The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
Metabolic Reprogramming of Stem Cell Epigenetics
Open accessAbstract
Summary For many years, stem cell metabolism was viewed as a by product of cell fate status rather than an active regulatory mechanism, however there is now a growing appreciation that metabolic pathways influence epigenetic changes associated with lineage commitment, specification, and self-renewal. Here we review how metabolites generated during glycolytic and oxidative processes are utilized in enzymatic reactions leading to epigenetic modifications and transcriptional regulation. We discuss how “metabolic reprogramming” contributes to global epigenetic changes in the context of naïve and primed pluripotent states, somatic reprogramming, and hematopoietic and skeletal muscle tissue stem cells, and the implications for regenerative medicine.
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Cites
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Cited by
Metabolic Control of Longevity
López-Otín, C., Galluzzi, L., Freije, J. M. P., Madeo, F., & Kroemer, G. (2016) · Cell · doi:10.1016/j.cell.2016.07.031 · Cited by 753
The impact of cellular metabolism on chromatin dynamics and epigenetics
Reid, M. A., Dai, Z., & Locasale, J. W. (2017) · Nature Cell Biology · doi:10.1038/ncb3629 · Cited by 515
Dell'Orso, S., Juan, A. H., Ko, K.-D., Naz, F., Perovanovic, J., Gutierrez-Cruz, G., Feng, X., & Sartorelli, V. (2019) · Development · doi:10.1242/dev.174177 · Cited by 243
Self-citationLin, B., Coleman, J. H., Peterson, J. N., Zunitch, M. J., Jang, W., Herrick, D. B., & Schwob, J. E. (2017) · Cell Stem Cell · doi:10.1016/j.stem.2017.09.008 · Cited by 90
Metabolic regulation of tissue stem cells
Shapira, S. N., & Christofk, H. R. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.04.004 · Cited by 82
Metadata
- Authors
- Ryall, J. G., Cliff, T., Dalton, S., & Sartorelli, V.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 17
- Issue
- 6
- Pages
- 651-662
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2186508575
- Cited by
- 328
- References
- 122
- FWCI
- 8.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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