Cited by 374Neurogenesis and neuroplasticity mechanismsCancer-related molecular mechanisms researchDevelopmental Biology and Gene Regulation

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The Long Noncoding RNA Pnky Regulates Neuronal Differentiation of Embryonic and Postnatal Neural Stem Cells

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Ramos, Alexander D., Andersen, Rebecca E., Liu, Siyuan John, Nowakowski, Tomasz Jan, Hong, Sung Jun, Gertz, Caitlyn C., Salinas, Ryan D., Zarabi, Hosniya, Kriegstein, Arnold R., Lim, Daniel A.·2015·Cell stem cell

DOI 10.1016/j.stem.2015.02.007PMC PMC4388801

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Abstract

While thousands of long noncoding RNAs (lncRNAs) have been identified, few lncRNAs that control neural stem cell (NSC) behavior are known. Here, we identify Pinky (Pnky) as a neural-specific lncRNA that regulates neurogenesis from NSCs in the embryonic and postnatal brain. In postnatal NSCs, Pnky knockdown potentiates neuronal lineage commitment and expands the transit-amplifying cell population, increasing neuron production several-fold. Pnky is evolutionarily conserved and expressed in NSCs of the developing human brain. In the embryonic mouse cortex, Pnky knockdown increases neuronal differentiation and depletes the NSC population. Pnky interacts with the splicing regulator PTBP1, and PTBP1 knockdown also enhances neurogenesis. In NSCs, Pnky and PTBP1 regulate the expression and alternative splicing of a core set of transcripts that relates to the cellular phenotype. These data thus unveil Pnky as a conserved lncRNA that interacts with a key RNA processing factor and regulates neurogenesis from embryonic and postnatal NSC populations.

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890
Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation
Trapnell, C., Williams, B. A., Pertea, G., Mortazavi, A., Kwan, G., van Baren, M. J., Salzberg, S. L., Wold, B. J., & Pachter, L. (2010) · Nature Biotechnology · doi:10.1038/nbt.1621 · Cited by 15,556
TopHat: discovering splice junctions with RNA-Seq
Trapnell, C., Pachter, L. S., & Salzberg, S. L. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp120 · Cited by 11,682
Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs
Rinn, J. L., Kertesz, M., Wang, J. K., Squazzo, S. L., Xu, X. H., Brugmann, S. A., Goodnough, L. H., Helms, J. A., Farnham, P., Segal, E., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.022 · Cited by 4,246
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
Mikkelsen, T. S., Ku, M., Jaffe, D. B., Issac, B., Lieberman, E., Giannoukos, G., Alvarez, P., Brockman, W., Kim, T.-K., Koche, R. P., et al. (2007) · Nature · doi:10.1038/nature06008 · Cited by 4,129
Genome Regulation by Long Noncoding RNAs
Rinn, J. L., & Chang, H. Y. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-051410-092902 · Cited by 4,091
Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry
Elias, J. E., & Gygi, S. P. (2007) · Nature Methods · doi:10.1038/nmeth1019 · Cited by 3,925
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
CPC: assess the protein-coding potential of transcripts using sequence features and support vector machine
Kong, L., Zhang, Y., Ye, Z., Liu, X., Zhao, S.-Q., Wei, L., & Gao, G. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm391 · Cited by 2,773
A Model for Random Sampling and Estimation of Relative Protein Abundance in Shotgun Proteomics
Liu, H., Sadygov, R. G., & Yates, J. R. (2004) · Analytical Chemistry · doi:10.1021/ac0498563 · Cited by 2,534

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Choudhury, S. R., Dutta, S., Bhaduri, U., & Rao, M. R. S. (2021) · NAR Cancer · doi:10.1093/narcan/zcab042 · Cited by 12
Studies on the Regulatory Roles and Related Mechanisms of lncRNAs in the Nervous System
Zhou, Z., Qi, D., Gan, Q., Wang, F., Qin, B., Li, J., Wang, H., & Wang, D. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6657944 · Cited by 13
A long noncoding RNA LOC103690121 promotes hippocampus neuronal apoptosis in streptozotocin-induced type 1 diabetes
Hao, L., Li, Q., Zhao, X., Li, Y., & Zhang, C. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.03.006 · Cited by 13
LncRNA RUS shapes the gene expression program towards neurogenesis
Schneider, M. F., Müller, V., Müller, S. A., Lichtenthaler, S. F., Becker, P. B., & Scheuermann, J. C. (2022) · Life Science Alliance · doi:10.26508/lsa.202201504 · Cited by 13
Targeting HOTAIRM1 ameliorates glioblastoma by disrupting mitochondrial oxidative phosphorylation and serine metabolism
Han, W., Wang, S., Qi, Y., Wu, F., Tian, N., Qiang, B., & Peng, X. (2022) · iScience · doi:10.1016/j.isci.2022.104823 · Cited by 13
The lncRNA Pnky in the Brain
Cho, K., & Hsieh, J. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.03.015 · Cited by 13
The Role of Long Noncoding RNAs in Diabetic Alzheimer’s Disease
Kim, Y., & Song, J. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7110461 · Cited by 13
Knockdown of long noncoding RNA WNT5A-AS restores the fate of neural stem cells exposed to sevoflurane via inhibiting WNT5A/Ryk-ROS signaling
Lu, G., Zhao, W., Rao, D., Zhang, S., Zhou, M., & Xu, S. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109334 · Cited by 13
MBNL1 regulates isoproterenol‐induced myocardial remodelling in vitro and in vivo
Xu, Y., Liang, C., Luo, Y., & Zhang, T. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16177 · Cited by 13
The MIR155 host gene/microRNA-627/HMGB1/NF-κB loop modulates fibroblast proliferation and extracellular matrix deposition
Li, J., Zhang, X., Wang, T., Li, J., Su, Q., Zhong, C. F., Chen, Z., & Liang, Y. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119085 · Cited by 13
The emerging roles of long non-coding RNAs in the nervous system
Altaf, S., Cummins, M. J., Ittner, L. M., & Mattick, J. S. (2025) · Nature reviews. Neuroscience · doi:10.1038/s41583-025-00960-z · Cited by 18
Identifying cortical specific long noncoding RNAs modified by m6A RNA methylation in mouse brains
Nie, Y., Tian, G. G., Zhang, L., Lee, T., Zhang, Z., Li, J., & Sun, T. (2020) · Epigenetics · doi:10.1080/15592294.2020.1861170 · Cited by 12
Regulation of LncRNAs and microRNAs in neuronal development and disease
Xuan, C., Yang, E., Zhao, S., Xu, J., Li, P., Zhang, Y., Jiang, Z., & Ding, X. (2023) · PeerJ · doi:10.7717/peerj.15197 · Cited by 12
Critical regulation of a NDIME/MEF2C axis in embryonic stem cell neural differentiation and autism
Bai, M., Ye, D., Guo, X., Xi, J., Liu, N., Wu, Y., Jia, W., Wang, G., Chen, W., Li, G., et al. (2020) · EMBO Reports · doi:10.15252/embr.202050283 · Cited by 12
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Kuruş, M., Akbari, S., Eskier, D., Bursalı, A., Ergin, K., Erdal, E., & Karakülah, G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.727747 · Cited by 12
LINC01119 negatively regulates osteogenic differentiation of mesenchymal stem cells via the Wnt pathway by targeting FZD4
Gao, H., Dong, H., Zheng, J., Jiang, X., Gong, M., Hu, L., He, J., & Wang, Y. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02726-1 · Cited by 12
Long non-coding RNAs in schizophrenia: Genetic variations, treatment markers and potential targeted signaling pathways
Cao, T., Zhang, S., Chen, Q., Zeng, C., Wang, L., Jiao, S., Chen, H., Zhang, B., & Cai, H. (2023) · Schizophrenia Research · doi:10.1016/j.schres.2023.07.027 · Cited by 12
Long Noncoding RNAs: Emerging Players in Medulloblastoma
Laneve, P., Rea, J. N., & Caffarelli, E. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00067 · Cited by 12
lncRNA‑MIAT facilitates the differentiation of adipose‑derived mesenchymal stem cells into lymphatic endothelial cells via the miR‑495/Prox1 axis
Dai, X., Luo, W. L., & Lv, C. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.11962 · Cited by 11
LncRNA Rik-203 Contributes to Sevoflurane Induced Neurotoxicity?
Zhang, L., Xue, Z., Yan, J., & Jiang, H. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00353 · Cited by 11
Bone marrow mesenchymal stem cells with PTBP1 knockdown protect against cerebral ischemia-reperfusion injury by inhibiting ferroptosis via the JNK/P38 pathway in rats
Shan, H., Gao, L., Zhao, S., Dou, Z., & Pan, Y. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.09.038 · Cited by 10
Construction of a lncRNA-associated competing endogenous RNA regulatory network after traumatic brain injury in mouse
Wang, S., Sun, Y., Hu, S., Lou, C., & Pan, Y. (2022) · Molecular Brain · doi:10.1186/s13041-022-00925-8 · Cited by 10
ZMYND8 suppresses MAPT213 LncRNA transcription to promote neuronal differentiation
Adhikary, S., Singh, V., Choudhari, R., Yang, B. C., Adhikari, S., Ramos, E., Chaudhuri, S., Roy, S., Gadad, S. S., & Das, C. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05212-x · Cited by 10
Spatiotemporal expression profiling of long intervening noncoding RNAs in Caenorhabditis elegans
Liu, W., Yu, E., Chen, S., Ma, X., Lu, Y., & Liu, X. (2017) · Scientific Reports · doi:10.1038/s41598-017-05427-5 · Cited by 11
Long non-coding RNA LHX1-DT regulates cardiomyocyte differentiation through H2A.Z-mediated LHX1 transcriptional activation
Yu, Q., Cai, B., Zhang, Y., Xu, J., Liu, D., Han, Z., Han, Z., Ma, Y., Jiao, L., Gong, M., et al. (2023) · iScience · doi:10.1016/j.isci.2023.108051 · Cited by 9
Sex-specific role for the long noncoding RNA Pnky in mouse behavior
Saha, P., Andersen, R., Hong, S. J., Gil, E., Simms, J. A., Choi, H., & Lim, D. A. (2024) · Nature Communications · doi:10.1038/s41467-024-50851-7 · Cited by 7
Functional Perspective and Implications of Gene Expression by Noncoding RNAs
Yan, Z., Yan, X., & Xu, H. (2015) · Cancer translational medicine · doi:10.4103/2395-3977.163805 · Cited by 9
Expression profiling and functional annotation of noncoding genes across 11 distinct organs in rat development
Wen, Z., Chen, G., Zhu, S., Zhu, J., Li, B., Song, X., Li, S., Shi, L. M., Zheng, Y., & Li, M. (2016) · Scientific Reports · doi:10.1038/srep38575 · Cited by 8
Non-Syndromic Intellectual Disability and Its Pathways: A Long Noncoding RNA Perspective
de Barros, I. I., Leão, V., de Santis, J. O., Rosa, R. C. A., Brotto, D. B., Storti, C. B., Siena, Á. D. D., de Molfetta, G. A., & Silva, W. A. (2021) · Non-Coding RNA · doi:10.3390/ncrna7010022 · Cited by 9
Recent Advances in Noncoding RNAs
Tutar, L. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.98151 · Cited by 9
Regulation of neuronal-glial fate specification by long non-coding RNAs
Wang, L., Liu, Y., Sun, S., Lü, M., & Xia, Y. (2016) · Reviews in the Neurosciences · doi:10.1515/revneuro-2015-0061 · Cited by 9
Transcriptional and Genomic Targets of Neural Stem Cells for Functional Recovery after Hemorrhagic Stroke
Zhang, L., Tao, W., Feng, H., & Chen, Y. (2017) · Stem Cells International · doi:10.1155/2017/2412890 · Cited by 8
Role of mammalian long non-coding RNAs in normal and neuro oncological disorders
Singh, N. (2021) · Genomics · doi:10.1016/j.ygeno.2021.07.015 · Cited by 9
Analysis of lncRNA sequences: FAM3D-AS1, LINC01230, LINC01315 and LINC01468 in endometrial cancer
Bieńkiewicz, J., Romanowicz, H., Szymańska, B., Domańska-Senderowska, D., Wilczyński, M., Stepowicz, A., Malinowski, A., & Smolarz, B. (2022) · BMC Cancer · doi:10.1186/s12885-022-09426-2 · Cited by 9
Pan-cancer multi-omics analysis of PTBP1 reveals it as an inflammatory, progressive and prognostic marker in glioma
Zheng, Y., Zhong, Y., & Zhang, Z. (2024) · Scientific Reports · doi:10.1038/s41598-024-64979-5 · Cited by 8
Insights into the therapeutic strategies for aging and aging-associated diseases
Dong, R., Wu, Q., Kan, J., Fu, C., Sorrentino, V., Chow, A., Lei, Y., Wu, D., Xu, Z., Du, J., et al. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02662-z · Cited by 12
Post‐transcriptional regulation of gene expression in neural stem cells
Kim, D. (2016) · Cell Biochemistry and Function · doi:10.1002/cbf.3181 · Cited by 7
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Lee, Y., Lee, H., Kim, M., & Shin, H. (2020) · Biomolecules · doi:10.3390/biom10020313 · Cited by 9
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Szeto, R. A., Tran, T. H., Truong, J., Negraes, P. D., & Trujillo, C. A. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.09.004 · Cited by 8
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Ebrahimie, E., Rahimirad, S., Tahsili, M. R., & Dehcheshmeh, M. M. (2021) · World Journal of Stem Cells · doi:10.4252/wjsc.v13.i10.1394 · Cited by 8
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Prodromidou, K., & Matsas, R. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04063-7 · Cited by 11
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Shi, L., Han, X., Liu, C., Li, X., Lu, S., Jiang, Q. L., & Yao, J. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.836031 · Cited by 8
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Delgado, R. N., Lu, C., & Lim, D. A. (2016) · Neurogenesis · doi:10.1080/23262133.2016.1187321 · Cited by 8
Differential long non-coding RNA and mRNA expression in differentiated human glioblastoma stem cells
Li, H., Li, H., Hao, Y., Jiao, Y., Li, Z., Yue, H., Xu, Z., Wang, S., Cao, Y. B., & Zhao, J. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5505 · Cited by 8
Long Noncoding RNA: Function and Mechanism on Differentiation of Mesenchymal Stem Cells and Embryonic Stem Cells
Zhu, J., Wang, Y., Yu, W., Xia, K., Huang, Y., Wang, J., Liu, B., Tao, H., Liang, C., & Li, F. (2018) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x14666181127145809 · Cited by 8
LncRNAs in ocular neovascularizations
Cissé, Y. (2019) · International Journal of Ophthalmology · doi:10.18240/ijo.2019.12.19 · Cited by 8
The contributory role of long non-coding RNAs (lncRNAs) in head and neck cancers: Possible biomarkers and therapeutic targets?
Dilmaghani, N. A., Khoshsirat, S., Bavarsad, M. S., Pourbagheri‐Sigaroodi, A., & Bashash, D. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174053 · Cited by 8
N-terminal domain of polypyrimidine-tract binding protein is a dynamic folding platform for adaptive RNA recognition
Damberger, F. F., Krepl, M., Arora, R., Beusch, I., Maris, C., Dorn, G., Šponer, J., Ravindranathan, S., & Allain, F. H. ‐. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae713 · Cited by 7
Single-cell analyses reveal distinct expression patterns and roles of long non-coding RNAs during hESC differentiation into pancreatic progenitors
Luo, H., He, Q., Yang, W. C., He, F., Dong, J., Hu, C.-F., Yang, X., Li, F., & Li, F. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03259-x · Cited by 7
Long non‐coding RNA LncTUG1 regulates favourable compression force‐induced cementocytes mineralization via PU .1/ TLR4 / SphK1 signalling
Wang, H., Li, T., Jiang, Y., Chen, S., Wu, Z., Zeng, X., Yang, K., Duan, P., & Zou, S. (2024) · Cell Proliferation · doi:10.1111/cpr.13604 · Cited by 7
Stem Cell Implants: Emerging Innovation for Stroke Recovery.
Colliander, R., Alleman, K., Diaz, M. J., Jimenez, M. J. D., King, P., Mirpuri, P., Cutler, C. B., & Lucke-Wold, B. P. (2023) · PubMed · Cited by 7
Breast cancer stem cells programs: enter the (non)-code
Salvador, M. A., Birnbaum, D., Charafe‐Jauffret, E., & Ginestier, C. (2016) · Briefings in Functional Genomics · doi:10.1093/bfgp/elw003 · Cited by 7
Posttranscriptional and translational control of neurogenesis
Alsina, F. C., & Silver, D. L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814405-3.00028-x · Cited by 6
The landscape of long noncoding RNA expression in the goat brain
Varela-Martínez, E., Luigi‐Sierra, M. G., Guan, D., López‐Béjar, M., Casas‐Díaz, E., Olvera‐Maneu, S., Gardela, J., Palomo, M. J., Osuagwuh, U. I., Ohaneje, U. L., et al. (2024) · Journal of Dairy Science · doi:10.3168/jds.2023-23966 · Cited by 7
Long Non-Coding RNA Lacuna Regulates Neuronal Differentiation of Neural Stem Cells During Brain Development
Ninou, E., Michail, A., & Politis, P. K. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.726857 · Cited by 6
[Long non-coding RNAs and hypoxic-ischemic brain damage].
Zhao, F., & Qu, Y. (2016) · PubMed Central · doi:10.7499/j.issn.1008-8830.2016.11.025 · Cited by 6
Identification of a De Novo Xq26.2 Microduplication Encompassing FIRRE Gene in a Child with Intellectual Disability
Miolo, G., Bernardini, L., Capalbo, A., Favia, A., Goldoni, M., Pivetta, B., Tessitori, G., & Corona, G. (2020) · Diagnostics · doi:10.3390/diagnostics10121009 · Cited by 5
A KO mouse model for the lncRNA Lhx1os produces motor neuron alterations and locomotor impairment
Pellegrini, F., Padovano, V., Biscarini, S., Santini, T., Setti, A., Galfrè, S. G., Silenzi, V., Vitiello, E., Mariani, D., Nicoletti, C., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105891 · Cited by 5
Harnessing the potential of long non-coding RNAs in the pathophysiology of Alzheimer's disease
Kaur, R., Pandey, S., Gupta, S. K., & Singh, J. P. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.115134 · Cited by 5
LncRNAs Regulate Vasculogenic Mimicry in Human Cancers
Ibarra-Sierra, E., Bermúdez, M., Villegas‐Mercado, C. E., Silva-Cázares, M. B., & López‐Camarillo, C. (2025) · Cells · doi:10.3390/cells14080616 · Cited by 5
The lncRNA MYRACL regulates human oligodendrocyte maturation and myelination
Tsarouchas, T. M., Vacante, F., Kazakou, N.-L., Wagstaff, L. J., Bennett, M., Zoupi, L., Gibson, E. M., Baker, A. H., & Williams, A. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.08.011 · Cited by 5
The Role of Non-coding RNAs in Alzheimer’s Disease: Pathogenesis, Novel Biomarkers, and Potential Therapeutic Targets
Saleh, O. M., Albakri, K. A., Altiti, A., Abutair, I., Shalan, S. S., Mohd, O. B., Negida, A., Mushtaq, G., & Kamal, M. A. (2023) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527322666230519113201 · Cited by 5
Identification of PAX6 and NFAT4 as the Transcriptional Regulators of the Long Noncoding RNA Mrhl in Neuronal Progenitors
Pal, D., Dutta, S., Iyer, D. P., Shriram, D., Bhaduri, U., & Rao, M. R. S. (2022) · Molecular and Cellular Biology · doi:10.1128/mcb.00036-22 · Cited by 5
LncRNA PNKY Is Upregulated in Breast Cancer and Promotes Cell Proliferation and EMT in Breast Cancer Cells
Hakiminia, F., Alipoor, F. J., Keshavarz, M., & Asadi, M. H. (2023) · Non-Coding RNA · doi:10.3390/ncrna9020025 · Cited by 5
Characterization of SOD1-DT, a Divergent Long Non-Coding RNA in the Locus of the SOD1 Human Gene
Guerra, M., Meola, L., Lattante, S., Conte, A., Sabatelli, M., Sette, C., & Bernardini, C. (2023) · Cells · doi:10.3390/cells12162058 · Cited by 5
Haunting the HOXA Locus: Two Faces of lncRNA Regulation
Lin, N., Dang, J. W., & Rana, T. M. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.04.010 · Cited by 5
Pnky Modulates Neural Stem Cell Proliferation and Differentiation Through Activation of Wnt/β-Catenin Signaling Pathway
Wu, H., Huang, J. L., Li, X., Song, Y., Chen, X., & Guo, Y. (2025) · Organogenesis · doi:10.1080/15476278.2025.2519641 · Cited by 4
Epigenetics: major regulators of embryonic neurogenesis
Shen, T., Ji, F., & Jiao, J. (2015) · 中国科学通报：英文版 · doi:10.1007/s11434-015-0871-3 · Cited by 4
What has single-cell transcriptomics taught us about long non-coding RNAs in the ventricular-subventricular zone?
Becker, J., Sun, B., Alammari, F., Haerty, W., Vance, K. W., & Szele, F. G. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.11.011 · Cited by 4
Regulation and intervention of stem cell differentiation by long non-coding RNAs: Mechanisms and therapeutic potential
Li, Y., Yao, Y.-N., Zhou, S.-A., & Wang, Y. (2025) · World Journal of Stem Cells · doi:10.4252/wjsc.v17.i7.107688 · Cited by 4
Transcriptional and epigenetic insights from stem cells and developing tissues
Lim, D. A. (2015) · Development · doi:10.1242/dev.122424 · Cited by 4
Long Noncoding RNAs
Panda, S., Shiras, A., & Bapat, S. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-811022-5.00022-x · Cited by 4
Hypoxia promoted renal cell carcinoma cell migration through regulating lncRNA-ENST00000574654.1.
Che, J., Yao, X., Wang, C., Zheng, J., & Guo, C. (2020) · PubMed Central · Cited by 4
Long Noncoding RNAs: Critical Regulators for Cell Lineage Commitment in the Central Nervous System
Dong, X., Muppani, N. R., & Wu, J. (2015) · Translational bioinformatics · doi:10.1007/978-94-017-7450-5_3 · Cited by 4
SCAR-6 elncRNA locus epigenetically regulates PROZ and modulates coagulation and vascular function
Ranjan, G., Sehgal, P., Scaria, V., & Sivasubbu, S. (2024) · EMBO Reports · doi:10.1038/s44319-024-00272-w · Cited by 3
The Role of Long Non-Coding RNA in Anxiety Disorders: A Literature Review
López-Rocha, L. D., Ruíz-Hernández, A., Martínez-Coronilla, G., Leija-Montoya, A. G., Peña-Peña, M., Sánchez‐Muñoz, F., Campoy, U. R., & González-Ramírez, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115042 · Cited by 4
Heterogeneity of Neural Stem Cells in the Ventricular–Subventricular Zone
Rushing, G. V., Bollig, M. K., & Ihrie, R. A. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-24108-7_1 · Cited by 4
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Authors: Ramos, A. D., Andersen, R. E., Liu, S. J., Nowakowski, T. J., Hong, S. J., Gertz, C. C., Salinas, R. D., Zarabi, H., Kriegstein, A. R., & Lim, D. A.
Affiliations: University of California, San Francisco (US)
San Francisco VA Medical Center (US)
Corresponding author: Lim, Daniel A.
ORCID: Ramos, Alexander D.
Andersen, Rebecca E.
Liu, Siyuan John
Nowakowski, Tomasz Jan
Hong, Sung Jun
Salinas, Ryan D.
Kriegstein, Arnold R.
Lim, Daniel A.
Venue: Cell stem cell
Publisher: Elsevier BV
Published: 2015-04
Volume: 16
Issue: 4
Pages: 439-447
ISSN: 1875-9777 (ISSN-L)
1934-5909
DOI: 10.1016/j.stem.2015.02.007
PMC: PMC4388801
OpenAlex: W1981435333
Cited by: 359
References: 56
Citations by year: 2026: 13 · 2025: 15 · 2024: 21 · 2023: 35 · 2022: 35 · 2021: 46 · 2020: 43 · 2019: 37 · 2018: 29 · 2017: 37 · 2016: 33 · 2015: 14
FWCI: 15.27
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 367 d)
Locations: Cell stem cell (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: U.S. Department of Veterans Affairs (I01BX000252)
National Science Council
National Institutes of Health (1f31ns080501-01a1, 5f30ns092319-02, 1dp2od006505-01)
University of California, San Francisco
National Institute of General Medical Sciences (T32GM007618)
National Institute of Neurological Disorders and Stroke (R01NS035710, F30 NS092319, R01 NS35710, F31 NS080501, 1F31NS080501-01A1)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD007470)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: long non-coding RNA, neural stem cells, neurogenesis, neuronal differentiation, PTBP1, alternative splicing, transit amplifying cells, embryonic cortex, postnatal brain, RNA processing
MeSH terms: Animals, Base Sequence, Brain, Cells, Cultured, Embryo, Mammalian, Humans, Mice, Inbred C57BL, Molecular Sequence Data, Neurons, Alternative Splicing, Heterogeneous-Nuclear Ribonucleoproteins, RNA, Small Interfering, Polypyrimidine Tract-Binding Protein, Mice, Embryonic Stem Cells, Neurogenesis, Neural Stem Cells, RNA, Long Noncoding

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The Long Noncoding RNA Pnky Regulates Neuronal Differentiation of Embryonic and Postnatal Neural Stem Cells

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