The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Neocortical Expansion Due to Increased Proliferation of Basal Progenitors Is Linked to Changes in Their Morphology
Open accessAbstract
The evolutionary expansion of the mammalian neocortex (Ncx) is thought to be linked to increased proliferative capacity of basal progenitors (BPs) and their neurogenic capacity. Here, by quantifying BP morphology in the developing Ncx of mouse, ferret, and human, we show that increased BP proliferative capacity is linked to an increase in BP process number. We identify human membrane-bound PALMDELPHIN (PALMD-Caax) as an underlying factor, and we show that it drives BP process growth and proliferation when expressed in developing mouse and ferret Ncx. Conversely, CRISPR/Cas9-mediated disruption of PALMD or its binding partner ADDUCIN-γ in fetal human Ncx reduces BP process numbers and proliferation. We further show that PALMD-induced processes enable BPs to receive pro-proliferative integrin-dependent signals. These findings provide a link between BP morphology and proliferation, suggesting that changes in BP morphology may have contributed to the evolutionary expansion of the Ncx.
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OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling
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Satb2 Is a Postmitotic Determinant for Upper-Layer Neuron Specification in the Neocortex
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Self-citationFate mapping of neural stem cell niches reveals distinct origins of human cortical astrocytes
Allen, D. E., Donohue, K. C., Cadwell, C. R., Shin, D., Keefe, M. G., Sohal, V. S., & Nowakowski, T. J. (2022) · Science · doi:10.1126/science.abm5224 · Cited by 67
Assessment of radial glia in the frontal lobe of fetuses with Down syndrome
Baburamani, A. A., Vontell, R. T., Uus, A., Pietsch, M., Patkee, P. A., Wyatt-Ashmead, J., Chin-Smith, E. C., Supramaniam, V. G., Donald Tournier, J., Deprez, M., et al. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01015-3 · Cited by 29
Progenitor-Based Cell Biological Aspects of Neocortex Development and Evolution
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Metadata
- Authors
- Kalebic, N., Gilardi, C., Stepien, B., Wilsch-Bräuninger, M., Long, K. R., Namba, T., Florio, M., Langen, B., Lombardot, B., Shevchenko, A., Kilimann, M. W., Kawasaki, H., Wimberger, P., & Huttner, W. B.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 24
- Issue
- 4
- Pages
- 535-550.e9
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2924749043
- Cited by
- 159
- References
- 17
- FWCI
- 6.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kalebic, N., Gilardi, C., Stepien, B., Wilsch-Bräuninger, M., Long, K. R., Namba, T., Florio, M., Langen, B., Lombardot, B., Shevchenko, A., Kilimann, M. W., Kawasaki, H., Wimberger, P., & Huttner, W. B. (2019). Neocortical Expansion Due to Increased Proliferation of Basal Progenitors Is Linked to Changes in Their Morphology. Cell Stem Cell. https://doi.org/10.1016/j.stem.2019.02.017
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
