The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Glucose and Glutamine Metabolism Regulate Human Hematopoietic Stem Cell Lineage Specification
Open accessOverview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-McDermott, E. M., McGettrick, A. F., Goel, G., Frezza, C., Bernard, N. J., Kelly, B., Foley, N. H., et al. (2013) · Nature · doi:10.1038/nature11986 · Cited by 4,176
DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622
Gao, P., Tchernyshyov, I., Chang, T.-C., Lee, Y.-S., Kita, K., Ochi, T., Zeller, K. I., De Marzo, A. M., Van Eyk, J. E., Mendell, J. T., et al. (2009) · Nature · doi:10.1038/nature07823 · Cited by 2,124
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase
Selak, M. A., Armour, S. M., MacKenzie, E. D., Boulahbel, H., Watson, D. G., Mansfield, K. D., Pan, Y., Simon, M. C., Thompson, C. B., & Gottlieb, E. (2005) · Cancer Cell · doi:10.1016/j.ccr.2004.11.022 · Cited by 2,108 · cited 1×
“Nevertheless, it is only more recently that we have appreciated the importance of specific intermediates of these pathways in regulating both physiological and pathological cellular processes (Fendt et al., 2013; Lyssiotis et al., 2013; Selak et al., 2005; Son et al., 2013; Tannahill et al., 2013).”
BackgroundSelf-citationMichalek, R. D., Gerriets, V. A., Jacobs, S. R., Macintyre, A. N., MacIver, N. J., Mason, E. F., Sullivan, S. A., Nichols, A. G., & Rathmell, J. C. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003613 · Cited by 2,091
Wise, D. R., DeBerardinis, R. J., Mancuso, A., Sayed, N., Zhang, X.-Y., Pfeiffer, H. K., Nissim, I., Daikhin, E., Yudkoff, M., McMahon, S. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810199105 · Cited by 2,001
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
Son, J., Lyssiotis, C. A., Ying, H., Wang, X., Hua, S., Ligorio, M., Perera, R. M., Ferrone, C. R., Mullarky, E., Shyh-Chang, N., et al. (2013) · Nature · doi:10.1038/nature12040 · Cited by 1,990
Shi, L. Z., Wang, R., Huang, G., Vogel, P., Neale, G., Green, D. R., & Chi, H. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110278 · Cited by 1,803
Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
Nicklin, P., Bergman, P., Zhang, B., Triantafellow, E., Wang, H., Nyfeler, B., Yang, H., Hild, M., Kung, C., Wilson, C., et al. (2009) · Cell · doi:10.1016/j.cell.2008.11.044 · Cited by 1,798
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
Pearce, E. L., Walsh, M. C., Cejas, P. J., Harms, G. M., Shen, H., Wang, L.-S., Jones, R. G., & Choi, Y. (2009) · Nature · doi:10.1038/nature08097 · Cited by 1,559
Simsek, T., Kocabas, F., Zheng, J., DeBerardinis, R. J., Mahmoud, A. I., Olson, E. N., Schneider, J. W., Zhang, C. C., & Sadek, H. A. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.07.011 · Cited by 1,101
Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells
Le, A., Lane, A. N., Hamaker, M., Bose, S., Gouw, A., Barbi, J., Tsukamoto, T., Rojas, C. J., Slusher, B. S., Zhang, H., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.009 · Cited by 1,095
Tohyama, S., Hattori, F., Sano, M., Hishiki, T., Nagahata, Y., Matsuura, T., Hashimoto, H., Suzuki, T., Yamashita, H., Satoh, Y., et al. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2012.09.013 · Cited by 1,037
Sinclair, L. V., Rolf, J., Emslie, E., Shi, Y.-B., Taylor, P. M., & Cantrell, D. A. (2013) · Nature Immunology · doi:10.1038/ni.2556 · Cited by 930
Takubo, K., Nagamatsu, G., Kobayashi, C. I., Nakamura-Ishizu, A., Kobayashi, H., Ikeda, E., Goda, N., Rahimi, Y., Johnson, R. S., Soga, T., et al. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2012.10.011 · Cited by 806
A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance
Ito, K., Carracedo, A., Weiss, D., Arai, F., Ala, U., Avigan, D. E., Schafer, Z. T., Evans, R. M., Suda, T., Lee, C.-H., et al. (2012) · Nature Medicine · doi:10.1038/nm.2882 · Cited by 729
Amino acid transporters ASCT2 and LAT1 in cancer: Partners in crime?
Fuchs, B. C., & Bode, B. P. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.04.005 · Cited by 680
Regulation of Glutaminase Activity and Glutamine Metabolism
Curthoys, N. P., & Watford, M. (1995) · Annual Review of Nutrition · doi:10.1146/annurev.nu.15.070195.001025 · Cited by 664
Identification of a Hierarchy of Multipotent Hematopoietic Progenitors in Human Cord Blood
Majeti, R., Park, C. Y., & Weissman, I. L. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.10.001 · Cited by 602
SUBSTRATE SPECIFICITY OF BRAIN HEXOKINASE
Sols, A., & Crane, R. K. (1954) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)65384-0 · Cited by 597
Metabolic switching and fuel choice during T‐cell differentiation and memory development
van der Windt, G. J. W., & Pearce, E. L. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01150.x · Cited by 563
Chen, K., Liu, J., Heck, S., Chasis, J. A., An, X., & Mohandas, N. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909296106 · Cited by 524
Self-citationOncogenic K‐Ras decouples glucose and glutamine metabolism to support cancer cell growth
Gaglio, D., Metallo, C. M., Gameiro, P. A., Hiller, K., Danna, L. S., Balestrieri, C., Alberghina, L., Stephanopoulos, G., & Chiaradonna, F. (2011) · Molecular Systems Biology · doi:10.1038/msb.2011.56 · Cited by 492
Liu, W., Le, A., Hancock, C., Lane, A. N., Dang, C. V., Fan, T. W.-M., & Phang, J. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203244109 · Cited by 483
The Ubiquitous Glucose Transporter GLUT-1 Is a Receptor for HTLV
Manel, N., Kim, F. J., Kinet, S., Taylor, N., Sitbon, M., & Battini, J.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00881-x · Cited by 459
Self-citationKanai, Y., & Hediger, M. A. (2004) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/s00424-003-1146-4 · Cited by 450 · cited 2×
“Blocking Glutamine Utilization Abrogates the Erythroid Differentiation Potential of CD34 Progenitors and Promotes Myeloid Differentiation While ASCT2 transports glutamine, it also transports other neutral amino acids (Kanai and Hediger, 2004).”
BackgroundHalofuginone Inhibits T H 17 Cell Differentiation by Activating the Amino Acid Starvation Response
Sundrud, M. S., Koralov, S. B., Feuerer, M., Calado, D. P., Kozhaya, A. E., Rhule-Smith, A., Lefebvre, R. E., Unutmaz, D., Mazitschek, R., Waldner, H., et al. (2009) · Science · doi:10.1126/science.1172638 · Cited by 421
Moreadith, R. W., & Lehninger, A. L. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)82128-0 · Cited by 414
Hu, J., Liu, J., Xue, F., Halverson, G., Reid, M., Guo, A., Chen, L., Raza, A., Galili, N., Jaffray, J., et al. (2013) · Blood · doi:10.1182/blood-2013-01-476390 · Cited by 389
Self-citationWellen, K. E., Lu, C., Mancuso, A., Lemons, J. M. S., Ryczko, M., Dennis, J. W., Rabinowitz, J. D., Coller, H. A., & Thompson, C. B. (2010) · Genes & Development · doi:10.1101/gad.1985910 · Cited by 377
Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells
Fendt, S.-M., Bell, E. L., Keibler, M. A., Olenchock, B. A., Mayers, J. R., Wasylenko, T. M., Vokes, N. I., Guarente, L., Heiden, M. G. V., & Stephanopoulos, G. (2013) · Nature Communications · doi:10.1038/ncomms3236 · Cited by 364 · cited 1×
“Nevertheless, it is only more recently that we have appreciated the importance of specific intermediates of these pathways in regulating both physiological and pathological cellular processes (Fendt et al., 2013; Lyssiotis et al., 2013; Selak et al., 2005; Son et al., 2013; Tannahill et al., 2013).”
BackgroundYu, W.-M., Liu, X., Shen, J., Jovanovic, O., Pohl, E. E., Gerson, S. L., Finkel, T., Broxmeyer, H. E., & Qu, C.-K. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2012.11.022 · Cited by 341
Chen, J.-Q., & Russo, J. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.06.004 · Cited by 327
Erythrocyte Glut1 Triggers Dehydroascorbic Acid Uptake in Mammals Unable to Synthesize Vitamin C
Montel-Hagen, A., Kinet, S., Manel, N., Mongellaz, C., Prohaska, R., Battini, J.-L., Delaunay, J., Sitbon, M., & Taylor, N. (2008) · Cell · doi:10.1016/j.cell.2008.01.042 · Cited by 243
Self-citationControl of glutamine metabolism by the tumor suppressor Rb
Reynolds, M. R., Lane, A. N., Robertson, B., Kemp, S., Liu, Y., Hill, B. G., Dean, D. C., & Clem, B. F. (2014) · Oncogene · doi:10.1038/onc.2012.635 · Cited by 216
Miharada, K., Karlsson, G., Rehn, M., Rörby, E., Siva, K., Cammenga, J., & Karlsson, S. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.07.016 · Cited by 170
Glut1-mediated glucose transport regulates HIV infection
Loisel-Meyer, S., Swainson, L., Craveiro, M., Oburoglu, L., Mongellaz, C., Costa, C., Martinez, M., Cosset, F.-L., Battini, J.-L., Herzenberg, L. A., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121427109 · Cited by 162
Self-citationSandulache, V. C., Ow, T. J., Pickering, C. R., Frederick, M. J., Zhou, G., Fokt, I., Davis‐Malesevich, M., Priebe, W., & Myers, J. N. (2011) · Cancer · doi:10.1002/cncr.25868 · Cited by 146
Fuchs, B. C., Finger, R., Onan, M. C., & Bode, B. P. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00330.2006 · Cited by 137
Cytidine triphosphate synthetase. Covalent intermediates and mechanisms of action
Levitzki, A., & Koshland, D. E. (1971) · Biochemistry · doi:10.1021/bi00794a008 · Cited by 122
Montel‐Hagen, A., Blanc, L., Boyer-Clavel, M., Jacquet, C., Vidal, M., Sitbon, M., & Taylor, N. N. (2008) · Blood · doi:10.1182/blood-2008-05-159269 · Cited by 91
Self-citationPancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance
Lyssiotis, C. A., Son, J., Cantley, L. C., & Kimmelman, A. C. (2013) · Cell Cycle · doi:10.4161/cc.25307 · Cited by 83
Erythroid glucose transporters
Montel‐Hagen, A., Sitbon, M., & Taylor, N. N. (2009) · Current Opinion in Hematology · doi:10.1097/moh.0b013e328329905c · Cited by 73
Self-citationLaval, J., Touhami, J., Herzenberg, L. A., Conrad, C., Taylor, N. N., Battini, J., Sitbon, M., & Tirouvanziam, R. M. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1201755 · Cited by 67
Self-citationLeukemia cells demonstrate a different metabolic perturbation provoked by 2-deoxyglucose
Miwa, H., Shikami, M., Goto, M., Mizuno, S., Takahashi, M., Imai, N., Ishikawa, T., Mizutani, M., Horio, T., Gotou, M., et al. (2013) · Oncology Reports · doi:10.3892/or.2013.2299 · Cited by 41
Coordination of glucose and glutamine utilization by an expanded Myc network
Kaadige, M. R., Elgort, M., & Ayer, D. E. (2010) · Transcription · doi:10.4161/trns.1.1.12142 · Cited by 36
Age-dependent changes in uptake and recycling of ascorbic acid in erythrocytes of Beagle dogs
Ogawa, E. (2008) · Journal of Comparative Physiology B · doi:10.1007/s00360-008-0258-8 · Cited by 12
Response: Species Diversity in GLUT Expression and Function
Montel‐Hagen, A., Kinet, S., Manel, N., Mongellaz, C., Prohaska, R., Battini, J., Delaunay, J., Sitbon, M., & Taylor, N. N. (2009) · Cell · doi:10.1016/j.cell.2009.04.009 · Cited by 11
Self-citation
Cited by
Stem cells and the impact of ROS signaling
Bigarella, C. L., Liang, R., & Ghaffari, S. (2014) · Development · doi:10.1242/dev.107086 · Cited by 632
Ryall, J. G., Dell’Orso, S., Derfoul, A., Juan, A., Zare, H., Feng, X., Clermont, D., Koulnis, M., Gutierrez-Cruz, G., Fulco, M., et al. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2014.12.004 · Cited by 575
The evolving metabolic landscape of chromatin biology and epigenetics
Dai, Z., Ramesh, V., & Locasale, J. W. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-020-0270-8 · Cited by 494
Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?
Engelen, S. E., Robinson, A. J. B., Zurke, Y.-X., & Monaco, C. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00668-4 · Cited by 425
Jacque, N., Ronchetti, A. M., Larrue, C., Meunier, G., Birsen, R., Willems, L., Saland, E., Decroocq, J., Maciel, T. T., Lambert, M., et al. (2015) · Blood · doi:10.1182/blood-2015-01-621870 · Cited by 387
Metadata
- Authors
- Oburoglu, L., Tardito, S., Fritz, V., de Barros, S. C., Merida, P., Craveiro, M., Mamede, J., Cretenet, G., Mongellaz, C., An, X., Klysz, D., Touhami, J., Boyer-Clavel, M., Battini, J.-L., Dardalhon, V., Zimmermann, V. S., Mohandas, N., Gottlieb, E., Sitbon, M., Kinet, S., & Taylor, N.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 15
- Issue
- 2
- Pages
- 169-184
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2006938530
- Cited by
- 291
- References
- 49
- FWCI
- 10.82
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.