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The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Functional Genomics Reveals a BMP-Driven Mesenchymal-to-Epithelial Transition in the Initiation of Somatic Cell Reprogramming

Samavarchi-Tehrani, Payman, Golipour, Azadeh, David, Laurent, Sung, Hoon-ki, Beyer, Tobias A., Datti, Alessandro, Woltjen, Knut, Nagy, Andras, Wrana, Jeffrey L.·2010·Cell Stem Cell
DOI 10.1016/j.stem.2010.04.015
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Crossref · 10.1016/j.stem.2010.04.015

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  • Work in mice identified a maturation phase window during reprogramming where cells were most probable to experience rejuvenation without becoming iPS cells.

    “work in mice identified a window, known as the maturation phase, during reprogramming where cells were most probable to experience rejuvenation without crossing the threshold and become iPS cells 96 .”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [96]

    The Introduction and Discussion describe a mouse fibroblast reprogramming model and identify initiation, maturation, and stabilization phases. They do not identify maturation as a window in which rejuvenation is most likely without cells becoming iPSCs; a search for rejuvenation found no passage making that connection. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Reprogramming can be divided into three phases: IP, MP, SP.

    “Reprogramming can be divided into three phases: the initiation phase (IP) where somatic expression is repressed and a mesenchymal-to-epithelial transition occurs; the MP, where a subset of pluripotency genes becomes expressed; and the stabilization phase (SP), where the complete pluripotency program is activated (Samavarchi-Tehrani et al., 2010; Figure 1A).”

    From Multi-omic rejuvenation of human cells by maturation phase transient reprogramming (2022) · cites this paper as Samavarchi-Tehrani et al., 2010

  • Beyond the window between days 10 and 17, cells would enter the SP and endogenous pluripotency genes would become activated, preventing cessation of reprogramming by withdrawing doxycycline alone.

    “Beyond this window, cells would enter the SP and the endogenous pluripotency genes would become activated, preventing the cessation of reprogramming by withdrawing doxycycline alone (Samavarchi-Tehrani et al., 2010).”

    From Multi-omic rejuvenation of human cells by maturation phase transient reprogramming (2022) · cites this paper as Samavarchi-Tehrani et al., 2010

  • Cells transition from the mesenchymal-to-epithelial state that is actively induced during the early phase and is required to progress through the reprogramming process.

    “At this point, cells also transition from the mesenchymal-to-epithelial state that is actively induced during this early phase and are required to progress through the reprogramming process [94][95][96] .”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [96]

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Citations

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Research works printed but not linked: 34

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  12. Ichida, 2009, A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog, Cell Stem Cell, 5, 491, 10.1016/j.stem.2009.09.012 · DOI · Paper page
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  18. Mitsui, 2003, The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells, Cell, 113, 631, 10.1016/S0092-8674(03)00393-3 · DOI
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Metadata

Authors
Samavarchi-Tehrani, P., Golipour, A., David, L., Sung, H.-K., Beyer, T. A., Datti, A., Woltjen, K., Nagy, A., & Wrana, J. L.
Venue
Cell Stem Cell
Publisher
Elsevier BV
Published
2010-07
Volume
7
Issue
1
Pages
64-77
ISSN
1934-5909
DOI
10.1016/j.stem.2010.04.015
Cited by
943
References
4
Language
en
Licence

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