Cited by 374Neurogenesis and neuroplasticity mechanismsCancer-related molecular mechanisms researchDevelopmental Biology and Gene Regulation

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The Long Noncoding RNA Pnky Regulates Neuronal Differentiation of Embryonic and Postnatal Neural Stem Cells

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Ramos, Alexander D., Andersen, Rebecca E., Liu, Siyuan John, Nowakowski, Tomasz Jan, Hong, Sung Jun, Gertz, Caitlyn C., Salinas, Ryan D., Zarabi, Hosniya, Kriegstein, Arnold R., Lim, Daniel A.·2015·Cell stem cell

DOI 10.1016/j.stem.2015.02.007PMC PMC4388801

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Abstract

While thousands of long noncoding RNAs (lncRNAs) have been identified, few lncRNAs that control neural stem cell (NSC) behavior are known. Here, we identify Pinky (Pnky) as a neural-specific lncRNA that regulates neurogenesis from NSCs in the embryonic and postnatal brain. In postnatal NSCs, Pnky knockdown potentiates neuronal lineage commitment and expands the transit-amplifying cell population, increasing neuron production several-fold. Pnky is evolutionarily conserved and expressed in NSCs of the developing human brain. In the embryonic mouse cortex, Pnky knockdown increases neuronal differentiation and depletes the NSC population. Pnky interacts with the splicing regulator PTBP1, and PTBP1 knockdown also enhances neurogenesis. In NSCs, Pnky and PTBP1 regulate the expression and alternative splicing of a core set of transcripts that relates to the cellular phenotype. These data thus unveil Pnky as a conserved lncRNA that interacts with a key RNA processing factor and regulates neurogenesis from embryonic and postnatal NSC populations.

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Additional file 5 of Single-cell analyses reveal distinct expression patterns and roles of long non-coding RNAs during hESC differentiation into pancreatic progenitors
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Additional file 9 of Single-cell analyses reveal distinct expression patterns and roles of long non-coding RNAs during hESC differentiation into pancreatic progenitors
Luo, H., He, Q., Yang, W., He, F., Dong, J., Hu, C.-F., Yang, X., Li, N., & Li, F. (2023) · Figshare · doi:10.6084/m9.figshare.22619012
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Additional file 4 of LINC01119 negatively regulates osteogenic differentiation of mesenchymal stem cells via the Wnt pathway by targeting FZD4
Gao, H., Dong, H., Zheng, J., Jiang, X., Gong, M., Hu, L., He, J., & Wang, Y. (2022) · Figshare · doi:10.6084/m9.figshare.19092643
Additional file 4 of Single-cell analyses reveal distinct expression patterns and roles of long non-coding RNAs during hESC differentiation into pancreatic progenitors
Luo, H., He, Q., Yang, W., He, F., Dong, J., Hu, C.-F., Yang, X., Li, N., & Li, F. (2023) · Figshare · doi:10.6084/m9.figshare.22618997
Additional file 3 of LINC01119 negatively regulates osteogenic differentiation of mesenchymal stem cells via the Wnt pathway by targeting FZD4
Gao, H., Dong, H., Zheng, J., Jiang, X., Gong, M., Hu, L., He, J., & Wang, Y. (2022) · Figshare · doi:10.6084/m9.figshare.19092640
Additional file 1 of Single-cell analyses reveal distinct expression patterns and roles of long non-coding RNAs during hESC differentiation into pancreatic progenitors
Luo, H., He, Q., Yang, W., He, F., Dong, J., Hu, C.-F., Yang, X., Li, N., & Li, F. (2023) · Figshare · doi:10.6084/m9.figshare.22618988
Additional file 3 of Single-cell analyses reveal distinct expression patterns and roles of long non-coding RNAs during hESC differentiation into pancreatic progenitors
Luo, H., He, Q., Yang, W., He, F., Dong, J., Hu, C.-F., Yang, X., Li, N., & Li, F. (2023) · Figshare · doi:10.6084/m9.figshare.22618994
Additional file 2 of Single-cell analyses reveal distinct expression patterns and roles of long non-coding RNAs during hESC differentiation into pancreatic progenitors
Luo, H., He, Q., Yang, W., He, F., Dong, J., Hu, C.-F., Yang, X., Li, N., & Li, F. (2023) · Figshare · doi:10.6084/m9.figshare.22618991
Additional file 8 of Single-cell analyses reveal distinct expression patterns and roles of long non-coding RNAs during hESC differentiation into pancreatic progenitors
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Additional file 7 of Single-cell analyses reveal distinct expression patterns and roles of long non-coding RNAs during hESC differentiation into pancreatic progenitors
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Additional file 15 of Single-cell analyses reveal distinct expression patterns and roles of long non-coding RNAs during hESC differentiation into pancreatic progenitors
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Additional file 17 of Single-cell analyses reveal distinct expression patterns and roles of long non-coding RNAs during hESC differentiation into pancreatic progenitors
Luo, H.-T., He, Q., Yang, W., He, F., Dong, J., Hu, C.-F., Yang, X., Li, N., & Li, F.-R. (2023) · Figshare · doi:10.6084/m9.figshare.22619039
Additional file 12 of Single-cell analyses reveal distinct expression patterns and roles of long non-coding RNAs during hESC differentiation into pancreatic progenitors
Luo, H.-T., He, Q., Yang, W., He, F., Dong, J., Hu, C.-F., Yang, X., Li, N., & Li, F.-R. (2023) · Figshare · doi:10.6084/m9.figshare.22619024
Additional file 13 of Single-cell analyses reveal distinct expression patterns and roles of long non-coding RNAs during hESC differentiation into pancreatic progenitors
Luo, H.-T., He, Q., Yang, W., He, F., Dong, J., Hu, C.-F., Yang, X., Li, N., & Li, F.-R. (2023) · Figshare · doi:10.6084/m9.figshare.22619027
Additional file 7 of LINC01119 negatively regulates osteogenic differentiation of mesenchymal stem cells via the Wnt pathway by targeting FZD4
Gao, H., Dong, H., Zheng, J., Jiang, X., Gong, M., Hu, L., He, J., & Wang, Y. (2022) · Figshare · doi:10.6084/m9.figshare.19092652
Additional file 11 of Single-cell analyses reveal distinct expression patterns and roles of long non-coding RNAs during hESC differentiation into pancreatic progenitors
Luo, H.-T., He, Q., Yang, W., He, F., Dong, J., Hu, C.-F., Yang, X.-F., Li, N., & Li, F.-R. (2023) · Figshare · doi:10.6084/m9.figshare.22619018
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Additional file 8 of LINC01119 negatively regulates osteogenic differentiation of mesenchymal stem cells via the Wnt pathway by targeting FZD4
Gao, H., Dong, H., Zheng, J., Jiang, X., Gong, M., Hu, L., He, J., & Wang, Y. (2022) · Figshare · doi:10.6084/m9.figshare.19092655
Additional file 6 of LINC01119 negatively regulates osteogenic differentiation of mesenchymal stem cells via the Wnt pathway by targeting FZD4
Gao, H., Dong, H., Zheng, J., Jiang, X., Gong, M., Hu, L., He, J., & Wang, Y. (2022) · Figshare · doi:10.6084/m9.figshare.19092649
Additional file 14 of Single-cell analyses reveal distinct expression patterns and roles of long non-coding RNAs during hESC differentiation into pancreatic progenitors
Luo, H.-T., He, Q., Yang, W., He, F., Dong, J., Hu, C.-F., Yang, X.-F., Li, N., & Li, F.-R. (2023) · Figshare · doi:10.6084/m9.figshare.22619030
Additional file 5 of LINC01119 negatively regulates osteogenic differentiation of mesenchymal stem cells via the Wnt pathway by targeting FZD4
Gao, H., Dong, H., Zheng, J., Jiang, X., Gong, M., Hu, L., He, J., & Wang, Y. (2022) · Figshare · doi:10.6084/m9.figshare.19092646
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Additional file 2 of lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization
Han, X., Guo, B., Zhao, S., Li, Y., Zhu, J., He, Y., Wang, J., Yao, Q., Shao, S., Zheng, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.24266076
Additional file 16 of Single-cell analyses reveal distinct expression patterns and roles of long non-coding RNAs during hESC differentiation into pancreatic progenitors
Luo, H.-T., He, Q., Yang, W., He, F., Dong, J., Hu, C.-F., Yang, X., Li, N., & Li, F.-R. (2023) · Figshare · doi:10.6084/m9.figshare.22619036
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Authors: Ramos, A. D., Andersen, R. E., Liu, S. J., Nowakowski, T. J., Hong, S. J., Gertz, C. C., Salinas, R. D., Zarabi, H., Kriegstein, A. R., & Lim, D. A.
Affiliations: University of California, San Francisco (US)
San Francisco VA Medical Center (US)
Corresponding author: Lim, Daniel A.
ORCID: Ramos, Alexander D.
Andersen, Rebecca E.
Liu, Siyuan John
Nowakowski, Tomasz Jan
Hong, Sung Jun
Salinas, Ryan D.
Kriegstein, Arnold R.
Lim, Daniel A.
Venue: Cell stem cell
Publisher: Elsevier BV
Published: 2015-04
Volume: 16
Issue: 4
Pages: 439-447
ISSN: 1875-9777 (ISSN-L)
1934-5909
DOI: 10.1016/j.stem.2015.02.007
PMC: PMC4388801
OpenAlex: W1981435333
Cited by: 359
References: 56
Citations by year: 2026: 13 · 2025: 15 · 2024: 21 · 2023: 35 · 2022: 35 · 2021: 46 · 2020: 43 · 2019: 37 · 2018: 29 · 2017: 37 · 2016: 33 · 2015: 14
FWCI: 15.27
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 367 d)
Locations: Cell stem cell (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: U.S. Department of Veterans Affairs (I01BX000252)
National Science Council
National Institutes of Health (1f31ns080501-01a1, 5f30ns092319-02, 1dp2od006505-01)
University of California, San Francisco
National Institute of General Medical Sciences (T32GM007618)
National Institute of Neurological Disorders and Stroke (R01NS035710, F30 NS092319, R01 NS35710, F31 NS080501, 1F31NS080501-01A1)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD007470)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: long non-coding RNA, neural stem cells, neurogenesis, neuronal differentiation, PTBP1, alternative splicing, transit amplifying cells, embryonic cortex, postnatal brain, RNA processing
MeSH terms: Animals, Base Sequence, Brain, Cells, Cultured, Embryo, Mammalian, Humans, Mice, Inbred C57BL, Molecular Sequence Data, Neurons, Alternative Splicing, Heterogeneous-Nuclear Ribonucleoproteins, RNA, Small Interfering, Polypyrimidine Tract-Binding Protein, Mice, Embryonic Stem Cells, Neurogenesis, Neural Stem Cells, RNA, Long Noncoding

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The Long Noncoding RNA Pnky Regulates Neuronal Differentiation of Embryonic and Postnatal Neural Stem Cells

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