Nowakowski, Tomasz J.

Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex

Nowakowski, T. J., Bhaduri, A., Pollen, A. A., Alvarado, B., Mostajo-Radji, M. A., Di Lullo, E., Haeussler, M., Sandoval-Espinosa, C., Liu, S. J., Velmeshev, D., et al. (2017) · Science

Neurogenesis and neuroplasticity mechanismsSingle-cell and spatial transcriptomics

Cited by 964

Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex

Pollen, A. A., Nowakowski, T. J., Shuga, J., Wang, X., Leyrat, A. A., Lui, J. H., Li, N., Szpankowski, L., Fowler, B., Chen, P., et al. (2014) · Nature Biotechnology

Single-cell and spatial transcriptomicsGenomics and Phylogenetic Studies

Cited by 920

Molecular Identity of Human Outer Radial Glia during Cortical Development

Pollen, A. A., Nowakowski, T. J., Chen, J., Retallack, H., Sandoval-Espinosa, C., Nicholas, C. R., Shuga, J., Liu, S. J., Oldham, M. C., Diaz, A., et al. (2015) · Cell

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 908

Cell stress in cortical organoids impairs molecular subtype specification

Bhaduri, A., Andrews, M. G., Mancia Leon, W., Jung, D., Shin, D., Allen, D., Jung, D., Schmunk, G., Haeussler, M., Salma, J., et al. (2020) · Nature

Neurogenesis and neuroplasticity mechanismsSingle-cell and spatial transcriptomics

Cited by 624

Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution

Pollen, A. A., Bhaduri, A., Andrews, M. G., Nowakowski, T. J., Meyerson, O. S., Mostajo-Radji, M. A., Di Lullo, E., Alvarado, B., Bedolli, M., Dougherty, M. L., et al. (2019) · Cell

Neurogenesis and neuroplasticity mechanismsPluripotent Stem Cells Research

Cited by 600

Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis

Fiddes, I. T., Lodewijk, G. A., Mooring, M., Bosworth, C. M., Ewing, A. D., Mantalas, G. L., Novak, A. M., van den Bout, A., Bishara, A., Rosenkrantz, J. L., et al. (2018) · Cell

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 595

Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia

Bershteyn, M., Nowakowski, T. J., Pollen, A. A., Di Lullo, E., Nene, A., Wynshaw-Boris, A., & Kriegstein, A. R. (2017) · Cell Stem Cell

Neurogenesis and neuroplasticity mechanismsPluripotent Stem Cells Research

Cited by 566

Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells

Nowakowski, T. J., Pollen, A. A., Di Lullo, E., Sandoval-Espinosa, C., Bershteyn, M., & Kriegstein, A. R. (2016) · Cell Stem Cell

Mosquito-borne diseases and controlNeurogenesis and neuroplasticity mechanisms

Cited by 529

Zika virus cell tropism in the developing human brain and inhibition by azithromycin

Retallack, H., Di Lullo, E., Arias, C., Knopp, K. A., Laurie, M. T., Sandoval-Espinosa, C., Mancia Leon, W. R., Krencik, R., Ullian, E. M., Spatazza, J., et al. (2016) · Proceedings of the National Academy of Sciences

Mosquito-borne diseases and controlVirology and Viral Diseases

Cited by 506

Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia

Eze, U. C., Bhaduri, A., Haeussler, M., Nowakowski, T. J., & Kriegstein, A. R. (2021) · Nature Neuroscience

Neurogenesis and neuroplasticity mechanismsSingle-cell and spatial transcriptomics

Cited by 427

Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma

Bhaduri, A., Di Lullo, E., Jung, D., Müller, S., Crouch, E. E., Espinosa, C. S., Ozawa, T., Alvarado, B., Spatazza, J., Cadwell, C. R., et al. (2020) · Cell Stem Cell

Glioma Diagnosis and TreatmentCancer Cells and Metastasis

Cited by 419

Development and arealization of the cerebral cortex

Cadwell, C. R., Bhaduri, A., Mostajo-Radji, M. A., Keefe, M. G., & Nowakowski, T. J. (2019) · Neuron

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 408

The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells

Ramos, A. D., Andersen, R. E., Liu, S. J., Nowakowski, T. J., Hong, S. J., Gertz, C. C., Salinas, R. D., Zarabi, H., Kriegstein, A. R., & Lim, D. A. (2015) · Cell stem cell

Neurogenesis and neuroplasticity mechanismsCancer-related molecular mechanisms research

Cited by 359

An analytical framework for whole-genome sequence association studies and its implications for autism spectrum disorder

Werling, D. M., Brand, H., An, J.-Y., Stone, M. R., Zhu, L., Glessner, J. T., Collins, R. L., Dong, S., Layer, R. M., Markenscoff-Papadimitriou, E., et al. (2018) · Nature Genetics

Autism Spectrum Disorder ResearchGenetic Associations and Epidemiology

Cited by 293

Single-cell analysis of prenatal and postnatal human cortical development

Velmeshev, D., Perez, Y., Yan, Z., Valencia, J. E., Castaneda-Castellanos, D. R., Wang, L., Schirmer, L., Mayer, S., Wick, B., Wang, S., et al. (2023) · Science

Single-cell and spatial transcriptomicsNeurogenesis and neuroplasticity mechanisms

Cited by 204

Type-I-interferon-responsive microglia shape cortical development and behavior

Escoubas, C. C., Dorman, L. C., Nguyen, P. T., Lagares-Linares, C., Nakajo, H., Anderson, S. R., Barron, J. J., Wade, S. D., Cuevas, B., Vainchtein, I. D., et al. (2024) · Cell

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 179

Radial glia require PDGFD-PDGFRβ signalling in human but not mouse neocortex

Lui, J. H., Nowakowski, T. J., Pollen, A. A., Javaherian, A., Kriegstein, A. R., & Oldham, M. C. (2014) · Nature

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 166

Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development

Nowakowski, T. J., Rani, N., Golkaram, M., Zhou, H. R., Alvarado, B., Huch, K., West, J. A., Leyrat, A., Pollen, A. A., Kriegstein, A. R., et al. (2018) · Nature Neuroscience

MicroRNA in disease regulationNeurogenesis and neuroplasticity mechanisms

Cited by 166

Tropism of SARS-CoV-2 for human cortical astrocytes

Andrews, M. G., Mukhtar, T., Eze, U. C., Simoneau, C. R., Ross, J., Parikshak, N., Wang, S., Zhou, L., Koontz, M., Velmeshev, D., et al. (2022) · Proceedings of the National Academy of Sciences

SARS-CoV-2 and COVID-19 ResearchLong-Term Effects of COVID-19

Cited by 159

Three-dimensional genome rewiring in loci with human accelerated regions

Keough, K. C., Whalen, S., Inoue, F., Przytycki, P. F., Fair, T., Deng, C., Steyert, M., Ryu, H., Lindblad-Toh, K., Karlsson, E., et al. (2023) · Science

Genomics and Chromatin DynamicsChromosomal and Genetic Variations

Cited by 113

The development and evolution of inhibitory neurons in primate cerebrum

Schmitz, M. T., Sandoval, K., Chen, C. P., Mostajo-Radji, M. A., Seeley, W. W., Nowakowski, T. J., Ye, C. J., Paredes, M. F., & Pollen, A. A. (2022) · Nature

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 111

Fate mapping of neural stem cell niches reveals distinct origins of human cortical astrocytes

Allen, D. E., Donohue, K. C., Cadwell, C. R., Shin, D., Keefe, M. G., Sohal, V. S., & Nowakowski, T. J. (2022) · Science

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 67

Optimal trade-off control in machine learning–based library design, with application to adeno-associated virus (AAV) for gene therapy

Zhu, D., Brookes, D. H., Busia, A., Carneiro, A., Fannjiang, C., Popova, G., Shin, D., Donohue, K. C., Lin, L. F., Miller, Z. M., et al. (2024) · Science Advances

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 63

CRISPRi-based screen of autism spectrum disorder risk genes in microglia uncovers roles of ADNP in microglia endocytosis and synaptic pruning

Teter, O. M., McQuade, A., Hagan, V., Liang, W., Dräger, N. M., Sattler, S. M., Holmes, B. B., Castillo, V. C., Papakis, V., Leng, K., et al. (2025) · Molecular Psychiatry

Neuroinflammation and Neurodegeneration MechanismsAutism Spectrum Disorder Research

Cited by 38