the Notch pathway in myeloid leukemia
Klinakis, A., Lobry, C., Abdel-Wahab, O., Oh, P., Haeno, H., Buonamici, S., de Walle, I. V., Cathelin, S., Trimarchi, T., Araldi, E., et al. (2011) · Nature · doi:10.1038/nature09999 · Cited by 210 · see citing works
Micro RNA s play a central role in molecular dysfunctions linking inflammation with cancer
Tili, E., Michaille, J., & Croce, C. M. (2013) · Immunological Reviews · doi:10.1111/imr.12050 · Cited by 208 · see citing works
Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancersPreprint
Krejci, A. B., & Bray, S. J. (2007) · Genes & Development · doi:10.1101/gad.424607 · Cited by 205 · see citing works
Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-κB inhibitor, DMAPT (LC-1)
Neelakantan, S., Nasim, S., Guzmán, M. L., Jordan, C. T., & Crooks, P. A. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.05.092 · Cited by 193 · see citing works
Worm, J., Stenvang, J., Petri, A., Frederiksen, K. S., Obad, S., Elmén, J., Hedtjärn, M., Straarup, E. M., Hansen, J. B., & Kauppinen, S. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp577 · Cited by 192 · see citing works
RBP-Jκ/SHARP Recruits CtIP/CtBP Corepressors To Silence Notch Target Genes
Oswald, F., Winkler, M., Cao, Y., Astrahantseff, K., Bourteele, S., Knöchel, W., & Borggrefe, T. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.23.10379-10390.2005 · Cited by 183 · see citing works
Dumortier, A., Durham, A., Piazza, M., Vauclair, S., Koch, U., Ferrand, G., Ferrero, I., Demehri, S., Song, L. L., Farr, A. G., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009258 · Cited by 165 · see citing works
Defective Notch activation in microenvironment leads to myeloproliferative disease
Kim, Y.-W., Koo, B., Jeong, H., Yoon, M.-J., Song, R., Shin, J., Jeong, D.-C., Kim, S., & Kong, Y. (2008) · Blood · doi:10.1182/blood-2008-03-148999 · Cited by 164 · see citing works
Notch pathway activation targets AML-initiating cell homeostasis and differentiation
Lobry, C., Ntziachristos, P., Ndiaye‐Lobry, D., Oh, P., Cimmino, L., Zhu, N., Araldi, E., Hu, W., Freund, J. E., Abdel-Wahab, O. I., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20121484 · Cited by 159 · see citing works
Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling
Fulzele, K. S., Krause, D. S., Panaroni, C., Saini, V., Barry, K. J., Liu, X., Lotinun, S., Baron, R., Bonewald, L. F., Feng, J. Q., et al. (2012) · Blood · doi:10.1182/blood-2012-06-437160 · Cited by 152 · see citing works
BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets
Tiberi, L., van den Ameele, J., Dimidschstein, J., Piccirilli, J., Gall, D., Herpoel, A., Bilheu, A., Bonnefont, J., Iacovino, M., Kyba, M., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3264 · Cited by 129 · see citing works
Kuhlencordt, P., Rosel, E. A., Gerszten, R. E., Morales‐Ruiz, M., Dombkowski, D., Atkinson, W. J., Han, F., Preffer, F. I., Rosenzweig, A., Sessa, W. C., et al. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00546.2002 · Cited by 129 · see citing works
Temporal Cre‐mediated recombination exclusively in endothelial cells using Tie2 regulatory elements
Forde, A., Constien, R., Gröne, H., Hämmerling, G. J., & Arnold, B. (2002) · genesis · doi:10.1002/gene.10117 · Cited by 128 · see citing works
Yao, D., Huang, Y., Huang, X., Wang, W., Yan, Q., Wei, L., Xin, W., Gerson, S. L., Stanley, P., Lowe, J. B., et al. (2011) · Blood · doi:10.1182/blood-2010-12-326074 · Cited by 103 · see citing works
A Subclass of Ras Proteins That Regulate the Degradation of IκB
Fenwick, C. W., Na, S.-Y., Voll, R. E., Zhong, H., Im, S., Lee, J. W., & Ghosh, S. (2000) · Science · doi:10.1126/science.287.5454.869 · Cited by 102 · see citing works
Fernández, L., Rodrı́guez, S., Huang, H., Chora, Â. F., Fernandes, J., Mumaw, C., Cruz, E., Pollok, K. E., Cristina, F., Price, J. E., et al. (2008) · Experimental Hematology · doi:10.1016/j.exphem.2007.12.012 · Cited by 73 · see citing works
Self-citationNotch3 and Canonical NF-κB Signaling Pathways Cooperatively Regulate Foxp3 Transcription
Barbarulo, A., Grazioli, P., Campese, A. F., Bellavia, D., Mario, G. D., Pelullo, M., Ciuffetta, A., Colantoni, S., Vacca, A., Frati, L., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002136 · Cited by 72 · see citing works
Chitteti, B. R., Cheng, Y., Streicher, D. A., Rodrı́guez, S., Carlesso, N., Srour, E. F., & Kacena, M. A. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22694 · Cited by 67 · see citing works
Self-citationSakano, D., Kato, A., Parikh, N., McKnight, K., Terry, D. E., Stefanovic, B., & Kato, Y. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.12.023 · Cited by 57 · see citing works
Nicastrin: Gatekeeper of the γ-Secretase Complex
Strooper, B. D. (2005) · Cell · doi:10.1016/j.cell.2005.07.021 · Cited by 49 · see citing works
Inhibition of NF-κB Activity by IκBβ in Association with κB-Ras
Chen, Y., Vallée, S., Wu, J., Vu, D., Sondek, J., & Ghosh, G. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.7.3048-3056.2004 · Cited by 49 · see citing works
Dual functions of cell-autonomous and non–cell-autonomous ADAM10 activity in granulopoiesis
Yoda, M., Kimura, T., Tohmonda, T., Uchikawa, S., Koba, T., Takito, J., Morioka, H., Matsumoto, M., Link, D. C., Chiba, K., et al. (2011) · Blood · doi:10.1182/blood-2011-06-357210 · Cited by 44 · see citing works
Schneider, A., Zhang, Y., Guan, Y., Davis, L. S., & Breyer, M. D. (2003) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00235.2002 · Cited by 43 · see citing works
Downregulation by lipopolysaccharide of Notch signaling, via nitric oxide
Kim, M., Park, J., Mo, J., Ann, E., Han, S.-O., Baek, S.-H., Kim, K. J., Im, S., Park, J.-W., Choi, E., et al. (2008) · Journal of Cell Science · doi:10.1242/jcs.019018 · Cited by 38 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Chen Y Vallee S Wu J Vu D Sondek J Ghosh G 2004 Inhibition of NF-kappaB activity by IkappaBbeta in association wtih kappaB-Ras Mol cell Biol 24 3048 3056 15024091 PMC371134
- Tili E Michaille JJ Croce CM 2013 MicroRNAs play a central role in molecular dysfunctions linking inflammation with cancer Immunol Rev 253 167 184 23550646
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NF-κB in biology and targeted therapy: new insights and translational implications
Guo, Q., Jin, Y., Chen, X., Ye, X., Shen, X., Lin, M., Zeng, C., Zhou, T., & Zhang, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01757-9 · Cited by 2,267 · see citing works
Haematopoietic stem cell activity and interactions with the niche
Pinho, S., & Frenette, P. S. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0103-9 · Cited by 990 · see citing works
Adult haematopoietic stem cell niches
Crane, G. M., Jeffery, E., & Morrison, S. J. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.53 · Cited by 712 · see citing works
MicroRNAs as regulatory elements in immune system logic
Mehta, A., & Baltimore, D. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.40 · Cited by 704 · see citing works
Kumar, B., García, M., Weng, L., Jung, X., Murakami, J. L., Hu, X., McDonald, T., Lin, A., Kumar, A. R., DiGiusto, D. L., et al. (2017) · Leukemia · doi:10.1038/leu.2017.259 · Cited by 445 · see citing works
Self-citationNormal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities
Schepers, K., Campbell, T., & Passegué, E. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.02.014 · Cited by 416 · see citing works
Passing the Vascular Barrier: Endothelial Signaling Processes Controlling Extravasation
Wettschureck, N., Strilić, B., & Offermanns, S. (2019) · Physiological Reviews · doi:10.1152/physrev.00037.2018 · Cited by 282 · see citing works
Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment
Dong, L., Yu, W., Zheng, H., Loh, M. L., Bunting, S. T., Pauly, M. G., Huang, G., Zhou, M., Broxmeyer, H. E., Scadden, D. T., et al. (2016) · Nature · doi:10.1038/nature20131 · Cited by 260 · see citing works
The hematopoietic stem cell niche in homeostasis and disease
Calvi, L. M., & Link, D. C. (2015) · Blood · doi:10.1182/blood-2015-07-533588 · Cited by 228 · see citing works
Endothelial microRNAs regulating the NF‐κB pathway and cell adhesion molecules during inflammation
Zhong, L., Simard, M. J., & Huot, J. (2018) · The FASEB Journal · doi:10.1096/fj.201701536r · Cited by 212 · see citing works
Physiological roles of miR‐155
Mashima, R. (2015) · Immunology · doi:10.1111/imm.12468 · Cited by 208 · see citing works
Myeloproliferative neoplasm stem cells
Mead, A. J., & Mullally, A. (2017) · Blood · doi:10.1182/blood-2016-10-696005 · Cited by 179 · see citing works
Inflammatory signaling regulates hematopoietic stem and progenitor cell emergence in vertebrates
He, Q., Zhang, C., Wang, L., Zhang, P., Ma, D., Lv, J., & Liu, F. (2014) · Blood · doi:10.1182/blood-2014-09-601542 · Cited by 170 · see citing works
Self-citationMyeloid malignancies and the microenvironment
Korn, C., & Méndez‐Ferrer, S. (2016) · Blood · doi:10.1182/blood-2016-09-670224 · Cited by 169 · see citing works
Fu, X., Wen, H., Li, J., Yang, Y., Wang, W., Liang, X., Nan, K., Yao, Y., & Tian, T. (2017) · Cancer Science · doi:10.1111/cas.13177 · Cited by 162 · see citing works
NOTCH regulation of the endothelial cell phenotype
Mack, J. J., & Iruela‐Arispe, M. L. (2018) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000425 · Cited by 160 · see citing works
Functional inhibition of mesenchymal stromal cells in acute myeloid leukemia
Geyh, S., Rodríguez‐Paredes, M., Jäger, P. S., Khandanpour, C., Cadeddu, R.-P., Gutekunst, J., Wilk, C. M., Fenk, R. R., Zilkens, C., Hermsen, D. F., et al. (2015) · Leukemia · doi:10.1038/leu.2015.325 · Cited by 152 · see citing works
Sun, D., Zhang, H.-D., Mao, L., Mao, C., Chen, W., Cui, M., Ma, R., Cao, H., Jing, C.-W., Wang, Z., et al. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000438535 · Cited by 150 · see citing works
Self-citationWhere Hematopoietic Stem Cells Live: The Bone Marrow Niche
Szade, K., Gulati, G. S., Chan, C. K. F., Kao, K. S., Miyanishi, M., Marjon, K. D., Sinha, R., George, B. M., Chen, J. Y., & Weissman, I. L. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7419 · Cited by 137 · see citing works
The interplay of leukemia cells and the bone marrow microenvironment
Duarte, D., Hawkins, E. D., & Celso, C. L. (2018) · Blood · doi:10.1182/blood-2017-12-784132 · Cited by 132 · see citing works
The microenvironment in human myeloid malignancies: emerging concepts and therapeutic implications
Medyouf, H. (2017) · Blood · doi:10.1182/blood-2016-11-696070 · Cited by 127 · see citing works
Losing Sense of Self and Surroundings: Hematopoietic Stem Cell Aging and Leukemic Transformation
Verovskaya, E. V., Dellorusso, P. V., & Passegue, E. A. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.04.006 · Cited by 122 · see citing works
miR-148a-3p Mediates Notch Signaling to Promote the Differentiation and M1 Activation of Macrophages
Huang, F., Zhao, J., Wang, L., Gao, C.-C., Liang, S.-Q., An, D., Bai, J., Chen, Y., Han, H., & Qin, H. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01327 · Cited by 118 · see citing works
Self-citationZhao, J., Huang, F., He, F., Gao, C.-C., Liang, S.-Q., Ma, P., Dong, G., Han, H., & Qin, H. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2019 · Cited by 115 · see citing works
Cheng, H., Hao, S., Liu, Y., Pang, Y., Ma, S., Dong, F., Xu, J., Zheng, G., Li, S., Yuan, W., et al. (2015) · Blood · doi:10.1182/blood-2015-01-623645 · Cited by 110 · see citing works
Briot, A., Civelek, M., Seki, A., Hoi, K. K., Mack, J. J., Lee, S. D., Kim, J., Hong, C., Yu, J., Fishbein, G. A., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20150603 · Cited by 111 · see citing works
Bewersdorf, J. P., & Zeidan, A. M. (2020) · Cells · doi:10.3390/cells9102310 · Cited by 116 · see citing works
Notch Signaling in the Regulation of Hematopoietic Stem Cell
Lampreia, F., Carmelo, J. G., & Anjos‐Afonso, F. (2017) · Current Stem Cell Reports · doi:10.1007/s40778-017-0090-8 · Cited by 99 · see citing works
Corradi, G., Baldazzi, C., Očadlíková, D., Marconi, G., Parisi, S., Testoni, N., Finelli, C., Cavo, M., Curti, A., & Ciciarello, M. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-1013-z · Cited by 97 · see citing works
Gata2 as a Crucial Regulator of Stem Cells in Adult Hematopoiesis and Acute Myeloid Leukemia
Menendez-Gonzalez, J. B., Vukovic, M., Abdelfattah, A., Saleh, L., Almotiri, A., Thomas, L.-A., Lizaso, A. A., Azevedo, A., Menezes, A. C., Tornillo, G., et al. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.07.005 · Cited by 97 · see citing works
The role of miR-155 in cigarette smoke-induced pulmonary inflammation and COPD
Smet, E. G. D., Eeckhoutte, H. P. V., Cobos, F. A., Blomme, E. E., Verhamme, F. M., Provoost, S., Verleden, S. E., Venken, K., Maes, T., Joos, G., et al. (2019) · Mucosal Immunology · doi:10.1038/s41385-019-0241-6 · Cited by 87 · see citing works
Leukemic Stem Cells: From Leukemic Niche Biology to Treatment Opportunities
Marchand, T., & Pinho, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.775128 · Cited by 89 · see citing works
Khalife, J., Radomska, H. S., Santhanam, R., Huang, X., Neviani, P., Saultz, J. N., Wang, H., Wu, Y.-Z., Alachkar, H., Anghelina, M. I., et al. (2015) · Leukemia · doi:10.1038/leu.2015.106 · Cited by 81 · see citing works
Yan, L., Lee, S., Lazzaro, D. R., Aranda, J. V., Grant, M. B., & Chaqour, B. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.646950 · Cited by 78 · see citing works
Ramalingam, P., Poulos, M. G., Lazzari, E., Gutkin, M. C., Lopez, D., Kloss, C. C., Crowley, M. J., Katsnelson, L., Freire, A. G., Greenblatt, M. B., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14478-8 · Cited by 78 · see citing works
Xue, Q., Yu, C., Wang, Y., Liu, L., Zhang, K., Fang, C., Liu, F., Bian, G., Song, B., Yang, A., et al. (2016) · Scientific Reports · doi:10.1038/srep26781 · Cited by 76 · see citing works
Poon, Z., Dighe, N., Venkatesan, S. S., Cheung, A. M. S., Fan, X., Bari, S., Hota, M., Ghosh, S., & Hwang, W. Y. K. (2018) · Leukemia · doi:10.1038/s41375-018-0310-y · Cited by 74 · see citing works
Aldehyde dehydrogenases inhibition eradicates leukemia stem cells while sparing normal progenitors
Venton, G., Pérez‐Alea, M., Baier, C., Fournet, G., Quash, G., Labiad, Y., Martin, G., Sanderson, F., Poullin, P., Suchon, P., et al. (2016) · Blood Cancer Journal · doi:10.1038/bcj.2016.78 · Cited by 74 · see citing works
miRNA in cardiac development and regeneration
Ouyang, Z., & Wei, K. (2021) · Cell Regeneration · doi:10.1186/s13619-021-00077-5 · Cited by 73 · see citing works
Pronk, E., & Raaijmakers, M. H. G. P. (2019) · Blood · doi:10.1182/blood-2018-10-844639 · Cited by 72 · see citing works
Notch signaling: its roles and therapeutic potential in hematological malignancies
Gu, Y., Masiero, M., & Banham, A. H. (2016) · Oncotarget · doi:10.18632/oncotarget.7772 · Cited by 72 · see citing works
An Exploration of the Role of MicroRNAs in Psoriasis
Huang, R., Li, L., Wang, M., Chen, X., Huang, Q., & Lu, C. (2015) · Medicine · doi:10.1097/md.0000000000002030 · Cited by 71 · see citing works
Oncogenic and Tumor-Suppressive Functions of NOTCH Signaling in Glioma
Parmigiani, E., Taylor, V., & Giachino, C. (2020) · Cells · doi:10.3390/cells9102304 · Cited by 71 · see citing works
Tumor Microenvironment in Acute Myeloid Leukemia: Adjusting Niches
Menter, T., & Tzankov, A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.811144 · Cited by 71 · see citing works
Noncoding RNAs regulate NF-κB signaling to modulate blood vessel inflammation
Cheng, H. S., Njock, M.-S., Khyzha, N., Dang, L. T., & Fish, J. E. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00422 · Cited by 69 · see citing works
Cell interactions in the bone marrow microenvironment affecting myeloid malignancies
Kokkaliaris, K. D., & Scadden, D. T. (2020) · Blood Advances · doi:10.1182/bloodadvances.2020002127 · Cited by 67 · see citing works
The Role of miR-155 in Antitumor Immunity
Kalkusova, K., Táborská, P., Stakheev, D., & Smrž, D. (2022) · Cancers · doi:10.3390/cancers14215414 · Cited by 67 · see citing works
MicroRNAs associated with the pathogenesis of multiple sclerosis
Huang, Q., Xiao, B., Ma, X., Qu, M., Li, Y., Nagarkatti, P. S., Nagarkatti, M., & Zhou, J. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.04.014 · Cited by 65 · see citing works
Rastegar-Moghaddam, S. H., Ebrahimzadeh-Bideskan, A., Shahba, S., Malvandi, A. M., & Mohammadipour, A. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01200-z · Cited by 64 · see citing works
Notch signaling at the crossroads of innate and adaptive immunity
Vanderbeck, A., & Maillard, I. P. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.1ri0520-138r · Cited by 61 · see citing works
Jahandideh, B., Derakhshani, M., Abbaszadeh, H., Movassaghpour, A. A., Mehdizadeh, A., Talebi, M., & Yousefi, M. (2020) · Human Immunology · doi:10.1016/j.humimm.2020.01.004 · Cited by 61 · see citing works
The Bone Marrow Microenvironment in Health and Myeloid MalignancyPreprint
Galán-Díez, M., Cuesta‐Domínguez, Á., & Kousteni, S. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031328 · Cited by 58 · see citing works
Unwinding circular RNA’s role in inflammatory pulmonary diseases
Bhat, A. A., Gupta, G., Goyal, A., Thapa, R., Almalki, W. H., Kazmi, I. A., Alzarea, S. I., Kukreti, N., Sekar, M., Meenakshi, D. U., et al. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02809-7 · Cited by 56 · see citing works
Notch signal integration in the vasculature during remodeling
Rostama, B., Peterson, S. M., Vary, C., & Liaw, L. (2014) · Vascular Pharmacology · doi:10.1016/j.vph.2014.10.003 · Cited by 54 · see citing works
Notch Receptor-Ligand Engagement Maintains Hematopoietic Stem Cell Quiescence and Niche Retention
Wang, W., Yu, S., Zimmerman, G., Wang, Y., Myers, J., Yu, V. W. C., Huang, D., Huang, X., Shim, J., Huang, Y., et al. (2015) · Stem Cells · doi:10.1002/stem.2031 · Cited by 52 · see citing works
Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis
Poulos, M. G., Ramalingam, P., Gutkin, M. C., Kleppe, M., Ginsberg, M. D., Crowley, M. J. P., Elemento, O., Levine, R. L., Rafii, S., Kitajewski, J., et al. (2016) · Nature Communications · doi:10.1038/ncomms13829 · Cited by 51 · see citing works
Cross-regulation between Notch signaling pathway and miRNA machinery in cancer
Majidinia, M., Darband, S. G., Kaviani, M., Nabavi, S. M., Jahanban‐Esfahlan, R., & Yousefi, B. (2018) · DNA repair · doi:10.1016/j.dnarep.2018.04.002 · Cited by 51 · see citing works
Lanfeng, Z., Tao, X., Fu, Q., Ge, C., Li, R., Li, Z., Zhu, Y., Tian, H., Li, Q., Liu, M., et al. (2019) · Oncology Reports · doi:10.3892/or.2019.7278 · Cited by 49 · see citing works
Sartorius, K., Swadling, L., An, P., Makarova, J. A., Winkler, C. A., Chuturgoon, A. A., & Kramvis, A. (2020) · Viruses · doi:10.3390/v12070746 · Cited by 49 · see citing works
Adding a “Notch” to Cardiovascular Disease Therapeutics: A MicroRNA-Based Approach
Marracino, L., Fortini, F., Bouhamida, E., Camponogara, F., Severi, P., Mazzoni, E., Patergnani, S., D’Aniello, E., Campana, R., Pinton, P., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.695114 · Cited by 48 · see citing works
miR-155 Inhibits Mouse Osteoblast Differentiation by Suppressing SMAD5 Expression
Gu, Y., Ma, L., Song, L., Li, X., Chen, D., & Bai, X. (2017) · BioMed Research International · doi:10.1155/2017/1893520 · Cited by 45 · see citing works
Self-citationPing, Z., Chen, S., Hermans, S. J. F., Kenswil, K. J. G., Feyen, J., van Dijk, C., Bindels, E. M., Mylona, A., Adisty, N., Hoogenboezem, R. M., et al. (2018) · Leukemia · doi:10.1038/s41375-018-0267-x · Cited by 45 · see citing works
Rizzo, P., Mele, D., Caliceti, C., Pannella, M., Fortini, C., Clementz, A. G., Morelli, M. B., Aquila, G., Ameri, P., & Ferrari, R. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2014.00384 · Cited by 44 · see citing works
Shi, H., Yin, Z., Koronyo, Y., Fuchs, D.-T. S., Sheyn, J., Davis, M. R., Wilson, J. W., Margeta, M. A., Pitts, K. M., Herron, S., et al. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01439-z · Cited by 44 · see citing works
Xiao, P., Dolinska, M., Sandhow, L., Kondō, M., Johansson, A., Bouderlique, T., Zhao, Y. H., Li, X., Dimitriou, M., Rassidakis, G. Z., et al. (2018) · Blood Advances · doi:10.1182/bloodadvances.2017013599 · Cited by 43 · see citing works
Aval, S. F., Lotfi, H., Sheervalilou, R., & Zarghami, N. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.05.020 · Cited by 42 · see citing works
Therapeutic Targeting of the Leukaemia Microenvironment
Kuek, V., Hughes, A. M., Kotecha, R. S., & Cheung, L. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136888 · Cited by 41 · see citing works
The Use of Nutraceuticals to Counteract Atherosclerosis: The Role of the Notch Pathway
Aquila, G., Marracino, L., Martino, V., Calabria, D., Campo, G. C., Caliceti, C., & Rizzo, P. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/5470470 · Cited by 41 · see citing works
Paz, J. L., Levy, D., Oliveira, B. A., de Melo, T. C., de Freitas, F. A., Reichert, C. O., Rodrigues, A., Pereira, J. C., & Bydlowski, S. P. (2019) · Cells · doi:10.3390/cells8050482 · Cited by 41 · see citing works
Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL
Rodrı́guez, S., Abundis, C., Boccalatte, F. E., Mehrotra, P., Chiang, M. Y., Yui, M. A., Wang, L., Zhang, H., Zollman, A., Bonfim-Silva, R., et al. (2019) · Leukemia · doi:10.1038/s41375-019-0653-z · Cited by 41 · see citing works
Self-citationEmerging role of various signaling pathways in the pathogenesis and therapeutics of atherosclerosis
Prashar, Y., Bais, S., & Gill, N. (2017) · Reviews in vascular medicine · doi:10.1016/j.rvm.2017.05.001 · Cited by 20 · see citing works
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia
Kang, Y.-A., Pietras, E. M., & Passegue, E. A. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20190787 · Cited by 38 · see citing works
Mosteo, L., Storer, J. A., Batta, K., Searle, E. J., Duarte, D., & Wiseman, D. H. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.635189 · Cited by 39 · see citing works
Kushwah, R., Guezguez, B., Lee, J. B., Hopkins, C. I., & Bhatia, M. (2014) · EMBO Reports · doi:10.15252/embr.201438842 · Cited by 35 · see citing works
Notch, lipids, and endothelial cells
Briot, A., Bouloumié, A., & Iruela‐Arispe, M. L. (2016) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000337 · Cited by 36 · see citing works
Kim, S., Song, J. H., Kim, S., Qu, P., Martin, B. K., Sehareen, W. S., Haines, D. C., Lin, P. C., Sharan, S. K., & Chang, S. (2016) · Oncotarget · doi:10.18632/oncotarget.7150 · Cited by 35 · see citing works
Sega, F. V. D., Aquila, G., Fortini, F., Vaccarezza, M., Secchiero, P., Rizzo, P., & Campo, G. C. (2017) · BioFactors · doi:10.1002/biof.1359 · Cited by 35 · see citing works
Fallati, A., Marzo, N. D., D’Amico, G., & Dander, E. (2022) · Cancers · doi:10.3390/cancers14143303 · Cited by 33 · see citing works
Aquila, G., Fortini, C., Pannuti, A., Delbue, S., Pannella, M., Morelli, M. B., Caliceti, C., Castriota, F., Mattei, M. D., Ongaro, A., et al. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1199-3 · Cited by 32 · see citing works
Notch Represses Transcription by PRC2 Recruitment to the Ternary Complex
Han, X., Ranganathan, P., Tzimas, C., Weaver, K. L., Jin, K., Astudillo, L., Zhou, W., Zhu, X., Li, B., Robbins, D. J., et al. (2017) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-17-0241 · Cited by 31 · see citing works
Aggarwal, V., Tuli, H. S., Varol, M., Tuorkey, M. J., Sak, K., Parashar, N. C., Barwal, T. S., Sharma, U., Iqubal, A., Parashar, G., et al. (2021) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2021.103403 · Cited by 29 · see citing works
Microenvironment and drug resistance in acute myeloid leukemia: Do we know enough?
Ganesan, S., Mathews, V., & Vyas, N. (2021) · International Journal of Cancer · doi:10.1002/ijc.33908 · Cited by 29 · see citing works
Liu, X., Ren, S., Ge, C., Cheng, K., Zenke, M., Keating, A., & Zhao, R. C. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402641 · Cited by 29 · see citing works
Evans, A. G., & Calvi, L. M. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12562 · Cited by 28 · see citing works
Wongchana, W., Lawlor, R. G., Osborne, B. A., & Palaga, T. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1401770 · Cited by 28 · see citing works
Microenvironmental regulation of hematopoietic stem cells and its implications in leukemogenesis
Seshadri, M. R., & Qu, C. (2016) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000251 · Cited by 28 · see citing works
MicroRNAs as Regulators of Phagocytosis
Gierlikowski, W., & Gierlikowska, B. (2022) · Cells · doi:10.3390/cells11091380 · Cited by 25 · see citing works
Concise Review: The Malignant Hematopoietic Stem Cell Niche
Yao, J.-C., & Link, D. C. (2016) · Stem Cells · doi:10.1002/stem.2487 · Cited by 25 · see citing works
Prognostic relevance of miRNA-155 methylation in anaplastic glioma
Schliesser, M. G., Claus, R., Hielscher, T., Grimm, C., Weichenhan, D., Blaes, J., Wiestler, B., Hau, P., Schramm, J., Sahm, F., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13452 · Cited by 25 · see citing works
Itkin, T., Kumari, A., Schneider, E. M., Gur‐Cohen, S., Ludwig, C., Brooks, R., Kollet, Ó., Golan, K., Khatib-Massalha, E., Russo, C. M., et al. (2017) · Leukemia · doi:10.1038/leu.2017.50 · Cited by 25 · see citing works
Zhou, J., Liang, A., Hong, J., Sun, J., Lin, X., Peng, Y., Wang, X., Sun, S., Xiao, D., Xu, K., et al. (2018) · Connective Tissue Research · doi:10.1080/03008207.2018.1483356 · Cited by 24 · see citing works
Chlorogenic acid and intestinal health: mechanistic insights and therapeutic applications
Xu, J., Zhao, X., Yang, S., Tang, M., Zhao, R., & Hu, S. (2025) · Food & Function · doi:10.1039/d5fo00853k · Cited by 23 · see citing works
Zhou, Y., Lian, H., Liu, K., Wang, D., Xiu, X., & Sun, Z. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4595 · Cited by 22 · see citing works
RetractedLi, J., Chen, S., Zhao, X., Zhang, M., & Xie, H.-T. (2017) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-20642 · Cited by 22 · see citing works
Sarkaria, S. M., Decker, M., & Ding, L. (2018) · BioEssays · doi:10.1002/bies.201700190 · Cited by 22 · see citing works
Regulation of Malignant Myeloid Leukemia by Mesenchymal Stem Cells
Tan, Z., Chen, K., Wong, M., Sun, M., Liu, Y., Yang, F., Wang, S., & Zheng, H. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.857045 · Cited by 21 · see citing works
MicroRNAs in Control of Stem Cells in Normal and Malignant Hematopoiesis
Roden, C., & Lü, J. (2016) · Current Stem Cell Reports · doi:10.1007/s40778-016-0057-1 · Cited by 21 · see citing works
Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals in Early T Cell Progenitors
Kobayashi, M., Nabinger, S. C., Bai, Y., Yoshimoto, M., Gao, R., Chen, S., Yao, C., Dong, Y., Zhang, L., Rodrı́guez, S., et al. (2016) · Stem Cells · doi:10.1002/stem.2559 · Cited by 21 · see citing works
Self-citationAn AC electrokinetics-based electrochemical aptasensor for the rapid detection of microRNA-155
Ondevilla, N. A. P., Wong, T., Lee, N., & Chang, H. (2021) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2021.113847 · Cited by 20 · see citing works
Immune dysregulation and potential targeted therapy in myelodysplastic syndrome
Zhang, X., Yang, X., Ma, L., Zhang, Y., & Wei, J. (2023) · Therapeutic Advances in Hematology · doi:10.1177/20406207231183330 · Cited by 19 · see citing works
- Authors
- Wang, L., Zhang, H., Rodriguez, S., Cao, L., Parish, J., Mumaw, C., Zollman, A., Kamoka, M. M., Mu, J., Chen, D. Z., Srour, E. F., Chitteti, B. R., HogenEsch, H., Tu, X., Bellido, T. M., Boswell, H. S., Manshouri, T., Verstovsek, S., Yoder, M. C., Kapur, R., Cardoso, A. A., & Carlesso, N.
- Affiliations
- Indiana University Indianapolis (US)
- University of Notre Dame (US)
- Indiana University School of Medicine (US)
- Purdue University West Lafayette (US)
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Carlesso, Nadia
- ORCID
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 15
- Issue
- 1
- Pages
- 51-65
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC4398997
- OpenAlex
- W2002889467
- Cited by
- 186
- References
- 45
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 10 · 2023: 11 · 2022: 14 · 2021: 18 · 2020: 13 · 2019: 20 · 2018: 19 · 2017: 25 · 2016: 19 · 2015: 21 · 2014: 7
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Purdue University Indianapolis (Indiana University) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs (IK6 BX004596, I01 BX002104)
- Indiana University-Purdue University Indianapolis
- National Heart, Lung, and Blood Institute (HL-55716, R01HL068256, R01HL055716, T35HL110854)
- National Cancer Institute (R01CA134777, R01CA173852)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK090948, R01DK097837)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR059357)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Keywords
- miR-155, Notch signaling, bone marrow microenvironment, NF-κB, RBPJ, hematopoiesis, mesenchymal stem cells, inflammatory cytokines, inflammation and cancer, microRNA repression
- MeSH terms
- Animals, Bone Marrow, Cell Line, Hematopoiesis, Humans, Myeloproliferative Disorders, Signal Transduction, Up-Regulation, Gene Expression Regulation, Neoplastic, Cytokines, NF-kappa B, Mice, Knockout, Inflammation Mediators, Hematologic Neoplasms, MicroRNAs, Mice, Immunoglobulin J Recombination Signal Sequence-Binding Protein, Receptors, Notch, Stem Cell Niche, Epigenetic Repression
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