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Cited by 40Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Remyelination in the central nervous system

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Franklin, Robin J.M., Bodini, Benedetta, Goldman, Steven A.·2024·Cold Spring Harbor Perspectives in Biology
DOI 10.1101/cshperspect.a041371PMC PMC10910446
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Abstract

The inability of the mammalian central nervous system (CNS) to undergo spontaneous regeneration has long been regarded as a central tenet of neurobiology. However, while this is largely true of the neuronal elements of the adult mammalian CNS, save for discrete populations of granule neurons, the same is not true of its glial elements. In particular, the loss of oligodendrocytes, which results in demyelination, triggers a spontaneous and often highly efficient regenerative response, remyelination, in which new oligodendrocytes are generated and myelin sheaths are restored to denuded axons. Yet remyelination in humans is not without limitation, and a variety of demyelinating conditions are associated with sustained and disabling myelin loss. In this work, we will (1) review the biology of remyelination, including the cells and signals involved; (2) describe when remyelination occurs and when and why it fails, including the consequences of its failure; and (3) discuss approaches for therapeutically enhancing remyelination in demyelinating diseases of both children and adults, both by stimulating endogenous oligodendrocyte progenitor cells and by transplanting these cells into demyelinated brain.

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200 of 247 shown

Cited by

Sorted by citations

Authors
Franklin, R. J. M., Bodini, B., & Goldman, S. A.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • University of Copenhagen (DK)
ORCID
Venue
Cold Spring Harbor Perspectives in Biology
Publisher
Cold Spring Harbor Laboratory
Published
2024-02-05
Volume
16
Issue
3
Pages
a041371
ISSN
1943-0264 (ISSN-L)
DOI
10.1101/cshperspect.a041371
PMC
PMC10910446
OpenAlex
W4391528828
Cited by
40
References
30
Citations by year
2026: 16 · 2025: 16 · 2024: 8
Type
posted content
Language
en
Open access
Locations
  • Cold Spring Harbor Perspectives in Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
Funders
  • National Institute on Aging (R01AG072298)
  • National Institute of Neurological Disorders and Stroke (R01NS110776)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
remyelination, demyelination, oligodendrocytes, oligodendrocyte precursor cells, myelin sheath regeneration, demyelinating disease, cell transplantation, remyelination failure, central nervous system regeneration
MeSH terms
Remyelination, Adult, Animals, Central Nervous System, Child, Demyelinating Diseases, Humans, Mammals, Myelin Sheath, Nerve Regeneration

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