The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Tet3 and DNA Replication Mediate Demethylation of Both the Maternal and Paternal Genomes in Mouse Zygotes
Open accessAbstract
SUMMARY With the exception of imprinted genes and certain repeats, DNA methylation is globally erased during pre-implantation development. Recent studies have suggested that Tet3-mediated oxidation of 5-methylcytosine (5mC) and DNA replication-dependent dilution both contribute to global paternal DNA demethylation, but demethylation of the maternal genome occurs via replication. Here we present genome-scale DNA methylation maps for both the paternal and maternal genomes of Tet3-depleted and/or DNA replication-inhibited zygotes. In both genomes, we found that inhibition of DNA replication blocks DNA demethylation independently from Tet3 function, and that Tet3 facilitates DNA demethylation by coupling with DNA replication. For both genomes, our data indicate that replication-dependent dilution is the major contributor to demethylation, but Tet3 plays an important role, particularly at certain loci. Our study thus defines the respective functions of Tet3 and DNA replication in paternal DNA demethylation and reveals an unexpected contribution of Tet3 to demethylation of the maternal genome.
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Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
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Self-citationTet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA
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Epigenetics: A landscape takes shape
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Self-citationTET enzymes, TDG and the dynamics of DNA demethylation
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Self-citationDemethylation of the zygotic paternal genome
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Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions
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“It is generally accepted that maternal DNA demethylation is solely mediated by replication-dependent dilution (Seisenberger et al., 2013; Wu and Zhang, 2014).”
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Cited by
TET-mediated active DNA demethylation: mechanism, function and beyond
Wu, X., & Zhang, Y. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.33 · Cited by 1,661
Self-citationMechanisms regulating zygotic genome activation
Schulz, K. N., & Harrison, M. M. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-018-0087-x · Cited by 555
Regulation of transposable elements by DNA modifications
Deniz, Ö., Frost, J. M., & Branco, M. R. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0106-6 · Cited by 486
The maternal-to-zygotic transition revisited
Vastenhouw, N. L., Cao, W. X., & Lipshitz, H. D. (2019) · Development · doi:10.1242/dev.161471 · Cited by 445
Dynamics of the epigenetic landscape during the maternal-to-zygotic transition
Eckersley-Maslin, M. A., Alda-Catalinas, C., & Reik, W. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0008-z · Cited by 431
Metadata
- Authors
- Shen, L., Inoue, A., He, J., Liu, Y., Lu, F., & Zhang, Y.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 15
- Issue
- 4
- Pages
- 459-471
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2111323820
- Cited by
- 264
- References
- 38
- FWCI
- 11.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Shen, L., Inoue, A., He, J., Liu, Y., Lu, F., & Zhang, Y. (2014). Tet3 and DNA Replication Mediate Demethylation of Both the Maternal and Paternal Genomes in Mouse Zygotes. Cell Stem Cell. https://doi.org/10.1016/j.stem.2014.09.002
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