The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Paneth Cell Multipotency Induced by Notch Activation following Injury
Open accessAbstract
SUMMARY Paneth cells are post-mitotic intestinal epithelial cells supporting the stem cell niche and mucosal immunity. Paneth cell pathologies are observed in various gastrointestinal diseases, however their plasticity and response to genomic and environmental challenges remains unclear. Using a knock-in allele engineered at the mouse Lyz1 locus, we performed detailed Paneth cell-lineage tracing. Irradiation induced a subset of Paneth cells to proliferate and differentiate into villus epithelial cells. RNA-seq revealed that Paneth cells sorted from irradiated mice acquired a stem cell-like transcriptome; when cultured in vitro, these individual Paneth cells formed organoids. Irradiation activated Notch signaling, and forced expression of Notch intracellular domain (NICD) in Paneth cells, but not Wnt/beta-catenin pathway activation, induced their dedifferentiation. This study documents Paneth cell plasticity, particularly their ability to participate in epithelial replenishment following stem cell loss, adding to a growing body of knowledge detailing the molecular pathways controlling injury-induced regeneration.
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Cited by
Chen, B., Scurrah, C. R., McKinley, E. T., Simmons, A. J., Ramirez-Solano, M. A., Zhu, X., Markham, N. O., Heiser, C. N., Vega, P. N., Rolong, A., et al. (2021) · Cell · doi:10.1016/j.cell.2021.11.031 · Cited by 325
Ascl2-dependent cell dedifferentiation drives regeneration of ablated intestinal stem cells
Murata, K., Jadhav, U., Madha, S., van Es, J., Dean, J., Cavazza, A., Wucherpfennig, K., Michor, F., Clevers, H., & Shivdasani, R. A. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2019.12.011 · Cited by 264
Burclaff, J., Bliton, R. J., Breau, K. A., Ok, M. T., Gomez-Martinez, I., Ranek, J. S., Bhatt, A. P., Purvis, J. E., Woosley, J. T., & Magness, S. T. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.02.007 · Cited by 242
Shao, X., Yang, H., Zhuang, X., Liao, J., Yang, P., Cheng, J., Lu, X., Chen, H., & Fan, X. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab775 · Cited by 158
Establishment of intestinal organoid cultures modeling injury-associated epithelial regeneration
Qu, M., Xiong, L., Lyu, Y., Zhang, X., Shen, J., Guan, J., Chai, P., Lin, Z., Nie, B., Li, C., et al. (2021) · Cell Research · doi:10.1038/s41422-020-00453-x · Cited by 138
Metadata
- Authors
- Yu, S., Tong, K., Zhao, Y., Balasubramanian, I., Yap, G. S., Ferraris, R. P., Bonder, E. M., Verzi, M. P., & Gao, N.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2018-07
- Volume
- 23
- Issue
- 1
- Pages
- 46-59.e5
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2807022503
- Cited by
- 282
- References
- 73
- FWCI
- 16.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yu, S., Tong, K., Zhao, Y., Balasubramanian, I., Yap, G. S., Ferraris, R. P., Bonder, E. M., Verzi, M. P., & Gao, N. (2018). Paneth Cell Multipotency Induced by Notch Activation following Injury. Cell Stem Cell. https://doi.org/10.1016/j.stem.2018.05.002
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