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Generation of Induced Progenitor-like Cells from Mature Epithelial Cells Using Interrupted Reprogramming

Guo, Li, Karoubi, Golnaz, Duchesneau, Pascal, Shutova, Maria V., Sung, Hoon-Ki, Tonge, Peter, Bear, Christine, Rogers, Ian, Nagy, Andras, Waddell, Thomas K.·2017·Stem Cell Reports
DOI 10.1016/j.stemcr.2017.10.022PMC PMC5785620
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  • Early transient events evoked by OSKM factors, such as somatic silencing and chromatin remodeling while reprogramming is initiated, seem to be required for both cellular rejuvenation and full reprogramming.

    “Despite these different contexts, 'early transient events' evoked by OSKM factors, such as somatic silencing and chromatin remodeling while reprogramming is initiated, seem to be required for both cellular rejuvenation and full reprogramming [74][75][76] .”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [75]

    The Introduction describes early OSKM-driven reprogramming, and the Results report temporary suppression of the Club-cell marker CCSP during induction. The paper does not establish chromatin remodeling or show that these early events are required for cellular rejuvenation and full reprogramming; the Discussion says the mechanism underlying its induced progenitor-like state remains to be clarified. The indexed copy provides section labels but no page numbers. (LLM, conf=0.84)

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  • Maturation phase partial reprogramming achieved more substantial rejuvenation than had been described before, at levels comparable to Guo et al.'s work in mice.

    “they achieved more substantial rejuvenation than had been described before at levels comparable to Guo et al.'s work in mice 74,75 .”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [75]

    The Discussion describes interrupted reprogramming of mature Club cells from mice into proliferating progenitor-like cells. It does not report a measure of rejuvenation or a level that could substantiate the claimed comparison; the Introduction describes the work as exploring early reprogramming states. No page numbers are available in our copy. (LLM, conf=0.80)

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  • Proliferative capacity was restored in induced progenitor-like cells and accompanied by a shift toward a transcriptionally intermediate state, characterized by minimal expression of embryonic stem cell-related genes and constitutive expression of tissue-specific profiles.

    “Proliferative capacity was restored and accompanied by a shift toward a transcriptionally intermediate state, characterized by a minimal expression of embryonic stem cell-related genes and the constitutive expression of tissue-specific profiles.”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [75]

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  • Expressing OSKM for 3 weeks in fully differentiated bronchiole secretory cells from 4F mice generated induced progenitor-like cells in vitro.

    “The authors generated 'induced progenitor-like cells' in vitro by expressing OSKM for 3 weeks in fully differentiated bronchiole secretory cells from 4F mice (Fig. 4a).”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [75]

  • Two weeks after DOX withdrawal, induced progenitor-like cells returned to their fully differentiated stage, preserving lineage commitment both in vitro and in vivo, as shown by repopulation of injured airway epithelium in vivo.

    “2 weeks after DOX withdrawal, cells returned to their fully differentiated stage by preserving their lineage commitment both in vitro and in vivo, as shown by their ability to repopulate injured airway epithelium in vivo 75 .”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [75]

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Metadata

Authors
Guo, L., Karoubi, G., Duchesneau, P., Shutova, M. V., Sung, H.-K., Tonge, P., Bear, C., Rogers, I., Nagy, A., & Waddell, T. K.
Venue
Stem Cell Reports
Publisher
Elsevier BV
Published
2017-12
Volume
9
Issue
6
Pages
1780-1795
ISSN
2213-6711
DOI
10.1016/j.stemcr.2017.10.022
PMC
PMC5785620
Cited by
33
References
5
Language
en
Licence
Funders
  • Astellas Clinical/Basic Research
  • Canadian Institute of Health Research (MOP-57885)
  • Ontario Research
  • CIHR Foundation (FDN-143231)

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